Sturnira hondurensis: 118993638 Help Entry 118993638         CDS       T07222                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism shon  Sturnira hondurensis Pathway shon04020   Calcium signaling pathway shon04371   Apelin signaling pathway shon04713   Circadian entrainment shon04921   Oxytocin signaling pathway shon04970   Salivary secretion shon05010   Alzheimer disease shon05012   Parkinson disease shon05020   Prion disease shon05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:shon00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118993638 (RYR3)    04020 Calcium signaling pathway     118993638 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     118993638 (RYR3)   09154 Digestive system    04970 Salivary secretion     118993638 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     118993638 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     118993638 (RYR3)    05012 Parkinson disease     118993638 (RYR3)    05020 Prion disease     118993638 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     118993638 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:shon04040]     118993638 (RYR3) Ion channels [BR:shon04040]  Voltage-gated cation channels   Ryanodine receptor    118993638 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  118993638 NCBI-ProteinID:  XP_036912036 LinkDB All DBs Position Unknown AA seq 4863 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKFVP PDLCVCSFVLEQSLSVRALQEMLASTGENGSEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLQEHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNANIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKATAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHVAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNCTAAPITLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGLAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRTNQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDTEGIRDLLGT TQFLSQASFIPGPIDTSQVVLSPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLSKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDVKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSKGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMVFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID STMDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECQSSFSRSPCLDGDAFQKRKQMQEI LSQTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLLQFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRKIRLYPDGSKRHGLPGVGLRTCLKPGFQFSTPCFVMTGEEHQ KQSPEIPLEILKTKALSMLREAVACSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEQSGEREEGAEKEEVSQVEEKAVEAGEKASKEAPVRGLLQTRLP ESVKLQMCELLSYFCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTKEFRSPPQEQINMLLNFQLGENCPCPDEIREELYDFHEDLLSHCGVPLEEEEEEEEV TSWAGKLCALVQKIQGLPKPETEQPAVEEQKCPTTLKELISQTMIRWAQEDHIQDADLVR MMFNLLRRQYDSIGELLQALRKTYSISQASVGDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNGESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIRISENPALDLPSQGYKREVTEDSEDEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDVAAHFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRTSASLDT VSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHSTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEHCKMPLKLLTNHYEQCWKYYCLP SGWGGCGLAVEEELHLTEKLFWGTFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQLSVDADGNFDPKPISTVNFSLPEKLEYIVTKYAEHSHDKWACEKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN