Rattus norvegicus (rat): 114486
Help
Entry
114486 CDS
T01003
Symbol
Braf
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X6
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01521
EGFR tyrosine kinase inhibitor resistance
rno01522
Endocrine resistance
rno04010
MAPK signaling pathway
rno04012
ErbB signaling pathway
rno04015
Rap1 signaling pathway
rno04024
cAMP signaling pathway
rno04062
Chemokine signaling pathway
rno04068
FoxO signaling pathway
rno04150
mTOR signaling pathway
rno04270
Vascular smooth muscle contraction
rno04510
Focal adhesion
rno04650
Natural killer cell mediated cytotoxicity
rno04720
Long-term potentiation
rno04722
Neurotrophin signaling pathway
rno04726
Serotonergic synapse
rno04730
Long-term depression
rno04810
Regulation of actin cytoskeleton
rno04910
Insulin signaling pathway
rno04914
Progesterone-mediated oocyte maturation
rno04928
Parathyroid hormone synthesis, secretion and action
rno04934
Cushing syndrome
rno05010
Alzheimer disease
rno05022
Pathways of neurodegeneration - multiple diseases
rno05034
Alcoholism
rno05160
Hepatitis C
rno05161
Hepatitis B
rno05200
Pathways in cancer
rno05205
Proteoglycans in cancer
rno05208
Chemical carcinogenesis - reactive oxygen species
rno05210
Colorectal cancer
rno05211
Renal cell carcinoma
rno05212
Pancreatic cancer
rno05213
Endometrial cancer
rno05214
Glioma
rno05215
Prostate cancer
rno05216
Thyroid cancer
rno05218
Melanoma
rno05219
Bladder cancer
rno05220
Chronic myeloid leukemia
rno05221
Acute myeloid leukemia
rno05223
Non-small cell lung cancer
rno05224
Breast cancer
rno05225
Hepatocellular carcinoma
rno05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
114486 (Braf)
04012 ErbB signaling pathway
114486 (Braf)
04015 Rap1 signaling pathway
114486 (Braf)
04068 FoxO signaling pathway
114486 (Braf)
04024 cAMP signaling pathway
114486 (Braf)
04150 mTOR signaling pathway
114486 (Braf)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
114486 (Braf)
09142 Cell motility
04810 Regulation of actin cytoskeleton
114486 (Braf)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
114486 (Braf)
04062 Chemokine signaling pathway
114486 (Braf)
09152 Endocrine system
04910 Insulin signaling pathway
114486 (Braf)
04914 Progesterone-mediated oocyte maturation
114486 (Braf)
04928 Parathyroid hormone synthesis, secretion and action
114486 (Braf)
09153 Circulatory system
04270 Vascular smooth muscle contraction
114486 (Braf)
09156 Nervous system
04726 Serotonergic synapse
114486 (Braf)
04720 Long-term potentiation
114486 (Braf)
04730 Long-term depression
114486 (Braf)
04722 Neurotrophin signaling pathway
114486 (Braf)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
114486 (Braf)
05205 Proteoglycans in cancer
114486 (Braf)
05208 Chemical carcinogenesis - reactive oxygen species
114486 (Braf)
09162 Cancer: specific types
05210 Colorectal cancer
114486 (Braf)
05212 Pancreatic cancer
114486 (Braf)
05225 Hepatocellular carcinoma
114486 (Braf)
05226 Gastric cancer
114486 (Braf)
05214 Glioma
114486 (Braf)
05216 Thyroid cancer
114486 (Braf)
05221 Acute myeloid leukemia
114486 (Braf)
05220 Chronic myeloid leukemia
114486 (Braf)
05218 Melanoma
114486 (Braf)
05211 Renal cell carcinoma
114486 (Braf)
05219 Bladder cancer
114486 (Braf)
05215 Prostate cancer
114486 (Braf)
05213 Endometrial cancer
114486 (Braf)
05224 Breast cancer
114486 (Braf)
05223 Non-small cell lung cancer
