Scophthalmus maximus (turbot): 118285745 Help Entry 118285745         CDS       T09850                                  Name (RefSeq) ryanodine receptor 3 isoform X3   KO K04963   ryanodine receptor 3 Organism smau  Scophthalmus maximus (turbot) Pathway smau04020   Calcium signaling pathway smau04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:smau00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118285745    04020 Calcium signaling pathway     118285745  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:smau04040]     118285745 Ion channels [BR:smau04040]  Voltage-gated cation channels   Ryanodine receptor    118285745 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Ago_Mid Motif Other DBs NCBI-GeneID:  118285745 NCBI-ProteinID:  XP_035465429 LinkDB All DBs Position 15:complement(13192203..13283433) Genome browser AA seq 4881 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICTFVLEQSLSVRALQEMLAKSGQNSEGAAQSGGHKTLLYGHAILLRHSFSSMYLAC LKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSISNGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGHDEVVTIPGSDQT EEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWSQPFRLRHLTTGHYLALTEDKG LVLQDRERSDTIATAFCFRASKEKLEQSPKRDIEGMGVAEIKYGDSLGFITHLATGLWLS YQAPDVKSSRLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTLLFKRFIRDL DCLGVKNWSLVALPVEEVLQTLNDLITYFQLPDAELEHEERQIKLRSLKNRQNLFKQEGM LTLVSNCIDRLNVYNSAAHFGECAGSEAGAAWKDILNLLYELLAALIRGNRNNCTQFSNN LDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQYKKWY YELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSFGFDGLHLWS GRIPRAVASLNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSF SAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKRDVDGVRDLLGTT QFMSQASFIPTPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGWSYGKIRDDNKRQ HPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRVVQVNPNAEDSLKKIKLPKNYMMSN GYKPTPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNPRLVL YVLLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQEGGQVAERLSIDKIRFFRVERTYSV TTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYRGHCLNMGSRLFGRCW HAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSLGLAQVGRMN LGKDASSFKYYTMCGLQEGFEPFSVNMNREVTMWFSKRLPTFVNVPKDHNHIAVTRIDGT IDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSFFKSSPVVDMNGVHEEDTLKVKHR YPLRSVRHSEESRRVDYSSITTYYHSVRVFAGQDPTDVWVGWVTPDYHYYSNNFNLSKNR TVTVTLGDERGRVHESVKRSNCYMVWGGDGTGAAHTSSRSNVDLEIGCLIDLATGLVTFT VNGKDISTSYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNAMPLSSAIFKSEHKNPVPQ CPPRLDVQTISAVLWSRMPNIFLKVETARVNERHGWVVQCVEPLQMLAVHIPEENRCVDI MELSEQEDMRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREG FYNVLISIHLETAKEARLMMKDEFIIPVTAETRSIRLFSDASKKHLPPGVGLSTSLKPRL NFAPPCFISTKREQHLYSPQIPLDALKEKAITMLTEAVQGGGHHIRDPVGGGVEYQFVPI LKLISTLLTMGVLGSDDVHKILLLIDPNVFREAHEEGATGATDKEGLTGAEEKAVEAGEE EAAKEAKQPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSKLQYNQ KFRYNELMLALNMSAAITARKTKEFRSPPQEQINMLLTFSMGEDCPCPTDIQEELYDFHN QLQLHCGIPMEEDEDEQDTSIKRRLLMLVNKIKGQSHKAEEPTEKEQAAPSNLKELISQT