KEGG   PATHWAY: sara04020
Entry
sara04020                   Pathway                                
Name
Calcium signaling pathway - Sorex araneus (European shrew)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
sara04020  Calcium signaling pathway
sara04020

Other DBs
GO: 0019722
Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101536845  STIM2; stromal interaction molecule 2 [KO:K18196]
101536867  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
101537046  FGF22; fibroblast growth factor 22 [KO:K04358]
101537252  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
101537266  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101537324  TACR2; substance-K receptor [KO:K04223]
101537622  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
101538067  MCOLN2; mucolipin-2 [KO:K04993]
101538128  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101538157  AVPR1A; vasopressin V1a receptor [KO:K04226]
101538217  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
101538265  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101538288  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
101538515  EDNRB; endothelin B receptor [KO:K04198]
101538630  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101538791  PDGFC; platelet-derived growth factor C [KO:K05450]
101538799  [KO:K10785]
101538826  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101538903  FGF23; fibroblast growth factor 23 [KO:K22428]
101538939  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101539165  GRPR; gastrin-releasing peptide receptor [KO:K04169]
101539197  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101539272  VEGFC; vascular endothelial growth factor C [KO:K05449]
101539279  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101539281  DRD5; D(1B) dopamine receptor [KO:K05840]
101539413  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101539433  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101539470  [KO:K04632]
101539505  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101539525  CASQ1; calsequestrin-1 [KO:K23468]
101539723  BDKRB2; B2 bradykinin receptor [KO:K03916]
101539776  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101539850  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101539868  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101539900  FGF21; fibroblast growth factor 21 [KO:K22429]
101539926  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101539989  BDKRB1; B1 bradykinin receptor [KO:K03915]
101540025  TFEB; transcription factor EB isoform X1 [KO:K15590]
101540039  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
101540160  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101540263  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101540320  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101540478  [KO:K10784]
101540672  FGF8; fibroblast growth factor 8 [KO:K04358]
101540734  P2RX6; P2X purinoceptor 6 [KO:K05221]
101540816  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101540859  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101540947  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
101541195  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101541555  CALM2; calmodulin [KO:K02183]
101541613  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101541620  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101541696  ADORA2A; adenosine receptor A2a [KO:K04266]
101541742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101541752  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101541792  EGF; pro-epidermal growth factor [KO:K04357]
101541806  OXTR; oxytocin receptor [KO:K04229]
101542000  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101542024  PTAFR; platelet-activating factor receptor [KO:K04279]
101542044  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101542138  FGF6; fibroblast growth factor 6 [KO:K04358]
101542202  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101542256  MST1; hepatocyte growth factor-like protein [KO:K23441]
101542258  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101542352  LHCGR; LOW QUALITY PROTEIN: lutropin-choriogonadotropic hormone receptor [KO:K04248]
101542363  P2RX3; P2X purinoceptor 3 [KO:K05217]
101542461  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101542542  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101542669  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101542691  TBXA2R; thromboxane A2 receptor [KO:K04264]
101542767  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101542799  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101542849  HRH2; histamine H2 receptor [KO:K04150]
101543012  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101543026  [KO:K04161]
101543062  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
101543389  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101543506  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
101543643  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
101543714  [KO:K05863]
101543858  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101543883  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101543901  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101543945  TNNC2; troponin C, skeletal muscle [KO:K12042]
101543973  [KO:K02183]
101543993  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101544164  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
101544230  F2R; proteinase-activated receptor 1 [KO:K03914]
101544250  FGFR1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
101544390  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
101544461  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
101544502  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101544808  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101544809  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
101544899  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
101545077  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
101545086  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101545171  ADORA2B; adenosine receptor A2b [KO:K04267]
101545302  CALML5; calmodulin-like protein 5 [KO:K02183]
101545451  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101545481  FGF10; fibroblast growth factor 10 [KO:K04358]
101545625  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101545763  SLC8A3; sodium/calcium exchanger 3 isoform X4 [KO:K05849]
101545851  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101545860  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101545984  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
101546311  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101546321  [KO:K04809]
101546372  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101546450  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
101546535  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101546682  ORAI2; protein orai-2 [KO:K16057]
101546696  [KO:K04345] [EC:2.7.11.11]
101546702  FGF9; fibroblast growth factor 9 [KO:K04358]
101546711  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101546778  [KO:K06856]
101546811  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101546825  PLN; cardiac phospholamban [KO:K05852]
101546941  CALML4; calmodulin-like protein 4 [KO:K02183]
101546946  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101546979  P2RX7; P2X purinoceptor 7 [KO:K05220]
101547011  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101547014  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
101547055  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101547089  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101547133  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101547149  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101547238  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101547575  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101547595  TACR1; substance-P receptor [KO:K04222]