114486 (Braf)
09172 Infectious disease: viral
05161 Hepatitis B
114486 (Braf)
05160 Hepatitis C
114486 (Braf)
09164 Neurodegenerative disease
05010 Alzheimer disease
114486 (Braf)
05022 Pathways of neurodegeneration - multiple diseases
114486 (Braf)
09165 Substance dependence
05034 Alcoholism
114486 (Braf)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
114486 (Braf)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
114486 (Braf)
01522 Endocrine resistance
114486 (Braf)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
114486 (Braf)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
114486 (Braf)
Protein kinases [BR:
rno01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
114486 (Braf)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
114486
NCBI-ProteinID:
XP_006236419
RGD:
619908
Ensembl:
ENSRNOG00000010957
LinkDB
All DBs
Position
4:complement(68375484..68510652)
Genome browser
AA seq
825 aa
AA seq
DB search
MAALSGGGGSSSGGGGGGGGGGGGGGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIP
EEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLG
NGADFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQTPTDVSRNNPKSPQKPIVRVFLPNK
QRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHV
EVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYD
QLDLLFVSKFFEHHPVPQEEAFSAETTLPSGCSSAPPSDSIGPQILTSPSPSKSIPIPQP
FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGAPLNQLMRCLRKY
QSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRE
RKSSSSSSSTEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAV
KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS
RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP
KIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2478 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagtggcggcggtggcagcagcagcggtggcggtggcggcggcggcggc
ggcggtggtggcggcggcggcggcggcgccgaacagggacaggctctgttcaatggcgac
atggagccggaggccggcgctggcgccgcggcctcttcggccgcggacccggccattcct
gaagaggtgtggaatatcaagcaaatgattaagttgacacaggaacatatagaggcccta
ttggacaagtttggtggggagcataacccaccgtcaatatacctggaggcctatgaagag
tacaccagcaagctagatgcccttcagcagagagagcagcagctgttggaatccctgggt
aatggagcagacttttctgtttctagctctgcatcaatggacaccgttacatcttcctcc
tcttctagcctttcagtgctaccgtcatctctttcagtttttcaaactcccacagatgta
tcacggaacaaccccaagtcaccacagaaacctatcgttcgtgtcttcctgcccaacaaa
cagaggacagtggtgcccgcaagatgtggtgtaacggtccgagacagtctaaagaaagca
ctaatgatgaggggtctcatcccagagtgctgtgctgtttacagaattcaggacggagag
aagaaaccaattggctgggacactgacatttcctggcttactggagaggagctacatgtt
gaagtactagagaatgttcctctgacaacccacaacttcgtacggaaaacttttttcacc
ttagcattttgtgacttttgccgaaagctgcttttccagggtttccgctgtcaaacatgt
ggttataagtttcaccagcgttgtagtacagaggttccactgatgtgtgttaattatgac
caacttgatttgctgtttgtctccaagttctttgagcatcacccagtaccacaggaggag
gccttctcagcagagactacccttccatctggatgctcttccgcacccccctcagactct
attgggccccaaatcctcaccagtccatctccttcaaaatccattccaattccacagccc
ttccggccagcagatgaagatcatcgcaatcagtttgggcaacgagaccgctcctcctcc
gctcccaatgttcatataaacacaatcgaacctgtcaatattgatgatttgattagagac
caggggtttcgtggggatggagcccctttgaaccagctgatgcgctgtcttcggaaatac
caatcccggactcccagccccctcctccattctgtccccagtgaaatagtgtttgatttt
gagcctggcccagtgttcagagggtcaaccacaggcttgtcggccaccccacctgcctca
ttacctggctcactcactaacgtgaaagccttacagaaatctccaggacctcagcgggaa
aggaagtcctcctcctcctcctcctccacggaagacagaagtcggatgaaaacacttggt
agaagagattcaagtgatgattgggagattcctgatggacagattacagtgggacagaga
attggatctgggtcctttggaactgtctacaagggaaagtggcatggcgacgtggcagtg
