Pleuronectes platessa (European plaice): 128451115 Help Entry 128451115         CDS       T09923                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism pplt  Pleuronectes platessa (European plaice) Pathway pplt04020   Calcium signaling pathway pplt04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pplt00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128451115    04020 Calcium signaling pathway     128451115  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pplt04040]     128451115 Ion channels [BR:pplt04040]  Voltage-gated cation channels   Ryanodine receptor    128451115 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Ago_Mid Motif Other DBs NCBI-GeneID:  128451115 NCBI-ProteinID:  XP_053290862 LinkDB All DBs Position 11:15179085..15293961 Genome browser AA seq 4883 aa AA seqDB search MVIRFKWSLFNCGRRYESLEDDEVVLQCVACIQKENRKLCLAAEGLGNRLCYLEPTSEAK YVPPDLCICTFVLEQSLSVRALQEMLAKSGQNSEGAAQSGGHKTLLYGHAILLRHSFSSM YLACLKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSISNGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGHDEVVTIPG SDQSEERQRIVNYETGKAGAKARSLWRMEPLRISWSGSHIRWGQPYRLRHLTTGHYLALT DDRGLVLQDREKSDTVSTTFCFRASKAMQEKLEQSPKRDIEGMGVAEIKYGDSLCFITHV ATGLWLSYQAPDVKSARLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTLLF NRFISGPNRALVALPIEEVLQTLNDLITYFQLPDAELEHEERQIKLRSLKNRQNLFKQEG MLTLVSNCIDRLNVYNSAAHFGECAGCEAGVAWKDILNLLYELLAALIRGNRNNCTQFSY NLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDV LCSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQYKKW YYELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSFGFDGLHLW SGRIPRAVASLNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKRDADGVRDLLGT TQFMSQASFIPTPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIEIGWSYGKIRDDNKR QHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRVVQVNPNAEDSLKKLKLPKNYMMS NGYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNPRLV LYVLLDERTKKSNRDSLREAIRTLIGYGYNIDPSDQEGGQVAERLSIDRVRFFRVERTYS VKMGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGFRGHCLNMGSHLFGRC WHAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSLGLSQVGRM NLGKDASTFKYYTVCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPRDHNHIAVTRIDG TIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSFFKSSPVIDMNGLHEEDALKVKH RYPLRSVRHSEESRRVDYGTITMYHHSVRVFAGQDPAGVWVGWVTPDYHYYSNNFNLSKN RSVTVTLGDERGRVHESVKRSNCYMVWGGDVTSAAHTSSRSNVDLEVGCMIDLATGLVTF TVNGKEISTTYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNSMPLSSAIFKSEHKNPVP QCPPRLDVQTINAVLWSRMPNIFLKVETARVNERHGWVVQCVEPLQMLAVHIPEENRCVD IMELSEQEDMRMFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLAGMLRE GFYNVLISIHLETAKEARLMMKDEFIIPVTAETRSIRLFSDASKKHLPPGVGLSTSLKPR