Serinus canaria (common canary): 103826585 Help Entry 103826585         CDS       T05755                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism scan  Serinus canaria (common canary) Pathway scan04020   Calcium signaling pathway scan04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:scan00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103826585 (RYR3)    04020 Calcium signaling pathway     103826585 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:scan04040]     103826585 (RYR3) Ion channels [BR:scan04040]  Voltage-gated cation channels   Ryanodine receptor    103826585 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 TBK1_ULD Motif Other DBs NCBI-GeneID:  103826585 NCBI-ProteinID:  XP_030096355 LinkDB All DBs Position Unknown AA seq 4871 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVASIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLASTGDNASEGAAQGGGHRTLLYGHAILLRHSFSEMYL TCLTSSRSQTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPICSGSNITEGYLLGGHVVRFFHGHDECLTIPSTD QNDSQHKKVFYETGGAGIRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGKYLALNED EGVVILDREKSDTASTAFCFRATKELKEKQESSLKRDIDGMGVPEIKYGDSICFVQHVAT ALWLTYKAQDAKSARLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTSLFSH FISGNNRALSPSALPVEEMAQTLQDLITYFQLPEEDLQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNDYNSAAHFAGIAREELGGTSWKEILNLLYKLLAALIRGNRNNCAQFS CNLDWLISKLDRLESSSGILEVLHCILIESPEALNLISEEHIKSIISLLDKHGRNYKVLD VLCSLCVCNGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKK WYFELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSFGFDGLHL WSGRVPRAVASVNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFSTEGFFFPVV SLSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMKLEPVKEYKRDFEGVRDLLG TTQFLSQASFIPCPIDTSQIALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNK RHHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHAHPAAEEDLKKVKLPKNYMM SNGYKPAPLDLSEVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRL VPYALLDERTKKSNRDSLREAVRTFAGYGYNIEPPDQEIADQTVEKVSIDKIRFFRVEQS YAVKSGKWYFEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQCWHQGSGFFG RSWQPGDVVGCMINLDDKSIIFTLNGELLITSKGSELAFADFGIENGFVPICALGLSQIG RMNLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIKIWRI DGTIESPPRLKVTHKTFGTQNSNSDMIYCRLSMPIEFHSSFNFGMGVENASSDVFQKRKH SQEIAPPSTTYFYSLRIFAGQDPSSVWVGWVTPDYHFYSENFDLNKNCTVTVTLGDERGR VHESVKRSNCYMVWGGDAIANSQRSGRSNVDIEIGCFVDLATGMVSFTANGRELGTCYQV EPNTKLFPATFLQPTSTNLIQFELGKLKNTMPLSAAIFKSEERNPIPQCPPRLDVQTITP VLWSRMPNSFLRVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMMF HYHTLKLYSSVSALGNTRVAFALCSHVDVSQLFFTIDNQYLPGLLRSGFYDLLISIHLEH AKQAKLMMSNEFIIPVTDETRNIKLYPDETKKHGLPGVGLSTCLKPAFNFSTPCFIATSE