Rattus norvegicus (rat): 24641 Help Entry 24641             CDS       T01003                                  Symbol Flg Name (RefSeq) filaggrin   KO K10384   filaggrin Organism rno  Rattus norvegicus (rat) Pathway rno04382   Cornified envelope formation Brite KEGG Orthology (KO) [BR:rno00001]  09150 Organismal Systems   09158 Development and regeneration    04382 Cornified envelope formation     24641 (Flg)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:rno04812]     24641 (Flg) Cytoskeleton proteins [BR:rno04812]  Eukaryotic cytoskeleton proteins   Intermediate filaments    Intermediate filament-binding proteins     24641 (Flg) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  S_100 EF-hand_7 EF-hand_1 Motif Other DBs NCBI-GeneID:  24641 NCBI-ProteinID:  NP_001380695 RGD:  2620 LinkDB All DBs Position 2:<181583801..181596464 Genome browser AA seq 7706 aa AA seqDB search MSTLLESITSMIDIFQQYSNNDKEEETLSKEELKELLEGELQAVLKNPNDQDIAEVFMQM LDVDHDDKIDFTEYLLMVLKLAQAYYETSKKRRSQTKESGKRNEHDYKGYEERREKVQRR HRRRNSGTDGKQENERSKSPRGRGNKRRGSSTISEESDTNRNSDTENKRHHHGSNRRQRR GSNSSDRKETRSKKHREVKERNAGIYNDGKDGQDWEVNYENCYYKTEESNREQREGRNHK TKESHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTR TGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHR RAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHS GAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRG QQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHR QQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREAAR DSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQ AGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQ SPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAG GQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSID SRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGV EETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARH EQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETI SRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSR PEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGR TREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQ GQASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASD SEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQ AHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHE DRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSS RGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEG HSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSR EAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQG AHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRH QHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARG RSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSG SRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTP GSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTS TTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDS HRHSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQR PSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPE SSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQR EAARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEA SGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESP AGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQR ASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTA TSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVY YYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHR AARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRR SETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATR HTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIES RRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRS GASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSES QASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQ QGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQR GSHQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGR TGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSS DSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAG SRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEA HTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQ RQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEE IARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRS ARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHA DSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQ GQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQ STDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQR HEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEH QQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGP GPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHS ESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGR GESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSS GSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQ AHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGH PQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSG RTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHA QSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGT AATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRAR HIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADT SSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRG SSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDE SDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDS TRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSG HSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPD TAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQ GRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSD YSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQ RQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSAR TQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQA TDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSA QRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHA GIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIA RHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQ TSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQER EHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASA SEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQA GSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTG SRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRA GSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHSGA GQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQ GSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQ GSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREAARDS SEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAG RRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSP DRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQ AADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSR RPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEE TEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQ ESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISR GRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPE QSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTR EASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQ ASGQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQ QQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAH SSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHEDR HEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRG QQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHS GAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREA QGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAH GGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQH EQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRS GASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSR GGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGS TRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTT HRRAGSSSGSQRASAGGQAADTSSRSGASQGQASGQGRAGSRSREAQGIARHGQSTDSHR HSGAGQAQAHTATSIDSRRPRGSSESQASDSEGHSDYSEAHTQGAHGGIQTSQRHEQRPS RGQQGSGHPQVYYYGVEETEDESDAQQGHHQQQQQQRQQQRQRHQHEQEREHEHQQPESS HRQQGSSGRTHRAARHEQESDSTRQRGSHQAHSSARTQEEIARGRSGASASEGPGPQREA ARDSSEHAQSRRSETISRGRSGHSTGRAHEDRHEQATDRSARSGSRGGQAGSHSESEASG GQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAG QQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQQAS VEGSDGYDSIVKSKYLSFSQSHCYYY NT seq 23121 nt NT seq  +upstreamnt  +downstreamnt atgtccactctcctggaaagcatcactagcatgattgacatattccaacaatactcaaac aatgataaggaggaggaaacactgagcaaagaagagctgaaggaacttctggaaggagaa ttacaagcagtcttgaagaatccaaatgaccaagacatagcagaggtcttcatgcaaatg ctagatgtggaccacgatgacaaaatagatttcactgagtatttactaatggtattaaag ctggcacaagcatattatgaaacatcaaaaaagagaagatcccaaacaaaagaatcagga aagagaaatgaacatgattataaaggatatgaagaaaggagagaaaaagtacaaagaaga cacaggcggaggaacagtggaactgatggaaagcaagaaaatgaacgatcaaaaagccca agaggaagagggaacaaaagacgaggatccagcactataagtgaggaaagtgacacaaac agaaatagtgatacagaaaacaaaaggcaccatcatggttcaaacagaaggcaaagaaga ggttccaattcatctgacaggaaagagacaagaagtaagaaacacagagaggtaaaagaa agaaatgctgggatctataacgatggaaaagacggacaagattgggaagtaaactatgaa aactgttattacaaaactgaagaaagtaacagggaacaaagagaaggacggaatcataaa acaaaagaatcgcacagtgagagcgaggcctccggtggtcaggccggccgcagaggcact gcagccaccaggcacacatctcgccccgaacagtctccagacactgctggccggaccgga tccagccgtggacagcagtccgcccaacgacatgctgactcaaccccgggcagcacaaga accggctccagaggaagaggagagtccccagctggccagcagtcccccgacagagccagg cacatcgaatccaggaggggtagaacccgggaggccagcgccagccagtccagtgacagc gaaggccattctggagcccatgccgggatcgggcaagggcagacctcaaccactcacagg agggcaggctccagctcagggagccagcgggcctctgctggtggccaagcagctgacacc tccagtcgctcaggggccagtcaaggccaggcatcaggccagggtcgtgcagggtcccga agcagggaagctcagggcatcgctcgtcatgggcagtcgacagacagccacaggcactct ggggccgggcaagcacaagcccacacagccacaagcattgacagcaggaggcctcgcggg tccagcgagagtcaggccagcgacagcgagggccactccgactactcagaagcacacaca cagggagcccacggtgggatccaaacaagccagaggcacgagcagcgaccctcccgaggc cagcagggctccggacacccccaggtgtactactatggtgtagaagaaaccgaggacgag