Scomber japonicus (chub mackerel): 128376867 Help Entry 128376867         CDS       T09718                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism sjo  Scomber japonicus (chub mackerel) Pathway sjo04020   Calcium signaling pathway sjo04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sjo00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128376867 (ryr3)    04020 Calcium signaling pathway     128376867 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sjo04040]     128376867 (ryr3) Ion channels [BR:sjo04040]  Voltage-gated cation channels   Ryanodine receptor    128376867 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  128376867 NCBI-ProteinID:  XP_053192696 LinkDB All DBs Position 17:complement(22814933..22917225) Genome browser AA seq 4953 aa AA seqDB search MEAKEPPILSQCGDDEVVLQSVAVIQKEHRKFCLGVEGLGNRVCYLEPTSEAKYVPPDLC VCNFVLEQSLSVRALQEMLANTGQNNEGSADHEKWRLIKKAGQGGGHRTLLYGHAILLRH SFSSMYLTCLKTSRSLTDKLSFDVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDLIL VSVSTERYLHLSISNGNIQVDASFMQTLWNVQPTCSSGNMAVGFLIGGHVMRLCHGHDES LTIPGAEKSGEEQRIVNYEAGKGASKARSLWRLEPLRISWSGSHIRWGQAFRLRHLSTGH YLALAEDRGLVLQDRDKSDTSATAFCFRPSKEKGDMGPKRDIEGMGVPEIKYGDSVCFVM HMATGLWLSYLAPDAKSSRLGPLKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTF LFANFIKDLDSISEGESSAVAGYVEEVVQTLNDLIEYFKQPDSELEHEEKQCLLRSLIKR QDLFKDEGMLTLVSKFIDRMNLYNSSAHFGEMAGEEAGAAWKDILNLLYELLASLIRGNR NNCTQFSRNLDWLVSKLERLESSSGILEVLHCILVESPEALNIIQRGHIKSIISLLYKHG RNHKILDVLCSLCVCNGVAVRANQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGVAE GSAQYKKWYFELVIDQVDHFVNGEPTHLRVGWANAKGYAPYPGGGEGWGGNGAGDDLYSY SYDGLHLWSGRIPRAVASINQHLLNSEDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTD GFFFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKEYKRDHD GVRDLLGTTHFLSQASFIPTPVDTSQIVLPPHLDNVRDKLAENIHELWGMNKIELGWTFG KVRDDNKRQHPCLVDFTKLPETERNYNVQMSSETLKTLLALGCHVAQVNVHAEDDLKKIK LPKDYMMSNGYKPAPLDLSDVKLTAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLK NRRNPRLVPYALLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEAIHVVDDKSVETIRF FRVEQTYAVKTGKWYFEFEALSGGDMRVGWARPGCRPDVELGTDNQAFVFDGYRGRRMHA GTRYFGHPWKKGDVVGCMIDMEDKSMIFTLNGELLITNKGSELCFTDFEAEDGFIPVCSL GLSQIGRMNLGKDASTFKYYTMCGLQEGFEPFGVNMNREITMWFSKRLPTFVKIPEDHLH IEVTRIDGTVDGPPCLKVTHKTFGTQNSNSDMVYCRLSMPVEFYSADMLLDESLKLSHPP REDGTIDYGSITTYYHSVRVFAGQDPASVWVGWVTPDYHYHCKNFRLGKMRTVTVTLGDE RGRVHESVQRGNCYMVCGADAVSPSSSSRSNSDLEIGCLIDLATGFVSFTANGKELPTSY QVEPNTKLFPAVFVRPTSSNLFQFEFVKIKDAMPLSSAIFKSEQRNPVPQCPLRLDVQTI MAVLWSRMPNTFLNVETARVSERHGWVVQCLEPLQIMAVHIPEENRCLDILELSELESLR KFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYDVLISIHL ETAKEARLMMNNEFIIPVTEETCSIKLFSDESKQHSLPGVGLSTSLKPRVNFSPVGIIST