DHQTSIPEIPLEILKSKAINMLTEAVQCSGSHIRDPVGGQVAFQFVPVLKLIATLLVMGV FDDDDVKQVLLLIDPTVFGDHKEEMEERTEKEEVTQIEEKAVEAGEKAIKQTKAPAKGLL QTRLPESVKLQMCHLLNYFCDCELQHRVEAIVSFADRYVSKLQYNQKYRYNELMQALNMS AALTAKKTKEFRSPPQEQINMLLNFQLGEDCPCPEEIREELYEFHDDLLIHCGIPLEEEE EEEEDSSLTGKLRSLMYKIKGPPKAEKLEPKEEEEKAPTTLKELISQTMVRWSQEDQIQD PELVRIMYSLLRRQYDSIGELLQALRKAYTISAASVKDTINLLAALGQIRSLLSVRMGKE EELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQQIAFPKMVASCC RFLCYFCRISRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALAL EEPDLDKVVTYLAGCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFANSESVEENA SVVVKLLIRRPECFGPDLRGEGGNGLLAAMQEAIRISENPSRDLPSQAYKREGDEEEEEE ETVHMGNAIMSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIP LKLSTVNKDGTVNEPDMSASFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRAS ASLDTVSLSTTEAALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSTLHTMYRLSKGR SLTKAQRDAIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWK YYCLPSGMGSYGIAAEEELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPD YLDTRIMSTLEKQTSVDPEGNFDPKPVNTSNLVLPEKLEYIVSKYAEHSHDKWAFEKTNS GWKYGVSLDENMKTHPLIRPFKTLAEKEKEIYRWPARESLKTMLALGWSLERTKEGGEAM IHQRENEKLRSISQSSQGNGYSPTPFDLSNVALSRELQGMVEVMAENYHNIWAKKKKMEL ESKGGGSHPLLVPYDTLTAKEKSRDREKAQELFKFLQVNGIIISRGLNDMELDASSMEKR FAFKFLKKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHC LYFLSSPSKILSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVNCLHILAQS LDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTV ALLPILTSIFEHISQYHFGIDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECL ASLAAAIPVAFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQLDRLIKEIN DLAESGARYTEMPHVIEVILPMLCNYLSYWWERGSESVPQSAGPCCTMITSEHLSIVLGN ILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLDKLKKKAMKIVMEEEQ LKADNKNDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMV AEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKAMQVKSGGQDQERKKSKR RGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSHRDTDEEVKEHLRNNLH LQEKSDDPAVKWQLNLYKDILKSDGPTDPEKNVERVQRISAALYHLEQVEQPLRSKKAVW HKLLSKQRKRAVVACFRMAPLYNLPRHKISNFFLSTFQRVWLEKVHEKTQYDRLILKLTT SPKKDEEEEEETEKNHPDPLHQIILYFSRSALTERSNLGHDPLYIAYSAMMAKSCQEEEE GDEDKEKTFEEKEMEKQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAI LNGGNTIVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGT LIVRERGEKVLQHDEFTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLL RLQESISDFYWYYSGKDVIDEPGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSR LWDAVVGFLHVFANMQMKLSQDSAQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQM VDTLVESSSNVEMILKFFDMFLKLKDLTNSDAFKEYDPDGKGIISKKEFQKAMEAQKQYI QSEIEFLLSCTEADENDMFNYVDFVERFHEPAKDIGFNVVVLLTNLSEHMPNDPRLQSLL EPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNE GGEQEKMELFVNFCEDTIFEMQLASQISETDSSERPEEEEEAEPAYVVDIGDDEEEEKSL EPASAFAVACVAVKKNVANFLKMVTVKNLRKQYRKVKKMTIKEMVKVFFSFFWILFVGTF QMFFSIVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVMEAEKAEGA EHGIRAELGEFVKSEKGEADIIADIFGIPTKKEGSKHGHDAGLGDIAEILGTEIQTPLEN TVHKKKRLQISEIAKEAGTQRKAEAEKADMEDGEKQDKAKEVQSEQLEEGKMKKKKRRHG QKIEKPEAVMANFFKALEIYQIKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPL DEVEEDSNLWNSFAEEEEEEGMVFFVLEESTGYMAPALRALAVIHTVISFVCVIGYYCLK VPLVVFKREKEVARKLEFDGLYITEQPTEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVI NKYGDLYGAERIAELLGLDKSALDFSPVEESEPEEASLVSWLSSIDTKYHIWKLGVVFTD NSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAV VVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAG DPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGND YFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGD CFRKQYEDQLG NT seq 14616 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggaggggaagatgagatacagttccttcgaactgatgatgaa gtagtacttcagtgtgttgccagcattcacaaagaacaaaggaagttttgcttggcagct gagggacttgggaatcgcctgtgctttttggagccaacatcagaagctaaatatgtccct ccagacctttgtgtctgtaatttcgtccttgagcagtccctgtctgtcagagccctccag gaaatgctggccagcacaggggacaatgctagtgaaggggcagcccaagggggtggccac cgcaccctgctgtacggccatgccattctgcttcgacattccttcagtgaaatgtatttg acatgtttaacatcatcaagatcccagacagataaacttgcatttgatgtgggattgcga gaaaatgcagcaggtgaggcatgctggtggacaatacaccctgcttctaagcaaaggtca gaaggagaaaaagttcgaataggtgatgaccttatcctggtcagcgtgtcctctgaaaga tacctgcatctctccgtgtcaaatggaaatattcaggtggatgcctcctttatgcagaca ctatggaatgtacatcctatatgctcaggaagcaatattacagaaggatatcttcttggt gggcatgtagtacgttttttccatggccatgatgagtgcttgacaattccatctacagac cagaatgattcacagcacaagaaagtattttatgaaactggaggagctggcattcgagca agatcgttgtggagagtagaaccccttcgaataagctggagtggaagtaacatcagatgg gggcagccttttcgtcttcgacacattacaacaggaaaatacttggctctgaatgaggat gaaggagtagtaatattagacagagaaaagtcagacacagcatcaacagccttctgtttt agagcaacaaaggagctgaaagaaaagcaggaatctagtctcaaacgtgacattgatgga atgggagtcccagaaataaagtatggagattcaatctgttttgtccaacatgtggccact gccttatggttgacttacaaagcacaggatgctaaatcagcacgtttgggtcccttgaaa agaaaggttatattacaccaagaaggtcatatggatgatggtctcacattacaaagatgc cagcgagaggaatcccaggctgctcgaatcattcgcaatacgacaagcttattcagccac ttcataagtgggaacaacagagcactgtcacccagtgccctgcctgttgaggagatggct cagactctgcaagacctgatcacttacttccagcttcccgaagaagatctgcaacatgaa gacaagcaaaacaaacttcgctcactcaaaaacagacaaaatctattcaaagaagaggga atgctggcactcgttctaaattgcattgatcgcctgaacgactacaacagtgcagctcat tttgcaggaattgcaagagaagaacttggtggtacatcatggaaagaaattttgaatctc ctttacaaattgttagctgctctcattcgtggcaacagaaacaactgtgctcaattttcc tgtaaccttgattggctaatcagtaaattggacagattagaatcttcctcaggtattttg