tccgatgcccagcaggggcaccaccagcagcagcaacagcagcggcagcagcagcggcag cggcaccagcatgaacaggaacgagaacatgaacaccaacagccagagtccagccacagg cagcaggggtccagtgggagaacgcaccgggcagctcgccatgaacaggaaagcgacagc accaggcaaaggggctctcaccaggcgcacagctccgctcgcacccaggaggagatcgca cgcggaaggtctggagccagtgccagtgagggtccggggccccagagggaggctgccagg gacagctctgagcacgcccagtccagaaggagcgagaccatcagccgtggacgctcagga cactccactgggagagcccacgaagaccgccacgagcaggcaacagaccgctctgcccgc tccgggtccaggggaggccaggccggctcccacagtgagagcgaggcctccggtggtcag gccggccgcagaggcactgcagccaccaggcacacatctcgccccgaacagtctccagac actgctggccggaccggatccagccgtggacagcagtccgcccaacgacatgctgactca accccgggcagcacaagaaccggctccagaggaagaggagagtccccagctggccagcag tcccccgacagagccaggcacatcgaatccaggaggggtagaacccgggaggccagcgcc agccagtccagtgacagcgaaggccattctggagcccatgccgggatcgggcaagggcag acctcaaccactcacaggagggcaggctccagctcagggagccagcgggcctctgctggt ggccaagcagctgacacctccagtcgctcaggggccagtcaaggccaggcatcaggccag ggtcgtgcagggtcccgaagcagggaagctcagggcatcgctcgtcatgggcagtcgaca gacagccacaggcactctggggccgggcaagcacaagcccacacagccacaagcattgac agcaggaggcctcgcgggtccagcgagagtcaggccagcgacagcgagggccactccgac tactcagaagcacacacacagggagcccacggtgggatccaaacaagccagaggcacgag cagcgaccctcccgaggccagcagggctccggacacccccaggtgtactactatggtgta gaagaaaccgaggacgagtccgatgcccagcaggggcaccaccagcagcagcaacagcag cggcagcagcagcggcagcggcaccagcatgaacaggaacgagaacatgaacaccaacag ccagagtccagccacaggcagcaggggtccagtgggagaacgcaccgggcagctcgccat gaacaggaaagcgacagcaccaggcaaaggggctctcaccaggcgcacagctccgctcgc acccaggaggagatcgcacgcggaaggtctggagccagtgccagtgagggtccggggccc cagagggaggctgccagggacagctctgagcacgcccagtccagaaggagcgagaccatc agccgtggacgctcaggacactccactgggagagcccacgaagaccgccacgagcaggca acagaccgctctgcccgctccgggtccaggggaggccaggccggctcccacagtgagagc gaggcctccggtggtcaggccggccgcagaggcactgcagccaccaggcacacatctcgc cccgaacagtctccagacactgctggccggaccggatccagccgtggacagcagtccgcc caacgacatgctgactcaaccccgggcagcacaagaaccggctccagaggaagaggagag tccccagctggccagcagtcccccgacagagccaggcacatcgaatccaggaggggtaga acccgggaggccagcgccagccagtccagtgacagcgaaggccattctggagcccatgcc gggatcgggcaagggcagacctcaaccactcacaggagggcaggctccagctcagggagc cagcgggcctctgctggtggccaagcagctgacacctccagtcgctcaggggccagtcaa ggccaggcatcaggccagggtcgtgcagggtcccgaagcagggaagctcagggcatcgct cgtcatgggcagtcgacagacagccacaggcactctggggccgggcaagcacaagcccac acagccacaagcattgacagcaggaggcctcgcgggtccagcgagagtcaggccagcgac agcgagggccactccgactactcagaagcacacacacagggagcccacggtgggatccaa acaagccagaggcacgagcagcgaccctcccgaggccagcagggctccggacacccccag gtgtactactatggtgtagaagaaaccgaggacgagtccgatgcccagcaggggcaccac cagcagcagcaacagcagcggcagcagcagcggcagcggcaccagcatgaacaggaacga gaacatgaacaccaacagccagagtccagccacaggcagcaggggtccagtgggagaacg caccgggcagctcgccatgaacaggaaagcgacagcaccaggcaaaggggctctcaccag gcgcacagctccgctcgcacccaggaggagatcgcacgcggaaggtctggagccagtgcc agtgagggtccggggccccagagggaggctgccagggacagctctgagcacgcccagtcc agaaggagcgagaccatcagccgtggacgctcaggacactccactgggagagcccacgaa gaccgccacgagcaggcaacagaccgctctgcccgctccgggtccaggggaggccaggcc ggctcccacagtgagagcgaggcctccggtggtcaggccggccgcagaggcactgcagcc accaggcacacatctcgccccgaacagtctccagacactgctggccggaccggatccagc cgtggacagcagtccgcccaacgacatgctgactcaaccccgggcagcacaagaaccggc tccagaggaagaggagagtccccagctggccagcagtcccccgacagagccaggcacatc gaatccaggaggggtagaacccgggaggccagcgccagccagtccagtgacagcgaaggc