Rattus norvegicus (rat): 100364027 Help Entry 100364027         CDS       T01003                                  Gene name Hkdc1 Definition (RefSeq) hexokinase HKDC1 isoform X1   KO K00844   hexokinase [EC:2.7.1.1] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00051   Fructose and mannose metabolism rno00052   Galactose metabolism rno00500   Starch and sucrose metabolism rno00520   Amino sugar and nucleotide sugar metabolism rno00524   Neomycin, kanamycin and gentamicin biosynthesis rno01100   Metabolic pathways rno01200   Carbon metabolism rno04066   HIF-1 signaling pathway rno04910   Insulin signaling pathway rno04930   Type II diabetes mellitus rno04973   Carbohydrate digestion and absorption rno05230   Central carbon metabolism in cancer Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00549   Nucleotide sugar biosynthesis, glucose => UDP-glucose rno_M00892   UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     100364027 (Hkdc1)    00051 Fructose and mannose metabolism     100364027 (Hkdc1)    00052 Galactose metabolism     100364027 (Hkdc1)    00500 Starch and sucrose metabolism     100364027 (Hkdc1)    00520 Amino sugar and nucleotide sugar metabolism     100364027 (Hkdc1)   09110 Biosynthesis of other secondary metabolites    00524 Neomycin, kanamycin and gentamicin biosynthesis     100364027 (Hkdc1)  09130 Environmental Information Processing   09132 Signal transduction    04066 HIF-1 signaling pathway     100364027 (Hkdc1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100364027 (Hkdc1)   09154 Digestive system    04973 Carbohydrate digestion and absorption     100364027 (Hkdc1)  09160 Human Diseases   09161 Cancer: overview    05230 Central carbon metabolism in cancer     100364027 (Hkdc1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100364027 (Hkdc1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     100364027 (Hkdc1) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.1  hexokinase      100364027 (Hkdc1) Membrane trafficking [BR:rno04131]  Autophagy   Mitophagy    Other mitophagy associated  proteins     100364027 (Hkdc1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Hexokinase_2 Hexokinase_1 VPS13_mid_rpt CSD Motif Other DBs NCBI-GeneID:  100364027 NCBI-ProteinID:  XP_038955090 RGD:  2321830 LinkDB All DBs Position 20 AA seq 915 aa AA seqDB search MFAVHLVAFYFTKLKEDQIKKVDRFLYHMRLSDETLVDIMARFQAEMEKGLGKDTNPTAS VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSEEGKQNVQMESQFYPMPNEITR GNGTELFDYVADCLADFMKTKDLTHKKLPLGFTFSFPCRQNKLEEGFLLSWTKKFKARGV QDTDVVNRLATAMKKHKDLDVDILALVNDTVGTMMTCAYDDPNCEVGVIIGTGTNACYME DMSNIDLVEGDEGRMCINTEWGAFGDDGTLEDIRTEFDRELDLGSLNPGKQLFEKMISGL YMGELVRLILLKMAKVGLLFGGAKSSALHTKGKIETQHVAAMEMSKEGLANTREILVDLG LDPSESDCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKLARLRTTVGMDGTLYKTH PQYPKRLHKVVRRLVPNCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDKVLALFHLT REQLLGVRDKMRAELEYGLKKKTHALATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRV LLVKIRKRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFS FPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMM TCGYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDIRT QYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFE TKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGAGMAAIVE KRREDQGLQHFKVTVGVDGTLYKLHPHFSRILQETVKDLAPQCDVTFMLSEDGSGKGAAL ITAVAKRLQQLPKDN NT seq 2748 nt NT seq  +upstreamnt  +downstreamnt atgtttgcagttcacttagtggcgttttacttcaccaagctgaaagaggaccagatcaag aaggtggacaggttcctgtaccatatgcggctctcggatgagacccttgtggacatcatg gcccgattccaggccgagatggagaaaggcttagggaaggacaccaaccccactgcctca gtgaagatgctgcccacattcgtcagggccattccagatggctcagaaaacggggaattc ctttccctggatctcggagggtccaagtttcgggtcctgaaggtgcaagtctcggaagag ggcaagcaaaatgtccagatggagagccagttctacccaatgcccaatgaaatcacccgt gggaatggcacggagctctttgactatgtagctgactgcctggcagatttcatgaagacc aaagatctgacgcacaagaagctgcctctgggcttcaccttttcttttccctgcagacag aataagttggaggagggcttcctgctgtcatggaccaagaagttcaaggcccggggagtt caggacacagacgtggtgaaccgtctggccaccgccatgaaaaagcacaaggacctggac gtggacatcctggccttggttaacgacactgtggggaccatgatgacttgtgcttatgat gatcccaactgtgaggtcggcgttatcattggaacaggcaccaacgcgtgttacatggag gacatgagcaacatcgaccttgtggaaggggacgagggaaggatgtgcatcaacacggag tggggggccttcggggacgatggcactttggaggacattcgcaccgagtttgacagagag ttggacctgggctcactcaaccccgggaagcagctgttcgagaagatgatcagcgggctg tacatgggggagctggtcaggctcatcttgctgaagatggccaaagttggtctcctgttt gggggtgcaaagtcctccgctctccacacaaagggcaagattgaaacacagcacgtggct gccatggagatgagtaaagaaggcctggccaatacgagagagatcctggtggatttgggc ctggacccctctgagtcagactgcatcgctgtccagcacgtgtgcaccatcgtctctttt cgctcggccaatctctgcgccgctgcgctggcagccatcttgactcgcctccgagagaac aagaagctggcccggctccgcaccacggtgggcatggatggaaccctctacaaaacacac cctcagtaccccaaacgcctacacaaagtggtgaggaggctggtcccaaactgtgatgtc cgcttcctcctatcagagagcggaagcaccaaaggggctgccatggtgaccgcagtggcc tctcgggtgcaggcccagcgtaagcagatcgataaggtgctggctttgttccatttgacc cgagagcaactcctgggtgtgcgggacaagatgcgggctgaacttgagtatgggctgaag aaaaaaactcacgctctggctacagtgaagatgcttcccacctacgtctatgggatgccc gatggcacagagaaaggaaagttccttgccctggacttggggggaactaacttccgcgtc ctccttgtaaagatcaggaagaggtcggtgcgaatgtacaacaagatctttgccatccct ctggagatcatgcagggcactggagaggagctctttgaccacattgtgcagtgcatcgct gacttcctggactatatgggcctcaagggcgcccagctgcctttgggcttcacattctcc ttcccctgcagacaaacatgcatcgacaaggggactctagtaggatggaccaaaggcttc aaggccaccgactgtgaaggggaggacgtggtggacatgctcagagaagccatcaagagg agaaacgagtttgacctggacatagttgcaatcgtgaatgacacggtggggaccatgatg acctgtggctatgaggatccccggtgtgagattggcttgattgcagggacaggaagcaac gtgtgctacatggaagaaatgaggaacattgagctggtggacggggatgaaggccggatg tgcgtcaacacggagtggggcgggtttggcgacaacggctgcatagatgacatccgcacg cagtacgacaaggaggtggatgagggctccctgaatgccggcaaacagaggtacgagaaa atgaccagtgggatgtacctgggggagattgtgaggcggatcctgatcgacctcacccgg caggggctcctcttccgagggcagatttcagagcgactccggaccaggggtatctttgaa accaaattcctgtctcagattgaaagtgaccggctggccctcctgcaggtcaggaggatc ctgcagcagctgggcctggacagcacctgcgaagacagcattgtggtgaaggaggtgtgc ggggctgtgtctcggagggctgcccagatgtgcggcgccggcatggctgccatcgtggag aaaaggagagaagaccagggcctccagcacttcaaggtcactgtgggcgtggacggcacc ctgtacaagctgcacccacacttctcccggatactgcaggagacagtgaaggacctggct cctcagtgcgacgtgactttcatgttgtcagaagacggcagcgggaagggagcagctctg atcacagctgtagccaagaggttacagcagctgccgaaggacaactag