gaagtgttgcactgcatcttgattgaaagcccagaagctttaaatctaatatctgaggaa cacatcaaatccattatttcactcttggataaacatgggcgcaattacaaggttctcgat gtgctttgctctctctgcgtctgtaacggagttgcagtccgcgccaatcagaatttgatc tgtgacaatttattgcccagaagagacttacttttgcaaacacgtttgattaatgatgtg acaagcataagaccaaacatatttttgggtgttgctgagggctctgcacagtacaagaag tggtactttgagttaataattgatcaggttgatccattcttgacggctgaacccacccac ttgcgtgttggatgggcctctacctcaggttatgctccctatcctggaggtggagaagga tggggaggcaatggtgttggtgatgacctctactcttttgggtttgatggccttcatctg tggtctggtcgggtacccagagctgttgcatctgtcaatcagcatttattagcatctgat gatgtggttagctgctgcttggatttaggtgtacccagcatttcattccgcattaatgga cagcctgtacagggaatgtttgagaacttcagtacagaagggtttttcttccctgtcgta agcttgtcagcaggtgtaaaagttcgtttcttgttgggtggacgtcatggagagtttaaa tttctgcctcctgctggctatgctccctgttatgaggcattgcttccaaaagagaagatg aaattggaaccagtcaaagaatataaaagagattttgaaggagtgagagatttgttgggt acgacacaatttctctcacaagcttcttttatcccttgtccaatagacaccagtcagatt gctcttccttttcatctggaaaagatcagggacaaactagctgaaaatatccatgaacta tggggcatgaataaaatagaactcggctggacatatggcaagatacgggatgataataaa aggcatcatccttgtcttgtggaattctcaaaactgcctgagacagagaagaattataat ctacaaatgtcaactgaaaccctcaaaacccttttggcccttggatgtcacattgttcat gctcatccagcagctgaggaagatcttaaaaaagtcaaacttcctaaaaattacatgatg tcaaatggatataaacctgcccctcttgatctttctgaagtgaaattgttaccttctcag gaatttctagttgacaaactagcagaaaatgctcataatgtctgggcaaaagatagaata aagcaaggatggacctatggcattcaacaggatcttaagaacaaacgtaatcctcggcta gtgccatatgcattattagatgaacggactaaaaaatcaaacagagacagcctccgtgaa gctgtcagaacatttgcaggctatggctataatattgagccacctgaccaagaaatagct gaccaaacagtggaaaaagtcagcattgacaagatacgatttttcagagtagaacagtcc tatgcagtgaagtctgggaagtggtactttgagtttgaagctgtgacaggtggagacatg cgtgttggctgggccaggccaggctgtcgacctgacatagagctgggagctgatgaccaa gcatttgtatttgaaggaagcaaaggccagtgttggcatcaaggcagcggattctttgga cgaagctggcaaccaggagatgtggttggttgtatgataaacttggatgacaagtcaatc atctttactctgaatggagagttgcttataaccagtaaaggttcagaacttgcatttgct gacttcggaatagaaaatggttttgttccaatttgtgcactgggcctatctcagattggt cgcatgaaccttggaatggatgccagtaccttcaagtattataccatgtgtggccttcag gaaggttttgaaccttttgctgttaacatgaaccgagatgttgctatgtggtttagcaaa cgcttaccaacttttgtcaatgtgccaaaaaatcatcctcacattaagatatggagaatt gatgggaccattgagagtccacctcggttgaaagttactcacaaaacatttggcacgcag aacagcaattcagacatgatatattgtcgtttgagtatgcccattgagttccactcatca ttcaacttcggcatgggtgtggagaatgcctcctctgatgttttccagaaacgaaagcac agccaagaaattgctcctccttctaccacatatttttactcactaaggatatttgctggc caagacccatcctctgtctgggttggctgggtaacaccagactatcatttttacagtgag aattttgacctaaacaaaaattgtacagtgacagttactttaggtgatgagagaggcaga gttcatgaaagtgtgaagcgcagcaactgctacatggtttggggaggagatgcaattgct aattcccagagatcaggtcgcagtaatgttgatatagaaattggatgctttgttgacctg