LNFAPPCFISNKREQHLYSPQIPLDALKEKSISMLTEAVQGGGHHIRDPVGGGVEYQFVP ILKLISTLLTMGVLVSEDVHKILLLVDPNVFRETHEEGVTGAADKEGIKGAEEKAVEAGE EEAAKEAKQPIKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSKLQYN QKFRYNELMLALNMSAAVTARKTKEFRSPPQEQINMLLTFSMGEDCPCPIGIQEELYVFH NQLQLHCGIPMEEEEDEKDTSFKGRLLMLVSRIKGQSHKAEEPTEKEQAAPSNLKELISQ TMVSWAQECHIQDPELVRKMFSLLRRQYDSIGELLRAMRKAYTISAVSVQDTINLLASLG QIRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGGDKS QEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAA SSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRF AVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDLPGS VQGFSSDVSADGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAIL RSLVPTEDLVGIISIPLKMPVVNKDVSVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSF LLHLLEVGFLLDLKAAASLDTEGLCTTETALAMNRYIGSAMLPLLTRCAPLFAGTEHHAS LLDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCKHLRPSMLQQLLHRLVFDVPLLTEYC KMPLRLLTNHYEQNWKYYCLPSGWGSYGTASEDELLLTKKIFWGVFDSLSQKKYDPELFK MAMPCLSAIAGALPPDYVDASISSTVEKPVSVDAQGNFDPKPINTANIALPEKLEHFANK YGEHSHEKWSAEKVLLGWKYGDCVDEKAKTHPQLRTYKALTEKEKEIYRWPIRESLKSML AMSWSIDRTKDGESMSLQRENEKMRKISQTSQANGFNPSPIDTSTVVLSRELQGMVEIVA ENYHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDFFRFLQINGYSITR GLKDLEQDSSSMEKRFAYRFLKKLLKYVDSAQEFISHLESMAANGKQDRSPHEQEIKFFA KVLLPLIDQYFKNHSLYFLSSPSRNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGS DSTTMVSCLHILAHTLDTRTVMKSGSEMVRVGLRTFFENAAEDLEKTFENLKLGKFTHSR SQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLYALGTGK NIYVERQLPALGHCLATLAGAMPVAFLEPMLNNYNPCSVFNTKSARERAILGIPDSVEDM CPGMPRLEGLIKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQPASGGSM CCTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARADLLKSHFLPTL EKLKKKTVKVVAEEELLKADSKGDTQEAELLILDEFAILCRDLYAFYPMLIRYVDNNRSR WLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDNKTKMSKSG GQDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYLLRETDD EVKDHIHQNLHLREKSEDPAVRWQLNLYKDIVMRSEGPPDPERVVDRIQRISAAVFNLEQ VEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLAYQRIWIETEEYS FEEKLVQDLATQPIVEEEEEEEVRKQPDPLHQLILHFSHNALTECSSLEEDPLYIAYADM MAKSCAEGEEEEEEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMISASKGRLGA MVTFTLKLGISILNGGNTVVQQKMLDYLKEKRDVGFFKSLSGLMMSCSVLDLNAFERQNK AEGLGMVTEEGSINVSERGSKVLQNDEFTQDLFRFLQLLCEGHNNDFQNFLRTQTGNTTT VNIIISTVDYLLRLQESISDFYWYYSGKDIIDEAGQRNFSQALAVAKQVFNSLTEYIQGP CIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMIVMMLSLLE GNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFREYDPESKGIISKKD FQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNVAVLLTNLSE HMPHDARLSTFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKE SKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDPVERTEEDEEDNQSVME NQEEEEEEEEDSMLESSSAFTIACISLKKSLCHFRQMLTLKSMRRRYRKFKKMSVKEMVR SFFSFFWMIITGLFHLVYSLIWGFFHILWTSMFGGGLVEGAKNMKVTDILGNMPDPTQFG IHGDVLETEKMEASEASALAQLGQMAQGEAAEADLMAELLNIQSKKEGKHGAEPGLGDVS EVVVGDAPSIASAVRQKKAQMAAKTSPLNGDYKSDSEKGDSEDGEKKDHDKSKDEGPPEP PAQEKKVPKKRLGPRKEPPEAFMASFFAGLEIYQTKMLNYLARNFYNLRFLALFVAFAIN FILLFYKVTGDYTDDEDPWNGQGRAGEEEDEGAVEYFVLQESTGYMAPTLRCLAILHTII SFLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVINTPSFPN NYWDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETVAKEASLVSWLSSIDTK YQVWKLGVVITDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNG KQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAG GGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDM ETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMY QERLWDFFPAGDCFRKQYEDQLG NT seq 14652 nt NT seq  +upstreamnt  +downstreamnt atggtaatcaggttcaagtggagtttatttaactgtggccgcagatatgagagtttggag gatgacgaagtggtgctccagtgcgtggcctgcatccagaaggagaaccgcaagctctgc ctggctgctgagggtctgggaaaccggctatgttatctggagcccacatctgaggcaaag tatgttcctccagacctgtgcatctgcacctttgtgctggagcagtctctgtcggtgcgg gccctgcaggagatgctggcgaagagcggacagaacagtgaaggggcagcgcagagtggc ggacacaagactctcctgtacggacatgccatcctcctgcgccattccttcagctctatg tacctggcctgtttgaagacatcaaggtcacagacggataagctgtcatttgatgtcggc ctgcaggaagattcaacaggtgaggcctgttggtggacaatccaccctgcctccaaacag agatccgaaggagagaaggtgcgcatcggcgatgatctcattctcgtcagcgtgtcctca gagcgatacctccacttatccatctccaatggcaacatccaggtggatgcctccttcatg caaaccctgtggaacgtccatcccatctgctctggcagcaacatagaggaaggctacctg ctgggtggtcatgtgatgcggctgttccatggacacgacgaggtcgtgaccatcccagga tcagaccagagtgaagagcggcaaaggatagtcaactatgagacgggtaaagctggtgcc aaggccaggtccttgtggaggatggagccactcagaatcagctggagcgggagccacatc cgctggggccagccttaccggctgcggcacctgaccaccggccactacctggcgctgact gacgacagggggttggtgctgcaggaccgggagaagtctgacaccgtctccacaaccttc tgcttcagagcctcaaaggcaatgcaggagaagctggagcagagccccaagcgggacatc gagggcatgggggtggcagagattaaatacggggactcgctctgcttcatcacgcacgtg gccacgggactctggctctcctatcaggcacctgatgtcaaatcggcccgtctgggtccc ctcaagagacgagcctgtctacattctgaaggtcacatggatgacggcttgaccctgcag cgatgtcaacacgaagagtcccgcgccgcacgcatcatccgcaacaccaccctcctcttc aaccgattcatcagtgggccaaacagggcactggtggccctgcccatagaggaggtgctc caaactctcaacgacctcatcacctacttccagctccccgacgccgagctggagcacgaa gagaggcagatcaagctgcgctcgctcaagaaccggcagaacctattcaaacaggaaggc atgctgactctggtgtccaattgtatcgaccgtctgaacgtgtacaatagtgccgcccac ttcggggagtgtgctgggtgcgaggccggtgtagcctggaaagacattctgaacctgctg tacgagctgctggcggcgttaatccgaggcaacaggaacaactgcacccagttctcctac aacttggactggctggtgagcaagctggagagactggagtcttcttcaggcatcctggaa gtcctgcactgcattctaattgagagccccgaggccctcaacatcatccagagaggacac