KRPQYLYSPQIPLVILKEKAISMLTEAVQGGGVHIRDPVGGKVEYQFVPILKLIGTLLIM GVLTSDEVRLILLLIDPNVFGDNKEKEAKGDEGSVSGEKEEVSKNEEKAVEAGEEETKES KPPVKGLLEKSLPESVKRQMCELLHYFCDCELKHRIEAIAAFADNFVSKLQFNQKYRYNE LMQALNMSAAVTAKKTKEFRSPPQEQINILLNFSTGDDCPCPEDIQDELVGFHEELRLHC GIPVEEEEEEQDTSIKGRLLSLVYKIKGPPQKAEVDPTEQEQAAPTNLKELISQTITTWA QESHIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVMDAINLLASLGQIRSLL SVRMGTEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFP KMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDN NGLALALEEPDLEKVVTYLAGCGLQSCAMLLAKGYPDLGWNPIEGERYLSFLRFAVFCNG ESVEENANVVVKLLIRRPECFGPALRGEGGQGLLAGMKGAIKISEDPALDLPKPSAVVNS GSSEEEGEIMHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTKDL VGIISIPLKMPVVNKDGSVTEPDMAACFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGF LPDLRASASLDTEVMSTTETALAMNRYIGSALLPLLTRCAALFANTEHYAQLIDSTLQTI YRLSKGRSLTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPMLTEYCKIALRLLTH HYEQNWKYYCLPSGMGSFGIASEEEIILTKKLFWGIFDSLSHKKYDSELFKMANSCLCAI AGALPPDFVDASLGGGATLEKQTSVDAQGNFDPKPINTANISLPEKLDYIANKYAEHSHD KWSSEKVSVGWKHGDNVDEHAKTHPLLKPYKALSEKERETYRWPVKESLKSMLAMGWNIE RTKEGEAIFQQRESDKQRKISESQVNGFSPTPMDLHNVTLSRELQGMVEVVAENYHNIWA KKKKTELISKGGGTHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAITRGLKDMEQD SSSMEKRFSYKFLKRLLKYVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLTD QTLRNHFLYFLSTPSKNLSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSC LHILTHSLDTRTVMKSGAELVKAGVRTFFENAAEDLEKLLEMLKLGKFVSRAQMKSVSQS INYVTVALLPILTALFEHIATYGFAVDLLLDDVQLSCYRILTCLYSLGTGKNIFVERHLP AFGESLATLVAAMPVAFLEPHLNAHNPLSVFNTKSPREQAILSMPDTVEEMCPEMPRLDR LLKDVNDVSESGARYSDMPQVIEVILPMLCNYLSYWWEKGPENSPPGTECCTMVTSEHLS IILGNILKILNSNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTLDKLKKKTVKVV SEEELLKADSKIDNQEAELLILDEFAVLCRDLYSFYPMLIRYVDNNRSRWLKGPNADSTE LFRMVADIFILWCKSHNFKREEQNFVVQNEINNLGFLTGEGKTKMSKSGGDQERKHKRRR GEYYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVMEHLRQNLHL QEKSDDPAVQWQLNLYKDVVVKSEEPENPEHTVVRVQSISAAVFHLEQVELPLRNKKCVW QKLLSKQRKRAVVACFRMAPLYNLPRHRAINFFIPAYERLWIEAEEYSFEEKLVQDLAVS TGLALPSPLVPCVGTPLPVLSAECFFSSAPVEPWERARVGTSPKAPRGPRSRRTKPFKQR SVRGQRLHDQLRRHRASSGARSSRKAGYAFLTAVKTPMKIVEEEVEEEAEIQPDPLHQLI LHFSHNALTERSHLEEDPLYIAYADMMAKSCAEDDEEEEEEEGKEKTFEEKEMEKQKILY QQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGISILNGGNVQVQQKMLKYLKEKRD GGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSIHTQRGSKVLQNDEFTKDLFR FLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDET GRLNFSKALDVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQD ASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMVDTLMESSSNVEMILKFFDMFL KLKDLTTSDNFKEYDPECKGMISKKEFQKSMESQKQYTQSEIEFLLSCAETDENDMFNYK EFVERFHEPAKDIGFNVAVLLTNLSEHMPRDSRLTTFLDLAESVLSYFEPYLGRIEIMGS AKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMQ LASQISEPDEAEQPEEDEEEEGYNILEELAAEEESALESASAFTTACRSIKKKISHVRQI VSLKTIRKKLKKVRKLSIKEIITGFFSFFWMLFTGFFKKIYSFIFGFFHLIWSSMFGGGL VEGAKNIKVTDILGNMPDPTQFGIHGDVIEGEKMEAIETAGNVDITMAPPTDIGEVDMMM EMLTGPKRDTGKHVEPGLGDVSELTAETSTTEQKKTVAAKPVESPESEPEKADTENQEKE DKPKEEEAKEPVAEEKPKSRSSQSKEESPAFMSSIFAILDVFLNKMLNYLARNFYNLRFL ALFVCFAINFILLFYKVTGEGDEDGDDENGWGEEEEDQDTFFDMDEFVLHESTGYMLPTL RFLAIFHTVISLVCLVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDR LVINTPSFPNNYWDKFIKRKVINKYGDLYGAERIAELLGLDKSALDFDPTVETEEREASL LSWLSSIDTKYHIWKMGVVLTDNYFLYLIWYSIMSVFGHFNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYL FHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELR DQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLMYLINKDETEHT GQESFVWKMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14862 nt NT seq  +upstreamnt  +downstreamnt atggaagcaaaagagccaccaattctgagccaatgtggggacgatgaagtggtgcttcag agtgtggccgtcatccagaaggagcatcgcaagttctgtctgggtgttgagggactcgga aaccgtgtttgttacctggaacccacatctgaagctaagtatgttcctccagacctgtgt gtttgtaactttgtgttggagcagtccctgtcagtacgggccctgcaggagatgttggct aacactgggcaaaacaacgaagggagcgctgaccatgaaaaatggaggttgattaaaaag gcgggtcaggggggaggacaccggaccctgctgtacggccatgccatcctcctacgccac tctttcagtagcatgtacttgacctgtttgaagacatcaaggtctctgacagacaagctg tcatttgatgtcggactacaagaagactcaataggcgaggcctgttggtggaccatccac cctgcgtcaaagcagagatcggaaggagagaaagtccgcatcggagacgacctgattctt gtcagcgtgtcaacggagagatacctgcacctctccatctccaatggcaacatccaggtg gatgcatccttcatgcagaccctgtggaatgtacagcctacctgctcatcaggcaacatg gctgtagggtttttgattggtggtcacgtgatgcgtctttgtcacggccatgatgagagc ttgaccatccctggagcagaaaagagcggggaggagcagaggatagtcaactatgaggcg ggtaagggagcgtcaaaagcccgctcactgtggagactggagcctctcaggatcagctgg agcggtagccacattcgttggggccaggccttccgactacgccacctctctactggccat tacctggccctggctgaagaccgtggactggtcctgcaggacagggacaagtctgacaca tcagccactgccttctgcttcaggccttccaaggaaaaaggagacatgggcccaaagagg gacatcgaaggtatgggggtgccagagatcaagtatggagactccgtctgtttcgtcatg catatggcgacaggactgtggctgtcttacctagcgcctgatgccaaatcatctcgtcta ggacctctgaagagaagggcctgcctgcattctgaaggccacatggatgacgggctgatc ctccaacgctgtcagcacgaggagtcccgtgccgcccgcatcatccgcaacaccacgttt ctatttgccaacttcatcaaggatttggacagcatatcagagggggagtcctcggctgtg gctgggtatgttgaagaggtggtgcagacattaaacgacctgattgaatatttcaagcag cccgactcagaactggagcatgaggagaaacagtgcctcctccgttcactcatcaaacgt caagatctcttcaaagatgagggcatgctcaccctcgtgtcaaaattcattgaccggatg aacctgtacaacagctctgcccacttcggagagatggctggggaggaggcgggcgctgcg tggaaggatatactcaacctcctctatgaactcttggcctcactgattcgtggaaacagg aacaactgcacccaattttctcgaaacctggattggttggtcagcaaactggaaagactg gaatcttcatcaggaatcctggaagttctccactgtatcttggttgaaagcccagaggct