Rattus norvegicus (rat): 25058 Help Entry 25058             CDS       T01003                                  Gene name Hk1 Definition (RefSeq) hexokinase-1   KO K00844   hexokinase [EC:2.7.1.1] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00051   Fructose and mannose metabolism rno00052   Galactose metabolism rno00500   Starch and sucrose metabolism rno00520   Amino sugar and nucleotide sugar metabolism rno00524   Neomycin, kanamycin and gentamicin biosynthesis rno01100   Metabolic pathways rno01200   Carbon metabolism rno04066   HIF-1 signaling pathway rno04910   Insulin signaling pathway rno04930   Type II diabetes mellitus rno04973   Carbohydrate digestion and absorption rno05230   Central carbon metabolism in cancer Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00549   Nucleotide sugar biosynthesis, glucose => UDP-glucose rno_M00892   UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     25058 (Hk1)    00051 Fructose and mannose metabolism     25058 (Hk1)    00052 Galactose metabolism     25058 (Hk1)    00500 Starch and sucrose metabolism     25058 (Hk1)    00520 Amino sugar and nucleotide sugar metabolism     25058 (Hk1)   09110 Biosynthesis of other secondary metabolites    00524 Neomycin, kanamycin and gentamicin biosynthesis     25058 (Hk1)  09130 Environmental Information Processing   09132 Signal transduction    04066 HIF-1 signaling pathway     25058 (Hk1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     25058 (Hk1)   09154 Digestive system    04973 Carbohydrate digestion and absorption     25058 (Hk1)  09160 Human Diseases   09161 Cancer: overview    05230 Central carbon metabolism in cancer     25058 (Hk1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     25058 (Hk1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     25058 (Hk1) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.1  hexokinase      25058 (Hk1) Membrane trafficking [BR:rno04131]  Autophagy   Mitophagy    Other mitophagy associated  proteins     25058 (Hk1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Hexokinase_2 Hexokinase_1 Sec23_helical Motif Other DBs NCBI-GeneID:  25058 NCBI-ProteinID:  NP_036866 RGD:  2796 UniProt:  P05708 LinkDB All DBs Structure PDB:  1BG3 Thumbnails Position 20 AA seq 918 aa AA seqDB search MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG AALITAVGVRLRGDPSIA NT seq 2757 nt NT seq  +upstreamnt  +downstreamnt atgatcgccgcgcaactactggcctattacttcaccgagctgaaggatgaccaagtcaaa aagattgacaagtatctgtacgccatgcggctctctgatgagattctgatagatatcctg acacgattcaagaaagagatgaagaatggcctctcccgggattataatccaacagcctcc gtcaagatgctgcccaccttcgtccggtccattccggacggctcagaaaagggggatttc attgccctggatctcggcgggtcttcctttcgaatcctgcgggtgcaggtgaaccacgag