aaaatgctgaatgtgacagcacccacacctcagcagttacaggccttcaaaaacgaagtc
ggagtactcaggaaaactcgacatgtgaacatcctccttttcatgggctattctacaaag
ccacagctggctattgttacacagtggtgtgaaggctccagcttatatcaccatctccac
atcattgagaccaaatttgagatgatcaaacttatagatattgcacggcagactgcacag
ggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatata
tttcttcatgaagacctcacggtaaaaataggtgactttggtttagccacagtgaagtcc
cgatggagtgggtcccatcagtttgaacagttgtctggatctattttgtggatggcaccc
gaagtaatcagaatgcaagataaaaacccatatagctttcagtcagacgtgtatgcattt
gggattgttctgtatgaactgatgactggtcagctaccttattcaaacatcaacaacagg
gatcagataatttttatggtgggacgaggatacctatctccagatctcagtaaggtacgg
agtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagac
gagagaccactctttccccaaattctcgcctctattgagctgctggcccgctcattgcca
aaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaacagaagat
tttagtctgtatgcttgtgcttctccaaaaacacccatccaagcagggggatatggagaa
tttgcagccttcaagtag
Rattus norvegicus (rat): 24703
Help
Entry
24703 CDS
T01003
Symbol
Raf1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01521
EGFR tyrosine kinase inhibitor resistance
rno01522
Endocrine resistance
rno04010
MAPK signaling pathway
rno04012
ErbB signaling pathway
rno04014
Ras signaling pathway
rno04015
Rap1 signaling pathway
rno04022
cGMP-PKG signaling pathway
rno04024
cAMP signaling pathway
rno04062
Chemokine signaling pathway
rno04068
FoxO signaling pathway
rno04071
Sphingolipid signaling pathway
rno04072
Phospholipase D signaling pathway
rno04140
Autophagy - animal
rno04150
mTOR signaling pathway
rno04151
PI3K-Akt signaling pathway
rno04210
Apoptosis
rno04218
Cellular senescence
rno04270
Vascular smooth muscle contraction
rno04360
Axon guidance
rno04370
VEGF signaling pathway
rno04371
Apelin signaling pathway
rno04510
Focal adhesion
rno04540
Gap junction
rno04550
Signaling pathways regulating pluripotency of stem cells
rno04613
Neutrophil extracellular trap formation
rno04625
C-type lectin receptor signaling pathway
rno04630
JAK-STAT signaling pathway
rno04650
Natural killer cell mediated cytotoxicity
rno04660
T cell receptor signaling pathway
rno04662
B cell receptor signaling pathway
rno04664
Fc epsilon RI signaling pathway
rno04666
Fc gamma R-mediated phagocytosis
rno04720
Long-term potentiation
rno04722
Neurotrophin signaling pathway
rno04726
Serotonergic synapse
rno04730
Long-term depression
rno04810
Regulation of actin cytoskeleton
rno04910
Insulin signaling pathway
rno04912
GnRH signaling pathway
rno04914
Progesterone-mediated oocyte maturation
rno04915
Estrogen signaling pathway
rno04916
Melanogenesis
rno04917
Prolactin signaling pathway
rno04919
Thyroid hormone signaling pathway
rno04921
Oxytocin signaling pathway
rno04926
Relaxin signaling pathway
rno04928
Parathyroid hormone synthesis, secretion and action
rno04929
GnRH secretion
rno04935
Growth hormone synthesis, secretion and action
rno05010
Alzheimer disease
rno05022
Pathways of neurodegeneration - multiple diseases
rno05034
Alcoholism
rno05132
Salmonella infection
rno05152
Tuberculosis
rno05160
Hepatitis C
rno05161
Hepatitis B
rno05163
Human cytomegalovirus infection
rno05164
Influenza A
rno05165
Human papillomavirus infection
rno05167
Kaposi sarcoma-associated herpesvirus infection
rno05170
Human immunodeficiency virus 1 infection
rno05200
Pathways in cancer
rno05205
Proteoglycans in cancer
rno05206
MicroRNAs in cancer
rno05207
Chemical carcinogenesis - receptor activation