MVSWAQECHIQDPELVRKMFSLLRRQYDSIGELLRAMRKAYTISAASVQDTINLLASLGQ IRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGGDKSQ EIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAS SVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFA VFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISEMPALDLPGSV HGVSSDVSADGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILR SLVPTEDLVGIISIPLKMPIINKDGSMTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFL LHLLEVGFLPDLKAATTLDTEVLCTTETALAMNRYIGSAMLPLLTRCAPLFAGTEHYASL IDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCKHLRPSMLQQLLHRLVFDVPLLTEYCK MPLRLLTNHYEQNWKYYCLPSGWGSYGTASEDELLLTKKIFWGVFDSLSQKKYDAELFKM AMPCLSAIAGALPPDYVDASISTTVEKSVSVDAQGNFDPKPINTANIAVPEKLEHFANKY AEHSHEKWSAEKVLLGWKYGDCVDEKAKTHPQLRTYKALTEKEKEIYRWPIRESLKSMLA MGWSVDRTKDGESMSQQRENEKMRKISQTSQANGFNPSPIDTSSVVLSRELQGMVELVAE NHHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDLFRFLQINGYSITRG LKDLEQDSSSMEKRFAYRFLKKLLKYVDSAQEFIAHLESMAASGKTDRSPHEQEIKFFAK VLLPLIDQYFKNHSLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGSD STTMVSCLHILAHTLDTRTVMKSGSETVRVGLRTFFENAAEDLEKTFENLKHGKFTHSRS QMKGVSQNINYTTVALLPILTALFEHITQYHFGVDLLLDDVQVSCYRILTSLYALGTGKN IYVERQLPALGQCLATLAGAMPVAFLEPLLNTYNPCSVFNTKSARERTILGIPDSVEEMC PGMPQLDGLVKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQPAIGGSVC CTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIIGKARADLLKSHFLPTLE KLKKKTVKVVAEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRW LKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDNKAKMSKSGG QDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYLLRDTDDE VKDHIHQNLHLREKSEDPAVRWQLNLYKDIVMRSEGLSDPERVVDRIQRISAAVFNLEQV EQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLAYQRIWIETEEYSF EEKLVQDLAKTQPKVEEEEEEEIRKQPDPLHQLILHFSHNALTECSSLEEDPLYIAYADM MAKSCAEGEEEEEEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMISASKGRLAA MVTFTLKLGISILNGGNTVVQQKMLDYLKEKRDVGFFKSLSGLMMSCSVLDLNAFERQNK AEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTT VNIIISTVDYLLRLQESISDFYWYYSGKDVIDEAGQRNFSQALAVAKQVFNSLTEYIQGP CIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMIVMMLSLLE GNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFREYDPESKGIISKKD FQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNVAVLLTNLSE HMPHDARLSTFLDLAESVHSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKE SKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDPVERPEEDEEDKQSVVD NQEEEEEKSVMLESSSAFTIACISLRKSLCHFRQILTLKSMRRRYRKFKKMSVKEMVRGF FSFFWMIITGLFHFVYSLIWGFFHILWTTMFGGGLVEGAKNMKVTDILGNMPDPTQFGIH GDVLETEKMEGREASALAQLGQMAQGDVAEADLMAELLNIQPKKEGKHGAEPGLGDVSEV VVGDAPSIASAVRQKKAQMAAKNRATIGDYKSDSEKGDSEDGEKKDHDKSKDEGPPERSA EEKKARKKRLGPRKEPPEAFMASFFAGLEIYQTKMLNYLARNFYNLRFLALFVAFAINFI LLFYKVTGDYSEDEDPWNGRGRAGEEEDEGALEYFVLQESTGYMAPTLRCLAILHTIISF LCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVINTPSFPNNY WDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEEAVAKEASLVSWLSSIDTKYH IWKLGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQ LVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGG IGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMET KCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQE RCWDFFPAGDCFRKQYEDQLG NT seq 14646 nt NT seq  +upstreamnt  +downstreamnt atggctgacggcggagagggagaggacgagatccagttcctcaggactgatgacgaagtg gtgctccagtgcgtggcctgcatccagaaggagaatcgcaagttctgcctggctgctgag gggctgggcaaccggctgtgttacctggagcccacatctgaggcaaagtatgttcctcca gacttgtgcatctgcacctttgtgctggaacagtccctgtcggtgcgggccctgcaggag atgctggctaagagcggacagaacagtgaaggggcagcgcagagtggcggacacaagact cttctgtacggacatgccatcctcctgcgccattccttcagctccatgtacctggcctgt ttgaagacatcacggtcacagacagataagctgtcctttgacgtcggcctgcaggaagac tcaacaggtgaagcctgttggtggacgatccaccctgcctccaaacagaggtcggaagga gagaaagtgcgcatcggggacgacctcattctcgtcagtgtgtcctctgagcgatacctt cacttatccatctccaatggcaacatccaggtggatgcttccttcatgcaaaccctgtgg aacgtccatcccatctgctctggcagcaacatagaggaaggctacctcctgggggggcat gtgatgcggctgttccatggacatgacgaggtggtgaccatcccggggtcggaccagacc gaggagcagcagaggatagtcaactatgagacgggtaaagccggtgccaaggccaggtcc ctgtggaggctggagccactcagaatcagctggagtgggagccacatccgctggagccag ccttttcgactgcggcacctgaccaccggtcactacctggccctgacagaggacaagggg ttggtgctacaggaccgggagaggtccgacactatcgccacagccttctgcttcagagcc tccaaggagaagctggagcagagccccaagcgggacatcgagggcatgggggtggcggag attaaatacggggactcactcggcttcatcacgcacttggccacgggactctggctgtcc tatcaggcacctgatgtcaaatcctcccgtctgggtcccctcaaaagacgagcgtgccta cattctgaaggtcacatggatgacgggctgaccctgcagcgctgtcaacacgaagagtcc cgcgccgcacgcatcatccgcaacaccaccctgctctttaaacgattcatcagagacctg gactgtctgggtgttaagaattggtcactggtcgccctgcctgtcgaggaggtgctccaa actctcaacgacctcatcacctatttccagctccctgacgccgagcttgaacacgaggag aggcagatcaagctgcgctcactcaagaaccgacagaaccttttcaaacaggaaggcatg ctgacactggtgtccaactgtatcgaccgactgaacgtgtacaacagtgcggcccacttc ggggagtgtgccgggtccgaggccggagcagcctggaaagacattctgaacctgctgtat gagctgctagcggcgctaatccgagggaacaggaacaactgcacccagttctccaacaac cttgactggctggtgagcaagctggagagactggagtcgtcttcaggcatcctggaagta ctgcactgcatcttaatcgagagccccgaggccctcaacataatccagagaggacacatc aagtccataatatcgctgctctacaagcacggacgtaaccacaagattctggatgtgctc tgctcgctgtgtgtgtgtaacggcgtagctgtgcggaccaatcagaacctcatctgtgat cacttgctgcccaagagagatctgctgctgcagacccagctggttaatgatgtccagagt atgaggccgaacatcttcctgggggtgagcgagggctcagctcagtataagaagtggtac tatgagctgatgattgaccaggtggaccactttgtgaccagcgagccctcccacctgaga gtgggctgggccaacaccaaaggatacgcaccgtaccccggagggggagagggttggggc ggcaatggagttggagacgacctctactcgtttggttttgatggactccacctctggtca ggtcgtatcccgcgggcggttgcatccttgaaccagcacatcctgacctcagaggatgtg gtgagctgctgcctggacctgggagcacccagcatctctttcagaatcaacggacagccc gtccagggcatgttcgagaacttcaatacagatggtctcttcttccccgtcgtcagcttc tcggcaggggtcaaggtgcgtttcctgttgggcggtcgacatggcgacttcaagttcctg cctccatcgagttatgctccatgttacgaggctctgctgccaaaagagaagatgaaggtg gagccggtgaaagagtacaagagggatgtggacggagtcagagacctgctgggcaccacc cagttcatgtcacaagcctccttcatccccaccccagtggaaaccagccagattgtgatg ccacctcatttggagaaggtccgggacaagctcgctgagaacattcatgaactgtggggc atgaataagattgagctcggttggtcttacggcaagataagggacgacaataagcggcag