aagaaccagaacgtcagcatggagtctgagatctacgacaccccagagaacatcgtgcat ggcagtggaacccagcttttcgatcatgtcgctgactgcctgggagacttcatggagaaa aagaagatcaaggacaagaagttacccgtgggattcacattttccttcccctgccgacaa tccaagatagatgaggctgtactgatcacgtggacaaagcggttcaaagccagtggcgtg gaaggagcggatgtggtcaagttgctgaataaagccattaagaagcgaggggactatgat gctaacattgtcgccgtggtgaatgacacagtagggaccatgatgacctgcggttatgat gaccaacagtgtgaagtcggcctgatcattggcacaggcaccaatgcttgctacatggag gaactgcgacacatcgacctggtggaaggcgacgaggggaggatgtgtattaacacggaa tggggagcctttggggatgatgggtccctggaagacatccgaaccgagtttgacagagag ttagaccgtggatctctcaaccctgggaagcagctgttcgagaagatggtgagcggcatg tacatgggggagctggtccggctaatcctggtgaagatggccaaggaaggcctcttattc gaagggcgcatcactccagagctgctcacgaggggaaagttcaacactagtgacgtgtcc gccattgaaaaggataaggaaggcattcaaaatgccaaggaaatcttaacccgcttggga gtggagccgtctgatgttgactgtgtgtcggtccagcacatctgcacgatcgtctccttc cgatcagccaacctggtggccgccacgctcggtgccatcttgaaccgcctgcgggacaac aagggcacaccacgcctgcggaccacggttggcgtggacggttctctctacaagatgcac ccacagtactcccggcggttccacaagaccctgaggcgcctggtgcctgactccgacgtc cgtttcctcctctcagagagtggcacgggcaagggggccgccatggtgacggcagtagcc taccgcctggctgagcagcaccggcagattgaggaaaccctggcccacttccgcctcagc aagcagacgctgatggaggtgaagaagaggctacggacagagatggaaatggggctgagg aaggagaccaacagcaaagctactgtcaaaatgctgccttcttttgtccggagcatcccg gatgggactgaacacggtgacttcctggccttggatcttggaggaacgaatttccgggtt ctgctggtaaagatccgcagtgggaaaaagagaacagtggaaatgcacaacaagatctac tccattcccctggaaatcatgcagggcaccggggatgagctgtttgaccacatcgtctcc tgcatctctgacttcctggactacatggggatcaaaggcccccggatgcctctgggcttc accttctcatttccctgccatcagacgaacctggactgtggaatcttgatctcatggaca aagggtttcaaagccactgactgtgagggccatgatgtagcctccttactgagggatgcg gtgaagaggagagaggaatttgacttggatgtggtggctgtggtcaacgacaccgtgggc accatgatgacctgtgcgtatgaagaacccacttgcgaaattggactcatcgtggggacg ggcaccaatgcctgctacatggaggagatgaagaatgtggagatggtggaggggaaccag ggccagatgtgcatcaacatggagtggggcgccttcggtgacaatgggtgtctggatgac atcagaacagactttgacaaagtggtggacgaatattctctaaactctgggaaacaaagg tttgagaaaatgatcagtgggatgtacctgggtgagatcgtccgtaacatcctgattgac ttcaccaagaaaggcttcctcttccggggacagatctccgaaccactcaagacccgaggc atctttgagaccaagtttctctctcagattgagagtgaccggttagcgctgctccaggtg cgggccatccttcagcagctgggtttgaacagcacgtgtgacgacagtatcctggtcaag accgtgtgtggggtggtgtccaagagggcggctcagctgtgtggtgccggcatggccgcc gtggtggaaaagatcagagagaacagaggcctagaccatctgaatgtaactgtgggagtg gatgggacgctctacaaacttcatccacacttctccagaatcatgcaccaaactgtgaag gaactgtcaccaaagtgtaccgtgtccttcctcctgtctgaagacggcagcggcaagggg gccgcccttatcacagctgtgggcgtgcggctcagaggagacccttcgatcgcctaa

