KEGG   PATHWAY: ppad04120
Entry
ppad04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Panthera pardus (leopard)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ppad04120  Ubiquitin mediated proteolysis
ppad04120

Other DBs
GO: 0016567
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109245111  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109245483  PARK2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
109245820  UBB; polyubiquitin-B [KO:K04551]
109246059  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
109246068  UBE2K; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
109246346  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
109246367  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
109246452  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
109246523  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
109246537  DDB1; DNA damage-binding protein 1 [KO:K10610]
109246571  [KO:K10580] [EC:2.3.2.23]
109246715  SYVN1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
109247336  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
109247481  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
109247632  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
109247817  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
109248140  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
109248280  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
109248333  [KO:K04506] [EC:2.3.2.27]
109249584  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
109249920  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
109250719  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
109250735  CUL4B; cullin-4B isoform X1 [KO:K10609]
109250767  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
109250790  KLHL13; kelch-like protein 13 isoform X1 [KO:K10447]
109250857  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
109250862  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
109251227  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
109251405  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
109251408  [KO:K20217] [EC:2.3.2.23]
109251620  UBA2; SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
109252035  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
109252119  CDC23; cell division cycle protein 23 homolog [KO:K03355]
109252147  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
109252156  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
109252438  UBE3C; ubiquitin-protein ligase E3C isoform X1 [KO:K10589] [EC:2.3.2.26]
109252474  [KO:K03872]
109253025  RFWD2; E3 ubiquitin-protein ligase RFWD2 isoform X1 [KO:K10143] [EC:2.3.2.27]
109253177  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
109253261  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
109253416  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
109254110  KEAP1; kelch-like ECH-associated protein 1 isoform X1 [KO:K10456]
109254231  FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
109254368  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
109254786  CDC20; cell division cycle protein 20 homolog isoform X1 [KO:K03363]
109255456  [KO:K02977]
109255974  FZR1; fizzy-related protein homolog [KO:K03364]
109255978  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
109256113  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
109256189  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
109256903  AIRE; autoimmune regulator [KO:K10603]
109257521  [KO:K16060]
109257526  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
109257736  CDC34; ubiquitin-conjugating enzyme E2 R1 isoform X1 [KO:K02207] [EC:2.3.2.23]
109258100  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
109258137  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
109258507  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
109258872  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
109259160  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
109259495  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
109259614  [KO:K09561] [EC:2.3.2.27]
109259623  [KO:K09561] [EC:2.3.2.27]
109259700  PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [KO:K10598] [EC:5.2.1.8]
109259714  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
109259738  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
109259931  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
109260099  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
109260138  [KO:K10595] [EC:2.3.2.26]
109260231  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
109260233  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
109260273  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
109260448  UBE2M; NEDD8-conjugating enzyme Ubc12 isoform X1 [KO:K10579] [EC:2.3.2.34]
109261310  KLHL9; kelch-like protein 9 [KO:K10447]
109262523  FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
109262632  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
109262710  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
109262788  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
109262874  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
109262946  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
109263403  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
109263464  [KO:K06689] [EC:2.3.2.23]
109264015  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
109264033  CUL4A; cullin-4A [KO:K10609]
109264296  RHOBTB1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
109264322  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
109264391  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
109264726  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
109264837  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
109264943  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
109264978  CUL3; cullin-3 isoform X1 [KO:K03869]
109265332  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
109265611  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
109266097  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
109266341  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
109266736  UBE2U; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
109267132  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
109267495  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
109267840  UBE2QL1; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
109268982  UBE2H; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
109269217  CUL1; cullin-1 isoform X1 [KO:K03347]
109269355  UBE2W; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109269357  ELOC; transcription elongation factor B polypeptide 1 isoform X1 [KO:K03872]
109269443  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
109269585  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
109269908  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
109269957  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
109270482  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
109270694  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
109270972  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
109271645  CUL7; cullin-7 [KO:K10613]
109271783  [KO:K03094]
109272360  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
109272538  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
109272793  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
109273410  DET1; DET1 homolog isoform X1 [KO:K10571]
109273874  FBXO2; F-box only protein 2 [KO:K10099]
109273918  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
109273942  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
109274087  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
109274776  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
109275670  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
109275752  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
109275859  FBXO4; F-box only protein 4 isoform X1 [KO:K10291]
109275882  [KO:K10580] [EC:2.3.2.23]
109276039  HERC3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
109276290  CUL2; cullin-2 [KO:K03870]
109276769  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
109276855  SOCS3; suppressor of cytokine signaling 3 isoform X1 [KO:K04696]
109277076  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
109277144  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme [KO:K10581] [EC:2.3.2.24]
109277334  RHOBTB2; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
109277470  UBE3B; ubiquitin-protein ligase E3B isoform X1 [KO:K10588] [EC:2.3.2.26]
109277581  FBXW8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
109277608  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
109277668  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
109277679  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
109278067  UBR5; E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
109278098  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
109278188  ELOB; transcription elongation factor B polypeptide 2 [KO:K03873]
109278269  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
109278280  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
109278321  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
109278523  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
109278558  UBE4A; ubiquitin conjugation factor E4 A isoform X1 [KO:K10596] [EC:2.3.2.27]
109278729  CUL5; cullin-5 [KO:K10612]
109279028  UBA3; NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
109279193  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
ppad03050  Proteasome
KO pathway
ko04120   

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