gctactggaatggtgtcattcacagccaatggaagagagcttggcacctgttatcaggtt gaaccaaacacaaagctttttccagcaacttttttacagcctacaagcactaacttgatt cagtttgaacttggtaaattaaagaataccatgcctttatcagcagcaatttttaaaagt gaagaaagaaatcctattcctcagtgtccccctcgccttgacgtgcagaccattacaccg gtgttatggagccggatgccaaacagcttcctcagagtagaaactgagcgtgtcagtgag cgtcacggctgggtggtacagtgcttggaacctctgcagatgatggcacttcatatccca gaagaaaacagatgcgttgatattttggaactctgtgaacaagaagatttgatgatgttt cactaccacactttaaagctctatagctcagttagtgctctaggtaacactagagttgct tttgcactttgtagccatgtggatgtatctcagcttttttttacaatagataatcaatac ttacccggacttctacgttctggattctatgacttgctcattagtattcacttggagcac gccaagcaagccaagctcatgatgagcaatgagtttatcattccagttacagatgaaact cgaaatattaaattatatcctgatgaaacaaagaagcatggtttacctggagtagggctt agcacttgtcttaaaccagcttttaatttttctactccatgctttattgcgaccagcgaa gatcatcagacatccatcccagagatacccctggagatattgaaatccaaggccataaat atgttaacagaggcagtgcagtgtagtgggagtcatatacgagaccctgttggaggacag gttgcattccagttcgttcctgttcttaagctgatagcaacactgcttgtaatgggtgtt tttgatgatgatgatgtgaagcaggtgttactcctcattgatcccacggtgtttggagac cacaaggaagaaatggaagagaggacagagaaggaagaagtgacacaaattgaagagaaa gctgtagaagctggggagaaagcaatcaaacaaacaaaagctcctgcaaagggcttgttg cagacaagattaccagaatctgttaaacttcagatgtgtcatttactcaattatttttgt gactgtgaactacaacacagagtggaagcaattgtatcgtttgcagaccgctatgtatca aaattgcagtataaccagaaatacaggtacaatgaactcatgcaagccttgaacatgtct gctgcattgactgccaagaagactaaagaatttcggtctcctcctcaagagcagattaat atgttgctgaattttcaactgggagaggattgtccctgtccagaggagattcgggaggag ctgtatgaatttcatgatgatcttctaattcactgtggtattccactagaagaagaggaa gaggaagaagaagattcctccttgactggcaaactccgttcattaatgtacaaaatcaaa ggtccaccaaaagcagaaaaattggagcctaaggaagaagaagagaaagctcctactacc ctgaaagaactcatttcacagacaatggtgcgctggtcccaggaagatcagatccaagat cccgaattagttcggattatgtacagcctccttcgcaggcagtatgacagcattggggag ctcctgcaagccctgaggaaagcatacactatcagtgctgcctctgtcaaggacaccatc aatctgcttgcagcactgggccagatccgctcacttctcagtgtgaggatgggaaaagag gaggaattgctaatgattaatggattaggggatataatgaacaacaaggtgttttatcag catcccaacttaatgagagtcttgggcatgcatgagactgttatggatgtgatggtaaat gtgcttggtggagataaatctcagcagatcgcttttccgaaaatggtggcaagctgctgt cggttcctgtgctacttctgtcgcattagccggcagaaccaaaaggccatgtttgagcac ctcagctacttactggaaaacagcagtgttggactggcatttccttcaatgaggggttcg acaccactcgatgtggcagcagcctctgtgatggacaacaacgagcttgcacttgcattg gaggagccagatcttgataaggttgttacctacctggcaggttgtggcctgcagagctgt ccagtgctgctggctaaaggatatccagacattggatggaacccaatagagggtgaacgt tacctgtcattcttgcggtttgcagtttttgctaacagtgaaagtgttgaggaaaatgca agtgttgttgtcaagctcctaattcgacggccagagtgcttcgggccagacctcagggga gaaggaggaaatggtttgctggctgctatgcaggaagctatcaggatctcagagaatcct agtcgtgaccttccttcccaggcatataaaagagaaggtgatgaggaggaagaggaagag