Salmo salar (Atlantic salmon): 106571102 Help Entry 106571102         CDS       T04363                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism sasa  Salmo salar (Atlantic salmon) Pathway sasa04020   Calcium signaling pathway sasa04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sasa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     106571102 (RYR3)    04020 Calcium signaling pathway     106571102 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sasa04040]     106571102 (RYR3) Ion channels [BR:sasa04040]  Voltage-gated cation channels   Ryanodine receptor    106571102 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 EF-hand_1 Motif Other DBs NCBI-GeneID:  106571102 NCBI-ProteinID:  XP_013999252 UniProt:  A0ABM3CY86 LinkDB All DBs Position ssa15:complement(19226325..19415578) Genome browser AA seq 4850 aa AA seqDB search MAEGGEGEDDIQFLRTDDEVVLQSVATIQKENRKFCLSVEGLGNRLCFLEPTSEAKYVPP DLCICCFILEQSLSVRALQEMLAHTVPNNEGKADHEQWAAQGGGHRTLLYGHAILLRHSF SGMYLTCLKTSRSLTDKLSFDVGLQEHSIGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSISNGSFQVDASFMQTLWNVQPTRSGSNVAVGFLCGGHVMRLCHGHDESLT IPGSEASEMEQRIVNYEMGKGTSKARSLWRLEPLRIGWSGSHIRYGQAFRLRHLSTGHYL ALTEEQGLVLQERDKSDTKSTAFCFRATKEKIESGTKNRDIEGMGVAEIKYGDSACFVMH VATGLWLSYQTPDAKASRIGPLKRRACLHAEGHMDDGLTLQRCQHEEARAVRIIRNTTVL FSHFIKGLDSIGRDKNVEVSMPNFDEVLQTLDDLIEYFKQPDSELEHEEKQTLLRSLIKR QDLFKEEGMLTLLVMCIDRLNLYNSAAHFGEHAGEKAGAAWKNILNLLYQLLASLIKGNR NNCTQFSRNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQKGHIKSIISLLYKHG RNHKILDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGVAE GSAQYKKWYFELMIDQVDHYVTSEPTHLRVGWASTKGYAPYPGAGEGWGGNGVGDDLYSY SFDGLYLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTD GFFFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMRVEAVKEYKRDHG GVRDLLGTTQILSQASFIPTPVDTSQIVLPPHLDNVRDRLAENIHELWGMNKIELGWSYG KVRDDNKRQHPCLVDFTKLPETESNYNLQMSSETLKTLLALGCHVTQTNVNAEEDLKKVK LPKDYVMSNGYKPTPLQLSEVKLTAGQEVLVDKLAENAHNVWAKDRVKQGWTYGIQQDVK SRRNPRLVPYALLDERTKKSNRDSLREAIRTLVGYGYDIDPPDQEACHIVERQSIETIRF FRVEQTYAVKTGKWYFEFEALTGGDMRVGWARPGCRSDFDLGMDDQAYVFDGYKGRRMHM GARFFGQSWNKGDVVGCMINMEDKSMVFTLNGELIITNKGSELCFVDFETEDGFIPVCCL AQSEIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNIPKDHNH IEVTRIDGTVDNPPCLKVTHKTFGTQQSNSDMLYCRLSMPVELHVPHVSADESQKLSQPP KEDGYGSITTYYHSVRVFAGQDPASVWIGWVTPDYHYHSKHFSLNKTRTVTVTLGDERGR VHESVRRSNCYMVCAGDVVGSSHSSSRSNIDLEIGCFVDLATGFLSFTANGKELATTYEL ESNSKLFPAVFVRPTSTNLFQFEFVKIKDAMPLSSAIFKSEQRNPVPQCPPRLDVQTIVA VLWSRMPNTFLTVETARVSERHGWVVQCLEPLQMMAVHIPEENRCLDILELSEVESLRKF HYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLMSIHLET AKEARLMMNNEFIIPVTDETRSIKLFPDESKRHSLPGVDLSTSLKPRLNFSPLSFITTKK