atcaagtccatcatatcgctgctctacaagcacggacgcaaccacaagattctggacgtg ctgtgctcgctgtgtgtgtgtaacggcgtggctgtgcgaaccaatcagaatctcatctgt gatcacttgctgcccaagagagatctgctgctgcaaacccagctggtcaacgacgtccag agtatgaggccaaacatcttcctgggggtgagcgagggctccgcacagtataagaagtgg tactatgagctgatgatcgaccaggtggaccactttgtgaccagcgagccctcccacctg agagtgggctgggccaacactaaaggatatgctccctaccccggaggaggagagggctgg gggggcaacggagtgggagatgacctctactcatttgggtttgacggactccacctctgg tcaggtcgtatcccgcgggcggttgcgtccctgaaccagcacatcctgacctcagaggat gtggtgagctgttgcctggacctgggagcacccagcatctcgttcagaatcaatggacag cccgtccagggcatgtttgagaacttcaacacagacggcctcttcttccccgtcgtcagc ttctctgcaggggtcaaggtccgttttctgttgggtggtcgacacggcgactttaagttc ctgcctccgtcgagttacgctccgtgttacgaggctctgctgcccaaagagaagatgaag gtggagccggtgaaagagtacaagagggatgcggacggagtccgagatctgctgggcacc acccagttcatgtcacaggcctccttcatccccacccccgtggaaaccagccagatcgtg atgccgcctcacttggagaaggttcgggacaaactggctgagaacattcatgagctgtgg ggcatgaataagatcgagatcggctggtcatacggcaagataagagatgataataagcgg cagcatccgtgcctggtggatttctccaagctgccagaaacggaaaagaactacaatttg cagatgtcgacagaaacgttgaagaccctgctggcattgggctgtcgcgtagttcaggtg aatccaaatgctgaggactcgctcaagaagctaaaactccctaagaactatatgatgtcc aatggttataagccatctcctctggacctgtcagacatcaaactgactccaggtcaggag ctgctggtggacaaactggcagagaacgcgcacaatgtgtgggccaaggaccggatcaaa cagggatggacgtacggaattcagcaggatctgaagagtaagcgtaaccctcgcctggtt ctctacgttctgctggatgagcgcaccaagaagtcaaacagggacagcctgagggaggct atccgaactctaattggctacggatacaacattgacccctcggaccaggaaggaggacaa gtggctgagcggctcagcatcgacagggtccgcttcttccgagtggagaggacatactcc gtgaagatggggaaatggtactttgaatttgaggcggtgacgggaggagacatgagagtg ggctgggccagacccggatgtaagccggacgtggagcttggcacggatgagcttgcattc gtttttgatggattcaggggccattgtctgaacatgggcagtcatttgtttgggcggtgc tggcatgctggagacgtggtcggctgtatgatcaacatggaggacaagtccatgatcttc acccttaatggggaaatcctcatcaccaccaagggctcagaactctgcttcaccgacttt gaaacggaggatgggtttattccggtgtgtagtcttggtttatctcaggtgggtcgcatg aatctggggaaagatgccagcaccttcaagtactacaccgtgtgtggccttcaggaaggg tttgaacccttcgccgtcaacatgaacagagaggtcaccatgtggttcagcaagcggctg ccaacttttgtcaacgtgccgagggaccacaaccacattgcagtgaccaggattgacggc accatcgacagccccccgtgtcttaaagtgacccacaagacgtttggcacccagaacagt aacgctgacatggtgttctgtcgcctcagcatgcctgtagagttccactccttcttcaag tccagtcctgttatcgacatgaacggcttgcacgaggaagatgcgcttaaagtgaaacac aggtacccgttgcgatctgtgaggcacagtgaggaaagcagacgggtggactacggcacc atcaccatgtaccatcattcagtgagggtcttcgctggtcaggaccctgccggggtgtgg gttggatgggttacccccgactaccattactacagcaacaatttcaacctcagcaagaac agatcggtgactgtgaccctgggcgacgagcgagggcgagtccacgagagtgtgaagagg agtaactgctacatggtgtggggaggtgatgtcaccagtgccgctcacacctccagtcgc agcaacgtggacctggaagtgggttgtatgatcgacctggcaaccggcctggtgacgttc