KEGG   PATHWAY: pyu04142
Entry
pyu04142                    Pathway                                
Name
Lysosome - Puma yagouaroundi (jaguarundi)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
pyu04142  Lysosome
pyu04142

Other DBs
GO: 0005764
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009693  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
121009749  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
121009871  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
121009927  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
121010257  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
121010386  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
121010405  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
121010555  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
121010577  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
121010945  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
121011229  HYAL2; hyaluronidase-2 isoform X1 [KO:K01197] [EC:3.2.1.35]
121011234  HYAL3; LOW QUALITY PROTEIN: hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
121011434  CLTB; clathrin light chain B isoform X1 [KO:K04645]
121012103  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
121013221  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
121013362  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
121013393  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
121013917  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
121013979  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
121014027  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
121014037  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
121014046  DNASE2; LOW QUALITY PROTEIN: deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
121014099  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
121014135  [KO:K01365] [EC:3.4.22.15]
121014161  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
121014190  [KO:K01365] [EC:3.4.22.15]
121014191  [KO:K01365] [EC:3.4.22.15]
121014499  AP1S3; AP-1 complex subunit sigma-3 isoform X1 [KO:K12395]
121015325  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
121015641  GBA; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
121015990  CD68; macrosialin [KO:K06501]
121016590  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
121017362  CTNS; cystinosin isoform X1 [KO:K12386]
121017497  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
121017600  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
121017656  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
121017788  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
121017906  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
121018020  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
121018024  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
121018954  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
121019377  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
121019512  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
121019547  LITAFD; LITAF domain-containing protein [KO:K19363]
121019560  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
121019667  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
121019733  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
121019952  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
121020283  ABCA2; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 2 [KO:K05642]
121021050  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
121021051  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
121021124  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
121021205  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
121021353  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
121021633  CTSE; cathepsin E isoform X1 [KO:K01382] [EC:3.4.23.34]
121021973  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
121022319  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
121022340  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
121022508  CLN3; battenin [KO:K12389]
121022602  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
121023123  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
121023312  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
121023776  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
121023933  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
121023963  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
121023992  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
121024295  [KO:K01365] [EC:3.4.22.15]
121024453  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
121024670  [KO:K12387]
121024811  [KO:K12403]
121024958  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
121025035  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
121025133  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
121025434  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
121025671  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
121026251  [KO:K01365] [EC:3.4.22.15]
121026350  [KO:K01365] [EC:3.4.22.15]
121026362  [KO:K01365] [EC:3.4.22.15]
121026917  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
121027000  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
121027009  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
121027380  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
121027622  SORT1; sortilin isoform X1 [KO:K12388]
121027720  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
121028126  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
121028270  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
121028400  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
121028401  [KO:K01197] [EC:3.2.1.35]
121028402  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
121029672  SLC17A5; sialin isoform X1 [KO:K12301]
121029833  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
121029886  CD164; sialomucin core protein 24 [KO:K06546]
121030012  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
121031065  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
121031527  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
121031584  [KO:K01319] [EC:3.4.21.20]
121031618  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
121031846  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
121032045  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
121032151  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
121032215  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
121032892  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
121033086  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
121033426  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
121034041  SCARB2; lysosome membrane protein 2 [KO:K12384]
121034053  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
121034669  CLTA; clathrin light chain A isoform X1 [KO:K04644]
121036756  [KO:K12382]
121036809  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
121037679  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
121037831  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
121038033  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
121038266  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
121038575  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
121039392  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
121039644  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
121039673  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
121039724  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
121039856  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
121040096  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
121040244  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
121040384  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
121040534  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
121040816  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
121040965  CD63; CD63 antigen [KO:K06497]
121041330  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
121041694  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
121041702  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
121041953  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
121042262  CTSH; pro-cathepsin H isoform X1 [KO:K01366] [EC:3.4.22.16]
121042327  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
121042385  AP3S2; AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
121042751  LAPTM4B; LOW QUALITY PROTEIN: lysosomal-associated transmembrane protein 4B [KO:K12387]
121043460  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
121044163  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
121044693  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
121045028  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
121045029  NAGLU; alpha-N-acetylglucosaminidase isoform X1 [KO:K01205] [EC:3.2.1.50]
121045323  GM2A; ganglioside GM2 activator [KO:K12383]
121045454  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
pyu00511  Other glycan degradation
pyu00531  Glycosaminoglycan degradation
pyu04130  SNARE interactions in vesicular transport
pyu04140  Autophagy - animal
pyu04144  Endocytosis
KO pathway
ko04142   

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