KEGG   Rattus norvegicus (rat): 114243
Entry
114243            CDS       T01003                                 
Symbol
Nox1
Name
(RefSeq) NADPH oxidase 1
  KO
K08008  NADPH oxidase 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04380  Osteoclast differentiation
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05417  Lipid and atherosclerosis
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114243 (Nox1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    114243 (Nox1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114243 (Nox1)
   05022 Pathways of neurodegeneration - multiple diseases
    114243 (Nox1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114243 (Nox1)
   05418 Fluid shear stress and atherosclerosis
    114243 (Nox1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    114243 (Nox1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    114243 (Nox1)
Membrane trafficking [BR:rno04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    114243 (Nox1)
SSDB
Motif
Pfam: NAD_binding_6 Ferric_reduct FAD_binding_8 NAD_binding_1 FAD_binding_6 Tetraspanin
Other DBs
NCBI-GeneID: 114243
NCBI-ProteinID: NP_446135
RGD: 620598
Ensembl: ENSRNOG00000048706
UniProt: Q9WV87
LinkDB
Position
X:complement(97279058..97332291)
AA seq 563 aa
MGNWLVNHWLSVLFLVSWLGLNIFLFVYVFLNYEKSDKYYYTREILGTALALARASALCL
NFNSMVILIPVCRNLLSFLRGTCSFCNHTLRKPLDHNLTFHKLVAYMICIFTAIHIIAHL
FNFERYSRSQQAMDGSLASVLSSLFHPEKEDSWLNPIQSPNVTVMYAAFTSIAGLTGVVA
TVALVLMVTSAMEFIRRNYFELFWYTHHLFIIYIICLGIHGLGGIVRGQTEESMSESHPR
NCSYSFHEWDKYERSCRSPHFVGQPPESWKWILAPIAFYIFERILRFYRSRQKVVITKVV
MHPCKVLELQMRKRGFTMEIGQYIFVNCPSISFLEWHPFTLTSAPEEEFFSIHIRAAGDW
TENLIRTFEQQHSPMPRIEVDGPFGTVSEDVFQYEVAVLVGAGIGVTPFASFLKSIWYKF
QRAHNKLKTQKIYFYWICRETGAFAWFNNLLNSLEQEMDELGKPDFLNYRLFLTGWDSNI
AGHAALNFDRATDVLTGLKQKTSFGRPMWDNEFSRIATAHPKSVVGVFLCGPPTLAKSLR
KCCRRYSSLDPRKVQFYFNKETF
NT seq 1692 nt   +upstreamnt  +downstreamnt
atgggaaactggctggttaaccactggctctcagttttgtttctggtttcttggttgggg
ctgaacatttttctgtttgtgtacgtcttcctgaattatgagaagtctgacaagtactat
tacacgagagaaattctcggaactgccttggccttggccagagcatctgctttgtgcctg
aattttaacagcatggtgatcctgattcctgtgtgtcgaaatctgctctccttcctgagg
ggcacctgctcattttgcaaccacacgctgagaaagccattggatcacaacctcaccttc
cataagctggtggcatatatgatctgcatattcacagctattcatatcattgcacatcta
tttaactttgaacgctacagtagaagccaacaggccatggatggatctcttgcctctgtt
ctctccagcctattccatcccgagaaagaagattcttggctaaatcccatccagtctcca
aacgtgacagtgatgtatgcagcatttaccagtattgctggccttactggagtggtcgcc
actgtggctttggttctcatggtaacttcagctatggagtttatccgcaggaattatttt
gagctcttctggtatacacatcaccttttcatcatctatatcatctgcttagggatccat
ggcctgggggggattgtccggggtcaaacagaagagagcatgagtgaaagtcatccccgc
aactgttcatactctttccacgagtgggataagtatgaaaggagttgcaggagtcctcat
tttgtggggcaaccccctgagtcttggaagtggatcctcgcgccgattgctttttatatc
tttgaaaggatccttcgcttttatcgctcccggcagaaggtcgtgattaccaaggttgtc
atgcacccatgtaaagttttggaattgcagatgaggaagcggggctttactatggaaata
ggacagtatatattcgtaaattgcccctcgatttccttcctggaatggcatccctttact