rno05208
Chemical carcinogenesis - reactive oxygen species
rno05210
Colorectal cancer
rno05211
Renal cell carcinoma
rno05212
Pancreatic cancer
rno05213
Endometrial cancer
rno05214
Glioma
rno05215
Prostate cancer
rno05218
Melanoma
rno05219
Bladder cancer
rno05220
Chronic myeloid leukemia
rno05221
Acute myeloid leukemia
rno05223
Non-small cell lung cancer
rno05224
Breast cancer
rno05225
Hepatocellular carcinoma
rno05226
Gastric cancer
rno05230
Central carbon metabolism in cancer
rno05231
Choline metabolism in cancer
rno05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
24703 (Raf1)
04012 ErbB signaling pathway
24703 (Raf1)
04014 Ras signaling pathway
24703 (Raf1)
04015 Rap1 signaling pathway
24703 (Raf1)
04370 VEGF signaling pathway
24703 (Raf1)
04371 Apelin signaling pathway
24703 (Raf1)
04630 JAK-STAT signaling pathway
24703 (Raf1)
04068 FoxO signaling pathway
24703 (Raf1)
04072 Phospholipase D signaling pathway
24703 (Raf1)
04071 Sphingolipid signaling pathway
24703 (Raf1)
04024 cAMP signaling pathway
24703 (Raf1)
04022 cGMP-PKG signaling pathway
24703 (Raf1)
04151 PI3K-Akt signaling pathway
24703 (Raf1)
04150 mTOR signaling pathway
24703 (Raf1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
24703 (Raf1)
09143 Cell growth and death
04210 Apoptosis
24703 (Raf1)
04218 Cellular senescence
24703 (Raf1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
24703 (Raf1)
04540 Gap junction
24703 (Raf1)
04550 Signaling pathways regulating pluripotency of stem cells
24703 (Raf1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
24703 (Raf1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
24703 (Raf1)
04625 C-type lectin receptor signaling pathway
24703 (Raf1)
04650 Natural killer cell mediated cytotoxicity
24703 (Raf1)
04660 T cell receptor signaling pathway
24703 (Raf1)
04662 B cell receptor signaling pathway
24703 (Raf1)
04664 Fc epsilon RI signaling pathway
24703 (Raf1)
04666 Fc gamma R-mediated phagocytosis
24703 (Raf1)
04062 Chemokine signaling pathway
24703 (Raf1)
09152 Endocrine system
04910 Insulin signaling pathway
24703 (Raf1)
04929 GnRH secretion
24703 (Raf1)
04912 GnRH signaling pathway
24703 (Raf1)
04915 Estrogen signaling pathway
24703 (Raf1)
04914 Progesterone-mediated oocyte maturation
24703 (Raf1)
04917 Prolactin signaling pathway
24703 (Raf1)
04921 Oxytocin signaling pathway
24703 (Raf1)
04926 Relaxin signaling pathway
24703 (Raf1)
04935 Growth hormone synthesis, secretion and action
24703 (Raf1)
04919 Thyroid hormone signaling pathway
24703 (Raf1)
04928 Parathyroid hormone synthesis, secretion and action
24703 (Raf1)
04916 Melanogenesis
24703 (Raf1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
24703 (Raf1)
09156 Nervous system
04726 Serotonergic synapse
24703 (Raf1)
04720 Long-term potentiation
24703 (Raf1)
04730 Long-term depression
24703 (Raf1)
04722 Neurotrophin signaling pathway
24703 (Raf1)
09158 Development and regeneration
04360 Axon guidance
24703 (Raf1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
24703 (Raf1)
05206 MicroRNAs in cancer
24703 (Raf1)
05205 Proteoglycans in cancer
24703 (Raf1)
05207 Chemical carcinogenesis - receptor activation
24703 (Raf1)
05208 Chemical carcinogenesis - reactive oxygen species
24703 (Raf1)
05230 Central carbon metabolism in cancer
24703 (Raf1)
05231 Choline metabolism in cancer
24703 (Raf1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