EKLRSTSQASQGNSYSPAPPDFSNVALSRELQGMVEVIAENYHNIWAKKKKVELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGVKDTELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEALVSSGKTERSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLGSGGCASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVNCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGRNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGLPDTVEAMCPDIPQLEGLMKEINGLAESG ARYTEMPHVIEVILPMLCNYLSYWWEQGPEHLPPGTGPWCTRITSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADSK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFIL WCKSNNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSVQTSL IVAALKKMLPIGLNMCTPGDQELISLAKSRYSFRDTDEEVKEHLRNNLHLQEKSDDPAVK WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEECSFEERLVQDLAQSPKAEEQEEEET ERHPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCRDGENEEEDEDKEKTFEE KEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQK MLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVL QNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESISDFYW YYSGKDIIDESGQHNFSKALVVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV EMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKKEFQKAMEGQKQYTPSEIDFLLSCA EADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFE PYLGRIEIMGGAKKIERVYFEISECSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFV NFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYTLEIEGEGEDDTSSEPASAFAMAC ASVKRSVATFLKRATLKNVRKQYRKVKKMAVKELVKVFFSFFWMLFLGLFRLFFALLGGL VQVLWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAVEAERAEVTELGISTELVH FIKGEKGDADIMSDLFGFYSKKEGGLKHGPEVGLGDLSEIVGKDEPPTLESTVRKKRKAQ AAEMRAAHEPEGKVESEKADMEDGEKEDQAREEQAKALWAEATKKKKRRHGQKVEKPEAF MANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVAN LWRSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIAHTIISLVCVVGYYCLKVPLVVFKR EKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPSNYWDKFVKRKVINKYGDLYG AERIAELLGLDKNALDFSPVEKTKAEAASLVSWLSSVDMKYHIWKLGVVFTDNSFLYLAW YTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRI VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHG FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYED QLG NT seq 14592 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggcggcgaggacgagatccagttcctgcggactgaagatgaa gtggttctccagtgcatcgccaccattcacaaggagcaaaggaagttctgcctggcggcc gagggacttggcaatcgcctgtgcttcctggaacccacttcagaagccaagtttgttcct ccagacctctgtgtctgcagttttgtgctggagcagtccctgtcggtcagagccctgcag gaaatgcttgccagcacaggggaaaatggcagcgaaggggcagcacaagggggtgggcac aggactctgctgtatggccacgcgattctcctgcgacactcctttagtggaatgtatcta acatgtttgactacgtcaagatcccagacggataaacttgcctttgatgtaggtctacaa gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagaggtct gagggagaaaaagttcgaattggagatgacctcattctcgtcagtgtttcctctgaaaga taccttcacctctcagtatcaaatgctaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttgga gggcatgtagtacgtcttttccatggtcatgacgagtgtttgacaataccgtctacagat cagaatgactcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc agatctctgtggagagtggaaccccttcggattagctggagtggcagtaatatcagatgg ggccaggctttccgactgcggcatctcaccacaggccactacctggccttgacagaggac caaggcctaatattgcaagaccggggaaagtcagacaccaaggctacagccttctccttc agggcatcaaaggaaatcaaggagaaactggattccagtcacaaaagagatatagaaggc atgggagttccagaaatcaagtacggagactctgtctgctttgtccagcacgtagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacatcccgccttgggcctctgaaa agaaaggtcatactccatcaggaaggccacatggatgatgggttaacactgcagagatgc