gagactgtgcacatgggaaatgcaatcatgtcattttactcagctctcatagatttactt ggacgctgtgcaccagaaatgcatcttattcaaagtggaaaaggggaagctattcgaatc aggtcaattcttcgatccctagtgccaactgaagatttggtggggattataagcatacca ctaaagttgtccacagttaacaaagatggcacagtaaatgagccagacatgtctgccagt ttctgtcctgatcataaagcacccatggtactcttcttggaccgtgtctatggtattaag gaccaaagcttcctccttcacctactggaagttggatttttaccagatttaagagcttct gcctctttggatacagtttctctgagcaccacggaggcagctctggcactaaacagatac atttgctcagctgtgtttccactgctcaagagatgtgctcccctcttttctggaacagag catcatgcctctctggtggactccacgcttcacacaatgtataggttatccaagggacgg tccctcacaaaggctcaaagagatgctattgaggaatgcctgcttgctatctgccaccat ttgcgtccctctatgctacaacagctcttgagaaggctggtttttgatgtgcccctgctc aatgaatactgtaaaatgcctctcaagcttctgacaaatcactatgagcagtgctggaaa tattactgtctgccttcaggaatgggaagctatggaattgcagcagaagaggagttacat ttaactgaaaaacttttctggggaatatttgattccttgtcccataagaagtatgatcca gagctctttcgaatggctttgccttgtctaagtgctatagctggtgccttgccccctgat tatttagatacacgaattatgtcaactttggaaaagcaaacttcagtggatccagaagga aattttgatcccaaacctgtcaacacatcaaaccttgtacttcctgagaagctggagtat attgtaagcaagtatgctgaacattcccacgataaatgggcctttgaaaagactaatagt gggtggaaatatggtgtttcactggacgaaaatatgaagactcacccattaataaggcct ttcaaaactttagctgaaaaggaaaaggaaatttatcgttggcctgccagagaatcattg aaaaccatgttggccttgggatggagcctagaaaggaccaaggagggaggagaagcaatg atacatcagcgtgaaaatgaaaagcttcgcagcatatctcagtctagtcagggaaatggg tatagcccaacaccatttgatctctctaatgtggcactttctagggagcttcagggaatg gttgaggtaatggcagaaaactaccataatatatgggccaaaaagaagaaaatggagttg gaaagcaaaggtggaggtagtcatcctttactggtaccttatgacacattgacagccaag gagaaatcacgggaccgtgaaaaggcacaggagctgtttaaattccttcaagtcaatggg ataatcatatctcggggcttgaatgacatggaattggatgcttcatccatggaaaagagg tttgcctttaagtttctgaagaaaattttaaaatatgttgattctgctcaagagtttatt gcgcatttggaagccattgtaaccagcggaaaaactgaaaaatctccacatgaccaggaa ataaaattctttgctaaagttcttttaccattggttgatcaatactttacaaatcactgc ctctacttcctgtcttctccatcaaaaatcctcagtagcagtggatatgcatcaaataag gaaaaggaaatggtagcaagcctgttctgcaaactagctgctcttgttagacataggatc tcactttttggaagtgattctgctacaatggtgaactgcctgcacatcttagctcagtct cttgacacacgaactgttatgaaatcaggatctgagcttgttaaagcaggactgcgggcc ttttttgaaaatgcagctgaagacttggaaaaaacttctgaaaatcttaaactgggaaaa tttactcattcaagaacacaaatcaagggtgtttcacagaatatcaattatactacagta gcattgttaccaatcttaacatcaatttttgaacatatttcacaatatcactttggaata gatttacttttgggtgatgtacaagtttcatgttacagaatcctttgtagcctctattcc cttgggactggaaagaacatctatgttgaaaggcagcgtcccgcgctgggtgagtgttta gcatctcttgcagcagccattccagtagcattccttgagccttccctcaaccactacaat ccactgtctgttttcaacacaaaaagtgcaagagaaagagcaattttaggtatgcctgat acagtagaagaaatgtgtccagagatccctcagctggatagactaataaaggaaataaat gatttagcagagtctggagcaaggtatactgaaatgcctcatgtaattgaggtgatctta cccatgctgtgcaactatttatcctactggtgggaaagagggtctgagagtgttcctcaa