24703 (Raf1)
09162 Cancer: specific types
05210 Colorectal cancer
24703 (Raf1)
05212 Pancreatic cancer
24703 (Raf1)
05225 Hepatocellular carcinoma
24703 (Raf1)
05226 Gastric cancer
24703 (Raf1)
05214 Glioma
24703 (Raf1)
05221 Acute myeloid leukemia
24703 (Raf1)
05220 Chronic myeloid leukemia
24703 (Raf1)
05218 Melanoma
24703 (Raf1)
05211 Renal cell carcinoma
24703 (Raf1)
05219 Bladder cancer
24703 (Raf1)
05215 Prostate cancer
24703 (Raf1)
05213 Endometrial cancer
24703 (Raf1)
05224 Breast cancer
24703 (Raf1)
05223 Non-small cell lung cancer
24703 (Raf1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
24703 (Raf1)
05161 Hepatitis B
24703 (Raf1)
05160 Hepatitis C
24703 (Raf1)
05164 Influenza A
24703 (Raf1)
05163 Human cytomegalovirus infection
24703 (Raf1)
05167 Kaposi sarcoma-associated herpesvirus infection
24703 (Raf1)
05165 Human papillomavirus infection
24703 (Raf1)
09171 Infectious disease: bacterial
05132 Salmonella infection
24703 (Raf1)
05152 Tuberculosis
24703 (Raf1)
09164 Neurodegenerative disease
05010 Alzheimer disease
24703 (Raf1)
05022 Pathways of neurodegeneration - multiple diseases
24703 (Raf1)
09165 Substance dependence
05034 Alcoholism
24703 (Raf1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
24703 (Raf1)
01522 Endocrine resistance
24703 (Raf1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
24703 (Raf1)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
24703 (Raf1)
Protein kinases [BR:
rno01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
24703 (Raf1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
ABC1
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
24703
NCBI-ProteinID:
NP_036771
RGD:
3531
Ensembl:
ENSRNOG00000010153
UniProt:
P11345
A6IKZ0
Structure
PDB
LinkDB
All DBs
Position
4:complement(148679534..148740265)
Genome browser
AA seq
648 aa
AA seq
DB search
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTASDSGVPAPPSFTMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq
1947 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggagcttggaagacgatcagcaatggtttcggactcaaagatgct
gtgtttgatggctccagttgcatctcccctacaattgttcagcagtttggctatcagcgt
cgggcctctgatgatggcaaactcacggattcttctaagacaagcaatactatccgggtt
ttcttgccgaataagcaaaggactgtggtcaatgtgcggaatgggatgagcttgcacgac
tgccttatgaaagctctgaaggttagaggcctgcagccagagtgctgtgcagtgttcaga
cttcttcaggagcacaaaggtaagaaagcacgcttagattggaacaccgacgccgcctct
ctgattggagaagaactgcaagtggattttttggatcacgttccactcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcaaaagttcctgcta
aatggatttcgatgtcagacttgtggctacaagtttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttgctgtttccaaattccact
gcaagtgacagtggagtcccagcaccaccctctttcacaatgcgtcggatgcgagaatct
gtttcccggatgcctgctagttcccagcacagatactccacaccccatgccttcactttc
aacacctccagcccttcctctgaaggttccctgtcccagaggcagaggtcaacgtccact
cccaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagccccaacaacctg
agcccaacaggctggtcacagcccaaaacccctgtgccagcacaaagagagagggcgcca
ggatctgggacccaggaaaaaaacaaaattaggcctcgtgggcagagagattcaagttat
tactgggaaatagaagccagtgaggtgatgctgtctactcggattggctcgggctccttt
ggcactgtgtacaagggcaagtggcatggagatgttgcagtaaagatcctaaaggtggtt
gacccaactccagagcaacttcaggccttcaggaacgaggtggctgttttgcgcaaaaca
cggcatgttaatatcctgctgttcatggggtacatgacaaaggacaacctggcgattgtg
acccagtggtgtgaaggcagcagtctctacaaacacctgcatgtccaggagaccaaattc
cagatgttccagctaattgacattgcccggcagacagctcagggaatggactatttacat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctc
acggtgaaaatcggagattttggtttggcaacagtgaagtcgcgctggagtggttctcag
caggttgaacagcccactggctctgtgctgtggatggccccagaagtaatccgaatgcag
gataacaacccgttcagcttccagtccgatgtctactcctatggcattgtgctgtatgag
ctgatgactggggagcttccctactcccacatcaacaaccgagaccagatcatcttcatg
gtgggccgtgggtacgcctccccagatcttagcaggctctacaagaactgccccaaggca
atgaagaggttggtggctgactgtgtgaagaaagtcaaagaagaaaggcctttgtttcct
cagatcctgtcttccattgagctgcttcagcactctctgccgaaaatcaacaggagcgcc
tctgagccttccctgcatcgggcagctcacactgaggacatcaatgcttgtacgctgacc
acatccccaaggctaccagtcttctag
Rattus norvegicus (rat): 64363
Help
Entry
64363 CDS
T01003
Symbol
Araf
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform 1
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01521
EGFR tyrosine kinase inhibitor resistance
rno01522
Endocrine resistance
rno04010
MAPK signaling pathway
rno04012
ErbB signaling pathway
rno04068
FoxO signaling pathway
rno04270
Vascular smooth muscle contraction
rno04650
Natural killer cell mediated cytotoxicity
rno04720
Long-term potentiation
rno04726
Serotonergic synapse
rno04730
Long-term depression
rno04810
Regulation of actin cytoskeleton
rno04910
Insulin signaling pathway
rno04914
Progesterone-mediated oocyte maturation
rno04928
Parathyroid hormone synthesis, secretion and action
rno05010
Alzheimer disease
rno05022
Pathways of neurodegeneration - multiple diseases
rno05034
Alcoholism
rno05160
Hepatitis C
rno05161
Hepatitis B
rno05200
Pathways in cancer
rno05205
Proteoglycans in cancer
rno05208
Chemical carcinogenesis - reactive oxygen species
rno05210
Colorectal cancer
rno05211
Renal cell carcinoma
rno05212
Pancreatic cancer
rno05213
Endometrial cancer
rno05214
Glioma
rno05215
Prostate cancer
rno05218
Melanoma
rno05219
Bladder cancer
rno05220
Chronic myeloid leukemia
rno05221
Acute myeloid leukemia
rno05223
Non-small cell lung cancer
rno05224
Breast cancer
rno05225
Hepatocellular carcinoma
rno05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
64363 (Araf)
04012 ErbB signaling pathway
64363 (Araf)
04068 FoxO signaling pathway
64363 (Araf)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
64363 (Araf)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
64363 (Araf)
09152 Endocrine system
04910 Insulin signaling pathway
64363 (Araf)
04914 Progesterone-mediated oocyte maturation
64363 (Araf)
04928 Parathyroid hormone synthesis, secretion and action
64363 (Araf)
09153 Circulatory system
04270 Vascular smooth muscle contraction
64363 (Araf)
09156 Nervous system
04726 Serotonergic synapse
64363 (Araf)
04720 Long-term potentiation
64363 (Araf)
04730 Long-term depression
64363 (Araf)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
64363 (Araf)
05205 Proteoglycans in cancer
64363 (Araf)
05208 Chemical carcinogenesis - reactive oxygen species
64363 (Araf)
09162 Cancer: specific types
05210 Colorectal cancer
64363 (Araf)
05212 Pancreatic cancer
64363 (Araf)
05225 Hepatocellular carcinoma
64363 (Araf)
05226 Gastric cancer
64363 (Araf)
05214 Glioma
64363 (Araf)
05221 Acute myeloid leukemia
64363 (Araf)
05220 Chronic myeloid leukemia
64363 (Araf)
05218 Melanoma
64363 (Araf)
05211 Renal cell carcinoma
64363 (Araf)
05219 Bladder cancer
64363 (Araf)
05215 Prostate cancer
64363 (Araf)
05213 Endometrial cancer
64363 (Araf)
05224 Breast cancer
64363 (Araf)
05223 Non-small cell lung cancer
64363 (Araf)
09172 Infectious disease: viral
