KEGG   PATHWAY: shr05010
Entry
shr05010                    Pathway                                
Name
Alzheimer disease - Sarcophilus harrisii (Tasmanian devil)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
shr05010  Alzheimer disease
shr05010

Disease
H00056  Alzheimer disease
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100913194  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100913241  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913330  [KO:K04741] [EC:3.4.22.-]
100913360  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100913375  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100913624  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100913653  [KO:K07375]
100913697  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100913747  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100913767  WNT11; protein Wnt-11 [KO:K01384]
100913862  [KO:K04741] [EC:3.4.22.-]
100913901  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100914143  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
100914229  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
100914278  [KO:K07374]
100914365  WNT9A; protein Wnt-9a [KO:K01064]
100914378  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
100914418  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
100914555  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
100914628  WNT3A; protein Wnt-3a [KO:K00312]
100914667  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
100914858  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
100914963  FZD10; frizzled-10 [KO:K02842]
100915037  SLC39A14; zinc transporter ZIP14 [KO:K14720]
100915095  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100915170  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
100915194  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
100915224  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100915297  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100915381  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100915385  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100915465  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
100915508  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100915617  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
100915675  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100915759  SLC39A10; zinc transporter ZIP10 [KO:K14716]
100915794  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
100915928  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100916028  SLC39A1; zinc transporter ZIP1 [KO:K14709]
100916079  RTN4; reticulon-4 isoform X4 [KO:K20720]
100916183  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100916300  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100916387  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100916485  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
100916627  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
100916636  FZD5; frizzled-5 [KO:K02375]
100916936  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
100916942  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100916996  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
100917145  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100917209  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
100917280  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
100917281  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100917433  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100917439  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100917535  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
100917554  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
100917619  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100917633  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
100917667  [KO:K21421] [EC:1.-.-.-]
100917765  WNT10A; protein Wnt-10a [KO:K01357]
100917883  SLC39A8; zinc transporter ZIP8 [KO:K14714]
100917926  WNT5A; protein Wnt-5a [KO:K00444]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100918116  IRS1; insulin receptor substrate 1 [KO:K16172]
100918120  NCSTN; nicastrin isoform X1 [KO:K06171]
100918219  TUBB; tubulin beta chain isoform X2 [KO:K07375]
100918238  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100918297  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100918306  WNT2; protein Wnt-2 isoform X3 [KO:K00182]
100918332  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100918389  WNT2B; protein Wnt-2b [KO:K00182]
100918408  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100918528  [KO:K02266]
100918532  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X7 [KO:K04958]
100918689  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100918785  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100918876  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100918897  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100918964  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100919089  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
100919162  WNT9B; LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
100919191  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100919227  [KO:K00414]
100919354  [KO:K08957] [EC:2.7.11.1]
100919401  [KO:K03944]
100919476  FZD6; frizzled-6 isoform X1 [KO:K02376]
100919498  FZD4; frizzled-4 [KO:K02354]
100919559  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
100919666  [KO:K03944]
100919671  [KO:K08738]
100919750  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100919788  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100919821  FZD3; frizzled-3 isoform X1 [KO:K02329]
100919883  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100919889  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
100919967  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100919976  RTN3; reticulon-3 isoform X1 [KO:K20723]
100919981  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
100919989  [KO:K02265]
100920008  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100920060  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100920165  [KO:K00411] [EC:7.1.1.8]
100920192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100920214  MAPT; microtubule-associated protein tau isoform X10 [KO:K04380]
100920269  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
100920293  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
100920408  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100920429  CALM2; calmodulin-2 [KO:K02183]
100920478  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
100920479  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
100920490  [KO:K07374]
100920562  [KO:K07374]
100920574  PSMC2; 26S proteasome regulatory subunit 7 isoform X1 [KO:K03061]
100920637  APOE; apolipoprotein E [KO:K04524]
100920745  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100920771  TUBB4B; tubulin beta-4B chain [KO:K07375]
100921025  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100921140  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100921226  SLC39A3; zinc transporter ZIP3 [KO:K14709]