cattctggagcccatgccgggatcgggcaagggcagacctcaaccactcacaggagggca ggctccagctcagggagccagcgggcctctgctggtggccaagcagctgacacctccagt cgctcaggggccagtcaaggccaggcatcaggccagggtcgtgcagggtcccgaagcagg gaagctcagggcatcgctcgtcatgggcagtcgacagacagccacaggcactctggggcc gggcaagcacaagcccacacagccacaagcattgacagcaggaggcctcgcgggtccagc gagagtcaggccagcgacagcgagggccactccgactactcagaagcacacacacaggga gcccacggtgggatccaaacaagccagaggcacgagcagcgaccctcccgaggccagcag ggctccggacacccccaggtgtactactatggtgtagaagaaaccgaggacgagtccgat gcccagcaggggcaccaccagcagcagcaacagcagcggcagcagcagcggcagcggcac cagcatgaacaggaacgagaacatgaacaccaacagccagagtccagccacaggcagcag gggtccagtgggagaacgcaccgggcagctcgccatgaacaggaaagcgacagcaccagg caaaggggctctcaccaggcgcacagctccgctcgcacccaggaggagatcgcacgcgga aggtctggagccagtgccagtgagggtccggggccccagagggaggctgccagggacagc tctgagcacgcccagtccagaaggagcgagaccatcagccgtggacgctcaggacactcc actgggagagcccacgaagaccgccacgagcaggcaacagaccgctctgcccgctccggg tccaggggaggccaggccggctcccacagtgagagcgaggcctccggtggtcaggccggc cgcagaggcactgcagccaccaggcacacatctcgccccgaacagtctccagacactgct ggccggaccggatccagccgtggacagcagtccgcccaacgacatgctgactcaaccccg ggcagcacaagaaccggctccagaggaagaggagagtccccagctggccagcagtccccc gacagagccaggcacatcgaatccaggaggggtagaacccgggaggccagcgccagccag tccagtgacagcgaaggccattctggagcccatgccgggatcgggcaagggcagacctca accactcacaggagggcaggctccagctcagggagccagcgggcctctgctggtggccaa gcagctgacacctccagtcgctcaggggccagtcaaggccaggcatcaggccagggtcgt gcagggtcccgaagcagggaagctcagggcatcgctcgtcatgggcagtcgacagacagc cacaggcactctggggccgggcaagcacaagcccacacagccacaagcattgacagcagg aggcctcgcgggtccagcgagagtcaggccagcgacagcgagggccactccgactactca gaagcacacacacagggagcccacggtgggatccaaacaagccagaggcacgagcagcga ccctcccgaggccagcagggctccggacacccccaggtgtactactatggtgtagaagaa accgaggacgagtccgatgcccagcaggggcaccaccagcagcagcaacagcagcggcag cagcagcggcagcggcaccagcatgaacaggaacgagaacatgaacaccaacagccagag tccagccacaggcagcaggggtccagtgggagaacgcaccgggcagctcgccatgaacag gaaagcgacagcaccaggcaaaggggctctcaccaggcgcacagctccgctcgcacccag gaggagatcgcacgcggaaggtctggagccagtgccagtgagggtccggggccccagagg 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gcacaagcccacacagccacaagcattgacagcaggaggcctcgcgggtccagcgagagt caggccagcgacagcgagggccactccgactactcagaagcacacacacagggagcccac ggtgggatccaaacaagccagaggcacgagcagcgaccctcccgaggccagcagggctcc ggacacccccaggtgtactactatggtgtagaagaaaccgaggacgagtccgatgcccag caggggcaccaccagcagcagcaacagcagcggcagcagcagcggcagcggcaccagcat gaacaggaacgagaacatgaacaccaacagccagagtccagccacaggcagcaggggtcc agtgggagaacgcaccgggcagctcgccatgaacaggaaagcgacagcaccaggcaaagg ggctctcaccaggcgcacagctccgctcgcacccaggaggagatcgcacgcggaaggtct ggagccagtgccagtgagggtccggggccccagagggaggctgccagggacagctctgag cacgcccagtccagaaggagcgagaccatcagccgtggacgctcaggacactccactggg agagcccacgaagaccgccacgagcaggcaacagaccgctctgcccgctccgggtccagg ggaggccaggccggctcccacagtgagagcgaggcctccggtggtcaggccggccgcaga ggcactgcagccaccaggcacacatctcgccccgaacagtctccagacactgctggccgg accggatccagccgtggacagcagtccgcccaacgacatgctgactcaaccccgggcagc acaagaaccggctccagaggaagaggagagtccccagctggccagcagtcccccgacaga gccaggcacatcgaatccaggaggggtagaacccgggaggccagcgccagccagtccagt 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ggtcaggccggccgcagaggcactgcagccaccaggcacacatctcgccccgaacagtct ccagacactgctggccggaccggatccagccgtggacagcagtccgcccaacgacatgct gactcaaccccgggcagcacaagaaccggctccagaggaagaggagagtccccagctggc