101547658  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
101547690  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101547782  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101547899  [KO:K04282]
101547928  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
101547979  ORAI3; protein orai-3 [KO:K16058]
101548050  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101548180  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101548205  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
101548400  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
101548477  VEGFA; vascular endothelial growth factor A isoform X3 [KO:K05448]
101548627  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
101548753  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101548820  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101549006  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101549127  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101549221  SLC8A1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
101549227  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101549236  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101549380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101549409  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
101549648  P2RX2; P2X purinoceptor 2 [KO:K05216]
101549665  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101549827  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101550238  [KO:K10784]
101550246  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101550339  FGF16; fibroblast growth factor 16 [KO:K04358]
101550347  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101550559  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101550786  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101550906  RYR1; ryanodine receptor 1 [KO:K04961]
101550939  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101551223  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101551516  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101551687  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
101551730  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101551790  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101551840  FGF18; fibroblast growth factor 18 [KO:K04358]
101551841  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101551947  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
101551961  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101552026  FIGF; vascular endothelial growth factor D [KO:K05449]
101552331  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101552377  DRD1; D(1A) dopamine receptor [KO:K04144]
101552535  CALML3; calmodulin-like protein 3 [KO:K02183]
101552586  NTSR1; neurotensin receptor type 1 [KO:K04211]
101552704  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101552794  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101552863  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101552920  FGF5; fibroblast growth factor 5 [KO:K04358]
101552994  FGF20; fibroblast growth factor 20 [KO:K04358]
101553153  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
101553272  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101553368  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101553428  AVPR1B; vasopressin V1b receptor [KO:K04227]
101553449  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101553484  [KO:K06856]
101553627  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101553733  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
101553872  TGFA; protransforming growth factor alpha [KO:K08774]
101554026  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101554088  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101554128  CCKAR; cholecystokinin receptor type A [KO:K04194]
101554155  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
101554247  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101554287  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101554401  CALM1; calmodulin isoform X1 [KO:K02183]
101554459  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101554482  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
101554669  TPCN1; LOW QUALITY PROTEIN: two pore calcium channel protein 1 [KO:K16896]
101554719  [KO:K04345] [EC:2.7.11.11]
101554737  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101554880  RYR2; ryanodine receptor 2 [KO:K04962]
101555035  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101555053  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101555223  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101555262  P2RX5; P2X purinoceptor 5 [KO:K05219]
101555290  FGF7; fibroblast growth factor 7 [KO:K04358]
101555338  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101555369  FGF2; fibroblast growth factor 2 [KO:K18497]
101555578  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101555764  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101555911  TACR3; neuromedin-K receptor [KO:K04224]
101555935  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101556185  TRDN; triadin [KO:K23449]
101556286  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101556288  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
101556443  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101556466  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
101556467  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101556499  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
101556628  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101556630  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101556800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101557003  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
101557019  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101557114  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101557190  NGF; beta-nerve growth factor [KO:K02582]
101557362  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
101557366  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101557440  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101557445  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
101557492  [KO:K06856]
101557538  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
101557741  TPCN2; two pore calcium channel protein 2 [KO:K14077]
101557809  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101557843  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101557862  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
101558086  MCOLN1; mucolipin-1 [KO:K04992]
101558256  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101558259  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101558347  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
101558483  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101558512  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101558545  FGF19; fibroblast growth factor 19 [KO:K22603]
101558680  P2RX1; P2X purinoceptor 1 [KO:K05215]
101558816  FGF4; fibroblast growth factor 4 [KO:K04358]
101558898  HRH1; histamine H1 receptor [KO:K04149]
101558918  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101558996  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101558999  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101559085  FGF3; fibroblast growth factor 3 [KO:K04358]
101559179  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101559221  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101559239  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101559307  CALM3; calmodulin [KO:K02183]
105943258  SMIM6; small integral membrane protein 6 [KO:K26468]
105943279  MRLN; myoregulin [KO:K22643]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
sara04010  MAPK signaling pathway
sara04070  Phosphatidylinositol signaling system
sara04210  Apoptosis
sara04720  Long-term potentiation
sara04730  Long-term depression
KO pathway
ko04020   

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