QQHLYSPQIPLGILKEKAISMLTEAVQGGGSHIRDPVGGSVEYQFVPILKLIGTLLIMGV LTSEEVRLILLLIDPNVFGEPEDEEAKVEEVEAAAGGGEKEEVSSNEVKAVEAGEEETKE VKMSVKGLLEKTLPESVKRQMCELLHYFCDCELKQRIEAIVSFSDSFVSKLQYNQKFRYN QLMLALNMSAAVTAKKTKEFRSPPQEQINILLNFAAGEDCPCPEEIQEDLYSFHDELRLH CGIPVEEEEEEEDTSIKGRLLAMLYKIKGPPKKLEEEPTEQEQAAPTNLKELISQTMASW AQECSIQDPELVRVMFSLLRRQYDGIGALLRAMRKSYTISAASVQDCVNLLASLGQIRSL LSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAF PKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAASSVMD NNSLALALEEPDLEKVVTYLAGCGLQSCAMLLAKGYPDIGWNPIEGERYLSFLRFAVFSN GESVEENSNTVVKLLIRRPECFGPALRGEGGNGLLAAMLEAIKISEDPALDLPSTAEGEP TGSGEEEEEEVVHTGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTT DLVGIISIPLKMPIVNKDGSVTEPDMSASFCPDHKAPMVLFLDRVYGVEDQSFLLHLLEV GFLPDLRASASLDTDVLSTTETALAMNRYIGSALLPLLTRCAGHFSGTEHYAALIDSTLH TIYRLSKGRSLTKAQRDSIEECLLAICKHLRPSMMQQLLRRLVFDVPLLTEYCKMPLRLL TEHYEQSWKYYCLPSGLGSSGMASEEELLLTKKLFWGILDSLSTKKFDSDLFKTGMACLC ATAGALPPDYVDASPGATLEKQASVDAHGNFDPKPINTANISLPEKLDYIANKFAEHSHV KWSSEKVTAGWKMGESVDDKAKTHPLLKPYKSLSEKERETYRWPVKESLKSMLAMGWNME RTKEGEAMFIEKQSKISESTQDNDNEFIPEPPLDLNNITLSRELQGMVEVVAENYHNIWA KKKKTELNSKGGGSHPLLVPYDTLTAKEKYRDREKAQDLFKFLQINGYIVTRDLKDMEPD SSSMEKRFAYTFLKRILKYVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLID MYFKNHSMYFLSSPSKNLSSSGYASNKEKEMITSLFCKMAALVRHRISLFGSDSAIMVSC LHILAHSLDTRTVMKSGSEMVKAGVRTLFENAAEDLEKTLEMLKLGKFSQSRSQMKGLTQ NITYATTALLPILTALFEHVTMHNFGVYLLVDDVQLSCYRIVTCLYSLGTGKHIFIERHL PALGECLATLVGAMPVAFLEPDLNAHNPLSVFNTKTPRERAILSMPDSVEEMCPEMPHLD RLLKDINDISESGARYTEMPQVIEVILPMLCTYLSYWWERGTENSAPHTACCTTVCSHHL SIILGNILKILNNNLGIDDAPWMKRIAVYSQPIICKAAADLLRSHFLPTLEKLRKKTVKV VAEEELLKADIKGDTQEAELLVLDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKRPDAQSN ELFTMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGESKTKMSKSGGDQDRKHKKR RGELYSVQTSLIVAALKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDEEVKDHLRENLH LQDKSDDLAVQWQMNLYKDVVVESEERTDPEQTVDRVQSISAAVFHLEQVEQPLRMKKCV FQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFVLGYVRLWIETEEYSFEEKLVQDLAK TPMKIVEEEEEEEVEIKPDPLHQLILHFSHNALTERSFLEEDPLYIAYADMMAKSCAEDE EEEEEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKL GISILNGGNVLVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVT DEGSIDSERGSKVLTNDDFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTLTVNIIISTVD YLLRLQESISDFYWYYSGKDIIDEAGQVNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLA HSRLWDAVVGFLHVFANMQMKLSQDSCQIELLKELMDLQQDMVVMMLSLLEGNVVNGTIG KQMVDTLVESSSNVEMILKFFDMFLKIKDLTTSDNFREYDPENKGVISKKDFQKSMENQK QYTQSEIEFLLSCAEADENDMFNYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDPRLA TFLEPAESVLNYFEPYLGRIEIMGGGKRIERVYFEISESSRTQWEKPQVKESKRQFIFDV VNEGGESEKMEMFVNFCEDTIFEMQLASQISEPDVVERPEEEEEEVHNLLEELAEEEENS ELEASSAFTMACISVKKKISNFRQMLTFKILKKQYKKSKKLSLKEMTVGFFSFFWTLFTG FFKGIYSLIFGFFHLIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVLEMEKAE VGDSVSGGTDQAIKPSDKAEQDILMQMINPTPKKGEGLKHVDPGLGDVSETPDTTATVEK KKAVKESKESEPEKADTEKKEKEDMAKEEEPKEEVAHEKPAPKSRNGQSKDAPTSFFASF LAGLEIYQAKMLNTLARNFYNMRFLALFVAFAINFILLFYRVTADEDSWTSSDDDDEEGG EEYFVLEESTGYMAPTLCFLAVFHTALSILCLIGYYFLKVPLVVFKREKGIARLLEFEGL YITEQPADDDITGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDLYGAERIAELLGLDKS ALDFDPTQETVVEAASLVSWLSSIDTKYHIWKMGVVLTDNSFLYLIWYATMSILGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DEDAPDMKCDDMMTCYLFHLYAGVRAGGGIGDELEDPAGDPYELWRILFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDLLG NT seq 14553 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaagatgacatccagttcttacgaactgatgatgaggtg gtgcttcaaagtgtcgccaccatccagaaagagaatcgcaagttttgtctgtccgtggag ggactcggtaatcgactatgcttcctggaacccacatctgaggctaagtatgttcctcca gacctgtgtatctgttgtttcatcctggagcagtccctgtctgtccgggcactgcaggag atgttggctcacacggtgcctaacaacgaagggaaagcggaccatgaacagtgggcggcc caggggggtggacaccggaccctgctctatggtcacgccatcctcctacgccactccttc agtggaatgtacctgacctgcttgaagacgtcaagatcgttgacagacaaactgtcattt gacgtgggattacaagaacattcaataggtgaggcatgctggtggaccatccaccctgcg tccaagcaaaggtcagagggagagaaggtccgtatcggagacgacctaatcctggtcagc gtgtccacagagaggtacctgcacctgtccatctctaacggtagtttccaggtggatgcc tcctttatgcagactctgtggaacgtccagcctacccggtcaggaagcaacgtggctgta ggattcctgtgtggtggtcacgtgatgcgtctgtgtcacggacatgatgagagtctgacc atacctggatcagaggccagcgagatggagcagaggatagtgaactatgagatgggtaaa ggaacatccaaggctcgctccctctggaggctggagcccctcaggatcggctggagcggt agccacattcgctatgggcaggcgttccgtctgcgtcacctgtccaccggtcactacctg gcgctaaccgaagagcagggtctggtcctacaggagagagataagtccgataccaagtcc accgctttctgcttcagggctaccaaggaaaagattgagtctggtacaaagaaccgggac attgaaggcatgggagtagcagagatcaagtacggagactcagcttgcttcgtcatgcat gtggctacagggctgtggttgtcctaccagacgcctgacgctaaagcctcccgtatagga cccctcaagagaagggcctgtctgcatgctgagggtcacatggacgacggtctgaccctt cagcgttgtcaacacgaggaggcacgggctgtacgcatcatcaggaacaccacagtcctc ttcagccacttcatcaagggtctggacagtataggaagggataagaacgtggaggtgtct atgcctaactttgacgaggtgttgcagacgctggatgatctgattgagtacttcaaacag cccgactcagagctggaacatgaggagaaacagactctgcttagatctctcatcaaacga caggacctcttcaaagaggagggcatgctgaccctgctggtgatgtgcattgaccgtctc aacctgtacaacagcgctgctcactttggagagcatgctggggaaaaggctggggcggca tggaagaacatcctcaacctactctaccaactactggcctctctgatcaaagggaaccgg aacaactgcacccagttctccaggaacctggactggctggtcagcaagctggagagactg gagtcctcatcaggtatcctggaggttctccattgcatcctgatagagtctcctgaagct