cagcagtcccccgacagagccaggcacatcgaatccaggaggggtagaacccgggaggcc agcgccagccagtccagtgacagcgaaggccattctggagcccatgccgggatcgggcaa gggcagacctcaaccactcacaggagggcaggctccagctcagggagccagcgggcctct gctggtggccaagcagctgacacctccagtcgctcaggggccagtcaaggccaggcatca ggccagggtcgtgcagggtcccgaagcagggaagctcagggcatcgctcgtcatgggcag tcgacagacagccacaggcactctggggccgggcaagcacaagcccacacagccacaagc attgacagcaggaggcctcgcgggtccagcgagagtcaggccagcgacagcgagggccac tccgactactcagaagcacacacacagggagcccacggtgggatccaaacaagccagagg cacgagcagcgaccctcccgaggccagcagggctccggacacccccaggtgtactactat ggtgtagaagaaaccgaggacgagtccgatgcccagcaggggcaccaccagcagcagcaa cagcagcggcagcagcagcggcagcggcaccagcatgaacaggaacgagaacatgaacac caacagccagagtccagccacaggcagcaggggtccagtgggagaacgcaccgggcagct cgccatgaacaggaaagcgacagcaccaggcaaaggggctctcaccaggcgcacagctcc 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ccccaggtgtactactatggtgtagaagaaaccgaggacgagtccgatgcccagcagggg caccaccagcagcagcaacagcagcggcagcagcagcggcagcggcaccagcatgaacag gaacgagaacatgaacaccaacagccagagtccagccacaggcagcaggggtccagtggg agaacgcaccgggcagctcgccatgaacaggaaagcgacagcaccaggcaaaggggctct caccaggcgcacagctccgctcgcacccaggaggagatcgcacgcggaaggtctggagcc agtgccagtgagggtccggggccccagagggaggctgccagggacagctctgagcacgcc cagtccagaaggagcgagaccatcagccgtggacgctcaggacactccactgggagagcc cacgaagaccgccacgagcaggcaacagaccgctctgcccgctccgggtccaggggaggc caggccggctcccacagtgagagcgaggcctccggtggtcaggccggccgcagaggcact gcagccaccaggcacacatctcgccccgaacagtctccagacactgctggccggaccgga tccagccgtggacagcagtccgcccaacgacatgctgactcaaccccgggcagcacaaga accggctccagaggaagaggagagtccccagctggccagcagtcccccgacagagccagg cacatcgaatccaggaggggtagaacccgggaggccagcgccagccagtccagtgacagc gaaggccattctggagcccatgccgggatcgggcaagggcagacctcaaccactcacagg agggcaggctccagctcagggagccagcgggcctctgctggtggccaagcagctgacacc tccagtcgctcaggggccagtcaaggccaggcatcaggccagggtcgtgcagggtcccga agcagggaagctcagggcatcgctcgtcatgggcagtcgacagacagccacaggcactct ggggccgggcaagcacaagcccacacagccacaagcattgacagcaggaggcctcgcggg tccagcgagagtcaggccagcgacagcgagggccactccgactactcagaagcacacaca cagggagcccacggtgggatccaaacaagccagaggcacgagcagcgaccctcccgaggc cagcagggctccggacacccccaggtgtactactatggtgtagaagaaaccgaggacgag tccgatgcccagcaggggcaccaccagcagcagcaacagcagcggcagcagcagcggcag cggcaccagcatgaacaggaacgagaacatgaacaccaacagccagagtccagccacagg cagcaggggtccagtgggagaacgcaccgggcagctcgccatgaacaggaaagcgacagc accaggcaaaggggctctcaccaggcgcacagctccgctcgcacccaggaggagatcgca cgcggaaggtctggagccagtgccagtgagggtccggggccccagagggaggctgccagg gacagctctgagcacgcccagtccagaaggagcgagaccatcagccgtggacgctcagga cactccactgggagagcccacgaagaccgccacgagcaggcaacagaccgctctgcccgc tccgggtccaggggaggccaggccggctcccacagtgagagcgaggcctccggtggtcag gccggccgcagaggcactgcagccaccaggcacacatctcgccccgaacagtctccagac actgctggccggaccggatccagccgtggacagcagtccgcccaacgacatgctgactca accccgggcagcacaagaaccggctccagaggaagaggagagtccccagctggccagcag tcccccgacagagccaggcacatcgaatccaggaggggtagaacccgggaggccagcgcc agccagtccagtgacagcgaaggccattctggagcccatgccgggatcgggcaagggcag acctcaaccactcacaggagggcaggctccagctcagggagccagcgggcctctgctggt ggccaagcagctgacacctccagtcgctcaggggccagtcaaggccaggcatcaggccag ggtcgtgcagggtcccgaagcagggaagctcagggcatcgctcgtcatgggcagtcgaca gacagccacaggcactctggggccgggcaagcacaagcccacacagccacaagcattgac agcaggaggcctcgcgggtccagcgagagtcaggccagcgacagcgagggccactccgac