Salmo salar (Atlantic salmon): 106587081 Help Entry 106587081         CDS       T04363                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism sasa  Salmo salar (Atlantic salmon) Pathway sasa04020   Calcium signaling pathway sasa04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sasa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     106587081    04020 Calcium signaling pathway     106587081  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sasa04040]     106587081 Ion channels [BR:sasa04040]  Voltage-gated cation channels   Ryanodine receptor    106587081 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Med16_bridge Motif Other DBs NCBI-GeneID:  106587081 NCBI-ProteinID:  XP_014030536 LinkDB All DBs Position ssa01:23049660..23216491 Genome browser AA seq 4904 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIHKENRKFCLTAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEHSLSVRALQEMLAKTGQNSEGRLIRKAAQGGGHRTLLYGHAILLRHSFSA MYLTCLKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVLRLFHGHDEVLTIP GSDQSDEQQRIVNYETGNAGAKARSLWRLEPLRISWSGSHIPWGQPFRLRHLTTGHYLSL TEERGVVLQDREKSDTSSTAFCFRASKEKLESSPKRDIEGMGMAEIKYGDSICFVMHVAT GLWLSYQAPDVKSSRLGPLKRRAFLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSH FIRDLDCLGGKNRASVALPIEEVLQTLYDLITYFQLPDAELEHEEKQIMLRSLKNRQNLF KQEGMLTLVSCCIDRLNVYNSAAHFGECAGAEAGASWKEILNLLYELLAALIRGNRNNCT QFSNNLDWLVSKLERLESSSGILEVLHCILTESPEALNIIQRGHIKSIISLLYKHGRNHK ILDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGLSEGSAQ YKKWYYELMIDQVDHFLTSDPSHLRVGWATNKGYAPYPGGGEGWGGNGVGDDLYSYGFDG LHLWSGRISRAVASINQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGLFF PVVSFSAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKMKVEPVKEYKRDMEGVRD LLGTTQFMSQASFIPTPVETSQIVMPPYLEKVRDRLAENIHELWGMNKIELGWSYGKRIR DDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVQVNANAEEDLKKIKLPK NYMMSNGYKPTPLELSDVKVTPGQELLVEKLAENAHNVWAKDRIKQGWTYGIQQDVKSKR NPRLVPYSLLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQDGAGHVVERLSIDKIRFFR VERTYAVLTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYKGHRLNMGS RFFGRCWQAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGL SQVGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFFNVPKNNNHIM VTRIDGTIDSPPCLKVSHRTFGTQNSNGDMVYCRLSMPVEFHSFFKTSPVMDMNGVHEEH ESLKLKHRHPLKSMRHSHDGIRGTDYSNITTYYYSVRVFAGQDPSCVWVGWVTPDYHYYS NHFNLSKNRTVTVTLGDERGRVHESVRRSNCYMVWGGDATSSGHSSSRSNVDLEIGCLID LATGLVTFTVNGKELATSYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNTMPLSAAIFK SEHKNPVPQCPPRLDVQTINSVLWSRMPNTFLKVETARVSERHGWVVQCLEPLQMLAVHI PEENRCVDIMELSEQEDLRMFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQ YLSGMLREGFYNVLISVHLETAKEARLMMNNEFIIPVTAETRSIRLFSDASKHHSPPGVG