agtgctgggccttgctgtacaatgataacatctgagcatctgagtattgttcttggaaac attctgaaaatcattaacaacaatctgggaatagatgaagcctcttggatgaaaagaatt gcagtttatgctcagcccatcatcagcaaagccagacctgatcttctcagatctcacttt attcctaccctggataaattgaagaaaaaagctatgaaaatagtgatggaagaagagcaa ctgaaagcagacaataaaaatgacacccaagaagctgagctactcattcttgatgagttt gctgtactttgtagagacctttatgccttctatccaatgttgatacgttatgtagacaac aacagagctaattggctaaagaaaccagatgcggattctgatgaactctttcgaatggtg gccgaagtttttatcctgtggtgtaaatcacataattttaaaagagaagaacaaaatttt gtgattcagaatgaaatcaacaatttggcatttttaacaggagacaccaagagcaagatg tctaaagctatgcaagtaaagtctggaggacaagaccaagagaggaagaaatcaaaacgt agaggggatttgtactccatacaaacatccttgattgtggctgcacttaaaaagatgctt cctattggtttgaatatgtgcactcctggagaccaagagctcatctctttggctaagact agatacagccatagggacacagatgaggaagtcaaagaacacctacgcaacaacttacac ttgcaggaaaagtctgatgatccagcagtgaaatggcagctaaatctgtacaaagacatt ttgaagagtgatggacctactgaccctgagaaaaatgtggagcgtgtgcaaaggatatcg gctgctctgtatcatctggagcaggttgaacaaccactgagatcaaaaaaagctgtttgg cacaaactcctgtcaaaacaacgcaaaagggctgttgttgcatgtttcagaatggcacca ttatacaacctgccaagacacaaaattagcaatttcttcctgagcacctttcaacgtgtt tggctggaaaaagtacatgaaaaaactcagtatgacaggcttatactcaagttaacgaca tctccaaaaaaagatgaagaggaagaagaagagactgagaaaaaccatcctgacccactt catcagattatcctctatttcagtcgcagcgctcttacagagagaagcaatctaggacat gatcctctatatattgcctattctgccatgatggcaaaaagctgtcaggaagaagaagag ggagacgaagataaagaaaagacatttgaggagaaagaaatggaaaagcagagaactctc tatcagcaagctcgcttgcatgatcgtggagctgcggagatggtccttcagatgattagt gcaagcaaaggtcatacaggacccatggtggttgaaacactgaaacttggtattgctatt ctaaatggtggaaacactatagttcaacagaaaatgctagactacctgaaggagaaaaag gatgctggattttttcaaagcctctctggcttgatgcagtcctgcagtgttcttgacttg aatgcgtttgagagacagaataaagcggaaggcctgggaatggtcactgaagaaggaact ctcatcgttcgtgagcgtggtgaaaaagtcttgcagcatgatgaatttactcgagatcta tttagatttttgcaacttctctgtgaagggcacaacaatgattttcaaaattacttacgt actcagatgggcaacaccacaacagtgaatattatcattagtactgttgactatctcttg cgtcttcaggaatccatcagtgacttctattggtactattcaggaaaggatgtcattgat gaaccaggacaacgtaacttttctaaagctttggctgtcaccaagcaaatattcaattct cttacagaatatatccagggcccttgcataggtaatcaacagagcctggctcatagtagg ctgtgggatgcagttgttggctttcttcatgtgtttgccaatatgcaaatgaaactttca caggactccgctcagattgaattgcttaaggaactgctagatctgctaaaggatatggta gtgatgcttttgtcactgcttgaaggtaacgttgtaaatggaactattggaaaacaaatg gtggacacccttgtagaatcatctagcaatgtagaaatgattttgaagttctttgacatg ttcctgaagttaaaagatctgactaattcagatgctttcaaagagtatgacccagatggt aaaggaatcatttccaagaaggaatttcagaaagccatggaggctcaaaagcaatacata cagtcagagattgaattcctgctgtcctgtacagaagctgatgaaaatgatatgttcaac tatgttgactttgtggaaagattccacgaaccagccaaagacattggatttaatgtagta gtactgctcacaaacctttcagagcacatgcctaatgacccacgccttcagagcttactt