KEGG   PATHWAY: ppsc03440
Entry
ppsc03440                   Pathway                                

Name
Homologous recombination - Paenibacillus psychroresistens
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ppsc03440  Homologous recombination
ppsc03440

Other DBs
GO: 0000724
Organism
Paenibacillus psychroresistens [GN:ppsc]
Gene
EHS13_11300  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
EHS13_35910  ssb; single-stranded DNA-binding protein [KO:K03111]
EHS13_00020  recF; DNA replication/repair protein RecF [KO:K03629]
EHS13_12985  recO; DNA repair protein RecO [KO:K03584]
EHS13_32355  recR; recombination protein RecR [KO:K06187]
EHS13_16140  recA; recombinase RecA [KO:K03553]
EHS13_23160  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
EHS13_11230  ruvA; Holliday junction branch migration protein RuvA [KO:K03550] [EC:3.6.4.12]
EHS13_11235  ruvB; Holliday junction branch migration DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
EHS13_13630  hypothetical protein [KO:K01159] [EC:3.1.21.10]
EHS13_11225  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
EHS13_19590  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
EHS13_24405  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
EHS13_15960  PolC-type DNA polymerase III [KO:K03763] [EC:2.7.7.7]
EHS13_00010  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
EHS13_32365  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
EHS13_12780  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
EHS13_01385  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
EHS13_20045  3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
EHS13_03955  3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
EHS13_22365  3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
EHS13_19660  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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