LSTSLKPRLNFYPPCFISTKREQHLYSPQIPLDALKEKAITMLTEAVQGGGHHIRDPVGG SVEYQFVPILRLIGTLLTMGVLGSQDVHKILLLIDPNVFAEHHEEAAAAVMEATEKEGLT GAEEKAVEAGEEEAAKEAKQPIKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSF SDSFVSKLQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSTGEDCPCP EDIQEELYAFHNELRLHCGIPMEEEDEEQDRSIKGRLLALVYKIKGQPLKTEEEPTEQEQ QAPSNLKELISQTMVSWAQECHVQDPELVRVMFSLLRRQYDSIGELLRAMRKSYTISAAS IQDTINLLASLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKIFYQHPNLMRVLGMHETVM EVMVNVLGGGKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASP AMRGSTPLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLDKGYPDIGWNP IEGERYLSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIK ISDNPAVDLPSSAQGVSSDASAEDDEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINK GKGEALRIRAILRSLVPTEDLVGIISIPLKMPVVHKDGTVTEPDMAASFCPDHKAPMVLF LDRVYGIEDQSFLLQLLDVGFLPDLQASASLDTEVLSTTETALAMNRYIGSAMLPLLTRC APHFAGTEHYAVLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCKYLRPSMLQHLLRR LVFDVPLLTEYCKMPLRLLTNHYEQSWKYYCLPSGWGSYGMASDEELLLTKKIFWGVLDS LSQRKYDADLFKMAMPCLSAISGALPPDYIDATISTTLEKPVSVDAQGNFDPKPISTANI SLPEKLEHVANKYAEHSHDKWSAEKVMLGWRYGDCIDEKAKTHPLLRTYKGLTEKEKDIY RWPVRETLKTMLAMGWNIDRTKDGETMSLRESEKMRKISQSSSHANGFNPTPIDTINVVL SRELQGMVEVVAENYHNIWAKKKKNDLGIRGGATHPLLVPYDTLTAKEKARDKEKAQDLF RFLQINGYAITRGLKDMEQDSSSMEKRFAYKFLKKLLKYVNSAQEFIAHLEVMATSGKTD KSPHEQEIKFFAKVLLPLIDQYFKNHCLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLA ALVRHRISLFGSDSTTMVSVLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKTL ENLKLGKFTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYR ILTSLYALGTGKNIYVERQLPALGECLATLAGAMPVAFLEPLLNKHNPCSVFNTKTARER AILGMPDAVEEMCPEMPRLDVLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWEK GPENQESPHSGGSVGGSVFSTTVTSEHLSLILGNILKILNSNLGIDEASWMKRIAVYAQP IITKARAVLLKSHFLPTLEKLKKKTVKVVTEEELLKADSKGDTQEAELLILDEFAVLCRD LYAFYPMLIRYVDNNRSRWLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEI NNLSFLTGDSKIKMSKSGGQDQERKHKRKRGEFYSIQTSLIVAALKKMLPIGLNMCTPGD QELISLAKTRYILKDTDDEVKEHLRQNLHLQEKSEDPAVRWQLNLYKDVMVKNEGPPDPE RTVFRVQSISAAVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHKSN NYFLNAYRRYWLEKMHENTDYDSLLSMLTKTQLKVEEEEEEEAEMQPDPLHQLILHFSHN ALTERSSLEEDPLYIAYADMMAKSCAEDEEEEDEEGKEKTFEEKEMEKQKTLYQQARLHD RGAAEMVLQMISASRGSLGPMVTFTLKLGISILNGGNILVQQKMLDYLKEKRDAGFFKSL SGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLC EGHNNDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIMDEAGQRNFS KALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIDL LKELLDLQKDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLT SSDNFKEYDPDSKGVISKKEFQKSMENQKQYSQSEIEFLLSCVEADENDMFNYEEFVERF HEPAKDIGFNVAVLLTNLSEHMPHDARLATFLDLAESVINYFEPYLGRIEIMGGAKRIER VYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQIS EPDSVERLEEEEEDSQSVEEEEEEEEEESMMESHSAFTNSCVSMRKNLSSFRQLLTFKSM RRQYRNFRKMSVREMVRGLFSFFWKIITGLFRFLYNLVWGFFHILWSSMFGGGLVEGAKN MKVTDILGNMPDPTQFGIHGDVLEAEKMEASEASSVAEMVQMAQGDKAEADLMAELLNIQ TKSQGGKHAAEPGLGDMGEVVGVDAPSLASAVKQKKAKEAATMEPANGDHKAEPEKADPE DEEKKDKDKAKEETPPESPPEEEKKAPKKRPGLKKEPPEAFMARFFSGLEIYQTKMLNYL ARNFYNLRFLALFVAFAINFILLFYKVTGDDGDDDDPDPWNGGGGTDEEDDEGGMEYFVL QESTGYMAPTLRFLAILHTVISFLCVVGYYYLKVPLTVFKREKEIARKLEFDGLYITEQP SDDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNP TEETVLKEASLVSWLSSVDTKYQCWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHL LDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDENQPD MKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQ GLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLM YLINKDETEHTGQESYVWKMYQERQWDFFPAGDCFRKQYEDQLG NT seq 14715 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggtgaaggggaggatgaaattcagttcttgagaactgatgatgaagtg gtgctccagtgtgtcgcctgcatccacaaggagaatcgcaagttctgcctgactgcagag gggctcggcaatcgactgtgctacctggaacctacatcagaggcaaagtatgtccctcca gacctgtgcatctgtaactttgtgctggagcattctctctctgtgcgggccctgcaggag atgctggctaagactggccagaacagtgaggggaggctcataagaaaggcggcccagggg ggcggacacaggacacttctgtatggacacgctatcctcctgaggcactccttcagcgct atgtatctgacctgtttaaagacatcaaggtcacagacagataagctgtcctttgatgtg gggctgcaggaggactcaacaggtgaagcctgttggtggaccatccatcctgcctccaaa cagaggtcagagggcgagaaggtgcgcatcggtgatgacctcatcctcgtcagcgtgtca tcagaacgataccttcacctgtccatctccaatggcaacatccaggtggacgcgtccttc atgcagactctgtggaatgtccaccccacctgctcaggcagcaacgtggaggagggttat ctgctgggtggccatgtgttgcgtctgttccacggtcatgatgaagttctgaccatccca ggttccgaccagagtgatgagcaacagaggatagtgaactatgagacggggaatgcagga gccaaggccaggtctctgtggaggctagagcctctgagaatcagctggagcgggagtcac attccctggggccagcccttccgtctccgccacctcaccacggggcactacctgtccctg acggaggagaggggggtggtgctgcaggaccgggagaagtctgacacatcctccactgcc ttctgctttagagcctccaaggaaaagctggagtcgagtccaaagcgggacatcgagggc atggggatggcagagattaagtatggggactcaatctgcttcgtcatgcatgtggctaca ggactctggctgtcctaccaggcgcctgatgtaaaatcatctcgcctgggccctctcaag agacgggctttcctccactctgagggtcatatggatgatgggctgaccttgcagcggtgt cagcacgaagagtcccgtgctgctcgcatcatccgtaacaccacccgcctcttcagtcac ttcatcagagacctagactgtctggggggtaagaaccgtgcatcagtagccctgcccatc gaggaggtcctccagactctctacgacctcatcacctacttccagctgcctgacgctgag ctggagcacgaggagaaacagatcatgctgcgctcgctcaagaaccgacagaacctcttc aaacaggaaggcatgctgactctggtgtcctgctgcatcgaccgtctcaacgtgtacaac agtgcagcccactttggggagtgtgccggggcagaggctggggcttcctggaaggaaatc ctcaacctgctctatgagctgctggcggcgctgatccgaggcaacaggaacaactgcacc cagttctccaacaaccttgactggctggtcagcaagctggagagactcgagtcctcctca