100921265  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100921270  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100921435  [KO:K02270]
100921508  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
100921540  FZD1; frizzled-1 [KO:K02432]
100921543  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100921548  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
100921684  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100921704  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
100921743  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X2 [KO:K06691]
100921875  TNF; tumor necrosis factor [KO:K03156]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100921973  WNT16; protein Wnt-16 [KO:K01558]
100922099  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
100922225  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
100922350  IL1B; interleukin-1 beta [KO:K04519]
100922461  [KO:K02267]
100922500  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100922533  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
100922600  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X3 [KO:K05208]
100922649  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100922691  [KO:K02263]
100922703  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100922728  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
100922757  [KO:K02187] [EC:3.4.22.56]
100922827  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
100922855  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100922864  DKK4; dickkopf-related protein 4 [KO:K02165]
100922938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100922983  [KO:K02270]
100922998  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100923039  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100923048  [KO:K00413]
100923107  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
100923123  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
100923199  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100923223  [KO:K07374]
100923277  SLC39A5; zinc transporter ZIP5 [KO:K14711]
100923300  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
100923381  WNT8A; protein Wnt-8a [KO:K00714]
100923392  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100923425  FZD7; frizzled-7 [KO:K02432]
100923576  AXIN1; axin-1 isoform X1 [KO:K02157]
100923814  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100923940  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100923972  TUBA1C; tubulin alpha-1C chain [KO:K07374]
100924072  KLC2; kinesin light chain 2 [KO:K10407]
100924173  [KO:K08957] [EC:2.7.11.1]
100924260  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100924267  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100924299  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100924322  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
100924347  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
100924415  WNT5B; protein Wnt-5b [KO:K00444]
100924525  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
100924549  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100924620  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100924710  [KO:K02263]
100924826  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100924829  IRS2; insulin receptor substrate 2 [KO:K07187]
100924888  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
100924949  [KO:K00134] [EC:1.2.1.12]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100925046  CALML4; calmodulin-like protein 4 [KO:K02183]
100925120  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100925183  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
100925362  WNT7B; protein Wnt-7b [KO:K00572]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925510  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100925706  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100925732  FADD; FAS-associated death domain protein [KO:K02373]
100925760  [KO:K06704] [EC:3.4.24.81]
100925826  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
100925883  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
100925884  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
100925931  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100926003  SLC39A9; zinc transporter ZIP9 isoform X2 [KO:K14715]
100926110  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100926225  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100926323  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100926409  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100926450  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
100926503  [KO:K04850]
100926601  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100926701  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
100926756  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100926795  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100927096  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
100927154  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
100927182  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100927191  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
100927252  [KO:K07827]
100927317  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100927339  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100927376  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
100927554  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100927621  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100927651  SLC39A6; zinc transporter ZIP6 isoform X1 [KO:K14712]
100927789  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100927801  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100927813  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100927917  PSMD6; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100927923  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
100928059  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100928083  [KO:K02270]
100928428  NDUFV2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100928430  [KO:K14710]
100928480  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100928719  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
100928744  [KO:K02264]
100928777  [KO:K00417]
100928800  NDUFC2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100928932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100928986  NRAS; GTPase NRas [KO:K07828]
100929004  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100929007  DKK1; dickkopf-related protein 1 [KO:K02165]
100929015  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100929017  CALM1; calmodulin-1 isoform X2 [KO:K02183]
100929070  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
100929168  [KO:K02833]
100929199  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
100929204  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100929426  [KO:K07827]
100929474  [KO:K00134] [EC:1.2.1.12]
100929676  BID; BH3-interacting domain death agonist [KO:K04726]
100929714  TUBB4A; tubulin beta-4A chain [KO:K07375]