ctgaacatcatccagaaaggacacatcaagtccatcatctccctgctctacaaacacgga cgcaaccacaagatcctggacgtcctgtgttctctctgtgtgtgtaacggagtggctgtg agagccaatcagaacctcatctgtgatcacctgcttcccaagagagacctgctcctgcag acacgattggtcaatgatgttcagagtatgagacccaacatcttcctaggagtggcggag ggttcagcccagtataagaagtggtactttgagctgatgatcgaccaggtggaccactat gtgaccagtgagccaactcacctgcgtgtgggatgggcctccactaagggttacgccccc tacccgggggctggagagggctgggggggcaatggggtgggtgatgacctctactcatac agctttgatggactctacctgtggtcaggccgtatcccccgggcggtggcctccatcaac cagcacctgttgaacagtgatgacgtggtgagctgttgtctggacctgggcgctccctcc atgtccttcaggatcaatgggcagccagtacagggcatgtttgaagacttcaacaccgac ggattcttcttccccgtggtcagcttctcagccggggtcaaggtgcgtttcctgttgggc ggtcgtcatggtgactttaagttcttgcccccggcgggttattccccgtgttacgaggcg ctactccccaaggagaagatgagggtggaggctgtgaaggagtacaagagggatcatgga ggggtcagggacctactggggacaacacagatcctctcccaggcctcattcatccccaca cctgtagacaccagccagattgttctgcctcctcacctggacaacgtgcgggacagactt gcagagaacatccatgaactgtggggcatgaacaagatcgaactgggctggtcctatggc aaggttcgagacgacaacaagaggcagcacccttgcctggtggatttcaccaagctgcct gaaacagagagtaactataacctgcagatgtctagtgaaactctcaagaccctgttggca ctgggatgtcatgtgacacagactaacgttaacgctgaggaagatctgaagaaagtcaaa ctgcccaaagactatgttatgtctaacgggtataagccaacgccactgcagctttctgag gtgaaactgacggctggtcaggaggttctggtagataaactggcggagaacgctcacaac gtgtgggccaaggacagggtcaaacaaggatggacgtacggcatccagcaggatgtgaag agcaggcgtaaccctcgcctggtgccttacgctctgctagacgagagaaccaagaagtct aacagagacagtctgagggaggccatcaggaccctggtgggatacggctatgacatcgac cccccagaccaagaggcctgtcatatcgtggagaggcagagcattgagacgatccggttc tttcgcgtagagcagacgtatgcagtgaagacagggaagtggtactttgagtttgaggcc ctgaccggtggggacatgagggttggctgggctagaccaggctgtaggtcagactttgac ctgggcatggacgaccaggcctacgtcttcgatggatacaagggtcgtcgtatgcacatg ggcgcacgtttcttcgggcagtcatggaacaaaggagacgtggtgggctgcatgatcaac atggaggacaagtctatggtcttcaccctcaacggagaactaatcatcactaacaaggga tccgagctctgcttcgtcgacttcgagacagaggatggcttcatcccagtgtgttgtctg gcccagtctgagattggccgtatgaacctggggaaggacgccagcacctttaagtactac accatgtgtggcctgcaggagggcttcgaacccttcgctgtcaacatgaaccgtgaggtc accatgtggttcagcaaacgcctgcctaccttcgtcaacatccctaaggaccacaaccac atcgaggtgacaaggatagatgggacagtggacaatccgccgtgtctgaaggtgacccac aagacatttgggacccagcagagcaacagtgacatgctgtactgcagactgagcatgcct gtagagctccacgttcctcatgtcagtgctgacgagtctcagaaactcagtcagccccca aaggaagatggttatggcagcatcacaacatactatcactcagtgagagtgtttgctggc caggacccggcgtcagtgtggattggctgggtaacccctgactaccattaccatagcaaa cacttcagcctcaacaagacacgcacggttaccgtaaccctgggagacgagaggggacga gtccacgagagtgttcggaggagtaactgctacatggtgtgtgctggagatgttgtcggc tcctcccactcctcatcccggtctaacatcgacctggagattggctgtttcgttgaccta gcaacaggctttctctccttcacagccaatggcaaggagctggccacaacctacgagttg