ggcattctggaggttctccactgcattctaactgagagcccggaggctttaaatatcatc cagagaggacacatcaagtccatcatctccctgctctacaaacatggacgcaaccacaag attctggatgtgctctgctccctctgtgtgtgtaacggggtggctgtaagagccaatcag aatcttatctgcgatcacctgctccctaaaagagatctgcttctccagacccgattggtc aatgacgtccaaagcatgaggcccaacatcttcctgggactgagtgagggctcggcccag tataagaagtggtactacgagctgatgattgaccaggtggaccacttcttgaccagcgac ccctctcacctgcgtgtgggctgggccaccaacaagggttacgccccttaccctggtgga ggggagggctgggggggcaacggggtgggggacgacctctactcttacggctttgacgga cttcatctctggtcaggtcgtatctcccgggcggtggcttctattaaccaacacatcctg acctctgaggatgtggtgagctgttgtctggacctgggagctcccagcatctccttcagg atcaatggacagcccgtacagggcatgttcgagaacttcaacatcgatggactcttcttc cctgttgtcagcttctctgctggcgtcaaggtgcgtttcctgttgggcggtcgtcatggc gacttcaagttcctgcctccgtcaggctacgctccgtgttacgaggccctgctgcctaag gagaagatgaaggtggagccagtgaaggagtacaagagggacatggagggggtccgagac ctgctggggaccacacagttcatgtcccaggcctccttcatacccacccctgtggagacc agccagatcgtcatgccgccatacctggagaaggtccgggacagactggctgagaatatc cacgagctgtggggcatgaacaagatagaactgggctggtcttatgggaagaggataagg gacgataacaagcggcagcacccctgcctcgtggatttttccaaactgcctgaaacagag aagaattacaacctgcagatgtcaactgaaaccttgaagaccctgctggcattaggctgc catgttgtccaggtcaacgccaacgctgaagaggacctgaagaagatcaaactccccaaa aactacatgatgtcgaatggttacaagcccacaccgctggagctgtctgacgtgaaagtg accccaggtcaggagctcctggtggagaaactggcggagaacgcccacaacgtgtgggcc aaggacaggatcaaacagggttggacctacggcattcagcaggatgtgaagagcaagcgg aaccctcgcctggtgccatattctttattagacgagcgcactaagaagtccaacagggac agcctccgagaggccatccggactctgattggatacggctacaacatcgaacctcccgac caggatggcgcaggccacgtggtggagagacttagcatcgacaaaatacgcttcttccgc gtggagaggacgtatgcggtcctgacagggaagtggtactttgagtttgaggcggtgacg ggaggagacatgcgtgtgggctgggccagacctggatgtaagcctgatgtagagctgggt actgatgagctggccttcgtcttcgatggatacaagggtcaccgtctgaacatgggcagc cgtttctttgggcgttgttggcaggcgggggatgtggtgggctgcatgatcaacatggag gacaagtctatgattttcaccctcaatggagagatcctcatcactaacaagggctccgag ctctgcttcgccgacttcgagacggaggacggttttatcccagtatgtagtctgggcctg tcccaggtgggtcgtatgaacctggggaaggatgccagtacctttaagtattacaccatg tgtggcctgcaggagggttttgaaccctttgctgtcaacatgaaccgtgaggtcaccatg tggttcagtaaacgcctccccacctttttcaatgtgccaaagaacaacaaccacataatg gtgaccagaatagatggcaccatcgacagccctccctgtctgaaggtgagtcacaggact tttgggacccagaacagtaatggtgacatggtatactgtcgtctgagcatgcccgtggag ttccactccttcttcaagaccagccctgtcatggacatgaacggagtgcacgaagagcac gagtccctcaaactcaaacacagacatccactgaagtccatgagacacagtcatgatgga ataagaggaacagattacagcaacatcaccacgtactactactctgtcagggtattcgct ggtcaggatccatcctgcgtgtgggtgggctgggtcacccctgactaccattactatagc aaccacttcaacctcagtaagaaccggacggtgacggttacccttggagacgagcgtggg cgggtccatgagagtgtgaggaggagtaactgctacatggtgtggggaggggatgccacc agctcaggccactcgtccagtcgcagtaacgtggacctggagataggctgcctcattgac