ctgaacatcatccagagagggcacattaagtccatcatctctctgctctataagcatgga cgcaaccataagattctggatgtcctgtgttccctctgtgtttgtaacggggtggcggtg agagccaatcagaatctgatctgtgacaacctgcttcccaaaagggacctgctgcttcag actcgactggtcaatgatgttcagagtatgaggccgaacatcttcctgggcgtggctgaa ggatcagctcagtataaaaagtggtattttgagctggtgatagaccaggtggaccacttt gtaaacggggagccgacccacctgagggtaggctgggccaacgctaaaggctacgctccg taccctggaggaggagaaggatggggaggcaatggtgccggggatgacttgtactcctac agctatgatggacttcacctctggtcaggccgaatccccagggccgtggcctccattaac cagcacctgctgaactcagaggatgtggtcagctgctgtctggatttgggcgctcccagc atgtccttcaggatcaacggtcagcccgtccagggcatgtttgaggacttcaacaccgat gggttcttcttccctgttgtcagcttctctgcgggtgtcaaggttcgcttcctgttgggc ggacgccacggagatttcaagttcctgccgcctgctggttactctccgtgctacgaggcg ctgttgcctaaagagaagatgcacgtggagcctgtgaaggagtacaagagggaccacgat ggggtccgtgacctgctcggaaccacccacttcctctctcaggcctccttcatccctact cctgttgacaccagccagattgttctaccccctcacctggacaacgtccgggacaagctg gcagaaaacatccacgaactgtgggggatgaacaagatcgaactgggctggaccttcggc aaggttcgcgatgacaacaagaggcagcacccttgcctcgtggatttcaccaagttgccc gaaaccgaaaggaactacaacgtacagatgtctagtgaaacacttaaaaccctgctggca cttggctgccatgttgctcaggtcaatgttcatgctgaggacgacctgaagaaaatcaaa cttcccaaagactacatgatgtctaatgggtataagcctgcgccactggacctttctgat gtgaaactgacagcaggtcaggaggttctagttgataaattggccgagaacgcacacaat gtgtgggccaaagacagaattaaacaaggatggacctatggcatccaacaggatttgaag aataggcgtaatcctcgtttagtgccatatgctttattggatgagcgcacaaagaaatct aatagagacagtctgagagaggccatcaggacaatggttggatatggatatgacatcgac cccccagaccaggaggccatccatgtggtggatgataagagcgttgagaccatccgcttc ttccgcgtggagcagacatatgctgtgaagacgggaaaatggtactttgagtttgaggcc ctgagcggaggcgatatgagggttggctgggccagacctggctgcaggcccgatgtggaa ctgggaacagacaaccaggccttcgtctttgatggatacaggggtcgacgtatgcatgca gggacccgctactttggacatccatggaaaaagggcgatgtggtcggttgcatgatcgat atggaggacaaatcaatgattttcactttaaacggagagctcctgatcaccaacaagggc tcagagctttgcttcacagacttcgaggcagaggacggtttcatccctgtgtgtagcctg ggcctgtctcagattggacgcatgaacctgggcaaggacgccagcacttttaagtactac accatgtgtggtctccaggaaggcttcgagcccttcggtgtaaacatgaaccgagagatc accatgtggttcagcaagcgcctgcccacttttgtcaaaatacccgaggaccacctgcat attgaggtgacaaggatcgatggaacggtagacggtcctccctgcctcaaggtcacccac aagacatttggcacccagaacagcaacagcgacatggtctactgtagactgagcatgcct gtggagttctactctgcggacatgctactagatgagtcgttgaaactcagccatcctcca agagaagacggaactatcgactacggaagcatcacaacttactaccactcggtgagagtg ttcgctggacaggatcctgcatctgtgtgggtgggctgggtcacacctgactatcattac cattgcaagaacttcagactcggcaagatgcggacggtcacagtcaccctgggagatgag aggggccgggtccatgagagtgtccagaggggtaactgctacatggtgtgtggagcagac gccgtcagcccgtcttcctctagccgctccaactctgacctggagatcggctgtctgatc gacctggccactggcttcgtctccttcactgccaacggcaaggagctgcccacaagttat caggtggagccaaataccaagctgttccccgcagtgtttgtacgccccaccagttcaaac