gagtccaacagcaagctgttccctgctgtgtttgtgcgtcccaccagcaccaacctcttc cagtttgagtttgtcaagatcaaggacgccatgcccctgtcgtcagccatctttaagagt gagcagcgtaaccctgtaccccagtgtccaccacgtctggacgttcagaccatcgtagcg gtgctgtggagccgtatgcccaacaccttcctcaccgttgagaccgccagggtctcagag agacacggctgggtggtgcagtgtctggagccactgcagatgatggctgttcatatacct gaggaaaacaggtgtctggacatcctggagctgtcggaggtagagagtctgaggaagttc cactaccacaccctgaagctctactgtgccctctgcgcattgggcaacacccgcgtggcg cacgccctctgctcccatctcgaccaatcgcagctgctttacaccatcgacaaccaatac ctgtccggcatgctgagagagggcttctataatgttcttatgagcatccacctggagaca gcgaaggaggcacgtctgatgatgaacaacgagtttattatccccgtgaccgatgagacg cgctccatcaagctgttccctgacgagtccaagagacactctctacccggggtagacctc agcacctctctgaaaccacgcctcaacttctcccctctctccttcatcaccaccaagaaa cagcagcacctctacagcccccagatccccctgggcatcctgaaggagaaggccatcagt atgcttactgaggcggtgcagggaggaggcagtcacatcagagacccagtagggggcagt gtggagtaccagtttgtccccatcctcaagctgattgggacactgctgatcatgggggta ctcaccagcgaggaggtgaggctgatcctgctcctcatcgatcccaacgtgttcggggag ccagaagatgaggaggcgaaggtggaggaggtggaggcagcagcaggaggaggagagaag gaggaagtgagcagcaacgaggtgaaggctgtggaggctggtgaggaggagaccaaggag gtcaaaatgtctgtgaagggactgctggagaagacactgcctgagtctgtcaaacgacag atgtgtgagctgcttcactacttctgcgactgtgagctgaagcaacgtatcgaggccatc gtgtccttctcagacagcttcgtgtccaagctgcagtacaaccagaagttccggtataac cagctgatgctggccctcaacatgtctgctgccgtcaccgccaagaagaccaaggagttc agatcccctcctcaggagcagatcaacatcctgttaaactttgctgctggggaggactgt ccctgtcctgaagagattcaggaagacctctacagcttccatgatgaactgagactgcac tgtggcatccccgtggaggaggaggaggaggaggaagacacgtctataaagggtcgtctg ctagccatgctctataagatcaaggggccgcccaagaaactagaggaggaacctacagag caggaacaagctgctcccaccaacctgaaggagttgatcagccagaccatggctagctgg gctcaggagtgcagcatccaggacccagagctggttcgtgtgatgttcagcctgctgaga cgtcagtacgacggcatcggagctttgctcagggccatgaggaagagttacaccatctct gctgcatcagtacaggactgtgtcaacctcctggcctctctgggccagatcagatcactg ctgtctgtacgcatggggaaagaagaagagaaactgatgatcgacggactgggtgacatc atgaacaacaaggtgttctaccagcaccccaacctgatgagggttctggggatgcatgag actgtcatggaggtgatggttaacgtgctgggaggagacaagtcacaggagatagcgttt cccaaaatggttgccagttgctgtcggttcctatgttacttctgtcgtatcagccgacag aaccagaaggccatgttcgaccatctgagttatctactggagaacagctccgtcggacta gcatccccagctatgaggggttctactcccctggacgtagcagcgtcttcagtgatggac aacaacagcctggccctcgctctggaggagcctgaccttgagaaggtggtgacctacttg gcaggttgtgggctgcagagctgtgccatgctgctggctaaaggataccctgacattggc tggaaccccatagaaggagagagatacctgtccttcctccgcttcgctgtcttcagcaat ggtgagagtgtggaggagaactctaacacggtggtgaagctgctgatcaggcgtccggag tgttttggtcccgctctgaggggagaggggggcaacggcctgctggcagccatgttggaa gccattaagatatcagaggaccctgctctggaccttccctctacagctgaaggagaacct actgggtctggtgaggaggaagaggaagaagtggtccataccgggaacgccatcatgtcc