Scomber japonicus (chub mackerel): 128374953 Help Entry 128374953         CDS       T09718                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism sjo  Scomber japonicus (chub mackerel) Pathway sjo04020   Calcium signaling pathway sjo04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sjo00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128374953    04020 Calcium signaling pathway     128374953  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sjo04040]     128374953 Ion channels [BR:sjo04040]  Voltage-gated cation channels   Ryanodine receptor    128374953 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  128374953 NCBI-ProteinID:  XP_053191148 LinkDB All DBs Position 16:complement(18740832..18839595) Genome browser AA seq 4899 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKSGQNSEGTRGPDRWRLIRKAAQSGGHKTLLYGHAIL LRHTFSSMYLACLKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDD LILVSVSSERYLHLSISNGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGH DEVVTLPGSDQSEEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLT TGHYLALTEDKGLVLQDQERSDTIATAFCFRASKEKLEQSPKRDIEGMGVAEIKYGDSLC FVMHVATGLWLSYQAPDVKSARLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRN TTLLFKRFIRDLDCLGVKNRALVSLPVEEVLQTLNDLITYFQVPDAELEHEERQIKLRSL KNRQNLFKQEGMLILVSNCIDRLNVYNSVAHFGECAGPEAGAAWKDILNLLYELLAALIR GNRNNCTQFSNNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLY KHGRNHKILDVLCSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLG VSEGSAQYKKWYYELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDL YSYGFDGLHLWSGRIPRAVASLNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENF NTDGLFFPVVSFSAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKR DVEGVRDLLGTTQFMSQASFIPTPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGW SYGKRIRDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRVVHVNPNAEDSL KKIKLPKNYMMSNGYKPTPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQ QDLKSKRNPRLVPYALLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQEGGQVVERLSID KVRFFRVERTYAVKAGKWYFEFDAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYRGH CLNMGSRLFGRCWHAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIP VCSLGLSQVGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNRELTMWFSKRLPTFVNVPK DHNHIAVTRIDGTIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSFFKSSPVVDMN GVHEEESLKVKHRYPLRSVRHSDESRRVDYSSITMYYHSVRVFAGQDPAGVWVGWVTPDY HYYSNNFNLSKNRSVTVTLGDERGRVHESLKRSNCYMVWGGDVTNAAHGSSRSNVDLEIG CLIDLATGLVTFTANGREMSTSYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNAMPLSS AIFKSEHKNPVPQCPPRLYVQTINAVLWSRMPNIFLKVETARVNDRHGWVVQCVEPLQML AVHIPEENRCVDIMELSEQEDMRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYT IDNQYLSGMLREGFYNVLISIHLETAKEARLMMKDEFIIPVTAETRSIRLFFDASKKHLP PGVGLSTSLKPRLNFTPPCFISIKREHLFSPQIPLDALKEKSISMLTEAVQGGGHHIRDP VGGGVEYQFVPILKLISTLLTMGVLCSEDVHKILLLIDPNVFRETREEGITGPTDKEGLT GTEEKAVEAGEEEAAKEAKQPIKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSF SDSFVSKLQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLTFSMGEDCPCP TDIQGELYDFHNQLQLHCGIPMEEDEDEQDTSIKGRLLNLVNKITGQPHKTEEPTEKEQE APSNLKELISQTMVSWAQECHIQDSELVRKMFSLLRRQYDSIGELLRAMRKTYTISAVSV QDTINLLASLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVME VMVNVLGGDKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPA MRGSTPLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPI EGERYLSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKI SETPALDLPGSVQGVSSDVSADGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKG KGEALRIRAILRSLVPTEDLVGIISIPLKMPITNKDGSVTEPDMSASFCPDHKAPMVLFL DRVYGIEDQSFLLHLLEVGFLSDLRAANSLDTEGLCTTETALAMNRYIGSAMLPLLTRCA PLFAGTEHYATLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLSVCKHLRPSMLQQLLRRL VFDVPLLTDYCKMPLRLLTNHYEQNWKYYCLPSGWGSYGTASEDELLLTKKIFWGVFDSL SQRKYDPELFKMAMPCLSAIAGALPPDYVDASISTTVEKPVSIDAQGNFDPKPINTANIA LPEKLEHFANKYAEHSHEKWSAEKVLLGWKYGDCVDEKAKIHPQLRTYKALTEKEKEIYR WPIRESLKSMLAMGWCIDRTKDGESMSQQRENEKMRKISQVSQANGFNPSPIDTSNVVLS RELQGMVEVLAENYHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDLFR FLQINGYSITRGLKDLEQDSSSMEKRFAYKFLKKLLKYVDSAQEFIAHLESMAASGKTDR SPHEQEIKFFAKVLLPLIDQYFKNHSLYFLSSPNKNLSSSGYASNKEKEMVTSLFCKLAA LVRHRISLFGSDSTTMVSCLHILAHTLDTRTVMKSGSELVRVGLRTFFENAAEDLEKTFE NLKLGKFTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRI LTSLYALGTGKNIYVERQLPALGQCLATLAGAVPVAFLEPLLNTYNPCSVYNTKNARERA ILGISDSVEQMCPGMPRLDGLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERG PENQPTSGGSICCTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARA DLLKSHFLPTLEKLKKKTVKVVAEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPM LIRYVDNNRSRWLKEPDADSNDLFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLT GDSKTKMAKSFKEKSGGQDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQE LISLAKTRYLLRDTDDEVKDHIRQNLHLREKSEDPAVRWQLNLYKDIVMRSEGPPDPERV VDRIQRISAAVFNLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINL FLLAYQRIWIETEEYSFEEKLVQDLAKTQPKVEDEEEEEVRKQPDPLHQLILHFSHNALT ECSSLEEDPLYIAYADMMAKSCADGEEEEEDEEGKEKTFEEKEMEKQKMLYQQARLHDRG AAEMVLQMISASKGRLDAIVTFTLKLGISILNGGNILVQQKMLDYLKEKRDVGFFKSLSG LMMSCSVLDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTTDLFRFLQLLCEG HNNDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIIDEAGQRDFSKA LAVAKQVFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLK ELLDLQKDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTS DSFKEYDPESKGVISKKDFQKSMENQKQYSQSEIEFLLSCTEADENDMFNYEQFVERFHE