ctcttccagtttgaatttgtcaagatcaaggatgccatgccgctctcctctgctatattt aaaagcgagcagaggaacccggtgccgcagtgccctctgcgactggacgtgcagaccatc atggccgtgctttggagccggatgccgaacaccttcctcaacgtggagacagctcgagtc agcgagaggcacggctgggtggtccaatgtctggaaccgctgcagataatggccgtgcac atacctgaggagaacaggtgtttggacatcctggagttatctgagcttgaaagcctgagg aagttccattaccacactttgaagctatactgtgccctgtgcgccctgggaaacacccgc gtagctcacgccctctgcagccatttggaccaatcacagctgctctacaccatcgacaac cagtacctttctggcatgttgagggagggcttctacgatgtccttatcagcatccatctt gagacagctaaggaggctcgcctaatgatgaacaacgagttcatcatccccgtgacagaa gagacatgctccatcaagctgttctccgatgagtccaagcagcattctttgcctggcgtc ggtctgagcacctccctgaaacctcgggtcaacttctcccccgtcggcatcatcagcacc aagcgtccgcagtacctctacagcccccagatcccattggtcatcctgaaggagaaagcc atcagcatgctcacagaggccgtgcagggcggaggcgtccacatccgagacccggtgggc ggaaaagtggagtaccagttcgtccccattctcaaactgatcggaacgctgttaatcatg ggggtcctaaccagcgatgaggtgagattgatcctcctcctgattgaccccaacgtgttc ggtgacaacaaagagaaggaggcgaagggggacgaagggtctgtgtccggggagaaggag gaggtgagcaagaacgaggagaaagccgtggaggccggagaggaggagacgaaggagagt aaaccacccgttaaaggtctgctggagaagtcattgcccgagtccgtcaaacgccagatg tgcgagctgctgcactacttctgcgactgcgagctgaagcaccgcatcgaggccatcgcc gccttcgccgacaactttgtgtccaagctgcagtttaaccagaagtaccgctacaacgag ctcatgcaggcgctcaacatgtctgccgccgtcaccgccaagaagaccaaagagtttcgt tcccccccgcaggagcagatcaacatcctgttgaatttcagtacaggggacgactgcccc tgtcccgaggacatccaagatgaacttgtcggcttccacgaagaattgcgactgcactgt ggaattccagtggaagaggaagaagaagagcaggacacttcaataaaaggacgtcttctg tctttggtgtataagatcaagggcccaccccagaaggcggaggtggaccccacagagcag gaacaggctgctcccactaacctgaaggagctgatctctcagactataactacctgggcc caggagtctcacatccaggacccagagctggtcagagtgatgttcagcctgctgaggagg cagtacgacggcatcggggagctgcttcgggctatgaaaaagtcctacaccatcagtgcc gcatccgtgatggatgctattaacctgctggcgtctctgggtcagatcaggtccctgctg tcagtgcgtatgggcacggaagaggagaaactcatgattgatggacttggtgacatcatg aacaacaaggttttctaccagcatcccaacctgatgagagtgctgggcatgcacgagact gtaatggaggtcatggtcaacgtgctgggaggagacaaatcacaggagatcgccttcccc aaaatggtggcgagctgctgtcgtttcttgtgctacttctgtcgtattagccgccagaac cagaaggccatgtttgaccacctgagctacctgctggaaaacagcagcgttgggcttgcc tctgaagccatgcgaggctccactcccctggatgtcgctgcatcttcagtgatggataac aacggcctggccctggccctggaggagcctgatctggagaaggtggtgacatacctggca ggttgtggtcttcagagttgtgccatgctgcttgccaagggttacccagacctgggctgg aaccccatagagggagagcgttatctgtccttcttgaggttcgctgtcttctgcaacggt gagagcgtggaggaaaatgctaacgtggtggtgaagctgctgatcaggcgtccagagtgt ttcggccccgccctgaggggagagggaggccagggtctcctggccggcatgaagggggcc atcaagatctctgaggatccagctctggacctgcccaaaccctctgctgttgtcaattct gggtccagtgaggaggagggagaaattatgcacatgggcaatgccatcatgtccttctac tcagcccttattgatctgctgggacgctgtgctcctgagatgcatcttatcaatgcaggt aaaggcgaggcgctgcggatccgagccatcctgcgttctctggttcccactaaggacctg