acagtcaatggcaaagagatttccacaacctaccaggtggagccgaacacaaagctcttc cctgctgtgtttgtgcgacccaccagcccgaacctcttccagtttgagctggctaaaata aagaattccatgcctctgtcatcggccatctttaagagtgaacacaagaacccggtgccc cagtgtccgccccgcctggacgtccagaccatcaacgcagtgctgtggagccgcatgccc aacatcttcctgaaggtggaaacggccagagtgaacgagcgacacggctgggtggtgcag tgtgtggagcccctgcagatgttggctgttcacatccccgaggagaaccggtgcgtggac atcatggagctgtctgagcaggaggacatgaggatgtttcactaccacaccctgaagctc tactgtgccctgtgcgctctgggcaacacccgcgtggcccacgccctctgcagccacctg gaccaatcccagctgctgtacaccatcgacaaccagtacctggcgggcatgttacgtgag ggcttctacaatgttctgatcagcatccacctggagaccgccaaggaagcccggctcatg atgaaggacgagttcatcatccccgtcacggccgagacgcgctccatccgtctgttttcc gacgcttccaaaaagcacctcccgccgggcgtggggctcagcacctcgctcaaaccacgc ctcaactttgccccgccctgtttcatcagcaacaagcgggagcagcatctgtacagtccc caaatcccgctggacgctctgaaggagaaatccatttccatgctgacggaggctgttcaa ggcggagggcaccacatccgagatcccgtgggagggggcgtggagtaccagtttgtgcca atcctgaagctcattagcaccctgctgacgatgggcgttctggtgagtgaggacgttcat aagatcctgctgctcgttgaccccaatgtgttccgggaaacacacgaggagggggtcaca ggggccgcagacaaagaaggaattaagggggcagaggagaaggcggtggaggctggagag gaggaggccgccaaagaggctaaacagccaatcaaagggctgctggagaagaggctgccg gagcccgtcaaacgacagatgtgcgagctgcttcactacttctgcgactgcgagctgaag caccgcatcgaggccatcgtgtcgttctccgacagctttgtctcgaagctgcagtacaac cagaagttccgctacaacgagctgatgctggccctcaacatgtctgccgctgtgacggcg aggaagaccaaggagttcaggtcgccccctcaagaacagatcaacatgctactgaccttc agtatgggcgaggactgtccgtgtccaatcggcatccaggaggagctttacgtttttcac aaccagctgcagctccactgtggaatccctatggaggaggaagaggacgagaaggataca tctttcaaaggtcgcctcctaatgctggtgagcaggattaaaggccagtcgcacaaagcg gaggagcccacggagaaggagcaagccgcaccatccaatctgaaggagctgatctctcag acgatggtcagctgggcccaggagtgtcacatccaggaccccgagctcgtccgtaagatg ttcagcctgctgaggaggcagtacgacagcattggtgagctgctccgggccatgaggaag gcctacaccatcagcgctgtgtctgtgcaggacaccatcaacctcctggcctccctgggg cagatcagatctctgctgtctgttcgcatggggaaagaagaggagaagctcatgattgac ggactcggcgacatcatgaacaacaaggtgttctaccagcaccctaacctaatgaggatc ctgggcatgcatgagactgtcatggaggtcatggtcaatgtgctcggaggagacaaatcc caggaaattgccttccccaagatggtggccagctgttgtcgcttcctgtgctacttctgc cggatcagccgtcagaaccagaaggccatgttcgaccacctcagttacctgctggagaac agcagcgtgggcctagcctccccagccatgaggggctccactcctctcgatgtggctgct tcctccgtgatggacaacaacggcctggctctggcactggaggaacctgatctagacaag gtggtcacctacctcgctggatgtggtctccagagttgcccaatgcttctggctaaaggt tatccagacataggttggaaccccatagaaggagaacgctacctttccttcttgcggttt gccgtcttcgtcaatggtgagagtgtggaggagaactccagtgtcgtggtaaagctgctc atccgtcgccccgagtgtttcggaccggccctgaggggagagggagggaacggcctgttg gcggccatgaaggaagccatcaagatctccgagacgccggcgttggacctgccgggctcc gtccagggattcagctctgacgtatctgccgacggggatgacgaggaagaagttgttcac