ctggccactggtctggtgaccttcactgtcaacggcaaggagctggccacctcctaccag gtggaacccaacacaaagctgtttcctgctgtatttgtgcgacctaccagccccaatctc ttccagtttgaactggccaagataaagaacaccatgcctctgtcggcggccatctttaag agtgagcataaaaacccagtgcctcagtgccctccgaggctggacgtccagaccatcaac tcagtgctgtggagccgcatgcccaacaccttcctaaaggtggagacggccagggtcagt gagagacacggctgggtggtgcagtgtctggagcccctgcagatgctggctgtgcacata cctgaggagaacaggtgtgttgacatcatggagctgtctgagcaggaggacctgaggatg ttccactaccacaccctgaagctctactgtgccctgtgtgcactgggcaatacccgtgta gcacacgccctctgcagccacctagaccaatcccagctgctctacaccatcgacaaccag tatctgtcgggcatgctgcgtgagggcttctacaacgtcctgatcagtgttcatctggag acggccaaggaggcccgccttatgatgaacaacgagttcatcatccccgtcaccgccgag actcgcagcatccgcctgttctccgacgcctccaagcaccactctcctcctggcgtgggc ctcagcacctccctgaagccccggctcaacttctaccctccttgtttcatcagcaccaag agggagcagcacctgtacagcccccagatccccctggatgccctgaaggagaaggccatc accatgctgaccgaggccgtgcagggcggtggccatcacatcagagaccctgtagggggc agcgtggagtaccagtttgtgcccatcctgaggctgattggcacgctgctcaccatgggc gtgctgggcagtcaggatgtccataagatcctgctgctcatcgaccccaacgtgttcgcg gagcatcacgaggaggcggccgccgcggtgatggaggccacggagaaggagggactgaca ggcgccgaggagaaggcggtggaggccggggaggaggaggcagctaaagaggccaagcag ccaatcaaaggtctgctggagaagaggctgcctgagccagtcaaacgacagatgtgtgag ctgcttcactacttctgtgactgtgagctgaagcatcgcatcgaggccatcgtgtctttc tcagacagctttgtctccaagctgcagtacaaccagaagttcaggtacaacgagctgatg ctggccctcaacatgtctgctgccgtcaccgccaagaagaccaaggagttccgctcccct ccccaagaacagattaacatgctgttgaacttcagtacgggggaggactgcccgtgtcca gaggacattcaggaggagctctatgccttccacaacgagctgcggctgcactgtggaatc cctatggaggaggaggatgaggagcaggacaggtctattaaaggtcgtctgctggccctg gtctacaagatcaaaggtcaacctctgaagactgaagaggagcccacagagcaggaacaa caagccccctccaacctgaaggagttgatctcccagaccatggtgagctgggctcaggag tgccacgtccaggaccccgagctggtcagagtgatgttcagcctactgaggagacagtac gacagcattggagagctgctccgggccatgaggaagagctacactatcagtgctgcctct atacaggacaccatcaacctgctggcttctctgggtcagatcagatcactgctgtccgta cgcatgggcaaggaggaggagaaactcatgatcgacggtctgggtgacatcatgaacaac aagatattctaccagcaccccaacctgatgcgcgtgctgggcatgcatgagacggtgatg gaggtgatggtcaacgtgctgggaggaggcaagtcccaggagatagcgttccccaagatg gtggccagctgctgtcgcttcctgtgttacttctgcaggatcagtcgtcagaaccaaaag gccatgtttgaccacctcagctaccttctggagaacagcagcgtaggccttgcatcccca gccatgagaggctccactcctctagacgtggctgcctcctctgtgatggacaacaacggc ctggccttggccctggaagagcccgacctggacaaggtggtgacatacctagcaggctgt gggctccagagctgtcccatgctgctggacaaaggttaccctgacatcggctggaacccc attgagggtgaacgctacctctccttcctgcgcttcgctgtatttgtcaatggtgagagt gtggaggagaactccagtgtggtggtgaagctactaatcaggcgtcctgagtgttttggc ccggctctgagaggagaggggggtaatgggctgctggcagccatgaaggaggccatcaaa atctcagataaccctgctgtggacttgccctcctccgcccagggggtcagctctgacgcg tctgctgaggacgatgaggaggaagaggtggtgcatatgggcaatgccatcatgtccttc