gttggcatcatcagcatccccctcaaaatgcctgtggttaataaagatggctcagtgaca gaacccgacatggcagcctgtttctgtccggaccacaaggcccccatggtgctcttcctg gacagagtgtatggcatcgaggaccagagttttctgctccagatgttggaggttggcttt ttgcctgacctccgagcttctgcatctttggacacagaggtgatgagcaccactgagacg gcgttggccatgaacaggtacatcggctcagccctgctgcctctgctgacccgctgcgcc gctctctttgccaacacggagcactacgcacagctgatcgactccacgctgcaaaccatc taccggctgtctaaaggacgctccctcaccaaagcccaaagggacgccatcgaggagtgt ctgctggctatctgcaagcatctacgtccctccatgatgcagcagctgctcagaagactg gtgttcgatgttcccatgctcaccgaatactgcaaaatagctctgaggctgctgacccac cactatgagcagaactggaagtactactgcttgccgtctggtatgggcagctttggcata gcgtctgaagaagagatcatcctcaccaagaaactcttctggggaatctttgactccctt tctcataagaagtatgattctgaacttttcaaaatggccaactcatgcctgtgtgccatc gctggagccctgcctcctgactttgtggatgccagtttagggggtggtgccacgctggag aaacagacatcagtggatgcacagggaaactttgaccccaaacccataaacactgccaac atctcccttcctgaaaaacttgattacattgccaacaaatatgcagagcattcccatgac aagtggtcctcagagaaggtgtcagtaggctggaaacatggagacaatgtggatgagcac gccaaaacccatccactgctgaagccttataaagctctgagtgagaaggagagagaaaca taccgatggccagtgaaggagtcactgaagagcatgctggctatgggctggaacattgag aggaccaaggagggagaagccatcttccaacaacgagagagcgacaaacaacgaaagatc tcagagtctcaggttaacggattcagtcctactccgatggacctgcacaatgtcactttg tcgagagagttacagggcatggtggaggtggttgcagaaaattaccacaacatctgggcc aagaagaaaaaaactgaactcattagcaaaggaggagggacccacccactgctggttccc tatgacaccctgacagctaaagagaaatacagagacagagagaaggcccaggagctcttc aagttcctgcaaatcagcggctatgccatcacaagaggtctgaaggacatggagcaggac tcatcatccatggagaagcgtttttcctacaagtttctcaagaggctgctgaaatatgtc gactctgcgcaggagtttatcgcgcacctcgaggctatggccaccagtggaaagacagac aaatcacctcatgaccaggaaatcaagttctttgcaaaggtgttactcccactgaccgat caaacccttaggaaccactttctctacttcctgtccacgcccagcaagaacctgagcagc tgtggctgtgcttccaacaaagagaaggagatggtcaccagcctgttctgtaagctggca gctcttgtcagacacaggatttctctctttggaagtgactcggcaatgatggtgagctgt ctgcacatcctcactcactccctcgacacaaggacagtgatgaagtctggcgcagagctg gtcaaagccggggttcgcactttctttgagaatgctgcagaggacctggagaagctgctg gagatgctcaaactggggaagttcgtgtcgcgtgcacagatgaagagcgtcagtcagagc atcaactacgttaccgtggcgctgctgcccatcctcaccgccttgttcgaacacatcgca acatacgggttcgcagtagacctgctgttggatgatgtgcagctgtcctgctaccggatc ctgacctgtttatactctttgggaacaggaaagaatatctttgtggagaggcatctgcca gcatttggggagagccttgccaccctggtagcagccatgcccgtagcgttcctggagcct catctaaacgcccacaacccgctttctgtcttcaacactaagagcccccgagagcaggcc atcctcagcatgccggacacagtggaggagatgtgtccagagatgcctcgtctcgacagg ctgctgaaagacgtcaatgatgtctcggagtctggagcgcgctacagtgacatgccacag gtgattgaggtgatccttcccatgctgtgcaattatctgtcctactggtgggagaaaggc ccggagaactcgcctccaggtactgagtgctgcaccatggtgacctctgaacacctcagc atcatcctgggaaacatactcaagatcctcaacagcaacctgggcattgatgacgccccc tggatgaagaggattgcagtctactctcaaccaatcatctgcaaagctggagcagacctg