KEGG   PATHWAY: pvb00260
Entry
pvb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudoalteromonas viridis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pvb00260  Glycine, serine and threonine metabolism
pvb00260

Module
pvb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pvb00260]
pvb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pvb00260]
pvb_M00555  Betaine biosynthesis, choline => betaine [PATH:pvb00260]
pvb_M00621  Glycine cleavage system [PATH:pvb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudoalteromonas viridis [GN:pvb]
Gene
J5X90_00215  [KO:K00133] [EC:1.2.1.11]
J5X90_00465  [KO:K00600] [EC:2.1.2.1]
J5X90_00470  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
J5X90_00475  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
J5X90_00480  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
J5X90_00655  [KO:K00928] [EC:2.7.2.4]
J5X90_01445  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J5X90_01535  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
J5X90_02680  [KO:K15633] [EC:5.4.2.12]
J5X90_03745  [KO:K00274] [EC:1.4.3.4]
J5X90_03935  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
J5X90_06465  [KO:K00600] [EC:2.1.2.1]
J5X90_06600  metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
J5X90_09125  [KO:K00639] [EC:2.3.1.29]
J5X90_09130  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
J5X90_09250  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
J5X90_10660  [KO:K00018] [EC:1.1.1.29]
J5X90_10715  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
J5X90_10720  gcvH; glycine cleavage system protein GcvH [KO:K02437]
J5X90_10725  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
J5X90_13320  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
J5X90_13325  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
J5X90_13675  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
J5X90_15265  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
J5X90_16305  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
J5X90_16485  [KO:K15918] [EC:2.7.1.31]
J5X90_16765  [KO:K01752] [EC:4.3.1.17]
J5X90_18015  [KO:K12972] [EC:1.1.1.79 1.1.1.81]
J5X90_19105  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
J5X90_19110  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
J5X90_19290  [KO:K00382] [EC:1.8.1.4]
J5X90_19770  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
J5X90_20760  [KO:K25316]
J5X90_20765  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pvb00010  Glycolysis / Gluconeogenesis
pvb00020  Citrate cycle (TCA cycle)
pvb00230  Purine metabolism
pvb00250  Alanine, aspartate and glutamate metabolism
pvb00270  Cysteine and methionine metabolism
pvb00290  Valine, leucine and isoleucine biosynthesis
pvb00300  Lysine biosynthesis
pvb00330  Arginine and proline metabolism
pvb00460  Cyanoamino acid metabolism
pvb00470  D-Amino acid metabolism
pvb00564  Glycerophospholipid metabolism
pvb00600  Sphingolipid metabolism
pvb00620  Pyruvate metabolism
pvb00630  Glyoxylate and dicarboxylate metabolism
pvb00640  Propanoate metabolism
pvb00680  Methane metabolism
pvb00860  Porphyrin metabolism
pvb00920  Sulfur metabolism
KO pathway
ko00260   

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