cagcgtgaggaatcccaggcggcccgcatcatccgcaacacaacagccttgttcagccag tttgtgagtgggaacaattgcacagctgcccccatcaccctgccgatagaagaggtccta cagaccttgcaggacttgatcgcctacttccagcccccggaggaggagatgcaacatgaa gacaagcagaacaagctccgctcactcaaaaacaggcagaatcttttcaaggaagaggga atgttggcccttgtgttaaattgcattgaccgcctaaacatctacaacagcgtcgcacac tttgcagggatcgcaagggaagagagtggcctggcctggaaggaaattctgaacctcctg tacaaattgctggctgccctcatccgtggaaacagaaacaattgcgctcaattctccaat aaccttgattggctaatcagcaaattggaccgactagagtcttcctcaggtatcttggaa gtcttgcactgcatcttgacggaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccttgttggataagcacgggcggaaccacaaggttctcgatgtg ctgtgctccctctgtctctgcaatggggtcgcagtgagaaccaaccagaaccttatctgt gacaacctgctgccccggagaaacctgctcctgcagacgcggctgattaatgacgtgaca agtattcgaccaaacatcttcctgggagtggctgagggctcagcacagtacaaaaagtgg tacttcgagctcatcatcgaccaggtggaccccttcctaacggcagagcccacacacctg cgggtgggctgggcctcttcctcaggctatgctccataccccggaggcggagaaggatgg ggaggcaacggtgttggggatgacctgtattcctatggctttgatggacttcacctttgg tcaggacgcattcccagagccgtggcctccatcaaccagcacctcctgaagtcagatgat gtggtgagctgttgcctggaccttggcgtgcccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaatttcaacacagatgggctcttcttccctgtggtgagc ttttcagcgggtgtcaaagtacgtttcctgatgggtgggcgtcacggagaatttaagttt ctgcctccctccggttatgccccttgctatgaagccttacttccaaaggaaaagatgaga ttggagcctgtcaaagaatataagcgtgacaccgaaggcatcagagatctcctgggaacc acccagttcctctcccaagcctccttcatcccaggccccatagacaccagccaggtggtt ttatcacctcacctagagaagatccgagacagactggctgaaaatatccacgagctttgg ggaatgaacaaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgcctggtggagttttcaaagcttcccgaaaccgagaagaattataaccta caaatgtcaactgaaaccttaaaaacgctcctagccttggggtgccacattgctcatgtg aatccagctgctgaagaggacctcaagaaggtcaaactgtccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctattacctcctcaggaa attttagtggataagcttgcagaaaatgcacataatgtctgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggacgtgaagaacaaaagaaatccccgtctggtg ccatatgcattactggatgagcgtaccaagaagtcaaacagggacagccttcgagaagct gttcggacgtttgttggttatggctataacatcgagccatccgaccaagaactagctgac cctgctgtggagaaagtcagcatagacaagatccggtttttccgggtagagcggtcttat gcagtgagatctggaaagtggtattttgagtttgaggtggtgactggaggagacatgcgt gttggctgggccaggccaggctgtcggcctgatgtggagctgggggccgatgaccaagcc tttgtgtttgaaggcagtaagggccagcgctggcatcaagggagtgggtatttcggacgg acctggcagccaggagacgtggtcggatgtatgatcaacctggatgatgcttcgatggtc ttcacactgaatggggagctgctgatcaccaacaaaggctcggaacttgccttcgcagac tacgagatcgagaatggctttgtgcccatctgctccctgggactgtctcagatcggccga atgaacctcgggatggatgccagtaccttcaagttttataccatgtgtggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagatgttgcgatgtggttcagcaagcgc ctcccgacattcgtcaacgtgccaaaggatcatccacatatagaggttgtgaggattgac agcaccatggacagccccccgtgcctcaaggtgacacacaagacgtttggcacccagaat agcaatgccagcatgatctactgccgcctgagcatgcccgtggagtgccagtcctccttc agccgcagcccctgtctggacggtgatgctttccagaaaaggaagcagatgcaagaaata ctctctcaaacaacaacacagtgctactatgcaatccgcatctttgccggacaggacccc tcctgcgtctgggttggatgggtaactccggactatcacttatacagtgaaaagtttgac ctgaataaaaactgtacagtgactgttactctgggggatgaaagaggccgggtccatgaa agtgtaaagcgcagcaactgctacatggtctggggtggagacatcgtggctacttcccaa cgatcgagtcgcagcaacgtggacctggagatcggctgcctcgtggatctggcaatgggc atgttgtccttctcagccaatgggagagaacttggcacctgttaccaggtggagcccaac accaaagtgtttccagcagtcttcctgcagcccacaagcacttctctgtttcagtttgaa ctgggaaagctgaagaatgcaatgcccttgtcagcagccatatttaagagtgaagagaag aacccagtccctcagtgtccgcctcggctggacgtgcaaaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagaccgagcgggtgagcgagcgccacggc tgggtggtgcagtgcttggagcccctgcagatgatggcgctccacatcccggaggagaac aggtgtgtggatatcctggagctctgtgagcaggaggacctgctgcagttccattaccac acgctgagactctacagcgcggtgtgtgccctgggaaacagccgagtagcctatgccctg tgcagccatgtggacctctcccagctcttctacgccattgacaacaagtacctccctggc ctgcttcggtctggtttctatgacctgctcatcagcatccacttggccaatgctaaggag agaaagctgatgatgaagaatgaatacatcatccccatcaccagcaccaccaggaaaatc cgcctgtacccagatggatcgaagaggcatgggctgcctggggtgggcttgagaacttgc ctcaagccgggcttccagttctccaccccttgctttgtcatgaccggtgaggagcaccag aagcagagccccgagattcccttagagattctgaagacgaaggcgctgagcatgctgaga gaggctgtggcgtgcagtggggctcacatccgagaccctgttgggggctctgtggagttc cagtttgtgcctgtgctgaagctcattggaaccctgctggttatgggggtgtttgatgat gatgacgttcggcagattctcctcctgattgatccgtctgtgtttggggagcagagtggg gagagagaagagggagcagagaaggaggaagtgagtcaggtggaggagaaggcagtggag gctggggaaaaggccagcaaggaggctccagtcagaggcttgttacagacccgactaccg gagtccgtcaagctgcagatgtgtgagctcctcagctatttctgtgactgtgagctgcag caccgagtggaagccattgtggcctttggtgacatctatgtctccaagctccaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcagccctgactgct cggaagaccaaggagttccgctcgcctccacaggagcagatcaacatgctccttaacttt caactgggagagaactgcccctgcccagacgagatccgggaagagctgtacgacttccac gaggaccttctctcacactgtggggtccccctggaggaagaggaggaggaagaggaggtc acctcctgggcgggcaaactctgtgccttggtgcagaaaatccaaggccttcccaagcca gaaacggagcagccggcggtggaggagcagaagtgccctaccacactgaaggaactcatc tcacagaccatgatccgctgggcccaggaggaccacattcaggatgcagacctcgtccgg atgatgttcaacctcctccggaggcagtatgacagcatcggggagctgctgcaagccctg aggaagacctacagcatcagccaggcctccgtgggcgacaccatcaacctgctggctgcc ctgggccagatccgctgcctcctcagcgtcaggatgggcaaggaagaggagctgctcatg atcaatgggctgggagacataatgaacaacaaggtgttttaccagcaccccaacctcatg cgcgtcctcggcatgcacgagacagtgatggaggtgatggtgaacgtgctgggtgcagag aagtcccagattgcttttccaaagatggtcgctagctgttgccgcttcctctgctatttc tgtcgaattagccggcagaatcagaaggccatgtttgagcatctaagttacctgctggag aatagcagtgttggcctagcctccccatcgatgaggggatccactccgctggatgtggca gcttcctcagtgatggataacaatgaattagccctgggcttagaggaaccagacctcgag aaggtggtgacttacttggcaggctgtggcctgcagagctgccccatgcttctggccaaa ggataccctgacgtcggctggaaccccatcgaaggggagcgctacctgtccttcctgagg tttgccgtctttgtgaacggtgaaagtgtagaagaaaatgctagtgtcgtggtcaagctt ctcatcagacgcccagagtgcttcggcccagccctgcggggtgaaggggggaacggcctg ttggctgccatgcagggcgccattaggatctcagagaacccagccctcgacctcccctct cagggatacaagcgagaagtcacagaggacagtgaagacgaagaagagatcgttcacatg ggcaacgcaattatgtcattttattcagctcttatagatctgctgggccgctgtgctcct gaaatgcaccttatccagacaggaaaaggcgaagccatccggatcaggtcaatcctacgc tccctggtccccaccgaggacttggttgggataatcagcatccccttgaaactgccctcc ctgaacaaagacgggtctgtcagtgagccggacgtggccgcccacttctgcccagaccac aaggcgcccatggtactgttcttggaccgcgtttacggcatcaaggaccagacgttcctg ctccacttgctggaggtcggttttttacctgacttaagaacctccgcctctctagataca gtttccctgagcaccacggaggctgccctggcgctgaatcggtacatatgttctgccgtg ctcccactcctcacaagatgcgcccctctctttgctggaacagaacactccacgtctttg atcgattccacactccagacaatatataggctttccaagggacgttccctcaccaaagct cagagagacaccatagaagaatgtttgcttgctatctgcaatcacctgaggccttccatg ctgcagcagctcctgcggcgtctcgtgtttgacgtgccccagctcaacgagcactgcaaa atgcccctgaagcttctgacgaaccactatgaacagtgctggaagtactactgcctgccg tccgggtgggggggctgcggcctcgccgtggaggaagagctgcacctgaccgagaagctc ttctggggcaccttcgactccctgtcccacaagaagtatgacccagaccttttccgaatg gccctgccttgtctcagtgccattgccggggccttgccaccagattacttagacaccagg atctcggccacgctggagaaacagctctcagtggatgcagacggcaacttcgaccccaag cctatcagcaccgtgaatttctccttgcctgaaaaattggagtacatcgtcaccaagtat gcggagcactcacacgacaaatgggcctgtgaaaagagtcagaatggatggaaatatgga