Pongo pygmaeus (Bornean orangutan): 129013793 Help Entry 129013793         CDS       T10128                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism ppyg  Pongo pygmaeus (Bornean orangutan) Pathway ppyg04020   Calcium signaling pathway ppyg04371   Apelin signaling pathway ppyg04713   Circadian entrainment ppyg04921   Oxytocin signaling pathway ppyg04970   Salivary secretion ppyg05010   Alzheimer disease ppyg05012   Parkinson disease ppyg05020   Prion disease ppyg05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:ppyg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     129013793 (RYR3)    04020 Calcium signaling pathway     129013793 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     129013793 (RYR3)   09154 Digestive system    04970 Salivary secretion     129013793 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     129013793 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     129013793 (RYR3)    05012 Parkinson disease     129013793 (RYR3)    05020 Prion disease     129013793 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     129013793 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ppyg04040]     129013793 (RYR3) Ion channels [BR:ppyg04040]  Voltage-gated cation channels   Ryanodine receptor    129013793 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  129013793 NCBI-ProteinID:  XP_063508620 LinkDB All DBs Position 16:38348467..38915107 Genome browser AA seq 4865 aa AA seqDB search MAEAGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHVAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNLAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNALPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVSWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDDEEEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAIGNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGVIVSRGMKDMELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSQFIPTLEKLKKKAVKTVQEEEQLKADG KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDFYSIQTS LIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKSDDPAV KWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEE TEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFE EKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQ KMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKV LQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFY WYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLH VFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTN VEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSC AEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYF EPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELF VNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSFEPASAFAMA CASVKRNVADFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTILGG IFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITTELV HFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRKA QAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEKLE AFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDV ANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVF KREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYL AWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT VVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMY RIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTP HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQY EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atggccgaagcgggagaaggaggcgaggacgagatccagtttctgaggactgaggatgaa gtggtactccagtgcatcgccaccattcataaggagcagaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagcgaagtacattcct ccagatctctgcgtctgcaattttgtgctggaacagtccctatctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacagggaggtggccac aggaccctgttatacggccatgcagttctcctgaggcactctttcagtggaatgtatcta acatgcttgactacatcaagatcccagacagacaaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggactatacatcctgcttccaaacagaggtcc gaaggagagaaagttcgaattggcgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatggtaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgccttttccacggtcacgatgaatgtttgacgataccatctacagac cagaatgattcccagcacaggaggatattctacgaagctgggggagctgggactcgagcc aggtctctgtggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggccaggctttccgactccggcatctcaccacaggccactacctggccttgacagaagac caaggccttatactgcaagaccgggcaaagtcagacaccaagtccacagctttctctttc cgggcatcaaaggaactcaaggagaaattagactccagtcacaagcgagacatagaaggc atgggagttccagaaatcaagtatggagattctgtctgctttgtgcagcacgtagccagt ggtctgtgggtgacctacaaagcacaagacgccaaaacttcccgcctgggacctctaaaa agaaaggtcatactccatcaggaaggccacatggatgatggattaacactgcagagatgc cagcgtgaggagtcccaggctgctcggatcatccggaacactacagccttattcagccag tttgtcagcggaaacaatcgcacagctgcccccatcaccctgcctatagaagaagtcctg cagaccctacaggacttgatcgcctacttccagcccccggaggaggagatgcgacatgaa gacaagcagaacaagctccgctcactcaaaaacagacaaaatcttttcaaggaagaggga atgttggctcttgtcttaaattgcattgaccgcttaaatatctacaatagcgtagcacac tttgcagggattgcaagggaagagagtggcatggcctggaaagaaattctgaacctcctc tacaaattgctggctgctctcattcgcggaaacagaaacaattgcgctcaattctccaat aaccttgattggctcatcagtaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttaactgaaagcccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcacgggcggaatcacaaggttctggatatc ctgtgctccctctgtctctgcaatggggttgcagtaagagccaaccagaatctgatctgt gacaacttgctgccccggagaaacctgctcctgcagacacgactgattaacgatgtaacc agtatccggccaaacatcttcctgggagtcgcggagggctcagcccagtacaagaagtgg tacttcgagctgattatcgaccaggtggaccccttcctaacagcagagcccacgcatctg cgggtgggctgggcctcttcctcaggctatgccccgtacccaggaggtggagaaggatgg ggaggcaatggtgttggcgacgacctgtactcctatggctttgatggacttcacctttgg tcaggccggatacccagagctgtggcttccatcaaccagcacctcctgagatcggatgat gtggtaagctgctgcctggacctcggggtgcccagcatctcattccgcatcaatggacag cccgtgcaggggatgtttgagaacttcaacacagacgggctcttcttccctgtgatgagc ttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagagtttaagttc ctgcctccgtctggctatgccccttgctatgaagccttacttccaaaagagaagatgaga ttggagcctgtcaaagaatataaacgtgatgctgatggcgttagagatctcttgggtacc acccagttcctctcccaagcctctttcatcccatgccccatagacaccagtcaggttgtt ttgccacctcacctagaaaagatccgagacagactagctgaaaacatccacgagctttgg ggaatgaataaaatagaacttggctggactttcggcaagatacgagatgacaataaaaga caacacccttgccttgtggagttttcaaagctccccgaaactgagaagaattataacctg caaatgtcaactgaaaccttaaaaaccctcctggccctggggtgccacattgctcatgtt aacctagctgctgaggaggatctcaagaaggtcaaactgcccaaaaactatatgatgtcc aacggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcgcacaatgtttgggcaaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccgtctggtg ccatatgcattactggacgagcgtaccaagaagtcaaacagggacagcctgcgggaagct gtgcgcacttttgttggttacgggtataacattgagccatcagaccaagaactagctgac tcggctgtggagaaggtcagcatagacaagatccgatttttccgggtagagcgatcttat gcagtgagatctggaaagtggtattttgagtttgaggtggtgactggaggagacatgcga gtcggctgggccaggccaggctgtcggcctgatgtcgagctgggggccgatgaccaagcc tttgtgtttgaaggcaacaggggccagcgttggcatcaaggaagtgggtattttgggcgt acctggcagccaggggatgtggtcggatgtatgattaacctggatgatgcttcaatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgagaatggcttcgtgcccatctgctgtctggggctatctcagatcggccgc atgaatctcgggacagacgccagtaccttcaagttttataccatgtgtggtctccaagag ggctttgagccttttgctgtcaacatgaacagagatgttgctatgtggttcagcaagcgc ctcccgacatttgtcaacgtgccaaaggatcatccacacatagaggtcatgaggattgat ggcaccatggacagccctccgtgtctcaaggtgacccataagacatttggcacacagaat agcaacgctgacatgatctattgccgcttgagcatgcctgtcgagtgccactcctccttc agccacagcccctgtctggacagtgaagctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgccatccgcatctttgctggacaggatcca tcttgtgtctgggtcggatgggtgactccagactatcacttgtacagtgaaaagtttgac ctgaataaaaactgcacagtgactgtcaccctaggggatgaaagaggccgggtccacgaa agcgtgaaacgcagcaactgctacatggtctggggtggggacattgtagccagttcccag agatcaaatcggagcaacgtggacctggagatcggctgtctcgtggatctggcgatgggc atgttgtccttctcagccaatggaaaggaactgggcacctgctaccaggtggagcctaat accaaagtgtttccagcagtcttcctgcagcctacaagtacttctttgtttcagtttgaa cttggaaagctgaagaatgcactgcccctgtcagcggccatattcaagagtgaagagaag aacccagtcccacagtgtccacctcggctggacgtccaaaccatccagcccgtgctctgg agccgcatgcccaacagcttcctgaaggtggagaccgagcgtgtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccccgaggagaac aggtgtgtggatatcctggagctctgtgagcaggaggacctgatgcggttccattaccac acgctgaggctctacagcgcggtgtgcgccctgggaaacagccgcgtggcctacgccctg tgcagccacgtggacctctcccagctcttctatgccattgacaacaagtacctccccggc ctccttcggtctggtttctatgacctgctcatcagcatccacctggccaacgccaaggag aggaagctgatgatgaagaacgagtacatcatccccattaccagcaccaccaggaatatc cgcctcttcccggacgagtccaagaggcatggactgcctggggtgggcctgagaacatgt ctcaagcccgggttcaggttctccaccccttgctttgttgtgactggtgaggatcaccaa aagcagagccctgagattccactggagagtctcaggacgaaggctctgagtatgctgaca gaggcagtgcagtgcagcggggcccacatccgagaccccgtaggggggtctgtggagttc cagtttgtgcctgtgctgaaactcattggaaccctgctggtcatgggcgtgtttgatgat gatgatgttcgtcagatcctcctcctgattgatccctctgtgtttggggagcatagtgcg gggacagaggagggagcagaaaaggaggaagtgacccaggtggaggagaaggctgtggag gctggggagaaggctggcaaggaggctcctgtcaaaggcttgttgcagactcgattaccc gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgcgactgtgagctgcag caccgagtggaggccattgtggcatttggtgacatttatgtctccaagctgcaggcaaat cagaagttccgctacaatgagctcatgcaggccttgaacatgtctgcggccctgactgcc cggaagaccaaagagttccgctcacccccacaggagcagatcaacatgctgcttaacttt caactgggagagaactgcccctgcccagaggagattcgggaggagctgtatgatttccat gaggaccttctccttcactgtggggttcctttggaagaagaggaagaggaggaggaggac acctcctggacaggaaaactctgtgccttggtttacaaaatcaaaggcccacccaagcca gagaaggagcagccgacggaggaggaggagagatgccccacaacattgaaggaactcatc tcacagacgatgatctgctgggcccaggaggaccagatccaggattcagagctggtccga atgatgttcaacctccttcggaggcagtatgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagccacacctctgtaagcgacaccatcaacctgctggctgcc ctgggccaaatccgctccctcctcagtgtcaggatgggcaaggaagaggagttgctcatg atcaatgggctgggagacataatgaacaacaaggtgttttaccagcatcccaacctcatg agagtcctgggcatgcacgagacggtgatggaggtgatggtgaacgtgttgggtacagag aaatctcagattgcatttccaaagatggttgctagctgttgccgtttcctttgctatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttatcttctggag aatagcagtgttggcctagcctccccgtcgatgaggggatccaccccgctggatgtggca gcttcctctgtgatggacaacaacgagttagcgctgagcttagaggaaccagacctcgag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgatgtcagctggaaccccattgaaggggaacgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgagagtgtggaagaaaacgccagcgttgtggtcaagctg ctcatcagacgcccagagtgcttcggcccggccctgcgcggtgaggggggaaacgggctg ttggcggccatgcagggtgccattaagatctctgagaacccagcgctcgacctcccctct caaggatacaaaagagaagtcagcacggaggacgatgaagaggaagaagaaatcgtgcat atgggcaatgcaattatgtcattttattcggcccttatagatctactgggccgctgtgct cctgaaatgcacctcatccagacaggaaagggggaagccatccgcatcaggtccatcctg cgctccctggtccccacagaagacctggttgggatcatcagcatccccttgaaactgccc tccctcaacaaagatgggtcggtcagtgagccagatatggcggccaacttctgccctgac cacaaggcacctatggttctgttcttggaccgcgtttatggcattaaggatcagactttt ctgctccacttgctggaggttggatttttacccgacctaagagcttctgcctctctagat acagtttccctaagcaccacagaggctgcgcttgcactaaataggtatatatgttctgct gtgctcccgctcctcacaagatgtgcccctctctttgccggaacagaacactgcacctct ctgattgattccacactgcagacaatatacaggctatccaagggacgttccctcaccaaa gcacaaagggacactatagaagaatgtttgcttgccattggcaatcacttgaggccttcc