100929783  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100929856  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100929945  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100930145  ATP5F1E; LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100930249  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100930278  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
100930357  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100930382  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
100930387  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
100930400  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100930539  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100930633  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100930636  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100930775  [KO:K02270]
100930815  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100930899  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
100930913  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100930936  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
100930993  [KO:K03096]
100931111  [KO:K00420]
100931119  WNT7A; protein Wnt-7a [KO:K00572]
100931153  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
100931338  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100931354  IRS4; insulin receptor substrate 4 [KO:K07187]
100931426  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
100931480  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100931481  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100931492  [KO:K00134] [EC:1.2.1.12]
100931580  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100931721  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100931761  BECN1; beclin-1 isoform X1 [KO:K08334]
100931777  ATG101; autophagy-related protein 101 [KO:K19730]
100931806  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
100931867  KIF5A; kinesin heavy chain isoform X3 [KO:K10396]
100931914  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
100931931  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
100931932  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100932104  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
100932119  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100932185  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
100932408  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100932473  RELA; transcription factor p65 [KO:K04735]
100932522  [KO:K07374]
100932536  FZD2; frizzled-2 [KO:K02235]
100932575  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100932600  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
100932609  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100932636  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100932664  [KO:K02271]
100932679  TUBB6; tubulin beta-6 chain [KO:K07375]
100932736  TUBB3; tubulin beta-3 chain [KO:K07375]
100932786  [KO:K07374]
100932979  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
100933088  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100933113  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100933361  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
100933375  [KO:K00419]
100933709  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100933723  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X2 [KO:K03030]
100933740  AXIN2; axin-2 isoform X1 [KO:K04385]
100933743  AGER; advanced glycosylation end product-specific receptor isoform X2 [KO:K19722]
100933750  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100933792  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100933826  WNT6; protein Wnt-6 [KO:K00445]
100933846  [KO:K00416]
100933884  [KO:K02272]
100934049  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100934059  [KO:K07375]
100934149  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100934267  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
100934269  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
100934290  WNT8B; protein Wnt-8b [KO:K00714]
100934311  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100934376  DKK2; dickkopf-related protein 2 isoform X2 [KO:K02165]
100934419  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100934448  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
100934493  [KO:K02268]
100934509  NOX4; NADPH oxidase 4 isoform X3 [KO:K21423] [EC:1.6.3.-]
100934645  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100934721  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100934749  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100934778  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100934809  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100934825  [KO:K00418]
100935134  CALM3; calmodulin-3 isoform X1 [KO:K02183]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100935307  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100935369  [KO:K00415]
100935398  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105749059  [KO:K03069]
105749132  IL1A; interleukin-1 alpha [KO:K04383]
105749219  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105749478  [KO:K00134] [EC:1.2.1.12]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105750215  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105750699  [KO:K02183]
105750762  IL6; interleukin-6 [KO:K05405]
105750812  [KO:K07374]
105751130  [KO:K08957] [EC:2.7.11.1]
111719270  [KO:K02266]
111719323  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
111720153  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
111721152  FZD8; frizzled-8 [KO:K02375]
111721251  [KO:K08738]
111721451  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
116419081  [KO:K02183]
116419101  [KO:K00134] [EC:1.2.1.12]
116419640  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
116419913  HRAS; GTPase HRas [KO:K02833]
116420693  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
116420883  [KO:K07374]
116422319  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
116423459  [KO:K02183]
116423460  [KO:K02183]
13826434  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
13826435  COX2; cytochrome c oxidase subunit II [KO:K02261]
13826436  COX3; cytochrome c oxidase subunit III [KO:K02262]
13826437  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
13826438  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
13826439  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
13826440  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
13826441  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
13826442  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
13826443  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
13826444  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
13826445  CYTB; cytochrome b [KO:K00412]
13826446  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
shr00190  Oxidative phosphorylation
shr03050  Proteasome
shr04020  Calcium signaling pathway
shr04140  Autophagy - animal
shr04141  Protein processing in endoplasmic reticulum
shr04210  Apoptosis
shr04310  Wnt signaling pathway
shr04910  Insulin signaling pathway
shr04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

DBGET integrated database retrieval system