atttccctggacgaaaatgtgaagacccatcccctgataaggcctttcaagacgttaacg gagaaggagaaggaaatttatcgctggccagccagagagtccctgaaaaccatgctggct gtgggctggactgtggagaggaccaaagaaggagaagccctcgttcaacaacgggaaaat gagaagcttcgaagcacgtcccaggccagccagggcaacagctacagcccggcccctccg gacttctccaacgtggcgctctccagagagctccagggaatggtggaggtcatagctgag aactatcacaacatctgggccaagaagaagaaggtggagctggagagcaaaggtggtggc agtcaccctcttttggtaccatatgacaccctgaccgccaaggaaaagtttagggaccga gagaaggcacaggacctgtttaaattcctccaagtgaatggcatcgtggtttctagaggc gtgaaggacacggagctggatgcctcctccatggaaaagaggtttgcctataaatttttg aagaagatcctgaaatacgttgattctgctcaagagttcattgcccacttggaagccctt gtcagcagcgggaaaactgaaaggtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccgctggtcgaccagtacttcaccaaccaccgcctctacttcctgtcgtcc cctctgaagcccctgggcagcggcgggtgcgcctcccacaaggagaaggagatggtggcc agcctgttctgcaaacttgctgctcttgttcggcacaggatttccctcttcgggagcgat tctactacaatggtgaactgccttcacatcttagctcagacgctggacacgaggaccgtc atgaagtcgggctcagagctggtgaaggccgggttacgagccttcttcgaaaacgcagcg gaagacttagagaagacttcggagaacctgaagctcgggaagtttacgcactccagaacg cagattaaaggcgtctctcagaacattaactacaccacggtggcgctgctccccatcctg acgtccatctttgagcacgtggcgcagcatcagtttggggtggatttactcttgggtgac gtgcagatttcatgctaccacatactgtgcagtctctactccctcgggacgggaaggaac atctatgttgaaagacaacgtcctgcccttggagaatgtctggcttccctggcagctgcc atcccagtggcgttcctggagcccacccttaaccgctacaacccactctcggtcttcaac accaaaacccccagggagagatctattctggggctgccggacacagtggaagcgatgtgt cctgacatcccccagctggaaggcctcatgaaagaaatcaacggcctggccgagtcgggg gcccggtacacagagatgccccacgtcatcgaggtgatcctgcccatgctctgcaactac ctgtcctactggtgggagcaggggcctgagcacctgccccccgggacagggccctggtgc acccgcatcacctcggaacacctcagcgtcatcctgggcaacatcctgaaaatcatcaac aacaacctgggcatcgacgaggcctcctggatgaagcgcattgcagtgtacgcccagcca atcatcagcaaagccaggcccgacctgctgagaagtcacttcatcccaactctggagaag ctgaagaagaaggctgtcaagaccgtgcaggaggaggagcagctgaaggccgacagcaaa ggggacacccaggaggcggagctcctcatcctggatgagttcgcagtgctctgcagagac ctctacgccttctaccccatgctgatccgctacgtggacaacaacagatctaactggctc aaaagccccgatgctgattctgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgcaaatctaacaacttcaagagggaagagcaaaattttgtgattcagaatgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggagggcag gaccaggaacggaagaagaccaagcggaggggagacttgtattccgtccagacctccctc atcgtggctgcgctcaagaagatgctgcccattggcttgaacatgtgcaccccaggagat caggagctgatctccctcgcaaagtcacggtacagctttagagacacagacgaagaagtg aaggaacacctgcggaacaacctgcacttgcaggaaaagtctgatgacccagctgtaaag tggcaactgaacctctacaaggatgttttgaagagtgaagaaccttccaatccagaaaag acagtggagcgtgtgcaaagaatttcagcagctgtcttccacctggagcaggtggagcag cctttgaggtccaagaaggcagtctggcacaaactgttgtctaagcagcggaaacgggcc gtggtggcctgtttcaggatggcccctctctacaacctgcccaggcaccgctctattaac ctcttcctccatggctatcagagattttggatagaaacagaggagtgttcctttgaagag agactagtacaggatttggctcagtctcccaaggcggaggagcaggaggaggaggagacg gaaaggcatccagacccacttcaccagatcattctccattttagccgcaatgccctcacg gagaggagcaaactggaagatgaccctttgtacacctcctattccagcatgatggccaag agttgtcgggatggggagaatgaagaagaagatgaagacaaggaaaaaacatttgaagaa aaagagatggaaaagcagaaaaccctgtaccagcaagctcggctgcacgagcgcggggct gcagagatggtccttcagatgatcagcgccagcaaaggtgagatgagccccatggtggtt gagactctgaagctggggatcgccattctgaatggaggcaacgcaggtgtgcagcagaaa atgttagattacctaaaggagaaaaaggatgctggattctttcagagcctttctggtcta atgcaatcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaaggc ctgggcatggttactgaggaaggaacactcattgttcgagagcgtggtgaaaaagtgctc cagaatgatgagttcacacgagatctctttagattcctacagttactttgtgaaggacat aacagtgactttcagaacttcctgcggactcagatggggaacaccaccaccgtgaacatc