atgttacagcaactcctgcgacgcctcgtttttgatgtgccgcaactcaatgaatactgc aaaatgcctctcaagcttctgacgaatcactatgaacagtgttggaagtattactgcctg ccttcaggatgggggagctacgggctagctgtggaagaagagctgcacctaacggagaag cttttctgggggatttttgactcgctctcccataagaaatatgacccagatcttttccga atggccctgccttgtctcagtgctatagctggggcgttgccaccagattatttagatacc agaatcacagccacattggagaaacagatctcagtggatgcggatggcaactttgaccca aaacctatcaacaccatgaatttttccttgcctgaaaaattggaatacatcgtcaccaag tatgctgagcattcacatgataaatgggcctgtgacaagagtcagagtggatggaaatat gggatttccctggatgaaaatgtgaagacccacccactgataaggcctttcaagacatta accgagaaggagaaggaaatttatcgctggcctgcccgagagtccctgaaaaccatgctg gctgtgggctggactgtggagaggaccaaagagggagaagctttggttcaacagcgggaa aatgagaagcttcgaagtgtgtcccaggccaaccagggcaacagctacagccctgctccc ctcgacctctcaaacgttgtgctctccagagagctccagggaatggtggaggtcgtggct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggcagtcaccctcttctggtaccatatgacaccttgactgccaaggaaaagttcaaggac cgggagaaggcacaggacctatttaagttcctccaggtgaatggcgtcatcgtttccagg ggtatgaaggatatggagctggatgcctcctccatggagaagaggtttgcctataagttc ttgaagaagatcctgaaatacgttgattctgctcaagaatttattgcccatttagaagcc attgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccactggttgaccagtacttcaccaatcatcgcctctacttcttgtca tcccctctgaagccccttagcagcagcggatatgcctcccataaggagaaagaaatggtg gccagcctgttctgcaaacttgccgctcttgttagacacagaatttccctctttggtagt gattctactacaatggtgagctgtcttcacatcttagctcagacgcttgacacaaggact gtcatgaagtcaggctcagagctggtgaaggctgggttacgagcattctttgaaaatgct gcagaagatttggagaagacttcagaaaacctgaaacttgggaagttcacccattcccga acgcagattaaaggcgtttctcagaatattaactacactacggtggctctgctccccatc ctgacgtccatctttgagcacgtcactcagcatcagtttggaatggatctactcttgggt gatgtgcagatttcatgctaccacatactgtgcagcctctactcccttgggacgggaaag aacatttatgttgaaaggcaacgccctgcccttggagaatgtctggcttcgctggcagct gccataccagtggcattcctggagcccacccttaatcgctacaatccactctcggtcttc aacaccaaaacccccagggagaggtctattctggggatgccagacacggtggaagacatg tgtcctgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggctgagtca ggggcccggtacacagagatgccccatgtcatcgaggtgatcttacccatgctctgcaac tacctgtcctactggtgggagcgggggcctgagaacctgccccccagcacagggccatgc tgcaccaaggtcacctctgaacacctcagtctcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgatgaggcctcctggatgaagcgcattgcagtgtatgcacag cccatcatcagcaaagccagacccgacctgctgagaagccaattcatcccaactctggag aagctgaagaaaaaggctgtcaagacggtgcaggaggaggagcagttgaaagccgatggc aaaggggacacccaggaggcggaactcctcatcctggacgagttcgcggtcctctgcaga gatctctatgccttctaccccatgctgatccgctacgtggacaacaacagatctaactgg ctgaaaagccctgatgctgattctgaccagctcttccgcatggtggcagaagtcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggagga caagaccaggagcggaagaagacaaagcggcggggagacttctattccatccagacctcc ctcatcgtggctgcactcaagaaaatgctgcccattggtttgaatatgtgtactccaggc gaccaggagctgatctccctcgcaaaatcacgatacagccatagggacacagacgaagag gtcagagaacatctgcggaacaacttgcacttgcaggaaaagtctgatgacccagctgta aaatggcaattgaacctctacaaggatgttctgaagagtgaagaacctttcaatccggaa aagacagtggagcgtgtgcagagaatttcagcagctgtcttccacctggaacaggtggaa cagcctttgaggtccaagaaggccgtctggcacaaactgttatcaaagcaacggaaacgg gcagtggtggcctgtttcagaatggcccctctctacaacctgcccaggcaccgctctatt aacctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaa gagaaactagtacaggatttggctaaatctccaaaggtggaagaggaggaggaggaagag acagaaaaacaacctgacccactacatcagatcattctctattttagccgcaacgctctc acggagaggagcaaattggaagacgaccctttgtacacctcctattccagcatgatggcc aagagttgtcaaagtggtgaggacgaagaagaagatgaagacaaggaaaaaacattcgaa gagaaagagatggagaagcaaaaaaccctctatcagcaagctcggctgcatgagcgtggt gctgcagagatggtccttcagatgataagcgctagcaaaggtgagatgagccccatggtg gttgagacgctgaagctggggatcgccattctgaacggaggcaatgctggtgtgcaacag aaaatgctagattacctaaaggagaaaaaggatgctggattctttcaaagcctttctggt cttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaa ggcctggggatggtgactgaagaaggaacactcattgttcgtgaacgtggtgaaaaagta ctccagaatgacgagttcacgcgtgatctctttagattcctacagttactttgtgaggga cataacagtgactttcagaacttcctgcggactcagatgggcaacaccaccaccgtgaat gtcatcatcagcactgtggactaccttctgcgtctgcaggaatcaatcagtgatttctac tggtattattcagggaaggacatcattgatgaatctggacagcacaatttttccaaagct ctggcagtcaccaagcagattttcaattctcttacagaatacatccagggcccttgcatt ggtaatcaacagagcctggctcacagcaggctgtgggacgccgtggttggcttcctccat gtctttgctaatatgcagatgaaactctctcaggattccagtcagatcgagctgctgaag gaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaat gtggtaaatggcaccattggcaagcagatggttgacacactggtagaatcatctaccaat gtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctca gacaccttcaaagaatatgacccagatggtaaaggaattatctccaaaaaagaattccag aaggccatggaagggcaaaaacagtacacgcagtcagagattgactttctcctgtcgtgt gcagaagctgatgagaatgacatgtttaattacattgattttgtagaccggttccatgag ccagccaaggacatagggtttaatgtggctgtgttattgacaaatctttctgaacacatg ccaaacgattcccgcctgaagtgtctgttggacccagcagaaagtgtgctaaattacttc gaaccctacctaggacgcattgagatcatgggtggggccaagaagattgagcgtgtttat tttgagattagtgaatccagtcgcactcagtgggagaagccccaggtgaaggaatctaag cgacagttcatttttgatgttgtcaacgaaggtggggagcaggaaaagatggagctgttt gtgaacttctgtgaggacaccatctttgaaatgcagttagcatctcagatctctgaatcc gattcagctgacaggccagaagaggaggaagaagatgaagattcttcttacgtgttagaa attgcgggtgaagaggaagaagacgggtctttcgagccggcctctgcatttgctatggcc tgtgcctctgtgaagaggaatgtcgccgacttcttgaagagagcaaccctgaagaacctc aggaagcagtacaggaacgtgaaaaagatgactgcgaaagagctggtgaaggtgctcttc tcctttttctggatgctgttcgtggggctattccagttgctcttcaccatcctgggagga atctttcagatcctctggagcacagtgtttggagggggcctggtagaaggggcaaagaac atcagagtgaccaagatcctgggtgacatgcctgacccaacccagtttggtatccatgat gacactatggaggctgagagggcagaggtgatggagccaggtatcaccactgaactagta cacttcataaagggggagaagggagatacagatatcatgtcagacctctttggactccac ccaaagaaggagggcagcttaaagcatgggcctgaagtgggtttgggtgacctctcagaa attattggcaaggatgaaccccctacattagagagtactgtacagaagaagaggaaagct caggcagcagagatgaaagcagcaaatgaagcagaaggaaaagtagaatccgagaaggca gacatggaagatggagagaaggaagacaaagacaaagaagaggagcaagctgagtacctg tggacagaagtgacaaaaaagaagaagcggcggtgtggtcagaaggttgagaagctggaa gctttcacagccaatttctttaaagggctggaaatctatcagaccaagttactgcattac ctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaac ttcatcctgcttttttataaggtcactgaagaacctttagaagaagagacagaggatgtt gcaaacctatggaattcctttaatgacgaggaagaggaagaagcgatggtattctttgtc cttcaggagagcaccgggtatatggcaccaacactgcgggccctggccatcatccacacc atcatctctctagtctgcgtggtgggctactactgcctgaaggtgcctttggtggtattc aaaagggaaaaagaaatcgccaggaagctggagtttgatggcctatatatcaccgaacag ccatctgaagatgacatcaaggggcagtgggaccgcttggtgatcaacacaccatctttt cctaataactactgggacaagtttgtaaagagaaaggtgatcaacaagtatggagatctc tacggagcagaacgcattgctgagcttctgggtttggacaaaaatgctcttgactttagc ccagtagaagagaccaaagcagaagcggcttctctggtgtcatggctaagttccatagac atgaagtaccatatctggaagcttggagttgtttttactgacaactcctttctctacctt gcctggtatacaaccatgtcagtcctgggccactacaataacttcttctttgctgctcac ctattggacatcgcaatgggcttcaagacactgaggaccattctgtcatctgtaactcac aatggcaaacagttggttctgactgttggtctcctggccgtggtggtttatctctatacc gtcgtggctttcaacttcttccgcaagttctacaacaaaagcgaagacgatgacgagccc gatatgaagtgcgacgacatgatgacgtgttaccttttccacatgtacgtgggagtgaga gcaggaggtggcattggtgatgaaattgaagaccctgctggtgatccttatgaaatgtat cgcattgtctttgacattaccttcttcttctttgtcattgtcatcttgctggccatcatt caaggtcttattattgatgctttcggagagctaagagaccagcaggaacaagtgcgagaa gatatggagactaaatgtttcatctgtgggattggcaatgactactttgacacgacccct catggttttgaaacacatacattacaagagcacaacttagccaactacttgttcttcctg atgtatttgattaataaagatgaaacagagcacacgggtcaggaatcttatgtctggaag atgtaccaagaaaggtgttgggatttcttcccagctggtgactgctttcgtaaacaatat gaagatcagcttggataa

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