ctgacctctgctccagaggaagaatttttctccattcatattcgagcagcaggggactgg
acagaaaatctcataaggacatttgaacaacagcactcaccaatgcccaggatcgaggtg
gatggtccctttggcacagtcagtgaggatgtcttccagtacgaagtggctgtactggtt
ggggcagggattggcgtcactccctttgcttccttcttgaaatctatctggtacaaattc
cagcgtgcacacaacaagctgaaaacacaaaagatctatttctactggatttgtagagag
acgggtgcctttgcctggttcaacaacttattgaattccctggaacaagagatggacgaa
ttaggcaaaccggatttcctaaactaccgactcttcctcactggctgggatagcaacatt
gctggtcatgcagcattaaactttgacagagccactgacgtcctgacaggtctgaaacag
aaaacctcctttgggagaccaatgtgggacaatgagttttctagaatagctactgcccac
cccaagtctgtggtgggggttttcttatgcggccctccgactttggcaaaaagcctgcgc
aaatgctgtcggcggtactcaagtctggatcctaggaaggttcaattctacttcaacaaa
gaaacgttctga

KEGG   Rattus norvegicus (rat): 66021
Entry
66021             CDS       T01003                                 
Symbol
Cybb
Name
(RefSeq) cytochrome b-245 beta chain
  KO
K21421  NADPH oxidase 2 [EC:1.-.-.-]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04066  HIF-1 signaling pathway
rno04145  Phagosome
rno04216  Ferroptosis
rno04217  Necroptosis
rno04613  Neutrophil extracellular trap formation
rno04621  NOD-like receptor signaling pathway
rno04670  Leukocyte transendothelial migration
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno05010  Alzheimer disease
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05140  Leishmaniasis
rno05171  Coronavirus disease - COVID-19
rno05415  Diabetic cardiomyopathy
rno05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    66021 (Cybb)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    66021 (Cybb)
  09143 Cell growth and death
   04216 Ferroptosis
    66021 (Cybb)
   04217 Necroptosis
    66021 (Cybb)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    66021 (Cybb)
   04621 NOD-like receptor signaling pathway
    66021 (Cybb)
   04670 Leukocyte transendothelial migration
    66021 (Cybb)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    66021 (Cybb)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    66021 (Cybb)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    66021 (Cybb)
   05020 Prion disease
    66021 (Cybb)
   05022 Pathways of neurodegeneration - multiple diseases
    66021 (Cybb)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    66021 (Cybb)
   05415 Diabetic cardiomyopathy
    66021 (Cybb)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    66021 (Cybb)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    66021 (Cybb)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.-  
   1.-.-
    1.-.-.-
     66021 (Cybb)
Membrane trafficking [BR:rno04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    66021 (Cybb)
SSDB
Motif
Pfam: NAD_binding_6 Ferric_reduct FAD_binding_8 FAD_binding_6 NAD_binding_1
Other DBs
NCBI-GeneID: 66021
NCBI-ProteinID: NP_076455
RGD: 620574
Ensembl: ENSRNOG00000003622
UniProt: Q9ER28
LinkDB
Position
X:complement(13360583..13392517)
AA seq 570 aa
MGNWAVNEGLSIFVILVWLGLNVFLFVKYYKVYDDEPKYNYTRKLLGSALALARAPAACL
NFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHL
FNVEWCVNARVGTSDPYSVALSNIGDKENEEYLNFAREKIKNPEGGLYVAVTRLAGITGI
VITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTSDSLKEHN
LDVCADKIKEWGKIKECPVPKFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
VTHPFKTIELQMKKKGFRMEVGQYIFVKRPAVSKLEWHPFTLTSAPEEDFFSIHIRIVGD
WTEGLFKACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPSASIL
KSVWYKYCDNATSLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERNNANFLSYNIYL
TGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPE
ALAKTLSKQSISNSESGPRGVHFIFNKENF
NT seq 1713 nt   +upstreamnt  +downstreamnt
atggggaactgggctgtgaatgagggactctccatctttgtcattctggtgtggttgggg
ctgaatgtcttcctctttgtcaagtattacaaggtttatgacgatgagcctaaatataat
tacactcgaaaacttcttgggtcagcactggctctggcccgggcacctgcagcctgcctg
aatttcaactgcatgctgatcttgctgccagtgtgtcggaatctcctctccttcctcagg
ggttccagtgcgtgttgctcaaccagaattcgaagacaactggacaggaaccttactttc
cataagatggtagcttggatgatagcacttcacacggccattcacaccattgcacatctg
ttcaacgtggagtggtgtgtgaatgccagagtcgggacttcggacccatattcagtagca
ctctctaacattggagacaaagaaaatgaagagtatctcaattttgctagagaaaaaatc
aagaaccctgaagggggcctgtatgtggctgtgactcggttggctggcatcacaggaatt
gtcatcacactgtgtcttatattgatcatcacatcctccaccaaaaccattcggaggtct
tactttgaagtgttctggtatacacaccatctctttgtgatcttcttcatcggccttgcc
atccatggagctgaacgaattgtacgtggacagacttcggacagtttgaaagagcataat
ttagatgtttgtgcagacaaaatcaaagaatggggaaaaataaaggagtgcccagtacca
aagtttgccggaaaccctcctatgacttggaaatggatcgtgggtcccatgttcctgtat
ctgtgtgagaggctggtgcggttttggcgatctcagcagaaggtggtcattaccaaggtg
gtcactcatcctttcaaaaccatcgagcttcagatgaagaagaagggattcaggatggag
gtgggacaatacattttcgtcaagcgtcccgcagtgtccaagctggagtggcaccctttc
accctgacctctgcccctgaggaagacttctttagcatccatatccgcattgttggcgac
tggacagagggactgttcaaagcctgtggctgtgataagcaggagtttcaagatgcctgg
aaactacctaagatagcagttgatgggccctttggtacagccagtgaagatgtgttcagc
tatgaggtggtgatgttagtgggagctgggattggagtcacgccctctgcctccattctc
aagtctgtctggtacaaatattgtgacaatgccaccagtctgagactcaaaaagatctac
ttctactggctgtgcagggacacgcatgcttttgagtggttcgcagacctgctgcagctc
ctggagacccagatgcaagaaagaaacaatgccaacttcctcagctacaacatctacctt
actggctgggatgaatctcaggccaatcactttgctgtgcaccacgatgaggagaaagat
gtgattacaggcctaaaacagaagactctgtatggacggcccaactgggataacgagttc
aagaccattgcaagtcaacaccccaacaccagaataggagtttttctgtgtggccccgaa
gccttggctaaaactctcagtaaacagagcatctccaactctgagtccggcccacgtgga
gtccacttcatcttcaacaaggaaaacttctaa

KEGG   Rattus norvegicus (rat): 85431
Entry
85431             CDS       T01003                                 
Symbol
Nox4
Name
(RefSeq) NADPH oxidase 4
  KO
K21423  NADPH oxidase 4 [EC:1.6.3.-]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04936  Alcoholic liver disease
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:rno00001]
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    85431 (Nox4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    85431 (Nox4)
   05022 Pathways of neurodegeneration - multiple diseases