Rattus norvegicus (rat): 25059 Help Entry 25059             CDS       T01003                                  Gene name Hk2 Definition (RefSeq) hexokinase-2   KO K00844   hexokinase [EC:2.7.1.1] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00051   Fructose and mannose metabolism rno00052   Galactose metabolism rno00500   Starch and sucrose metabolism rno00520   Amino sugar and nucleotide sugar metabolism rno00524   Neomycin, kanamycin and gentamicin biosynthesis rno01100   Metabolic pathways rno01200   Carbon metabolism rno04066   HIF-1 signaling pathway rno04910   Insulin signaling pathway rno04930   Type II diabetes mellitus rno04973   Carbohydrate digestion and absorption rno05230   Central carbon metabolism in cancer Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00549   Nucleotide sugar biosynthesis, glucose => UDP-glucose rno_M00892   UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     25059 (Hk2)    00051 Fructose and mannose metabolism     25059 (Hk2)    00052 Galactose metabolism     25059 (Hk2)    00500 Starch and sucrose metabolism     25059 (Hk2)    00520 Amino sugar and nucleotide sugar metabolism     25059 (Hk2)   09110 Biosynthesis of other secondary metabolites    00524 Neomycin, kanamycin and gentamicin biosynthesis     25059 (Hk2)  09130 Environmental Information Processing   09132 Signal transduction    04066 HIF-1 signaling pathway     25059 (Hk2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     25059 (Hk2)   09154 Digestive system    04973 Carbohydrate digestion and absorption     25059 (Hk2)  09160 Human Diseases   09161 Cancer: overview    05230 Central carbon metabolism in cancer     25059 (Hk2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     25059 (Hk2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     25059 (Hk2) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.1  hexokinase      25059 (Hk2) Membrane trafficking [BR:rno04131]  Autophagy   Mitophagy    Other mitophagy associated  proteins     25059 (Hk2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Hexokinase_2 Hexokinase_1 FGGY_N Motif Other DBs NCBI-GeneID:  25059 NCBI-ProteinID:  NP_036867 RGD:  2797 Ensembl:  ENSRNOG00000006116 UniProt:  P27881 LinkDB All DBs Position 4 AA seq 917 aa AA seqDB search MIASHMIACLFTELNQNQVQKVDQFLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAA VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMR GSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV EGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYME EMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGM YMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEEDKDGIEKAYQILMRLG LNPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKH PHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLS HEQLLEVKRRMKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV LLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGF TFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG TMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDD LRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG IFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA VVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKG AALITAVACRIREAGQR NT seq 2754 nt NT seq  +upstreamnt  +downstreamnt atgatcgcctcgcatatgatcgcctgcttattcacggagctcaaccaaaaccaagtgcag aaggttgaccaatttctctaccacatgcgtctctcagatgagacccttctggagatttct