tactcagaagcacacacacagggagcccacggtgggatccaaacaagccagaggcacgag cagcgaccctcccgaggccagcagggctccggacacccccaggtgtactactatggtgta gaagaaaccgaggacgagtccgatgcccagcaggggcaccaccagcagcagcaacagcag cggcagcagcagcggcagcggcaccagcatgaacaggaacgagaacatgaacaccaacag ccagagtccagccacaggcagcaggggtccagtgggagaacgcaccgggcagctcgccat gaacaggaaagcgacagcaccaggcaaaggggctctcaccaggcgcacagctccgctcgc acccaggaggagatcgcacgcggaaggtctggagccagtgccagtgagggtccggggccc cagagggaggctgccagggacagctctgagcacgcccagtccagaaggagcgagaccatc agccgtggacgctcaggacactccactgggagagcccacgaagaccgccacgagcaggca acagaccgctctgcccgctccgggtccaggggaggccaggccggctcccacagtgagagc gaggcctccggtggtcaggccggccgcagaggcactgcagccaccaggcacacatctcgc cccgaacagtctccagacactgctggccggaccggatccagccgtggacagcagtccgcc caacgacatgctgactcaaccccgggcagcacaagaaccggctccagaggaagaggagag tccccagctggccagcagtcccccgacagagccaggcacatcgaatccaggaggggtaga acccgggaggccagcgccagccagtccagtgacagcgaaggccattctggagcccatgcc gggatcgggcaagggcagacctcaaccactcacaggagggcaggctccagctcagggagc cagcgggcctctgctggtggccaagcagctgacacctccagtcgctcaggggccagtcaa ggccaggcatcaggccagggtcgtgcagggtcccgaagcagggaagctcagggcatcgct cgtcatgggcagtcgacagacagccacaggcactctggggccgggcaagcacaagcccac acagccacaagcattgacagcaggaggcctcgcgggtccagcgagagtcaggccagcgac agcgagggccactccgactactcagaagcacacacacagggagcccacggtgggatccaa acaagccagaggcacgagcagcgaccctcccgaggccagcagggctccggacacccccag gtgtactactatggtgtagaagaaaccgaggacgagtccgatgcccagcaggggcaccac cagcagcagcaacagcagcggcagcagcagcggcagcggcaccagcatgaacaggaacga gaacatgaacaccaacagccagagtccagccacaggcagcaggggtccagtgggagaacg caccgggcagctcgccatgaacaggaaagcgacagcaccaggcaaaggggctctcaccag gcgcacagctccgctcgcacccaggaggagatcgcacgcggaaggtctggagccagtgcc agtgagggtccggggccccagagggaggctgccagggacagctctgagcacgcccagtcc agaaggagcgagaccatcagccgtggacgctcaggacactccactgggagagcccacgaa gaccgccacgagcaggcaacagaccgctctgcccgctccgggtccaggggaggccaggcc ggctcccacagtgagagcgaggcctccggtggtcaggccggccgcagaggcactgcagcc accaggcacacatctcgccccgaacagtctccagacactgctggccggaccggatccagc cgtggacagcagtccgcccaacgacatgctgactcaaccccgggcagcacaagaaccggc tccagaggaagaggagagtccccagctggccagcagtcccccgacagagccaggcacatc gaatccaggaggggtagaacccgggaggccagcgccagccagtccagtgacagcgaaggc cattctggagcccatgccgggatcgggcaagggcagacctcaaccactcacaggagggca ggctccagctcagggagccagcgggcctctgctggtggccaagcagctgacacctccagt cgctcaggggccagtcaaggccaggcatcaggccagggtcgtgcagggtcccgaagcagg gaagctcagggcatcgctcgtcatgggcagtcgacagacagccacaggcactctggggcc gggcaagcacaagcccacacagccacaagcattgacagcaggaggcctcgcgggtccagc gagagtcaggccagcgacagcgagggccactccgactactcagaagcacacacacaggga gcccacggtgggatccaaacaagccagaggcacgagcagcgaccctcccgaggccagcag ggctccggacacccccaggtgtactactatggtgtagaagaaaccgaggacgagtccgat gcccagcaggggcaccaccagcagcagcaacagcagcggcagcagcagcggcagcggcac cagcatgaacaggaacgagaacatgaacaccaacagccagagtccagccacaggcagcag gggtccagtgggagaacgcaccgggcagctcgccatgaacaggaaagcgacagcaccagg caaaggggctctcaccaggcgcacagctccgctcgcacccaggaggagatcgcacgcgga aggtctggagccagtgccagtgagggtccggggccccagagggaggctgccagggacagc tctgagcacgcccagtccagaaggagcgagaccatcagccgtggacgctcaggacactcc actgggagagcccacgaagaccgccacgagcaggcaacagaccgctctgcccgctccggg tccaggggaggccaggccggctcccacagtgagagcgaggcctccggtggtcaggccggc cgcagaggcactgcagccaccaggcacacatctcgccccgaacagtctccagacactgct ggccggaccggatccagccgtggacagcagtccgcccaacgacatgctgactcaaccccg