ttctactcggcgcttattgacctgctgggacgctgcgctcctgagatgcatctgatcaac aagggtaaaggcgaggccttgcgtatccgggccatcctgcgctccctggttcctactaca gatctggtcggcatcatcagtataccactcaagatgcccatcgtcaataaagatggtagt gtgacggagccagacatgtcggctagtttctgtccggaccacaaggccccaatggtgttg ttcctggatcgtgtgtacggcgtggaggaccagagcttcctgctacacctgttggaggtg ggcttcctgcctgacctccgtgcctccgcttccctggacacggatgtgctgagcaccaca gagacagctctggccatgaataggtacattggttcggccctgcttcccctgctgaccagg tgtgctggccacttctcgggcacagagcactacgcagcgctcattgactctaccctccac actatctatcggctgtccaagggacgctccctcaccaaggcccagagagactctatcgag gagtgtctgctcgccatctgcaaacacctgcgtccctccatgatgcagcagctgctgaga cgtctggtgttcgatgttcccctgctcacagaatactgcaagatgccactcaggctgtta actgaacactatgagcagagctggaagtactactgtcttccctcgggtctggggagctcc ggcatggcctcagaggaagaactgctgctcaccaaaaaactcttctggggaatactcgac tccctctcaacaaagaagtttgactctgacctgttcaagactggcatggcctgtctgtgc gctaccgctggggcgttgccacctgactatgtggatgccagccctggtgccaccctggag aagcaggcgtctgtggatgcacacggcaacttcgaccccaaacccattaacactgccaat atctcccttccagagaaactggactacatcgccaacaagtttgcagagcattcccacgtc aagtggtcctcagagaaggtgacagcgggttggaaaatgggagagagtgtggatgacaag gctaaaactcacccactgctgaagccctataaatcgctcagtgagaaggagagagaaacg taccgctggccagtgaaggagtctctaaagagcatgctggctatgggttggaacatggag aggaccaaagagggagaggccatgttcatcgagaaacaaagcaagatctccgagtccact caggacaacgataacgaattcatcccggaaccaccattggatctgaacaatattactcta tccagagagttgcaggggatggtggaggtcgtagcagagaactaccacaacatctgggcc aagaagaagaagactgagctgaacagtaaaggaggagggagccacccgttgctggtgccc tatgacaccctgacagccaaggagaagtacagagacagagagaaggcccaggatctcttt aagttcctgcagatcaatggatatatcgtcaccagagacctgaaggacatggagccggac tcatcgtccatggagaagaggtttgcctacacgttcctcaagaggattctgaagtatgtg gactcagctcaggagttcattgctcacctggaggccatggccaccagtggaaagacagac aaatcacctcacgatcaggaaatcaaattctttgccaaggtgctgctacctctcatagac atgtactttaagaaccacagcatgtacttcctgtcctcgcccagtaagaacctgagcagc agtggctacgcctctaacaaagagaaggagatgatcaccagccttttctgtaagatggca gctcttgtcagacacaggatttcactctttgggagcgactcggctattatggtgagctgt ctacacatcctggctcattccctggacacaaggacagtgatgaagtcaggctcagagatg gtgaaggctggggtcaggacgttatttgagaacgcagcggaggacctagagaagaccctg gagatgctgaaactggggaagttcagccagtccaggagccagatgaagggcttgacccag aacatcacctacgccaccaccgctctgctgcccatcctcacagctctgttcgaacacgtc accatgcacaactttggagtctacctgctggtggatgatgtccagctgtcgtgctatcgc atcgtgacctgtctctactcactgggcacggggaaacacatcttcatagagaggcaccta ccagccctaggggagtgtctggccaccctggtaggagccatgcctgtagctttcctggag cctgatctcaacgctcacaaccccctgtctgtcttcaacaccaagacaccgcgagagagg gccatcttgagtatgcctgactctgtggaggagatgtgtccagagatgcctcatctggat cgcctgctgaaggacatcaacgacatctcagagtctggagctcgctacacagagatgcca caggtgattgaggtgatcctgcccatgttgtgtacatacctgtcctactggtgggagaga