PAKDIGFNVAVLLTNLSEHMPNDARLSTFLDLAESVLSYFEPYLGRIEIMGGAKRIERVY FEISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEP DPVERPEEDEDDKQSVVENQEEEEEESVMLESSSAFTIACISMRKSLGHFRQLLTLKSMR RQYRKFRKMSIREMVRGFFSFFWMIITGLFHFVYSLIWGFFHILWTTMFGGGLVEGAKNM KVTDILGNMPDPTQFGIHGDVLETEKMEANEASALSEMGQMAQGDAAEADLMAELLNIQP KKEGKHGTEPGLGDVSEVVVGDAPSIASAVRQKKAQLAAKKKASNGDYKSDSEKGDSDDG EKKDHDKAKDDNPPEPSVEEKRAPKKRTGQKKEPPEAFMASFFAGLEIYQTKMLNYLARN FYNLRFLALFVAFAINFILLFYKVTGDYSDDEDPWNGRGRAGEEEEEGALEYFVLQESTG YMAPTLRCLAILHTIISFLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDI KGQWDRLVINTPSFPNNYWDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETV IKEASLVSWLSSIDTKYHIWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAM GFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDD MMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIID AFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINK DETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14700 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggagaaggagaggatgaaatccagttcctcagaactgatgatgaagtg gtcctccagtgcgtggcctgcatccagaaggagaatcgcaagttctgcctggctgctgag gggctgggcaacaggctgtgttacctggagcccacatctgaagcaaagtatgttcctcca gacctgtgcatctgtaactttgtgttggagcagtctctgtcagtacgggccctgcaggag atgctggctaagagcggacagaacagtgaagggacacgcggcccggaccgatggaggctc ataaggaaggcagcgcagagtggcggacacaagactcttctgtacggacacgctatcctc ctgcggcataccttcagctccatgtacctggcctgtttgaagacatcaaggtcacagaca gataagctgtcctttgatgttggcctgcaggaggattcaacaggtgaggcttgttggtgg acgatccaccctgcctccaagcagagatcggaaggagagaaggtgcgcatcggtgatgac ctcatccttgtcagcgtgtcctctgagcgataccttcatttatccatctccaatggcaac atccaggtggacgcctcctttatgcagacactatggaatgtccatcccatctgctctggt agcaacatagaggaaggctacctgttaggtggccatgtgatgaggctgttccacggacat gatgaagtagtgaccctcccaggatcagaccaaagtgaggagcagcagaggatagtcaac tatgagacgggtaaagctggtgccaaggccaggtccttgtggaggttggagccactccga atcagttggagtgggagccacatccgctggggtcagcccttcagactgcggcacctgacc actggtcactaccttgccctgactgaggacaaggggttggtgctgcaggaccaggagagg tccgacaccatcgccaccgccttctgcttcagagcttctaaggagaagctggagcagagc cccaagcgggacatcgagggcatgggggtggcagaaattaaatatggggactcactctgt ttcgtcatgcacgtggccacgggactctggctctcctaccaggcacctgatgtcaaatct gcccgtctgggtcccctcaagagacgagcatgcctacattctgaaggtcacatggatgac gggttgaccctgcagcgctgtcaacacgaggagtcccgagcggcacgcatcatccgcaac accacgctactctttaaacgattcatcagagacctggattgtttgggtgttaagaatagg gcactggtctccctgcccgtcgaggaggtgctccaaaccctcaatgacctcatcacctat ttccaggtccctgacgctgagctggagcacgaagagaggcagatcaagctacggtcactc aagaataggcagaatctattcaaacaggaaggcatgctgattctggtgtctaactgcatt gaccgtctgaacgtgtacaacagtgtggcccattttggggagtgtgctgggccagaggca ggagcagcttggaaagacattctcaatctgctgtatgagttgctggcggccttaattaga