atgggaaacgccattatgtccttctactctgcgcttattgatcttctgggacgttgcgcc ccagaaatgcatctcatcaacaaggggaaaggtgaagctctgcgtatccgtgcaatcctg cgctctctggtgccaacagaggacctcgttggaattatcagcatacccctcaaaatgcct gtcgtcaacaaagacgtatcggtgacggagcccgacatgtcggcctgcttttgtccggac cacaaggcccccatggtgctgtttctggacagggtgtacggtattgaggaccagagcttt ttgcttcacctgcttgaagtgggctttctgctcgacctgaaggctgcggcctctctggat acggaggggctgtgcaccacggagacggccctggccatgaaccgctacatcggctctgcc atgctgcccctcctcacccgctgtgccccgctcttcgccggcacggagcaccacgccagc ctcctcgactccaccctccacaccatctaccgcctctccaagggccgctcgctcaccaag gcccagagagatgccatagaggagtgtctgctggctgtctgcaaacacctccgtccctcg atgctgcagcagctcctgcaccgcctcgtctttgacgtgcccttgctgacggaatactgc aagatgccgctcaggctgctgaccaaccactatgagcagaactggaagtactactgcctc ccgtcgggctggggcagctacggcaccgcatctgaggatgaactgctgctcaccaagaaa atcttctggggagtgtttgattctctgtcacagaagaaatatgacccggagctgtttaag atggccatgccttgcctcagtgccatagctggagctttgccaccagactatgttgatgcc tccattagttcgactgtggaaaagcctgtttcggtggatgctcagggcaactttgacccc aaacccatcaatactgctaacattgctctcccggagaagctcgagcactttgccaacaaa tacggcgagcactctcatgagaaatggtctgcagagaaggtgctgctgggatggaaatac ggagactgtgtcgatgagaaggccaagactcatcctcagcttaggacctacaaagctcta acagagaaggagaaggagatttacagatggccaatcagagagtccctgaagagcatgctg gcaatgagctggagcatcgacaggaccaaggatggagagagcatgtctctgcagagggag aacgagaaaatgagaaagatatctcagacctcacaggcaaatgggttcaatccgagcccg atagacaccagcaccgtggttctatccagggagctgcaggggatggtggagatagtggct gaaaattaccataacatctgggccaaaaagaagaaaagtgaccttggaagcagaggtggg ggaacacaccctctgctggtgccctacgacacgctgacagccaaggagaaggcgcgtgat cgagagaaggctcaggacttttttcgcttcctgcaaatcaatggctacagcatcacaaga ggattgaaggacctggagcaggattcttcgtccatggagaagaggttcgcctatcgcttc ctcaagaagctgctcaagtatgtcgactcagcgcaggagttcatctcccatctagagtcc atggctgccaatggaaaacaagacaggtcccctcatgaacaagaaatcaagttttttgcc aaagttctactccccctcatcgaccagtacttcaagaaccactcgctctacttcctctcc tcccctagtaggaacctgagcagcagcggctacgcctccaacaaggagaaggagatggtc accagcctgttttgtaaactggcagctcttgtcagacataggatttcactctttgggagc gactccaccaccatggtgagctgtctgcacatcctggcgcacactctggacaccaggacg gtgatgaagtcgggctcagagatggtgcgggtcggcttgaggacgttcttcgagaacgcc gcagaggacctggagaagacgttcgagaacctgaagctggggaagttcacgcactcccgc tcgcagatgaaaggggtgtcgcagaacatcaactacaccaccgtggctctgctccccatc ctcacggctctgttcgagcacatcacccagcaccactttggagtggacctgctgttggat gatgtccaagtgtcctgctatcgaatcctcaccagcctctatgcactgggcactggaaaa aacatctacgtagaaagacagctgcctgctctcggtcactgtctggccaccctggctggg gccatgcctgtggccttcttggagcctatgctcaacaattacaacccctgctcggttttt aataccaagagtgcccgagaacgagccatcttaggtataccagactcggtggaggatatg tgtcccgggatgccgcggctggaaggcctgataaaggacatcaatgacatggctgagtcg ggggcgcggtacacagagatgcctcacgtcatcgaggtggtgctgcccatgctctgcaac