ggcagcacaagaaccggctccagaggaagaggagagtccccagctggccagcagtccccc gacagagccaggcacatcgaatccaggaggggtagaacccgggaggccagcgccagccag tccagtgacagcgaaggccattctggagcccatgccgggatcgggcaagggcagacctca accactcacaggagggcaggctccagctcagggagccagcgggcctctgctggtggccaa gcagctgacacctccagtcgctcaggggccagtcaaggccaggcatcaggccagggtcgt gcagggtcccgaagcagggaagctcagggcatcgctcgtcatgggcagtcgacagacagc cacaggcactctggggccgggcaagcacaagcccacacagccacaagcattgacagcagg aggcctcgcgggtccagcgagagtcaggccagcgacagcgagggccactccgactactca gaagcacacacacagggagcccacggtgggatccaaacaagccagaggcacgagcagcga ccctcccgaggccagcagggctccggacacccccaggtgtactactatggtgtagaagaa accgaggacgagtccgatgcccagcaggggcaccaccagcagcagcaacagcagcggcag cagcagcggcagcggcaccagcatgaacaggaacgagaacatgaacaccaacagccagag tccagccacaggcagcaggggtccagtgggagaacgcaccgggcagctcgccatgaacag gaaagcgacagcaccaggcaaaggggctctcaccaggcgcacagctccgctcgcacccag gaggagatcgcacgcggaaggtctggagccagtgccagtgagggtccggggccccagagg gaggctgccagggacagctctgagcacgcccagtccagaaggagcgagaccatcagccgt ggacgctcaggacactccactgggagagcccacgaagaccgccacgagcaggcaacagac cgctctgcccgctccgggtccaggggaggccaggccggctcccacagtgagagcgaggcc tccggtggtcaggccggccgcagaggcactgcagccaccaggcacacatctcgccccgaa cagtctccagacactgctggccggaccggatccagccgtggacagcagtccgcccaacga catgctgactcaaccccgggcagcacaagaaccggctccagaggaagaggagagtcccca gctggccagcagtcccccgacagagccaggcacatcgaatccaggaggggtagaacccgg gaggccagcgccagccagtccagtgacagcgaaggccattctggagcccatgccgggatc gggcaagggcagacctcaaccactcacaggagggcaggctccagctcagggagccagcgg gcctctgctggtggccaagcagctgacacctccagtcgctcaggggccagtcaaggccag gcatcaggccagggtcgtgcagggtcccgaagcagggaagctcagggcatcgctcgtcat gggcagtcgacagacagccacaggcactctggggccgggcaagcacaagcccacacagcc acaagcattgacagcaggaggcctcgcgggtccagcgagagtcaggccagcgacagcgag ggccactccgactactcagaagcacacacacagggagcccacggtgggatccaaacaagc cagaggcacgagcagcgaccctcccgaggccagcagggctccggacacccccaggtgtac tactatggtgtagaagaaaccgaggacgagtccgatgcccagcaggggcaccaccagcag cagcaacagcagcggcagcagcagcggcagcggcaccagcatgaacaggaacgagaacat gaacaccaacagccagagtccagccacaggcagcaggggtccagtgggagaacgcaccgg gcagctcgccatgaacaggaaagcgacagcaccaggcaaaggggctctcaccaggcgcac agctccgctcgcacccaggaggagatcgcacgcggaaggtctggagccagtgccagtgag ggtccggggccccagagggaggctgccagggacagctctgagcacgcccagtccagaagg 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cgcgggtccagcgagagtcaggccagcgacagcgagggccactccgactactcagaagca cacacacagggagcccacggtgggatccaaacaagccagaggcacgagcagcgaccctcc cgaggccagcagggctccggacacccccaggtgtactactatggtgtagaagaaaccgag gacgagtccgatgcccagcaggggcaccaccagcagcagcaacagcagcggcagcagcag cggcagcggcaccagcatgaacaggaacgagaacatgaacaccaacagccagagtccagc cacaggcagcaggggtccagtgggagaacgcaccgggcagctcgccatgaacaggaaagc gacagcaccaggcaaaggggctctcaccaggcgcacagctccgctcgcacccaggaggag atcgcacgcggaaggtctggagccagtgccagtgagggtccggggccccagagggaggct gccagggacagctctgagcacgcccagtccagaaggagcgagaccatcagccgtggacgc tcaggacactccactgggagagcccacgaagaccgccacgagcaggcaacagaccgctct gcccgctccgggtccaggggaggccaggccggctcccacagtgagagcgaggcctccggt ggtcaggccggccgcagaggcactgcagccaccaggcacacatctcgccccgaacagtct ccagacactgctggccggaccggatccagccgtggacagcagtccgcccaacgacatgct gactcaaccccgggcagcacaagaaccggctccagaggaagaggagagtccccagctggc cagcagtcccccgacagagccaggcacatcgaatccaggaggggtagaacccgggaggcc agcgccagccagtccagtgacagcgaaggccattctggagcccatgccgggatcgggcaa 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