ggaaacaggaacaactgcacccagttctccaacaacttggactggctggttagcaagctg gagagactggagtcttcttcaggcatcctggaggttctacactgcattctaattgagagc cccgaggccctcaacatcatccagagaggacacatcaagtccatcatatcactactctac aagcacgggcgaaatcacaagattctggatgtgctctgctcgctatgtgtgtgtaacggc gtagctgtgcgaaccaatcagaaccttatctgtgatcatttgctgcccaagagagatctg ctgctgcaaacccagctggtcaatgatgtccaaagtatgagaccaaacatcttcctcggg gtgagcgagggctcagctcagtataagaagtggtactatgagctgatgattgaccaggtg gaccactttgtgaccagtgagccctcccacctgagagtgggctgggccaacactaaaggc tatgctccgtaccctgggggtggagagggctgggggggtaatggcgttggagatgatctc tattcctatggttttgatggacttcacctctggtcaggtcgtatcccacgggcggttgcg tctcttaaccagcacattctgacctcagaggatgtggtgagctgttgtctggacctggga gctcccagcatctctttcagaattaacggacagcccgttcagggcatgtttgaaaatttc aacacagacgggctcttcttccctgtcgtcagcttctctgcaggggtcaaggtacgattc ctgttgggtggtcgacatggcgactttaaatttctgcctccttcaagttatgctccatgt tacgaggctctgctgccgaaagagaagatgaaggtggagccagtgaaagagtacaagaga gatgtggaaggagtccgagatttgctgggaaccactcagttcatgtcacaggcctctttc attcccacacctgtggaaaccagccagattgttatgccgcctcatttggaaaaggttcgg gacaagctggctgaaaacatccatgagctgtggggcatgaataagattgagctgggctgg tcgtatggcaagaggataagggatgataataagcggcagcatccatgcctggtggatttc tccaagctgccagaaactgaaaagaactacaatctgcagatgtcaacagaaactctaaag accctgttggcattgggctgccgtgttgttcacgtcaatccaaatgcagaggactccctc aaaaagataaaactcccaaagaactacatgatgtccaatggttataagccgacccctttg gacctctctgacataaaactgaccccgggtcaggagctgctggtagacaaacttgcagag aatgcgcacaatgtgtgggccaaggaccgtatcaaacaggggtggacctacggcatacag caggatctaaagagtaagcgcaaccctcgcctggttccctatgctctgctagatgagcgc accaagaagtcaaatcgggatagcctacgggaagctatccgcaccctgataggctatgga tacaatattgagccttcagaccaggaaggcggacaagtagttgagcggctcagcattgac aaagtccgcttcttcagagtagagaggacatatgcggtgaaggccgggaagtggtacttt gaatttgacgctgtaacgggaggagacatgagagtgggctgggcgaggcctggatgtaag ccagatgtggagcttggcacagatgagctggcttttgtctttgatggatacaggggccac tgtctgaacatgggcagccgtttgttcgggcggtgctggcatgctggggacgtggtgggc tgtatgatcaacatggaggacaagtctatgatcttcacacttaatggagagatactcatt accaccaagggctctgaactttgtttcactgactttgaaactgaggatgggttcattcca gtgtgtagccttggcctgtcacaagtgggtcgtatgaacctggggaaagatgctagcacc ttcaagtactacacaatgtgtggccttcaggaaggatttgaaccctttgctgtcaacatg aaccgtgagctcaccatgtggttcagcaagcgtctgcctacctttgtcaatgtgccgaag gaccacaaccacatcgcagtcaccagaattgacggcactatcgacagccccccctgtctt aaagtcacccacaagacatttggcacccagaacagcaacgctgacatggtgttttgtcgt ctcagcatgcccgtggagtttcactccttcttcaagtctagtcctgttgtagacatgaat ggagtgcatgaagaagagtctcttaaagtcaaacacagatatccattaagatctgtgagg catagtgatgaaagcagacgagtggactacagcagcatcactatgtactaccactctgta agggtcttcgctggccaggaccctgctggtgtgtgggttggctgggttactccagactac cattactatagcaacaactttaacctcagcaagaacagatcagtgactgtaaccctgggt gacgagcgaggacgggtccacgagagcctgaagaggagtaactgctacatggtgtggggt