atcatcagcaccgtggactaccttctgcgtcttcaggaatcgatcagtgatttctactgg tattattcagggaaggacataattgatgagtctggacagcacaatttttccaaagctctg gtggtcaccaagcagattttcaattcccttacagaatacatccagggcccttgcattggg aaccagcagagcctggctcacagcaggctgtgggacgcggtggtcggcttcctccacgta tttgctaacatgcagatgaaactctcacaggattccagtcagatcgagctgctgaaggaa ctcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtg gtaaatggaactattggcaagcagatggttgacacactggtagagtcatctaccaatgta gaaatgatcttgaaattctttgacatgttcttgaaactgaaagacttaaccagctcagat gccttcaaagaatatgacccagatgggaaagggattatctccaaaaaagaattccagaag gccatggaagggcaaaagcagtacacgccatcagagattgactttctcctttcatgtgca gaagctgatgagaatgacatgtttaattacatcgattttgtagaccggttccatgagccg gccaaggacataggctttaacgtggcagtgctattgacaaatctgtcagagcacatgcca aacgactctcgccttaagtgcctgttggacccagcggaaagtgtgctgaattacttcgaa ccatacctaggacgtattgagattatgggtggggccaagaaaattgagcgtgtttatttt gagatcagtgaatgtagccgaactcaatgggaaaagccccaagtgaaggaatctaagcga cagttcatctttgacgttgtcaatgaaggtggagaacaggaaaagatggagctgtttgta aacttctgtgaggataccatctttgaaatgcagttagcatctcagatctctgaatctgac tcagccgacaggccagaagaggaggaggaagacgaagactcttcttacacgttagaaatc gagggtgaaggggaggatgacacgtcctccgagcctgcctctgcattcgccatggcctgc gcctccgtgaagagaagtgttgccacctttctaaagagggcaaccctgaagaacgtcagg aagcaatacaggaaagtgaaaaagatggctgtgaaggagctggtaaaggtgtttttctct ttcttctggatgttgttcctggggctgttccggttgttcttcgccctattgggaggactc gttcaggtcctctggaacacagtgtttggagggggccttgtagaaggggcaaagaatatc agggtgaccaagatcctgggggacatgcctgacccaacccagtttggtatccatgatgac gccgtggaggctgagagggcagaagtgactgagctgggtatctccactgaactggtacac ttcataaagggggagaagggagatgcggacattatgtcagatctttttggattctactca aagaaagaaggtggcttgaagcatgggcccgaagtgggtttgggtgacctctctgagatt gttggcaaagatgaaccccctacgctagagagtactgtacggaagaaaaggaaagcacag gcggcagagatgagagcagcccatgagccagaaggaaaagtagaatccgagaaagcagac atggaagatggggagaaggaggatcaagccagagaagagcaagccaaggccctatgggca gaagccacaaaaaagaagaagcgacggcatggccagaaagtcgagaagcctgaagccttc atggctaatttcttcaaagggctggaaatctatcagaccaagctgctgcattacctggcc aggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaacttcatc ctgctcttttacaaggtcacggaagaacccctagaggaggagacggaagacgtggccaac ctgtggcgttcttttaacgatgaggaagaggaagaagccatggtgttctttgtcctgcag gagagcaccgggtacatggccccgacgctgcgggccctggccattgcccataccatcatc tctctggtctgtgtggtgggctactactgcctgaaggtccctttggtggtattcaaacga gaaaaagagattgccaggaagctggagtttgatggcctgtatattaccgaacagccatct gaagatgacatcaaagggcaatgggaccgcttggtaatcaacacaccatcttttcctagt aactactgggacaagtttgtgaagagaaaggtgatcaacaagtatggtgacctctacgga gcggagcgcatcgctgaactcctgggtttggacaaaaatgcccttgactttagcccggta gaaaagaccaaagcagaggcggcctctctggtgtcatggctaagctctgtcgacatgaag taccacatctggaagctgggagttgttttcactgacaattcctttctctaccttgcctgg tacacaaccatgtcagtcctgggccactacaacaacttcttcttcgccgctcacctgctg gatatcgccatgggcttcaagaccctgaggactattctatcatctgtgactcataacggc aaacagctggttttgactgtgggtctcctggccgtggtggtttatctctacaccgtggtg gcattcaacttcttccgcaagttctacaacaagagtgaggatgatgatgagcccgacatg aagtgtgatgacatgatgacgtgttacctgttccacatgtacgtgggggtgagagctggc ggaggcattggcgatgaaattgaagaccctgctggtgatccctatgaaatgtaccgcatt gtctttgacattacctttttcttctttgtcattgtcatcttgctggccatcattcaaggt cttattatcgatgcttttggagagctgagagaccagcaggaacaagtgcgagaagatatg gagaccaaatgtttcatctgtgggatcggcaatgactattttgacacgacccctcatggc tttgaaacacatacattacaagagcacaacttagccaactacttgttcttcctgatgtat ttgattaacaaagacgaaacagagcacacgggtcaggagtcctacgtctggaagatgtac caggaaaggtgttgggacttcttccccgctggcgactgctttcggaaacaatatgaagat cagcttggataa

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