tactctgccctcatcgacctactgggacgctgtgccccagagatgcacttgatcaacaag ggtaaaggggaggccctgcgcatccgtgccatcctgcgctccctagtgcccactgaagac ctggtgggcatcatcagcatacccctcaaaatgcctgtcgtccacaaagacggcactgtg acagagcctgatatggcagccagtttctgcccggaccacaaggcccccatggtgctgttc ctggaccgggtctatggtatcgaggaccaaagcttcctacttcagctgctggacgtgggc ttcctgcccgacctgcaagcctctgcttctctggacacggaggtactcagcaccacagag acagctctggccatgaataggtacatcggctctgccatgctgcccctgctcacccgctgt gccccccacttcgctggcacagagcactacgccgtgctcatcgactccacgctgcacacc atctacaggctgtccaagggccgctctctcaccaaggcccagagagacgcaatcgaggag tgtctgctggccgtctgcaagtacctccgtccctccatgctgcagcatctcctgcgacgc ctcgtctttgacgtgcccttgctgacggagtactgcaagatgcctctcaggctcctgaca aaccactacgagcagagctggaagtactactgtctgccgtcaggctggggcagctacggc atggcctcagacgaggagctgctcctcacaaagaagatcttctggggcgtcttggattcg ctctcacagaggaagtacgatgcagatctctttaagatggccatgccctgtctgagtgcc atatctggggccttaccgcctgactacatagacgccaccatcagcaccaccctggagaag cctgtgtctgtggacgctcagggcaatttcgaccccaagcccataagcacagccaacata tctcttccagagaaactggaacatgttgccaacaaatatgctgagcattcccatgacaaa tggtcagcagagaaggtgatgttgggatggaggtatggggactgtatagatgagaaggcc aagactcaccctctactcaggacctacaaaggtctgacagagaaggagaaggatatctac aggtggccggtgagggagactctaaagaccatgctggctatgggctggaacatcgacagg accaaggatggagagaccatgtccctacgggagagtgagaagatgcgcaagatctcccag tcctcttctcatgctaacggtttcaacccaaccccaatagacaccatcaatgtggttctg tctagagagttacagggcatggtggaggttgtggctgagaattatcacaacatctgggct aagaagaagaagaatgaccttggaattagaggtggggcaactcaccctctgctggtgccc tatgacaccctgaccgccaaagagaaggcccgggacaaagagaaagcccaggacctgttc cgcttcctgcagatcaacggctacgccatcaccagaggtctgaaggacatggagcaggac tcttcctccatggagaagaggtttgcttacaagttcctcaagaagctgctgaagtatgtg aactcagcccaggagttcattgcccaccttgaggtcatggctaccagtgggaagacagac aagtcgcctcatgagcaagaaatcaagtttttcgccaaagtcctcctccctctgatagac cagtacttcaagaaccactgtctctacttcctgtcttctcccagtaagaacctgagcagc agcggctacgcctctaataaggagaaggagatggtcaccagcctgttctgtaaactggca gctcttgtcagacacaggatttccctatttgggagtgactccaccaccatggtgagcgtt ctccacatcctggcccacacactggacaccaggacggtgatgaagtctggctcagagctg gtgaaggcggggttaaggacgttcttcgagaacgcagcggaggacctggagaagaccctt gagaacctgaagttggggaagttcacccactcccgctcacagatgaagggcgtgtcccag aacatcaactacaccacggtggcactactgcccatcctcactgccctgtttgaacacatc acccagcaccactttggagtggacctgctcttggatgatgtccaagtgtcctgctatcgt atcctgaccagcctctatgcgctcgggactgggaaaaacatctatgtggaaaggcagctg ccggccctgggggagtgtctggccaccctggcaggggccatgcctgtggccttcctggag cccctgctcaacaaacacaacccctgctctgtgttcaacaccaagaccgccagggaacgc gccatcctgggcatgccagacgcggtggaggagatgtgtccggagatgcctcgtctagac gtcctgatgaaggacatcaacgacatgtctgagtctggggcgcgctacacagagatgccc cacgtcatcgaggtggtgctgcccatgctgtgtaactacctgtcttactggtgggagaag