ggcgatgtgaccaacgctgctcatggctcgagtcgcagcaatgtggacctggagattggc tgtctgatagacctggctactggcttagtgactttcactgccaatggcagagagatgtca acatcctatcaggtggaaccaaacaccaagctcttccctgctgtatttgtgcgacccacc agccctaacctcttccagttcgaactagctaaaataaagaatgccatgcctctgtcatca gccatctttaagagtgaacataagaacccagtcccccagtgtccaccccgtctatatgtc cagaccatcaacgcagtgctgtggagccgcatgcccaacatcttcctcaaggtggaaacg gcaagggtcaatgatagacacggttgggtggtccagtgtgtggagcccctgcagatgttg gctgtacacatacctgaggagaacaggtgtgtcgacatcatggagctatctgagcaggag gacatgaggaagttccactaccacaccttgaagctctactgtgcactgtgtgctctaggc aacacccgtgtggctcacgccctctgcagccacctagaccaatcacagctcttatacacc atcgacaaccagtacctgtctggcatgttacgcgagggcttctacaatgtcctgatcagc atccacctggagacagccaaagaagcacgactcatgatgaaagatgagttcatcatcccg gtcacagctgagacacgctccatccgcctcttttttgatgcctccaaaaagcacctcccg ccaggggtggggcttagcacctcgctcaaaccccgcctcaactttactccaccctgtttc atcagcatcaaacgggaacatttgtttagtccccaaatcccactggatgcattgaaggag aaatcaatttcaatgttgacagaggctgttcaaggtggtgggcaccatatccgtgatccc gtaggaggtggtgtagagtaccagtttgtgccaattttgaagctcattagcaccctgctg actatgggtgtgctatgtagtgaggatgtacataagatcttactgctcattgatccaaat gtgttcagagagacacgtgaggaaggaattacaggtcccacagacaaggaaggactaaca ggaacagaggagaaggctgtggaagcaggagaagaggaggcagctaaagaggctaaacag ccaataaaaggacttctggagaagaggctgcctgagcctgtcaaacgacagatgtgcgaa ctgcttcactatttctgcgattgcgagctgaagcatcgcatcgaggccattgtgtcattt tctgacagctttgtctccaagctgcagtacaaccagaagttccgctacaacgagctaatg ctggccctcaatatgtctgcagctgtcactgcgaagaagaccaaagagttccgctcgcct cctcaagaacagatcaacatgctgctgaccttcagtatgggtgaggactgtccatgtcca acagacatccagggggaactctatgattttcacaaccagctgcagctccactgtggaatc cctatggaggaagatgaagacgagcaagatacatctattaaaggtcgcctcctcaatctg gtgaacaagatcacaggacagcctcataaaacagaggaacccacggagaaggagcaagag gcaccatccaatctgaaggagttgatttcccagaccatggtcagctgggcccaggagtgt cacatccaggactcagagctggtccgtaagatgttcagcctgctgaggaggcagtacgac agcattggagagctcctccgtgccatgaggaagacttacaccatcagtgctgtctcggtc caggacaccatcaaccttttagcctctcttggtcagattagatcactgctgtctgttcgt atggggaaagaggaggaaaagcttatgattgatggattgggtgacatcatgaacaacaag gtgttctaccagcaccccaacctaatgagaatactgggcatgcatgagactgtaatggag gtcatggtcaatgttctcggaggagacaaatcccaggaaattgccttccccaagatggtt gccagctgttgtcgcttcctgtgctacttctgccggatcagccgccagaaccagaaagcc atgttcgaccatcttagctacctgctagagaatagcagcgtgggtctcgcttcaccagct atgaggggctccactcctctggatgtggctgcttcctctgtgatggacaacaacggcctg gctctggcactggaagaacctgatctggataaggtggtcacctacctggcaggttgtggt ctccagagttgtccgatgcttctggctaaaggctatccggacattggctggaaccccatt gagggagagcgttacctctctttcttgcggtttgcagtcttcgtcaatggtgagagcgtg gaggagaactcaagtgttgtggtaaaattgctcatccgtcgtccagagtgtttcggaccc gcccttaggggagagggagggaacggcctgctggctgccatgaaggaagccatcaagatc tctgagacacctgctttagacctgccaggctccgtccagggagttagctctgacgtgtct