KEGG   PATHWAY: rno04962Help
rno04962                    Pathway                                

Vasopressin-regulated water reabsorption - Rattus norvegicus (rat)
In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.
Organismal Systems; Excretory system
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rno04962  Vasopressin-regulated water reabsorption

Ortholog table
Rattus norvegicus (rat) [GN:rno]
24221  Avp; arginine vasopressin [KO:K05242]
25108  Avpr2; arginine vasopressin receptor 2 [KO:K04228]
24896  Gnas; GNAS complex locus [KO:K04632]
25289  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:]
64508  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:]
302950  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:]
25636  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:]
293508  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:]
362456  Arhgdib; Rho GDP dissociation inhibitor beta [KO:K12462]
360678  Arhgdia; Rho GDP dissociation inhibitor alpha [KO:K12462]
360500  Arhgdig; Rho GDP dissociation inhibitor gamma [KO:K12462]
81646  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
310616  Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048]
362165  Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048]
362339  Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048]
314638  Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048]
500131  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
25386  Aqp2; aquaporin 2 [KO:K09865]
81830  Rab11a; RAB11a, member RAS oncogene family [KO:K07904]
79434  Rab11b; RAB11B, member RAS oncogene family [KO:K07905]
29489  Dync1h1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
65209  Dync2h1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
116659  Dync1i2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
29564  Dync1i1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
252902  Dync1li1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
81655  Dync1li2; dynein, cytoplasmic 1 light intermediate chain 2 [KO:K10416]
298767  Dync2li1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417]
58945  Dynll1; dynein light chain LC8-type 1 [KO:K10418]
140734  Dynll2; dynein light chain LC8-type 2 [KO:K10418]
29167  Dctn1; dynactin subunit 1 [KO:K04648]
299850  Dctn2; dynactin subunit 2 [KO:K10424]
84428  Dctn4; dynactin subunit 4 [KO:K10426]
308961  Dctn5; dynactin subunit 5 [KO:K10427]
290798  Dctn6; dynactin subunit 6 [KO:K10428]
24803  Vamp2; vesicle-associated membrane protein 2 [KO:K13504]
60355  Nsf; N-ethylmaleimide sensitive factor, vesicle fusing ATPase [KO:K06027] [EC:]
81803  Stx4; syntaxin 4 [KO:K13502]
64633  Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
100361891  Rab5al1; Rab5a, member RAS oncogene family-like 1 [KO:K07887]
288779  Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
287709  Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
25293  Aqp4; aquaporin 4 [KO:K09866]
65133  Aqp3; aquaporin 3 [KO:K09876]
C00001  H2O
C00575  3',5'-Cyclic AMP
Boone M, Deen PM
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Pflugers Arch 456:1005-24 (2008)
Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
Localization and trafficking of aquaporin 2 in the kidney.
Histochem Cell Biol 130:197-209 (2008)
Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D
Physiology and pathophysiology of renal aquaporins.
J Am Soc Nephrol 10:647-63 (1999)
Marples D, Frokiaer J, Nielsen S
Long-term regulation of aquaporins in the kidney.
Am J Physiol 276:F331-9 (1999)
Ward DT, Hammond TG, Harris HW
Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.
Annu Rev Physiol 61:683-97 (1999)
Fenton RA, Moeller HB
Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.
Prog Brain Res 170:571-9 (2008)
Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA
Aquaporins in the kidney: from molecules to medicine.
Physiol Rev 82:205-44 (2002)
Deen PM, van Balkom BW, Kamsteeg EJ
Routing of the aquaporin-2 water channel in health and disease.
Eur J Cell Biol 79:523-30 (2000)
Bonilla-Felix M
Development of water transport in the collecting duct.
Am J Physiol Renal Physiol 287:F1093-101 (2004)
Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA
Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
Physiol Genomics 32:229-53 (2008)
Nguyen MK, Nielsen S, Kurtz I
Molecular pathogenesis of nephrogenic diabetes insipidus.
Clin Exp Nephrol 7:9-17 (2003)
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