tatctgtcctactggtgggagaggggccccgagaatcagccggccagtgggggcagtatg tgttgcaccaccgtcacctcggagcacctcagcctcatcctgggcaacatcctcaagatc ctcaacaacaatctgggcatagatgaggcctcgtggatgaagaggatcgcagtgtacgtg cagcccatcatcagcaaggcccgtgctgacctgctgaagagccacttcctgcccacgctg gagaagctgaagaagaagacggtgaaggtggtggctgaggaggagctgctgaaggccgac agtaagggagacacccaggaggccgagctgctcatcctggacgagtttgccatcctctgc agggacctgtacgccttctaccccatgctcatccgctacgtggacaacaacaggtccagg tggctgaaagaaccagacgctgactccaatgagctgttcagaatggtggctgagattttc atcctctggtgcaagtcacataatttcaaaagagaggagcagaactttgtggttcagaat gaaattaacaacctttccttcttgactggagataataaaacaaagatgtcaaagtctgga ggacaagaccaggagaggaaacataagaaaaggcgaggtgagttctattctatccaaacc tcgctgatcgtagctgctttgaagaagatgctgccaatcggcctcaacatgtgcacaccg ggggaccaggagctcatatctctggccaagactcgctacctcctgagagagacagatgat gaggtcaaagaccacatccatcagaatctgcatctcagagaaaagtcggaggaccctgca gtgaggtggcagctaaacctctacaaggatatagtgatgaggagcgaggggcctccggac cctgagagggtggtggaccggatccagaggatctctgctgcggtcttcaacctggagcag gtggagcagcccctgagatccaaaaagtgtgtttggcagaagctgctgtccaagcagagg aagcgagcggttgtggcctgcttccgcatggctccactctataatctaccaaggcatcgc tctattaacctcttcctcctggcctatcagagaatatggatagaaacagaggagtactcc tttgaggagaagctagtgcaggatcttgcaacgcagcccattgtggaggaagaggaagag gaggaggttagaaaacaaccggacccacttcaccagctcattctgcatttcagccacaac gctctgactgagtgcagttctttggaagaagaccccctgtatattgcatatgcagatatg atggcaaagagttgtgcggaaggtgaagaagaagaagaggaggaaggaaaagaaaaaaca tttgaggaaaaggaaatggagaagcagaagatgctttatcagcaggccagactccatgat cgaggggctgcagagatggtgctgcagatgatcagtgccagtaaaggtcgacttggtgct atggtgacattcaccctcaagctgggcatctccattctgaacggggggaacacagtggtc cagcagaaaatgctcgactacctgaaggaaaaaagagatgttggctttttcaaaagtttg tctggactgatgatgtcttgcagtgttctggacttgaatgcttttgaaaggcaaaacaaa gctgaaggtctggggatggttactgaagaaggatcaatcaacgtgagtgagcggggttcc aaggttctgcagaacgatgagttcactcaggacctctttaggtttctgcagcttctctgt gagggccacaacaatgattttcagaacttcctgagaactcagacagggaacacaactaca gtcaacatcatcatcagcactgtggactacctcctcagactccaggaatccatcagtgat ttctactggtactactctggtaaggacatcatcgacgaggccggtcagaggaacttctcc caagctctggcagtggccaaacaagtcttcaactcattaactgagtatatacagggtccg tgcatcgggaaccagcagagtctggcccacagcagactgtgggacgctgtggtgggattc ctgcacgtgtttgccaatatgcagatgaagctatcacaggactccagtcagattgaatta ctgaaggagctgctggacctgcagaaggacatgatcgttatgatgctgtctctactcgaa ggtaacgttgtcaatggcaccatcggcaaacaaatggtggacactttagtggaatcttcc agcaatgtggagatgatcctgaaattcttcgatatgttcctcaagttgaaggacttgacc acgtccgacagcttcagggagtacgaccctgagagcaaagggatcatctcaaagaaggat ttccagaagtccatggagaaccagaagcagtactcccagtctgagatcgagttcctcctc tcgtgtgccgaggcggacgagaacgacatgttcaactacgagcagtttgtggagaggttt cacgaacccgccaaagacattggctttaatgtagccgtgctgctgaccaatctctctgag cacatgcctcacgacgctcgcctctcaacgttcctcgacctggcagagagcgttctcagc