aggcggttccggaaggagatggagaaagggctaggagctaccacgcaccctacagcagct gtgaaaatgttgcctacctttgtgaggtcaactccggatgggacagaacatggggagttc ctggctctggatcttggaggaaccaacttccgtgtgctccgagtaagggtgacggacaat ggcctccagagagtggagatggagaaccagatctacgccatccctgaggacatcatgcgg ggcagtggaacccagctgtttgaccacatcgccgaatgcctggccaacttcatggacaag ctacaaatcaaagagaagaagctccctctgggtttcaccttctcgttcccctgccaccag acaaaactggatgagagttttttggtctcgtggactaaggggttcaagtccagtggcgtg gaaggcagagatgtggtggacctgatccggaaggctatccagcgcagaggggactttgac attgacattgtggccgtggtgaatgacacagttgggaccatgatgacttgtggctatgat gatcagaactgcgagattggtctcattgtgggcactggcagcaacgcctgctacatggag gaaatgcgtcatattgacatggtggagggagatgaggggcgcatgtgcatcaacatggag tggggagcctttggggacgacggtacactcaatgacatccgaaccgagtttgaccgagag atcgacatgggctcgctgaaccctgggaagcagctgtttgagaagatgattagcgggatg tacatgggggagctggtcaggctcatcctggtgaagatggccaaggcagagctgttgttc caagggaaactcagcccagaactccttaccactggctccttcgagaccaaagatgtctcg gatattgaagaggataaggatggaatcgagaaggcctaccaaatcctgatgcgcctgggt ctgaatccattgcaggaggattgtgtggccacgcaccgaatctgccagattgtgtccacg cgctcggccagtctgtgcgcagccaccctggccgcggtgctgtggcgaatcaaagagaac aagggcgaggagcgacttcgctccaccatcggtgtcgatggctccgtctacaagaaacat ccccattttgccaagcgtctccataaggcagtgaggaggctggtgcccgactgtgatgtc cgcttcctccgctctgaggatggcagcggcaagggggctgctatggtgacggcggtggct taccgtctggctgaccaacaccgggcccgccagaagaccctggagtctctgaagctgagc cacgagcagcttctggaggttaagagaagaatgaaggtggaaatggagcagggtctgagc aaggagacgcatgcggtcgcccctgtgaagatgctgcccacttacgtgtgtgccactcca gatggcacagagaaaggagacttcttggccttggatcttggaggaacaaacttccgggtc ctgctggtgcgtgtgcgtaatggcaagcggaggggcgtggagatgcataacaagatctac tccatcccacaggaggttatgcatggcactggggaagagctcttcgaccacattgtccag tgcattgcggacttcctggagtacatgggcatgaagggcgtgtccctgcctttgggtttc acattctccttcccttgccagcagaacagcctagaccagagcatcctcctcaagtggaca aagggattcaaggcatctggctgcgagggtgaggatgtggtcaccttgctgaaggaagcg attcaccggcgagaggagtttgacctggatgtggttgccgtggtgaatgacacagttggg actatgatgacttgtggctacgaagaccctcactgtgaagttggcctcattgttggcacc ggaagcaacgcctgctacatggaagagatgcgtaatgtggagctggtggacggagaggag ggacggatgtgtgtcaacatggagtggggagcatttggggacaatggctgcctggatgac ttgcggaccgtgtttgatgttgctgtggatgagctttctctcaaccctggcaaacagagg ttcgagaagatgatcagcggcatgtacttgggagagattgtgcgcaacattctcatcgat ttcacgaagcgggggctgctcttccgaggccgcatctcagagcgcctcaagacaagggga atctttgaaactaagttcctgtctcagatagagagcgactgcctagccctgctacaggtt cgtgccatcctgcgccacctagggctggagagcacgtgcgatgacagcatcatcgtgaag gaggtgtgcactgtggttgcccggcgcgctgcacagctctgtggcgcaggcatggccgcc gtagtggacaagataagagagaaccgtgggctggacaacctcaaagtgacagtgggcgtg gacgggactctgtataagcttcatcctcactttgccaaggtcatgcatgagacggtgaga gatctggctccgaaatgtgacgtgtccttcctggaatccgaggacggcagtgggaaggga gcagctctcatcactgccgtggcctgccgcatccgggaggctgggcagagatag