ggaacagagaactctgctccacacacagcctgctgcaccaccgtgtgctcccaccacctc agcatcatcctggggaacatcctcaagatcctcaacaacaacctgggcatcgacgacgct ccctggatgaagaggatcgcagtctactctcagccaatcatctgcaaggctgcagcggac ctactgaggagtcacttcctgcccactttagagaaactcaggaagaagacagtgaaggtg gtggcagaggaggagctgctgaaggctgacattaaaggagacactcaggaagctgagctt ctcgtcctggatgagtttgctgtcctctgtagagacctgtacgccttctacccaatgctc atccgctacgtggacaacaacagatccagatggttgaagaggcctgatgctcagtccaac gagctcttcactatggtggctgagatcttcattctctggtgtaaatcacacaacttcaaa agggaagagcagaactttgtggttcagaatgaaatcaacaacctgtctttcctgactgga gaaagtaaaaccaagatgtccaagtcaggtggtgaccaggataggaagcacaagaagcgg cgtggagagttatactctgtccagacctctctgatcgtagccgcactgaagaagatgctg cccatcggactcaacatgtgcaccccaggagaccaggagctcatctcactggccaagata agatacagtctgaaagacacagacgaagaggtgaaggatcacttgcgtgagaacctccat cttcaggacaagtctgatgacctggcagtgcagtggcagatgaacctgtataaggatgtg gtggtggagagtgaggaacgtacagacccagaacaaactgtggacagagtacagagcatc tctgctgcagtcttccacctggagcaggtggaacagcctctgaggatgaagaagtgtgtg tttcagaagctgctgtccaaacagcgtaaacgtgctgtggtggcctgcttccgcatggct cctctctacaacctccccaggcatcgttctattaacctcttcgtgttgggctatgtgaga ctatggatagagacagaggagtactcctttgaggagaagctagtgcaggacctggcaaaa accccgatgaagatcgtggaggaggaagaagaggaggaggttgagattaagccagaccca cttcatcagcttatccttcacttcagccacaacgccctcacagagagaagtttcttggaa gaagatccgctgtatattgcatatgcagacatgatggcaaagagttgtgcagaggatgaa gaggaggaagaggaggaagaggggaaagagaagacatttgaggagaaggaaatggagaag cagaagatcttgtaccagcaggccagactccacgcccgtggggctgctgagatggtgcta cagatgatcagcgccagtaaaggtcgactaggtcctatggtgacctgcaccctcaaactg ggcatctccatcctcaacggaggtaacgtgctggtccagcagaaaatgctggattacctg aaagagaaaagagacgcaggctttttcaagagtttgtcaggcctcatgcagtcctgcagt gtcctggacttgaatgcctttgagagacagaacaaagcggaaggtctggggatggtgaca gatgaaggctccatcgacagtgagcggggttccaaagttctgacgaatgatgacttcacc aaagatctcttccggtttttgcaactgctctgtgaggggcacaacggggatttccaaaac ttcctgagaacacaaacaggaaacacattgacagtcaacattatcatcagcacagtggac tacctgctacgccttcaggaatctatcagtgacttctactggtattattctgggaaagac attatcgacgaggcagggcaggtcaacttctccaaagccttagctgtcgcaaagcagatc tttaactcactcactgagtacatccagggcccatgtattgggaaccagcagagtctggcc cacagcagactgtgggatgcagtggtgggattcctgcatgtgtttgccaacatgcagatg aagctgtcccaggactcgtgtcagattgagctgctgaaggaattgatggaccttcagcag gacatggtggtgatgatgctgtcactgctcgagggcaacgtggtgaatggaacaatagga aagcagatggtagacactctggtggagtcctccagcaacgtagagatgatcctcaagttc ttcgacatgttcctcaagatcaaggacctgacaacgtctgacaacttcagggagtacgac cccgagaacaagggggtgatctccaagaaagatttccagaagtccatggagaaccagaag cagtacacccagtcggagatcgagttcctgctctcctgcgctgaggccgacgagaacgac atgttcaactacgaggagtttgtggagcggttccacgagccggccaaagacatcggcttc aacgtagccgtgctgctcaccaacctctctgagcacatgcctcacgatccccgtctggcc