ggcccagagaaccaggagtctccgcacagcgggggaagtgttgggggcagtgtcttctcc accaccgtcacctcagaacacctcagcctcatcctgggaaacatcctgaagatcctcaac agcaacctgggcatcgatgaggcctcctggatgaagaggatcgcagtgtacgcccagccc atcatcactaaggccagggctgttctgttgaagagtcacttcctgcctacactggagaag ttgaagaagaagacagtgaaggtggtgacggaggaggagctactgaaggctgacagtaag ggagatacccaggaggctgagctgctcatcctggatgagttcgctgtgctctgcagagac ctctacgccttctacccaatgctcatccgctatgtagacaacaacaggtcgaggtggctg aaagaaccagacgctgactccaatgaactcttcagaatggtggctgagatcttcatcctc tggtgcaaatcacataacttcaaaagggaagagcagaactttgtggttcagaatgaaatc aacaacctgtcattcctgactggtgatagcaagatcaagatgtcaaagtcagggggtcag gaccaggagaggaagcataagaggaagcgaggagagttctactccatccagacctccctg atcgttgctgccctgaagaagatgctgcccattggactcaacatgtgcacccccggggac caggagctcatctccctggccaagacacgctatatcctgaaagacacagatgatgaagtg aaggagcatttgcggcagaatctgcaccttcaagagaagtcagaggaccctgcagtgcgg tggcagctgaacctgtataaggatgtgatggtgaagaacgaggggcctccagaccctgag aggacagtgttccgggtccagagcatctcagctgcagtctttcatctggagcaggttgag cagccattgaggtctaagaagtgtgtgtggcagaagctgctgtccaagcagagaaagcgt gcggtggtggcctgcttccgcatggctcctctctacaacctgcccaggcacaaaagtaat aattacttcctgaacgcctaccgacgctattggcttgaaaaaatgcatgagaacacagac tatgacagtctgctctccatgctaacgaagacccaactgaaggtggaggaggaggaagag gaggaggcagagatgcagccagaccctcttcatcagctcatcctgcatttcagtcacaat gcgctcactgagcggagttctttggaagaggatcctttgtatattgcatatgcagacatg atggcaaagagttgtgcagaagatgaagaagaggaagatgaagaaggaaaggagaaaacg tttgaggaaaaagagatggagaaacagaagactctgtaccagcaggccagactgcatgac agaggagctgctgagatggtgttacagatgatcagtgccagcagaggttcacttgggccc atggtgacctttaccttgaagctgggcatctctatactcaacggcggcaacatactggtt cagcagaaaatgcttgactatctgaaggaaaaaagagatgctggctttttcaagagttta tcaggactcatgcagtcgtgcagtgtcctggatttgaatgcattcgaaaggcaaaacaaa gcggaaggtcttgggatggtgactgaggaaggatcaatcaacgtgagtgagcggggttcc aaggtactgcagaacgatgagttcactaaggatctctttaggtttctgcaactgctctgt gagggacacaacaatgacttccaaaacttcttgcggactcagacagggaacacaaccaca gtaaatatcatcatcagcactgtggactacctgcttcgtctgcaggaatccatcagtgat ttctactggtactactctgggaaagacatcatggatgaggctggccagcggaacttctcc aaagccctggctgtggctaagcagatcttcaactctctcactgagtacatacagggcccg tgtattgggaaccagcagagtctggcccacagcaggctatgggatgcagtggtgggcttc ctgcatgtgtttgccaatatgcagatgaagctctcacaggactcaagtcagattgactta ttgaaggagctgctggacctgcagaaggacatgatcgtgatgatgctctcccttctggaa ggtaatgttgtcaacggaactattggcaaacagatggtggacaccctggtggagtcctcc agcaatgtagagatgatcctcaagttcttcgacatgttcctcaaactcaaagacctgacc tcctcggacaacttcaaggagtacgacccggacagcaagggagtgatctccaagaaagaa ttccagaagtccatggagaaccagaagcagtactcccagtcagagattgagttcctgctc tcctgcgtcgaggctgacgaaaatgacatgttcaactatgaggagtttgttgaacgtttt catgaaccagccaaggacattggttttaacgtggcggtcctgctcaccaacctatcagaa cacatgcctcacgacgcccgtctagccaccttcctggacctggccgagagcgtgatcaac