Rattus norvegicus (rat): 25060 Help Entry 25060             CDS       T01003                                  Gene name Hk3 Definition (RefSeq) hexokinase-3   KO K00844   hexokinase [EC:2.7.1.1] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00051   Fructose and mannose metabolism rno00052   Galactose metabolism rno00500   Starch and sucrose metabolism rno00520   Amino sugar and nucleotide sugar metabolism rno00524   Neomycin, kanamycin and gentamicin biosynthesis rno01100   Metabolic pathways rno01200   Carbon metabolism rno04066   HIF-1 signaling pathway rno04910   Insulin signaling pathway rno04930   Type II diabetes mellitus rno04973   Carbohydrate digestion and absorption rno05230   Central carbon metabolism in cancer Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00549   Nucleotide sugar biosynthesis, glucose => UDP-glucose rno_M00892   UDP-N-acetyl-D-glucosamine biosynthesis, eukaryotes, glucose => UDP-GlcNAc Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     25060 (Hk3)    00051 Fructose and mannose metabolism     25060 (Hk3)    00052 Galactose metabolism     25060 (Hk3)    00500 Starch and sucrose metabolism     25060 (Hk3)    00520 Amino sugar and nucleotide sugar metabolism     25060 (Hk3)   09110 Biosynthesis of other secondary metabolites    00524 Neomycin, kanamycin and gentamicin biosynthesis     25060 (Hk3)  09130 Environmental Information Processing   09132 Signal transduction    04066 HIF-1 signaling pathway     25060 (Hk3)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     25060 (Hk3)   09154 Digestive system    04973 Carbohydrate digestion and absorption     25060 (Hk3)  09160 Human Diseases   09161 Cancer: overview    05230 Central carbon metabolism in cancer     25060 (Hk3)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     25060 (Hk3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     25060 (Hk3) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.1  hexokinase      25060 (Hk3) Membrane trafficking [BR:rno04131]  Autophagy   Mitophagy    Other mitophagy associated  proteins     25060 (Hk3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Hexokinase_2 Hexokinase_1 Motif Other DBs NCBI-GeneID:  25060 NCBI-ProteinID:  NP_071515 RGD:  2798 Ensembl:  ENSRNOG00000026235 UniProt:  P27926 LinkDB All DBs Position 17 AA seq 924 aa AA seqDB search MAAIEPSGLHPGERDSSCPQEGIPRPSGSLELAQEYLQQFKVTMTQLQQIQASLLCSMEQ ALKGQDSPAPSVRMLPTYVRSTPHGTEQGDFLVLELGATGASLRVLWVTLTGTKEHSVET RSQEFVIPQEVILGAGQQLFDFAARCLSEFLDAYPVENQGLKLGFNFSFPCHQTGLDKST LISWTKGFRCSGVEGQDVVQLLRDAIQRQGTYNIDVVAMVNDTVGTMMGCELGTRPCEVG LIVDTGTNACYMEEARHVAALDEDRGRTCVSIEWGSFYDEEALGPVLTTFDDALDHESLV PGAQRFEKMIGGLYLGELVRLVLVHLSQHGVLFGGCASPALLSQNSILLEHVAKMEDPAT GIAHVHTVLQGLGLSPQASDAELVQRVCMAVCTRAAQLCASALAAVLSRLQHSREQQTLH VAVATGGRVFEWHPRFLCILKETVMLLAPECDVSFIPSVDGGGRGVAMVTAVAARLATHR RILEETLAPFQLSLEQLTAVQAQMREAMIRGLQGESSSLRMLPTYVRATPDGSERGDFLA LDLGGTNFRVLLVRVAEGSVQITNQVYSIPEYVAQGSGQKLFDHIVDCIVDFQKRQGLSG QSLPLGFTFSFPCKQLGLDQGILLNWTKGFNASGCEGQDVVYLLREAIRRRQAVELNVVA IVNDTVGTMMSCGYDDPCCEMGLIVGTGTNACYMEELRNVASVPGDSGHMCINMEWGAFG DDGSLSMLGTCFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQKT QCLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLTLTSDDALMVLEVCQAVSRRAAQL CGAGVAAVVEKIRENRGLQELTVSVGVDGTLYKLHPHFSRLVSVTVRKLAPQCTVTFLQS