05161 Hepatitis B
64363 (Araf)
05160 Hepatitis C
64363 (Araf)
09164 Neurodegenerative disease
05010 Alzheimer disease
64363 (Araf)
05022 Pathways of neurodegeneration - multiple diseases
64363 (Araf)
09165 Substance dependence
05034 Alcoholism
64363 (Araf)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
64363 (Araf)
01522 Endocrine resistance
64363 (Araf)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
64363 (Araf)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
64363 (Araf)
Protein kinases [BR:
rno01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
64363 (Araf)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
ABC1
zf-RING-like
Pkinase_fungal
TUG-UBL1
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
64363
NCBI-ProteinID:
NP_071977
RGD:
2148
Ensembl:
ENSRNOG00000010838
UniProt:
P14056
A6JZR6
LinkDB
All DBs
Position
X:complement(1227392..1292356)
Genome browser
AA seq
604 aa
AA seq
DB search
MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEVPSNLSVNELL
TPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFS
TDAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYY
WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTR
HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA
KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQD
PNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAM
RRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAA
RLVP
NT seq
1815 nt
NT seq
+upstream
nt +downstream
nt
atggaaccaccacgaggccctcctgctagtggggctgagccatctcgggcagttggcact
gtcaaagtgtacctgcctaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctatgactctttggacaaggccctcaaggtgcggggtctcaatcaggactgctgtgtg
gtctacagactcatcaaaggaagaaagacagtcactgcctgggacacagccattgcacct
ctggatggcgaggagctcattgtggaggtcctggaagatgtgccactgaccatgcacaat
tttgtacggaagacattcttcagtttggccttctgtgacttctgccttaagtttctgttc
cacggctttcgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacggtctgcgttgacatgagtaccaaccgccgacagttctaccacagcatccaggat
ttgtctggaggctccaggcagcaggaggttccctcaaatctctctgtgaatgagctgcta
accccccagggtcccagtccctttacccagcaacgtgaccaggagcacttctccttccct
gcccctgccaatcccccactgcagcgcatccgctccacatctactcctaacgtccacatg
gtcagcaccacagctcccatggactccagcctcatgcagtttactgctcagagcttcagc
accgatgctgctggtagaggtggtgatggagctcctcggggtagccctagcccagctagt
gtgtcttcagggaggaagtccccacattccaagttacctgcagaacagcgggaacggaag
tccttggcagatgaaaagaaaaaagtgaagaacctggggtaccgggactcaggctattac
tgggaggtgccacccagtgaggtacagctgttgaagaggatcgggacaggctcttttggc
actgtgtttcgggggcgttggcatggcgatgtagctgtgaaagtgctcaaggtggcccaa
cctaccgctgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaagacacga
catgtcaacattttgctgtttatgggtttcatgactcggccagggtttgccatcatcaca
cagtggtgtgagggttccagcctctaccaccacctacatgtggctgacacgcgctttgac
atggtccagctcattgatgtggcccggcagactgcccagggcatggactacctccacgcc
aagaacatcattcaccgagacctaaagtccaacaatatcttcctacatgaggggctcaca
gtcaagattggtgacttcggcctggccacagtgaagacacgatggagtggggcccagccc
ttagagcagccctcagggtctgtgctgtggatggcagctgaggtgatccgaatgcaggac
ccgaacccctacagcttccagtcggatgtctatgcctatggtgttgtgctctatgagctt
atgaccggctcactgccctacagccacattggcagccgtgaccagatcatctttatggtg
ggtcgtggctatctgtctccggacctcagcaaaatcttcagtaattgccccaaagccatg
aggcgcttgctgactgactgcctcaagttccagcgggaggagcggcctctatttccccag
attctggccacgatcgagctgctgcagcggtcactccccaagattgagcggagtgcctcc
gaaccctccttgcaccgtacccaggctgatgagttgcctgcctgccttctcagcgcagcc
cgccttgtgccttag
DBGET
integrated database retrieval system