tacttcgagccctacctgggccgcatcgagatcatgggcggggccaagcgcatcgagagg gtctactttgagatcagtgagtccagtcgtacgcagtgggagaagccccaggtcaaagag tccaagagacagttcatctttgacgtggtcaacgagggcggggagagcgagaagatggag ctgtttgtcaacttctgtgaggacaccatctttgagatgcaactagcctcccagatctct gagcctgactcagtggagcgtctcgaggaggaggaggaggacagccagagtgtggaggag gaagaggaggaggaagaggaggagagcatgatggagtctcactcagccttcacaaactcc tgtgtctccatgaggaagaacctgtccagcttccgccagctgctcaccttcaagagcatg cggcggcagtacaggaatttcaggaagatgagtgtgagggagatggtaagaggattattc tccttcttctggaagataatcacgggcctcttccgcttcctctataacctggtgtggggc ttcttccacattctgtggtcctccatgtttggtgggggcctggtggagggggccaagaac atgaaggttacagacatcctggggaacatgcctgaccccacacagtttggtatccatggc gacgtgctggaggcagagaagatggaggcgagcgaggcatcgtcggttgcagagatggtc cagatggcccaaggggacaaggcagaggccgacctgatggctgagctgctcaacatccaa accaagagccaggggggcaagcacgcagccgagccaggtctgggggacatgggtgaagtg gtgggggttgacgccccctctttagccagtgccgtcaaacagaagaaggccaaggaggct gctactatggagcctgccaatggagatcacaaagccgagccagagaaagcagacccagag gacgaggagaagaaagacaaggacaaagccaaagaggagactccacctgagtccccacca gaagaggagaagaaggcccccaagaagagaccgggactaaaaaaagagcccccagaggcc ttcatggccagattcttctctggcctggagatctatcagaccaagatgttgaactatctg gccagaaacttctacaacctgcgtttcttagcgttgttcgttgctttcgccatcaacttt attcttctcttctacaaagtgactggcgatgacggggatgacgatgatccagacccctgg aatggtggtggaggtactgatgaagaggatgatgaaggtgggatggagtattttgtcctg caggagagcaccggctacatggcacccacactacgcttcctggccatactacacacagtc atctctttcctgtgtgtggtgggatactactacctgaaggtgcctctgacggtgttcaag agagagaaggagatcgccaggaagctggagtttgacggcctctacatcacagagcagccg tcagacgatgacatcaaaggacagtgggaccgcctcgtcatcaacaccccttccttccct aataactactgggacaagtttgtgaaacgcaaggtgatcaataagtatggagatctgtat ggagcagagaggatagcagagctgctggggctggataagagtgctctggacttcaacccc acagaggagacagtgctgaaggaggcatcgctggtgtcctggttgagctctgtcgacacc aagtaccaatgctggaaaatgggtgtggtgtttacagacaattcgttcctgtacctggtg tggtacaccaccatgtccatcctgggtcactacaacaacttcttcttcgctgcccatctg ctggacatcgccatgggcttcaagaccctccggaccattctgtcctcagtcacccacaat ggcaaacagctggttctgactgtaggtctactggcggttgtggtgtatctgtacactgtg gtggccttcaacttcttccgcaagttttacaacaagagtgaggatgagaaccagccggat atgaagtgtgacgacatgatgacttgctacctgttccacatgtatgttggtgtgagggca gggggtggcatcggagacgagatagaggaccctgcgggcgacccctacgagctctaccgc atcctcttcgacatcaccttcttcttcttcgtcattgtcatcctgctggctatcatccag ggtctgatcattgatgcttttggagagctgagagaccaacaggagcaagtgaaagaggat atggagaccaaatgtttcatctgtggcatcggcaatgactactttgacacgacgcctcac ggctttgagacacacaccttacaagagcacaacttggccaactacctgtttttcctgatg tacctcatcaacaaagatgagacagaacacactggccaggagtcatacgtgtggaagatg taccaggagaggcaatgggactttttccccgctggagactgtttcagaaagcagtatgag gatcagcttggatag

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