    85431 (Nox4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    85431 (Nox4)
   04933 AGE-RAGE signaling pathway in diabetic complications
    85431 (Nox4)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.3  With oxygen as acceptor
    1.6.3.-
     85431 (Nox4)
SSDB
Motif
Pfam: Ferric_reduct NAD_binding_6 FAD_binding_8 NAD_binding_1
Other DBs
NCBI-GeneID: 85431
NCBI-ProteinID: NP_445976
RGD: 620600
Ensembl: ENSRNOG00000013925
UniProt: Q924V1
LinkDB
Position
1:140900886..141078844
AA seq 578 aa
MALSWRSWLANEGVKHLCLLVWLSLNVLLFWKTFLLYNQGPEYYYIHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTVLAYLRGSQKVPSRRTRRLLDKSKTLHITCGITICIFSGVHV
AAHLVNALNFSVNYSEHFLALNAARYQNEDPRKLLFTTVPGLTGVCMVVVLFLMVTASTY
AIRVSNYDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNLDTHPPGCISLNRTPSQNMSIA
DYVSEHFHGSLPGGFSKLEDHYQKTLVKICLEEPKFQAHFPQTWIWISGPLCLYCAERLY
RCIRSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALENHPFTLTMCP
TETKATFGVHFKVVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFQWFADLLYVLH
NKFWQENRPDFVNIQLYLSQTDGIQKIIGEKYHTLNSRLFIGRPRWKLLFDEIAKCNRGK
TVGVFCCGPSSISKTLHNLSNRNNSYGTKFEYNKESFS
NT seq 1737 nt   +upstreamnt  +downstreamnt
atggcgctgtcctggaggagctggctggccaacgaaggggttaaacacctctgtctgctt
gtttggctgtccctaaatgtcctgcttttctggaaaaccttcctgctgtacaaccaaggg
ccagaatactactacatccaccagatgttgggcctaggattgtgtttgagcagagcttct
gcatctgtcctgaacctcaactgcagcctgatccttttacccatgtgccgcacagtcctg
gcttaccttcgcggatcacagaaggtccctagcaggagaacaagaagattgttggacaaa
agcaagactctacatatcacctgtggcataactatttgtattttctcaggtgtgcatgta
gctgcccacttggtgaacgccctgaacttctcagtgaactatagtgaacatttccttgca
ctgaatgcagcaagataccagaatgaggatcccagaaagcttctcttcacaactgttccg
ggcctgacaggtgtctgcatggtggtggtattgttcctcatggttacagcttctacctat
gcaataagagtttctaattatgatatcttctggtatactcacaacctcttctttgtcttc
tacatgctgctgctgctgcatgtttcgggtggcttgttgaagtatcaaaccaatttagac
actcaccctcctggctgtatcagtcttaaccggaccccatctcagaatatgtccatagca
gactacgtctcagaacattttcatggatctttgcctggagggttttcaaaattagaagat
cattaccagaaaacactggtgaagatttgcctggaagaacccaagttccaagctcatttc
ccacagacctggatttggatttctggacctttgtgcctatactgtgctgagagactttac
cgatgcatccggagcaacaaacctgtcaccattatctcagtaatcaatcatccctcagat
gtcatggaactccgtatgatcaaagaaaactttaaagcaagacctggccagtatattatt
ctacattgtcccagtgtatcagcattagaaaaccacccatttactctcacaatgtgtcct
actgaaaccaaagcaacatttggtgtccactttaaagtagtaggagactggacagaaaga
ttccgagatttactactgcctccatcaagccaagattctgagattctgcccttcattcaa
tctagaaactaccccaagttatacattgatggcccatttggaagtccatttgaggagtca
ctgaactatgaagttagtctgtgtgtggctggaggcattggggtcactccgtttgcatcg
atactaaacactctactggatgactggaaaccatacaagctaagaagactgtattttatc
tgggtctgcagagacatccaatcattccagtggtttgcagacttgctctatgtgctgcat
aacaagttttggcaagaaaacagacctgactttgtgaacatccagctgtacctcagtcaa
acagatgggatacagaagataattggagaaaaataccacacattgaattctagacttttt
attgggcgtcctcggtggaagcttttatttgatgaaatagcaaaatgtaacagagggaaa
acagttggagttttctgctgtggacccagttctatttccaagactcttcataatttgagt
aaccggaacaactcatatgggacaaaatttgaatacaataaagaatctttcagctaa

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