gagcctgcagaaagtgttcttaattactttgaaccataccttggccgtattgaaataatg ggtggggccaagaaaatagaaagagtttactttgaaatcagtgaatccagtagaatgcag tgggagaagccacaggtgaaggaatctaaaagacagttcatatttgatgttgtaaacgaa ggtggagagcaagaaaaaatggagctctttgtgaatttctgtgaagacacaatttttgaa atgcagttagcatcccagatctctgaaacagattcctctgagaggcctgaggaggaggaa gaggcagagcctgcttatgtagtggatattggagatgatgaggaagaagaaaagtccctg gaacctgcttcagcttttgcagtggcctgtgttgcagtgaagaagaatgttgccaacttt ttgaaaatggtcactgtgaagaaccttaggaaacaatataggaaagttaaaaagatgaca ataaaagagatggtgaaagtgtttttctcctttttctggatcctatttgtagggacattc caaatgttcttttctatagtgtgggggatattccagattctttggagcactgtatttggg ggtggcctggttgaaggagccaaaaacataaaagttacaaaaatattaggggatatgcct gatccaacacagtttggaatccatgatgatgttatggaagcagaaaaagctgaaggtgct gagcatggcataagagctgaacttggggagtttgtgaagagtgaaaagggagaagctgac ataatcgcagatatttttggcattcctacaaagaaagaaggatcaaaacatggtcatgat gctggacttggagatattgcagaaatccttggtactgagatccagacacctttggaaaac acagttcataagaaaaaaagattacagatatctgaaattgcaaaagaagctggaacccaa agaaaagcagaagctgagaaggctgacatggaagatggtgagaaacaagataaagcaaag gaagtacaatctgagcagctagaagaggggaaaatgaagaaaaagaagagaaggcatggt caaaaaattgagaaaccagaggctgttatggctaacttcttcaaagctttggaaatttat cagataaaaatgcttcattacttggcaagaaatttttacaacttaaggtttcttgctcta tttgttgcatttgccatcaattttattcttctgttttacaaggtgacagaagagccactt gatgaagtagaggaagactctaatctctggaactcctttgctgaagaggaggaagaggag ggcatggtgttttttgttttagaagaaagcactggctacatggcacctgctctcagagca ctggcagttattcatactgtcatctcctttgtctgtgtgattggatattactgcctaaag gtccctctggttgtattcaagagagaaaaggaggtggctagaaagctggaatttgatgga ctgtacataactgaacaaccaactgaggatgatattaaaggacaatgggatcgccttgtt ataaatactccgtccttccctaacaattactgggacaaatttgtgaaacggaaggttatt aacaagtacggagatttatatggagcagagcgcattgcagaacttctgggtttggacaaa agtgcccttgattttagtccagtggaagagagcgaaccagaagaggcctctcttgtgtca tggctaagctccattgatacaaagtaccacatttggaagctcggagttgttttcactgat aattcatttttatacttagcttggtacacaactatgtctatccttgggcactacaacaac ttcttctttgctgctcatctgctggatattgctatgggttttaagacattgagaactatt ttgtcttcagtcactcacaatggcaagcagcttgtgcttactgtgggactcctggctgta gtagtgtacctttacactgtggtggctttcaacttcttccgcaaattctacaacaaaagt gaagatgaagatgaaccagacatgaagtgtgacgacatgatgacgtgttacctgttccac atgtatgtgggtgtaagagctggtggtggcattggagatgaaattgaggatcctgctgga gacccttatgaaatgtaccgaattgtctttgacatcacatttttcttctttgtcattgtt atcctactggccattattcaaggtctgattattgatgcttttggtgaattaagagaccag caagaacaagtgagggaagacatggagaccaaatgctttatttgtggaatcggcaatgac tactttgacacaactccacatggctttgaaacacatactttgcaagaacataacttggca aactatctgttcttcttaatgtatctaattaacaaggatgaaactgaacatactggccag gaatcatttgtgtggaagatgtaccaagaaagatgttgggattttttcccagcaggggac tgcttcagaaaacagtatgaggatcagcttggctaa

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