tacttcgaaccttatctgggtcgcatcgagatcatggggggagccaagcgcatcgagaga gtctacttcgagatcagcgagtcgagtcgtacccagtgggaaaagcctcaggtgaaggag tccaagcgacagtttatctttgatgtcgtcaatgaaggcggcgagagcgagaagatggaa ctgtttgttaacttctgtgaggacaccatctttgagatgcagctggcttctcaaatttca gagcccgacccggtggagcgaacggaggaagatgaggaagacaaccagagtgtcatggag aaccaggaggaggaggaggaggaggaggaggacagcatgttagagtcttcatctgccttc acaattgcctgcatctctttgaaaaaaagcctctgtcacttccgccaaatgctaacactg aagagcatgaggcggcggtacaggaaattcaagaagatgagcgtgaaggagatggtgcgc agcttcttctccttcttctggatgatcatcactggactcttccacttggtctacagcctg atttggggtttcttccacatcttgtggaccagcatgtttggcggtggtctcgttgaaggg gctaagaatatgaaggtgacagacattttgggcaacatgccggaccccacccagtttggc atccatggagacgttttggagacagagaagatggaggcgagcgaagcgtcagcgttggcg cagctgggtcagatggctcagggggaagcggcggaggcagacctgatggccgagctcctg aacatacagtccaaaaaggaggggaagcacggggctgagccggggctgggggatgtgtct gaggtggtggtgggggacgctccatccatcgccagtgctgtcaggcagaagaaagcacag atggcagcgaagacgagtcctttgaatggagactacaaatccgattcagagaaaggagac tcggaagatggggaaaagaaggaccatgacaagtccaaagatgaaggtcctccagagccc cccgcacaggagaagaaagtcccgaagaaaaggctcggcccgagaaaagaaccaccagag gccttcatggccagcttcttcgctggcctggaaatctaccagaccaagatgctgaactac cttgcccgaaacttctacaacctccgcttcctggcactttttgtcgcctttgccatcaac ttcattctgctcttctacaaagtaaccggtgattacacagacgatgaagacccctggaat ggtcaaggtagagccggcgaggaggaagatgaaggggcggttgagtacttcgtcctgcag gagagcacaggctacatggcgccaacgcttcgctgtctggcaatactacacaccatcata tctttcctgtgtgtagtgggatactactatctgaaggttccgctggtggtgttcaaacgg gagaaggagatagcgaggaagctggagttcgccggcctctacatcacggagcagccgtct gatgatgacattaaagggcagtgggaccgactggtcattaatacaccttcattcccaaac aactactgggataaatttgtcaaacggaaagtgatcaaaaagtacggagacctgtacgga gcggagcggatagcagagctgctgggtttagataaaagtgccctggatttcaacccgaca gaggaaactgttgccaaggaggcttcgctggtgtcatggttgagctcaatcgataccaag taccaagtgtggaaattgggagtggtgatcacagacaactcattcctgtatctagtgtgg tacaccaccatgtccattctgggccactacaacaacttcttcttcgccgctcatctcctg gacatcgccatgggcttcaagaccctccgcaccatcctgtcctctgtcacgcacaacggc aaacagctggtgttgacggtgggcctgctggcagtggtggtctacctctacactgtggtg gccttcaacttcttcagaaagttctacaacaagagcgaggacgaggacgagccggacatg aagtgtgatgacatgatgacgtgctacctgttccacatgtacgttggggtgagggccggc gggggcatcggggacgagatcgaggacccggcgggtgacccttatgagctctaccgcatc ctcttcgacatcaccttcttcttcttcgtcatcgtcatcctgctggccatcatccagggt ctgatcatcgatgcctttggcgagctgagggaccaacaggaacaagtgaaagaggacatg gagaccaaatgcttcatatgtgggatcggtaacgattacttcgacacgacgccgcatgga tttgagactcacaccttacaagagcacaacttggcaaactacctgtttttcttgatgtac cttatcaacaaggacgagacagagcacaccggtcaggagtcatatgtgtggaagatgtac caggagcggttgtgggatttcttcccagctggcgattgcttccgcaaacagtacgaagat cagctcgggtag

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