ctgagaacccacttcctgcccacactggacaaactaaagaagaagactgttaaggttgtg tctgaagaggagctgctgaaggccgacagtaaaattgacaaccaggaggcggagctgctc attctggatgagttcgctgtgctctgcagagacctctactctttctaccccatgctcatc cgatacgtggataacaacaggtctaggtggctgaaagggcccaatgcagactccactgag ctcttcagaatggtggctgacatcttcatcctctggtgcaagtcacataactttaagcgt gaggagcaaaactttgtggttcagaatgagatcaacaatttgggcttcctaactggagaa ggcaagacaaagatgtccaagtcaggcggggaccaggagaggaaacacaagcgtcggcgt ggagaatactactccatccagacctctctgatcgttgctgcactaaaaaagatgctgccc atcggtctcaacatgtgcaccccaggtgaccaggagctcatctccctggccaagatacgc tatagtctgaaagacacagatgatgaggtgatggagcacttgcgtcagaatctccatctt caggaaaagtctgatgacccggcagtccagtggcagttgaacctgtacaaagacgtggtg gtgaagagcgaggaaccagaaaacccagaacacacagtggtcagagtccaaagcatctct gctgctgttttccatctggagcaggtggagctgcctctgaggaataagaagtgtgtgtgg cagaagctgctgtccaagcagcgtaaacgtgctgtggtggcttgcttccgcatggctccc ctctacaatctacccaggcatcgcgctatcaacttcttcatcccggcctatgagagacta tggatagaggcagaggagtactcctttgaggagaagctagttcaggatctggcagtaagt actgggctcgccttgccctcgcccctcgtgccctgcgttggcacccctctgccagtcctg tctgccgaatgcttctttagctccgcgcctgtcgagccttgggagcgcgcccgggtgggg acgtcgcccaaagcacccaggggcccccgctctaggcgtacaaaacccttcaaacagaga tccgtcaggggtcagaggctgcatgaccaactcaggagacacagggccagctccggcgct cgcagctctagaaaagcaggctatgcctttctgacagcagtgaaaacccccatgaagatt gtggaggaggaggtagaggaagaggccgagatccagccagatcctcttcaccaactcatc ctccacttcagtcacaacgctctgacagagagaagtcacttggaagaagaccctttgtat attgcatatgcagacatgatggcaaagagctgtgctgaggatgatgaagaagaagaagag gaagaagggaaagagaagacatttgaggaaaaggagatggaaaagcagaagatcctgtat cagcaggcgaggctgcatgcacgtggggctgctgagatggtgctgcagatgattagcgcc agtaaaggtcgtctgggccccatggtgacctgcaccctcaaactgggtatctccatccta aatggaggcaatgtgcaagttcagcagaaaatgcttaagtacctgaaagagaaaagagat ggaggctttttcaagagtctctctggtctgatgcagtcttgcagtgtcttggacttgaat gcatttgagaggcaaaacaaagcagaaggactcggcatggtgacagaagaaggttcaatc cacactcagcggggttctaaggtgctacagaatgatgagtttactaaagatctgttccgg tttttgcaacttctgtgtgaggggcacaatggagatttccagaacttcctgagaacccaa actggaaacacaaccacagtcaacatcattatcagcactgtcgactatctgctccgtctt caggaatctatcagtgacttctactggtactattctggcaaagatgtcattgatgagact ggaagactcaacttctccaaagctttagatgtagccaagcagatattcaactcactgact gagtatattcagggtccgtgtattgggaaccagcagagtctggctcacagcagattgtgg gatgcagttgtgggcttcttgcatgtatttgccaacatgcagatgaagctatctcaggat gccagtcagattgagctgttgaaagagctgatggatttacagaaggacatggttgtcatg ttgttgtctctactagagggtaatgtggtgaatggaacaattggaaagcagatggttgac accctaatggaatcatctagcaatgttgaaatgatcctcaagttcttcgatatgttcctc aagctgaaggacctgaccacctcagacaacttcaaggagtatgatcctgagtgtaagggc atgatctcaaagaaggagttccagaagtccatggagagccagaagcagtacacacagtca gagattgagttcctgctctcttgtgcagagaccgatgagaatgacatgttcaattacaag gagtttgtagagcgattccatgagccagccaaagatatcggcttcaacgtggcagtgctg