accttcctggaaccggccgagagcgtgctgaactacttcgaaccgtacctgggtcgcatc gagatcatgggcggagggaagcgcatcgagagggtctattttgagatcagcgagtccagt cgtacacaatgggagaagccacaggtcaaagagtccaagagacagttcatctttgacgtg gtcaacgaggggggagaaagcgagaagatggagatgtttgtgaacttctgcgaggataca atctttgagatgcagcttgcgtctcagatctcggagcccgacgtggtggagcgcccggaa gaggaagaggaggaggtgcacaacttgttagaagagcttgcagaggaagaggagaatagc gagctggaggcttcctcggctttcaccatggcctgcatctccgtcaagaagaagatctcc aacttcagacagatgctgaccttcaagatcctcaagaagcagtacaaaaagtccaagaag ctgagcttgaaggagatgaccgttgggttcttctccttcttctggacgctctttacaggg ttcttcaaggggatctacagcctcatcttcggattcttccacctcatctggtcatccatg ttcggaggcgggctcgtcgaaggagccaagaacatgaaggtgacagacatcttgggtaac atgcccgaccccacccagtttggtatccacggcgatgtgttggagatggagaaagccgag gttggtgattctgtgtcgggcgggacagaccaggccatcaaaccgtcggacaaggcagag caggacatcttaatgcagatgattaatcccacaccaaagaaaggggaagggttaaaacat gtagatcctggactgggagacgtctctgagactcctgataccaccgccactgtggagaag aagaaggccgttaaagaaagtaaagagtcagaaccagagaaagcagacacagagaagaag gagaaggaagacatggccaaggaggaggagcctaaagaggaagtggctcatgagaagccc gcccccaagtccagaaacggccaatcaaaggatgctcctacttccttctttgccagcttc ttggctgggctggagatctaccaggccaagatgctgaacacactggctcgaaacttctac aacatgcgtttcctggctctgtttgtggcgtttgccatcaacttcattctactgttctac agggtgactgctgatgaggactcctggactagttctgatgatgatgatgaggaaggtggt gaggagtactttgtcctggaggagagtacaggctacatggctcctacactgtgtttcctg gctgtgttccacactgccctctctatcctctgcttgattggctactactttctcaaggtg cctctggtggtgtttaagagagagaaaggaatcgccaggctgttggagtttgaaggtctc tacatcacagagcagccggcagacgatgacatcacaggacagtgggaccgcctcgtcatc aacaccccgtccttccctaataattactgggacaagtttatcaaacggaaggtcattaat aagtatggagacctgtatggagctgagcggatagctgagctgttgggtctggataagagc gccctggacttcgaccctactcaggagactgtggtggaggcggcttctcttgtgtcgtgg ttgagctctatcgacaccaagtaccacatctggaaaatgggagtggtgctgactgacaac tcgttcctgtacctgatctggtacgccaccatgtccatcctggggcactacaacaacttc ttcttcgctgcccatctgttggacatcgccatgggcttcaagaccctccggaccatcctg tcctccgtcactcacaatggaaaacagttggtgctgactgtagggctgttggcggtggtg gtgtatctgtacactgtggtggccttcaacttcttcaggaagttctacaacaagagcgag gacgaggacgcccctgacatgaagtgtgacgacatgatgacttgctatctgttccacctg tacgccggggtgagggccggcggtggtatcggtgatgagcttgaggacccggctggagac ccctacgagctgtggcgtatcctctttgacatcaccttcttcttcttcgtcatcgtcatc ctcctggccatcatccagggtttgattattgatgcgtttggggaactgagagaccagcag gagcaggtgaaggaggatatggagactaaatgcttcatctgtggaattggaaatgactac tttgacacgacaccccacggctttgagacccacaccttacaagagcacaaccttgccaac tacctcttcttcctgatgtacctcatcaacaaggacgagactgaacacaccggtcaggag tcgtacgtgtggaagatgtaccaggagagatgctgggacttcttccctgcaggggactgt ttcaggaagcagtatgaggacctgcttgggtag

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