EDGSGKGAALVTRVACRLTQMACV NT seq 2775 nt NT seq  +upstreamnt  +downstreamnt atggccgccattgagccttctggtctgcacccgggagaaagagactcaagctgcccccag gagggcattccaaggccctcaggtagcttagaactggcacaggaatacttgcaacaattc aaggtgaccatgacacagctgcagcagatccaagccagtcttctgtgttccatggagcag gcgctgaagggacaggacagtcccgctccttctgtccggatgttgcccacatacgtgagg tccacaccacatggcaccgagcaaggagacttcctggtgctggagctgggggccacagga gcctcactacgtgtgttgtgggtaacactgacgggcaccaaggaacacagcgtggagacc aggagccaggagtttgtgatccctcaagaggtgatcctaggtgctggccagcagctcttt gactttgctgcccgctgcctctctgaattcctggatgcataccccgtggagaatcagggt ctgaagcttgggtttaatttctcttttccttgtcaccagacaggcttggacaagagcacc ctcatttcctggacaaaaggttttaggtgcagtggtgtggaaggccaggatgtggtccag ttgctaagggatgccattcagaggcaggggacctacaatattgatgtggtagccatggtg aatgacacagtgggtaccatgatgggctgtgagctgggcaccaggccatgtgaagtcggg cttattgtagacactggtaccaatgcctgttatatggaggaagcgaggcacgtggcagct ctggatgaggaccgcggccgtacctgtgtcagcatcgagtggggctccttctatgacgaa gaggccctagggccagtactgaccaccttcgacgatgccctggaccacgagtccctggtt cctggtgctcagaggtttgagaagatgattggtggcctttacttgggtgagctggtaagg ctggtgctggtccacttgtcccagcatggggtcctctttggtggctgcgcctctcctgcg ttgctgagtcaaaacagcatcctcctggaacatgtggccaaaatggaggaccctgccact gggatagcccacgtccacacagtcctgcagggcttgggtctgagccctcaggcctcagat gctgagctcgtgcagcgcgtgtgcatggctgtgtgcacgcgagctgcccagctctgtgcc tctgccctggctgcagtcctatcccgcctccagcacagcagggagcagcagacactgcac gtggccgtggccactggagggcgagtgttcgaatggcaccccaggttcctctgcatccta aaggagacggtaatgctcttggccccagagtgtgatgtctccttcatcccctctgtggat ggtggtggccggggtgtggcaatggtgactgctgtggcagcccgcctggctacccacagg cgcatcctggaagagaccctggcaccatttcagctgagcttggagcagctgacagcggtg caggcacaaatgcgggaagccatgatcagggggcttcaaggagagagctcctccctccgc atgctgcccacttacgtccgagcaacgcccgatggcagcgaacgaggtgacttcctggct ttggacctagggggcaccaacttccgtgtcctgttggtacgcgtggccgagggcagtgtt cagatcaccaaccaggtctactctattcctgagtatgtagcccagggctctggacagaag ctctttgatcatattgtggactgcatcgtggacttccagaagaggcaaggccttagcgga cagagcctacccctgggtttcaccttctcttttccttgcaagcagcttggcctggaccag ggcatcctcctcaactggactaaggggttcaatgcatcaggctgcgagggccaagatgtt gtgtatttattacgggaagccattaggcgcagacaggcagtggagctgaatgtggttgcc attgtcaatgacacggtggggaccatgatgtcctgtggctatgatgatccctgttgtgag atgggcctcattgtcggaaccggtaccaacgcctgctatatggaagaactccggaatgtg gcgagtgtgcccggggactcaggccacatgtgtatcaacatggagtggggtgcctttggg gatgacggctcactgagcatgctcggcacctgctttgatgctagcgtggaccaggcatcc atcaacccaggcaaacagaggtttgagaaaatgatcagcggaatgtacctgggggagatc gtccgccatatcctcctgcacttaaccagtcttggagttctcttccggggccagaagacg caatgccttcagaccagggacatctttaagaccaagtttctctccgagattgagagcgac agcctggccctgcgtcaggtccgagccatcctggaggacctggggctgactctgacgtct gatgatgccttgatggtcctagaggtgtgccaggctgtgtcccgcagggccgcccaactc tgcggggcaggtgtggctgcagtggtggaaaagatacgggagaaccggggcctgcaggag ctgacagtgtctgtgggagtggatgggacgctctacaagctacatccccacttctccagg ctggtgtcagtgacagttcggaagctagcccctcagtgcacagtcacctttttgcaatcg gaggatgggtctgggaaaggggcagcgttggtcactcgtgtcgcttgccgcctgacccag atggcctgcgtttga

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