ctgaccaacttatctgaacacatgccgcgtgactccagacttaccaccttcttagatctg gcagagagcgtgcttagctactttgagccatatctgggacgtattgaaatcatgggtagc gcaaagcgcatagagagggtttactttgagatcagtgaatccagccgggagcagtgggag aagccgcaggtcaaagagtccaagcgtcagttcatctttgatgtggtcaacgagggtggt gagagtgagaagatggaaatgtttgttaatttctgtgaggacaccatctttgagatgcag ctggcttcacagatctctgagccagacgaggctgaacaacctgaggaggacgaagaggag gagggatacaacatcctggaagaattggctgcagaggaagaaagcgccttggagtctgcc tcagccttcaccactgcatgccgctcaatcaagaagaagatcagccatgtccgccaaatt gtttctcttaagactatccgcaagaagctgaagaaagtcaggaaactgagcatcaaagag attatcacaggtttcttctccttcttctggatgctcttcaccggcttctttaagaaaatc tatagcttcatctttggtttcttccacctcatctggtcatccatgtttggcggtggtctt gttgagggagccaagaacataaaagtgacagatatccttggaaacatgcctgatccaacc cagtttggcatccatggagatgtgattgaaggagagaaaatggaggccatagagacagca ggaaacgtagatataaccatggcaccaccaacggacataggagaggtcgacatgatgatg gagatgctgactgggcctaagagggatactggaaaacatgtggagccaggcctgggtgat gtgtctgagctgacagcagagacctcaactacagagcaaaagaagaccgttgctgctaag cctgtcgaaagccctgagagtgaaccagagaaagcagacacagagaaccaggagaaggag gacaagccaaaagaggaagaagctaaggagccagttgccgaggaaaagcccaaatcaaga tccagtcagtccaaagaggagtcacctgccttcatgtcgagtatctttgctattctggat gtctttctgaacaagatgctgaactatctggctcgtaacttctacaatctgcgtttcctg gctctgtttgtgtgttttgccatcaacttcattttactcttctacaaggtcactggtgaa ggtgatgaagacggggatgatgaaaacggctggggtgaggaagaggaagatcaggacaca ttctttgacatggatgagtttgtgcttcacgagagcaccggctacatgttaccaaccctg cgcttcttggctatattccacaccgtcatctccctcgtttgtttggtcgggtactactgt ctcaaggttcctttggtggtgtttaagagagagaaggaaatcgccaggaagcttgaattt gatggtctctacatcactgaacagccgtctgacgatgacatcaagggccaatgggatcga cttgtcatcaacactccatctttccccaacaactattgggacaagttcatcaagcgcaag gtgatcaacaaatatggtgacctgtacggagctgaacgcatcgcagaactgttaggcctg gataaaagcgctctggactttgaccccacagtggagactgaagagagggaagcctctctg ctctcctggctgagctccattgatacaaagtaccacatctggaaaatgggcgttgttttg actgacaattacttcctgtatctgatctggtacagcattatgtccgtttttggacatttc aacaacttcttcttcgctgcccacctgctggacattgccatgggcttcaagacccttcgc accatcctgtcttctgtcacacacaacggaaagcagcttgtactgactgtgggtctgctg gcggtggtcgtctatttgtacaccgtggtggcctttaacttcttcaggaagttctacaac aagagcgaggatgaagacgagcccgacatgaagtgtgacgatatgatgacatgctatttg ttccacatgtatgtgggcgtgagagctggaggcggtatcggagacgagttggaggaccca gctggagacccctatgaactctaccgtatcttatttgacattaccttcttcttcttcgtc attgtcatcttgctggccatcattcagggtttgattattgatgcctttggtgagctgaga gaccagcaggagcaggtgaaggaggacatggagaccaaatgcttcatctgtggcattggg aacgactattttgaccggacgcctcacgggtttgaaacccacaccttacaagagcacaac ctagctaactacctattcttcctgatgtacctgattaacaaggatgagactgaacacacg ggtcaggagtcatttgtgtggaagatgtaccaggagagatgctgggacttcttccccact ggagactgcttccgtaagcaatatgaggaccagttgggttag

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