gctgatggtgacgatgaggaggaggttgttcatatgggcaatgccatcatgtctttctac tctgccctcattgacctgttgggacgttgtgctcctgagatgcacctcatcaacaaaggg aaaggtgaagctctacgtattcgtgccattttacgctctctagtgcctactgaggacctc gtgggaattattagcataccactcaaaatgcccatcaccaacaaagatggttcagtgaca gagccggacatgtcagccagcttttgtccagaccacaaggctcctatggtgctgtttctg gacagggtgtacggtattgaggaccagagctttctgcttcacctgctcgaagtgggcttc ctctctgacctgagggctgcaaactccttggatacggagggtctgtgtactaccgagaca gcgctggctatgaaccgctacattggatctgccatgcttcccctcctcacccgctgcgcc cctctcttcgctggcacagagcactatgccacccttatcgactccactctgcacaccatc taccgcctttccaagggccgttcactcaccaaggctcagagagacgccatagaggaatgc ctgctgtctgtctgcaagcaccttcgtccctctatgctgcagcagctcctgcgccgcctc gtctttgatgtgcccttgcttacagattactgcaagatgcctctcaggctgctaacaaac cactatgaacagaactggaagtactactgcctcccatcgggctggggaagctacggtact gcatctgaggatgaactactgctcaccaagaagatcttctggggcgtgtttgattctctg tcccagaggaaatatgacccagagctattcaagatggccatgccttgcctcagtgccata gctggagctttgccacctgactatgtggatgcctccattagtactactgtggagaagcct gtttctatagacgctcagggcaactttgaccccaaacccatcaatacagctaacattgcc cttccagagaagcttgagcactttgccaacaaatatgcagagcattcccatgagaaatgg tcggcagagaaggtgctgctggggtggaaatatggagactgtgtggatgaaaaggccaag attcaccctcagctcaggacctacaaagctctgacagagaaggagaaggagatttacaga tggccaattagggagtccctaaagagtatgctggcaatgggatggtgcatcgacaggacc aaggatggagagagcatgtctcaacagagggaaaatgagaaaatgcgaaagatctctcag gtctctcaggcaaatggatttaatccaagcccgattgacacaagcaacgttgttctgtcc agagaattacaggggatggtggaggtgctggctgagaattaccataacatctgggccaag aagaaaaagagtgaccttggaagcagaggtggaggaacacaccctctgctggtgccctac gacacgctgacagccaaggagaaggcccgtgatcgagagaaggcgcaggaccttttccgc tttctgcaaatcaatggatacagcatcacaagaggtctgaaggacttagagcaggattca tcttccatggagaaaaggtttgcctataagttcctcaagaagctgctgaagtatgttgac tcagcccaggagttcatcgcccacttggagtccatggctgccagtggaaaaacagatagg tcacctcatgaacaggaaatcaagttttttgccaaagttcttctccccctcatcgaccag tacttcaagaaccactctctctactttctctcctcacccaataagaacctgagcagcagc ggttatgcctccaacaaggagaaggagatggtcaccagcctgttttgtaaactggcagct cttgtcagacataggatttcactctttgggagtgactccaccaccatggtgagctgtctt cacatcctggcgcacaccctggacaccaggacagtgatgaagtcgggctcagagctggtg agggtgggcctgaggacattctttgagaacgctgcagaggacctggagaagacttttgag aacctgaagctggggaagttcactcactctcgctcacagatgaaaggggtgtcgcaaaat atcaactacaccactgtcgctttgctccccatcctaaccgctctgtttgagcacatcact cagcaccattttggagtcgacctgcttttggatgatgtccaagtgtcctgctatcgaatc ctgaccagtctgtatgcgctgggcactgggaaaaacatctatgtagaaagacagctgcca gctctcggtcagtgtttggccaccctggctggggcagtgcctgttgctttcctggagcca ctgctcaacacttacaacccctgctctgtctacaataccaagaatgcacgtgaacgagcc atcctcggcatttcagactcagttgaacagatgtgtcctgggatgccgcgtttggacggt ctgatgaaagacatcaatgacatggctgagtctggagcacggtacacagagatgcctcat