Rattus norvegicus (rat): 84598 Help Entry 84598             CDS       T01003                                  Symbol Jak1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism rno  Rattus norvegicus (rat) Pathway rno01521   EGFR tyrosine kinase inhibitor resistance rno04151   PI3K-Akt signaling pathway rno04217   Necroptosis rno04380   Osteoclast differentiation rno04550   Signaling pathways regulating pluripotency of stem cells rno04621   NOD-like receptor signaling pathway rno04630   JAK-STAT signaling pathway rno04658   Th1 and Th2 cell differentiation rno04659   Th17 cell differentiation rno05140   Leishmaniasis rno05145   Toxoplasmosis rno05152   Tuberculosis rno05160   Hepatitis C rno05161   Hepatitis B rno05162   Measles rno05163   Human cytomegalovirus infection rno05164   Influenza A rno05165   Human papillomavirus infection rno05166   Human T-cell leukemia virus 1 infection rno05167   Kaposi sarcoma-associated herpesvirus infection rno05168   Herpes simplex virus 1 infection rno05169   Epstein-Barr virus infection rno05171   Coronavirus disease - COVID-19 rno05200   Pathways in cancer rno05203   Viral carcinogenesis rno05212   Pancreatic cancer rno05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     84598 (Jak1)    04151 PI3K-Akt signaling pathway     84598 (Jak1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     84598 (Jak1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     84598 (Jak1)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     84598 (Jak1)    04658 Th1 and Th2 cell differentiation     84598 (Jak1)    04659 Th17 cell differentiation     84598 (Jak1)   09158 Development and regeneration    04380 Osteoclast differentiation     84598 (Jak1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     84598 (Jak1)    05203 Viral carcinogenesis     84598 (Jak1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     84598 (Jak1)   09162 Cancer: specific types    05212 Pancreatic cancer     84598 (Jak1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     84598 (Jak1)    05161 Hepatitis B     84598 (Jak1)    05160 Hepatitis C     84598 (Jak1)    05171 Coronavirus disease - COVID-19     84598 (Jak1)    05164 Influenza A     84598 (Jak1)    05162 Measles     84598 (Jak1)    05168 Herpes simplex virus 1 infection     84598 (Jak1)    05163 Human cytomegalovirus infection     84598 (Jak1)    05167 Kaposi sarcoma-associated herpesvirus infection     84598 (Jak1)    05169 Epstein-Barr virus infection     84598 (Jak1)    05165 Human papillomavirus infection     84598 (Jak1)   09171 Infectious disease: bacterial    05152 Tuberculosis     84598 (Jak1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     84598 (Jak1)    05140 Leishmaniasis     84598 (Jak1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     84598 (Jak1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:rno01001]     84598 (Jak1) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      84598 (Jak1) Protein kinases [BR:rno01001]  Non-receptor tyrosine kinases   JAK family [OT]    84598 (Jak1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 ABC1 RIO1 SH2 Motif Other DBs NCBI-GeneID:  84598 NCBI-ProteinID:  NP_445918 RGD:  69056 Ensembl:  ENSRNOG00000011157 UniProt:  G3V9W2 LinkDB All DBs Position 5:complement(115780248..115888841) Genome browser AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLDREPLRLGSGEYTAEEL CIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELS RCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKEKNKLKRKKLDYNKHKKEDDRNKLR EEWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVS CFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGT LLDYKDDEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD FSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agcttcaagaagacggaggtgaagcaggtggcccctgagccaggagtggaagtgactttc tatctgttggacagggagcccctccgcctgggcagcggagagtacaccgcggaggagctg tgcatcagggccgcacaggaatgcagtatctctcctctctgccacaacctcttcgccttg tatgatgagagcaccaagctctggtatgctccaaaccacatcatcactgtggatgacaaa atgtctctccggctgcactaccgcatgaggttctactttaccaactggcatggaaccaat gacaatgaacagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaag aaaaaggttccagaagcaaccccactccttgatgccagttcactggagtatctgtttgcg cagggacagtatgatttgatcaaatgcctggctcccattcgggaccccaagacagagcaa gatggacatgatattgagaatgagtgcctgggcatggctgtcctggccatctcacactat gccatgatgaagaagatgcagttgccagagcttcccaaagacatcagctacaagcgatat attccagaaacattgaataaatccatcagacagaggaatcttcttaccaggatgcgaata aataatgttttcaaggatttcttgaaggaatttaacaacaagaccatctgtgacagcagt gtgtctacacacgacctgaaggtgaagtacctggctaccttggaaaccttaaccaagcat tatggagccgagatatttgagacttctatgctcctgatttcatcagaaaatgagctgagt cggtgccattccaacgacagtggcaatgttctctatgaagtcatggtaacaggaaatctc gggatccagtggcggcagaaaccaaatgttcttcctgttgaaaaggaaaaaaataaactg aagcggaaaaaactggactataataaacacaagaaggaggatgacagaaacaaactccgg gaagagtggaacagtttttcctatttccccgagattacccacattgttatcaaggagtct gtggtcagcattaacaaacaggacaacaagaacatggaactaaagctctcttctcatgag gaagccttgtccttcgtgtccctggtagatggctacttccggctcactgcagatgctcac cattacctctgtactgatgtggctcccccgctgattgtccacaacatacagaatggctgt cacggtccaatctgcacagaatatgccatcaataagctgcggcaggaggggagtgaggag gggatgtacgtgctgaggtggagctgcaccgactttgacaacattcttatgactgtcagc tgcttcgaaaagtccgaggtattgggtaatcagaagcagttcaagaactttcagattgag gtgcagaagggccgctacagcctgcatggctctgttgaccactttcccagcctgagagac ctcatgaaccacctcaagaagcagatcctgcgcacggacaatataagctttgtgctgaaa cgctgctgtcagcctaagcctcgagaaatctccaacctacttgtagccactaagaaagcc caggagtggcagcctgtctactctatgagccagctgagtttcgatcggatccttaagaaa gatattatccaaggtgagcaccttggcagaggcacaagaacacatatctattctgggacc ctgctggattacaaggacgatgaaggaattgctgaagaaaagaagataaaagtgattctc aaagtcctagaccctagccaccgggacatttcactggccttctttgaggcagccagcatg atgagacaggtttcccacaaacacatcgtgtacctctacggcgtctgtgtccgagatgtg gaaaatatcatggtggaagagtttgtggagggggggccattggatctcttcatgcaccgg aaaagtgatgcacttactaccccttggaagtttaaagttgccaaacagctggccagcgcc ctgagttacttggaagataaagacctcgttcatggaaatgtgtgcactaaaaacctcctc ctggcccgtgagggcattgacagtgacattggcccgttcatcaagcttagtgaccctggc atcccagtctctgtgctgaccaggcaagagtgcatagagcgaattccctggatcgctcct gagtgtgttgaagactccaagaacctgagtgtggctgctgacaagtggagctttggaacc acactctgggaaatctgctacaatggcgagatcccactcaaggacaagaccctcattgag aaagagaggttttatgaaagccgctgcaggccagtgacaccatcttgcaaggagctagct gacctcatgactcgctgcatgaactatgatcccaaccagagacctttcttccgagccatc atgagggacattaacaagctggaggagcagaatccagacattgtttcagaaaagcagcca ataacagaggtggatcccactcattttgaaaagcgtttcctaaagaggattcgtgacttg ggagagggtcactttgggaaggttgagctctgcagatatgatcctgagggagacaacaca ggggaacaggtagctgtcaagtccctgaagcctgagagtggaggtaaccacatagctgat ctgaagaaggagatagagatcttacggaacctctaccacgagaacattgtgaagtataaa ggaatctgcatggaagacggagggaatggtatcaagctcatcatggagtttctgccttcg ggaagcctaaaggaatatctgccaaagaataagaacaaaatcaacctcaaacagcagcta aaatatgccatccagatttgtaaggggatggactatctgggctctcggcaatatgttcac cgggacttagcagcaagaaatgtccttgttgagagtgaacaccaagtgaagatcggagac tttggtttaaccaaagcaattgagaccgataaggagtactacacagtcaaggatgaccgg gacagcccagtgttttggtacgctccggagtgtttaatccagtgtaaattttatatcgcc tctgatgtctggtcttttggagtgacactgcacgagttgctcacgtactgtgactcagat tttagtcccatggccttgttcctgaaaatgataggcccaactcatggccagatgacagta acacggcttgtgaatactctgaaagaaggaaagcgcctgtcctgtccacccaactgtccc gatgaggtttatcagcttatgagaaaatgctgggaattccaaccatctaatcggacaacc tttcagaaccttattgaaggatttgaagcacttttaaaataa

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