gtgatcgaggtagtactgcccatgctttgtaactatctatcctattggtgggagagggga cctgagaaccagccaactagcgggggcagcatctgctgcaccaccgtcacctcggagcac ctcagtctcattcttggcaacatcctcaagatcctcaataacaacctgggcattgatgag gcctcctggatgaagaggattgcagtgtatgtgcaacccataatcagcaaggcccgtgcg gacctgcttaagagccacttcctacctacactggagaagctgaagaagaagacggtaaag gttgtggctgaggaggagctgttaaaggcagacagtaaaggagacacgcaggaggccgag ctgctcatcctggacgagtttgctgtcctctgcagggacctgtacgccttttaccctatg ctcatccgctacgttgataacaacaggtccaggtggctgaaagaaccggatgctgactcc aatgacctcttcagaatggttgctgaaatctttattctctggtgcaagtcacataatttc aaaagagaagagcagaactttgtggtccagaatgaaatcaacaacctttccttcctgact ggagatagtaagactaagatggctaagtcctttaaggaaaagtctggtggacaagaccag gagaggaagcacaaaaaaaggcgtggcgagttctactctatccaaacctctctgattgtg gctgctctgaagaagatgttaccaattggcctaaacatgtgtaccccaggggaccaagaa ctcatctccctggccaagactcgctacctcctgagagacacagatgacgaggtcaaagac catattcggcagaatctacaccttcgagaaaagtcagaggaccctgctgtgaggtggcag ctaaatctttacaaagacatagtgatgaggagtgagggccctccagaccctgagagggtg gtggaccggatccagaggatctctgctgctgtcttcaacctggagcaggtggagcagcca ctgagatccaagaaatgtgtatggcagaagttgctgtccaagcagaggaagcgagcggtc gtggcctgcttccgcatggctccactttataatctgccaaggcatcgctctattaacctc ttcctcctggcctatcagagaatatggatagaaacagaggagtactcttttgaggagaag ctagtgcaggaccttgcaaaaacacagcccaaagtggaggatgaggaagaagaggaggtc agaaagcagccagaccctcttcaccagctcattctgcatttcagccacaatgctctgacc gagtgcagttctttggaggaggatcctttgtatattgcatatgcagatatgatggcaaag agttgtgcagatggtgaagaagaggaagaagatgaggaaggaaaagagaaaacatttgag gaaaaggagatggagaaacaaaagatgttgtaccagcaggcaagactgcatgaccgaggg gctgcagagatggtgctccagatgatcagtgccagcaaaggtcgacttgatgctatcgtg actttcaccctcaaacttggcatttctattctcaacgggggaaacatactggtccagcag aaaatgctggactacctgaaggaaaaaagagacgttggctttttcaaaagtttatctgga ctgatgatgtcttgcagtgtcctggacttgaatgcttttgagaggcaaaacaaagcagag ggtctggggatggttactgaggaaggatcaatcaacgtgagtgagcggggttccaaggta ctgcagaatgatgagttcactacagatctctttaggtttctgcagcttctctgtgagggt cacaacaatgattttcagaacttcctaaggactcagacagggaacacaactacagtcaac attatcattagtactgtagattacctactaagactccaggaatccattagtgatttttat tggtactactctggtaaggatattattgatgaagctggtcagagggacttctccaaagca ctggcagtggctaagcaggtgttcaactctttaactgagtatatacagggtccatgtatt ggaaaccaacagagtctggctcacagcaggctgtgggatgcagtggtgggcttcctccat gtttttgcaaacatgcagatgaagttatcccaggactccagtcagattgaattattgaag gagctgctggacctgcagaaggacatgatcgtcatgatgctgtctcttctcgaaggtaat gttgtcaacggtaccattggaaaacaaatggtggacaccttggtggaatcttccagcaat gtggagatgatcctaaagttcttcgacatgttcctgaagttgaaggacttgaccacctcg gacagcttcaaggaatacgaccctgagagcaaaggtgtaatctcaaagaaggatttccag aagtccatggagaaccagaagcagtattcccaatctgagattgagtttcttctctcttgt actgaggctgatgaaaatgacatgttcaactacgagcagtttgtggagagatttcatgaa cctgccaaggacattggctttaatgtagctgttttactaaccaatctctcagagcacatg cctaatgatgctcgcctctcaacattccttgacctggctgagagtgttcttagctacttt gagccttatttgggtcgcattgagatcatgggtggagccaagcgcatcgagagagtttac tttgagattagtgagtcgagtcgtacccagtgggaaaagcctcaggtcaaggaatccaag cggcagtttatctttgatgtggtcaacgaaggtggggagagcgagaagatggaactgttt gtcaacttctgtgaggacaccatctttgagatgcaattagcttctcaaatttcagagccg gacccagtggagcgtccagaggaagacgaagatgacaaacagagtgtggtggagaaccag gaggaagaagaggaagagagtgtgatgttggagtcatcatcagccttcacaattgcctgc atctccatgagaaagagcctcggccactttcgccagctgctcactctcaagagcatgagg cggcagtacagaaaattcaggaagatgagcataagggagatggtacgaggcttcttctct ttcttctggatgatcataacgggcctcttccactttgtctacagcctcatttggggtttc ttccacatcttgtggaccactatgtttgggggtggcctcgttgaaggtgccaagaacatg aaggtaacagacattttgggaaacatgccagatcccactcagtttggaatacatggagat gtgttagagacggagaagatggaggcaaatgaagcatcagctttgtcggagatggggcag atggctcaaggggatgcagcagaagcagacttgatggctgagttgctcaacatacagcct aaaaaggagggaaagcacgggactgagccgggtctgggggatgtgtcagaggtagtagtg ggggatgctccatccatagccagtgctgtcaggcagaagaaggcacagttggctgcaaag aagaaggcttcaaatggagactacaagtctgattcagagaaaggagattcagatgatggt gagaagaaggaccatgacaaggccaaagatgataaccctccggagccttcagtggaggag aagagagccccaaagaagaggactgggcagaagaaagaaccaccagaggccttcatggcc agcttcttcgctggcttggaaatctatcagaccaagatgctgaactacctggcgagaaac ttctacaacctccgattcttggcactttttgttgcctttgctatcaactttattcttctc ttctacaaagtgacaggtgattactcagacgatgaagacccttggaatggtcgaggaaga gctggggaggaggaggaggaaggtgccctagagtatttcgtcttgcaggagagcacaggt tacatggcgccaacgcttcgctgcctggcaatactccacactatcatatctttcctgtgt gtagtgggatactactacctgaaggtgcctctggtagtgttcaagcgggagaaggagata gcaagaaaactggagtttgcagggctctacatcacagagcagccatctgatgatgatatc aaaggacagtgggacagactggttattaacacgccttcttttcctaacaactactgggat aaatttgtcaaacgcaaagtgatcaaaaagtacggagatctgtatggagcggagagaata gcagagctgctggggttggataaaagtgctctggatttcaaccctacagaggaaactgtc atcaaggaggcctcactggtgtcatggttgagctcaatcgatacaaagtaccatatctgg aaaatgggggtggtgtttacagacaattcattcctgtatctagtatggtacaccaccatg tccattctgggccactacaacaacttcttttttgccgcccatctgctggacatcgccatg ggcttcaagaccctccgcaccatcctgtcctctgttacacataatggcaaacagctggtg ttgacggtcggcctgctggcagttgtggtctatctctacacggtggtggccttcaacttt ttcaggaagttctacaacaagagtgaggatgaggatgagccagacatgaagtgtgatgac atgatgacttgttacctgttccacatgtacgttggagtgagagcaggaggaggcattggg gatgagattgaggatccagccggtgatccctatgagctctaccgtatcctttttgacatc accttcttcttcttcgtcatcgtcatcctcctggccatcattcagggtttgatcattgat gcctttggagagctgagagaccagcaggaacaagtcaaagaggacatggagaccaagtgt ttcatttgtgggatcggtaatgactacttcgacacaacacctcacggctttgagactcac accttacaagagcacaatttggccaattacctgttcttcctgatgtaccttatcaacaag gacgagaccgagcacactggccaggagtcatatgtgtggaagatgtaccaggagcgctgc tgggatttcttcccagctggagactgcttccgcaaacagtacgaagatcagcttggatag

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