catccatgcctggtggacttctccaagctgccagagacggaaaagaactacaatttgcag atgtcaacagaaactctgaagaccctgttggcattgggctgtcgtgtagttcaggttaat ccaaatgccgaggactccctcaagaagataaaactccctaagaactacatgatgtccaac ggatataagccaacacccctggacctgtccgacatcaaactgactccaggtcaggagctg ctggtggacaaactggctgaaaatgcgcacaacgtgtgggccaaggaccggatcaaacag ggatggacctacggcattcaacaggatctgaagagtaagcgtaaccctcgcctggttctc tacgttctgctggatgagcgcaccaagaagtcgaacagggacagcctgcgggaggctatc cgcactctgattggctacggatacaacattgagccctcagaccaggaaggcggacaagtg gccgagcgactcagcatcgacaagatccgctttttcagagtggagaggacgtactcggtg acgaccggcaaatggtactttgaatttgaggccgtgacaggaggagacatgagagtgggc tgggccagacctggctgtaagccagacgtggaacttggcacagatgagcttgctttcgtc tttgatggatacaggggccattgtctgaacatgggcagccgcttgttcgggcggtgctgg catgctggggatgtggtcggctgtatgatcaacatggaggacaagtccatgatcttcacg cttaatggagagatcctcatcaccaccaagggctctgaactctgcttcactgactttgaa acggaggatgggttcattccagtgtgtagtctcgggctggctcaggtgggtcgcatgaat ctggggaaagatgcgagctccttcaagtactacaccatgtgtggcctgcaggaagggttc gaacccttctcggtcaacatgaacagagaggtcaccatgtggttcagcaagcgtctgccg acttttgtcaatgtgccgaaggaccacaaccacatcgcagtgaccaggattgacggcacc atcgacagccccccgtgtcttaaagtgacacacaagacgtttggcacccagaacagcaac gctgacatggtgttttgtcgtctcagcatgcccgtagagttccactccttcttcaagtcc agtccggttgtggacatgaacggagtgcacgaggaagacaccctgaaagtgaaacacagg tatccattgaggtctgtgaggcacagtgaagaaagtagacgagttgactacagcagcatc accacgtactatcactcggtgagggtcttcgctggtcaggacccaactgatgtgtgggtt ggatgggttacccccgactaccattactacagcaacaatttcaacctcagcaaaaacaga acggtgactgtgaccctgggtgacgagcggggacgagtccatgagagtgtgaagaggagt aactgctacatggtgtggggaggcgacgggaccggtgctgctcacacctccagtcgtagc aacgtggacttggagattggctgtctgatagacctggctactggactggtgacgttcact gtcaatggcaaagatatatccacatcctaccaggtggaaccaaacaccaagctcttccct gctgtgtttgtgcgaccaaccagccccaacctcttccagtttgagctggctaaaataaag aacgccatgcctctgtcgtcagccatctttaagagtgaacacaagaacccggtgccacag tgtccgccccgtctcgatgtccagaccatcagtgcggtgctgtggagccgcatgcccaac atctttctgaaggtggaaacggccagagtcaatgagagacacggctgggtggtgcagtgt gtggagcccctgcagatgttggctgtacacatacctgaggagaacaggtgtgtcgacatc atggagctgtctgagcaggaggacatgaggaagttccactaccacaccctgaagctctac tgtgccctctgtgctctgggcaacacccgagtggcccacgcactctgcagccacctcgac caatcccagctgttgtacaccatcgacaaccagtacctgtcaggcatgttgcgtgagggc ttctacaatgttctgatcagcatccacctggagacggccaaagaggcgcggctcatgatg aaagacgagttcatcatccccgtcacggcggagacgcgctccatccgtctcttttctgat gcctccaaaaagcacctcccgccaggggtggggcttagcacttcgctcaaaccgcgcctc aacttcgccccgccctgtttcatcagcaccaaacgggagcaacatctgtacagtccccag atcccactggacgcactgaaggagaaggccatcacgatgttgaccgaggccgttcaaggt ggagggcaccacatccgagatcccgtcgggggaggtgtggagtaccagtttgtgccaatc ctgaagctcatcagcaccttgctgactatgggcgtgttagggagtgacgatgttcacaag atcctactgctcatcgaccccaatgtgttcagagaggcacacgaggagggggccacgggg gccacagacaaagaaggactcacgggggccgaggagaaggcagtggaagctggggaagag gaggcagccaaagaggctaaacagccaatgaaaggactgctggagaagaggctgcctgag cccgtcaaacgacagatgtgcgagctgcttcactatttctgcgactgtgagctgaagcac cgcatcgaggccatcgtgtcgttctccgacagcttcgtctcgaagctgcagtacaaccag aagttccgctacaatgagctgatgctggccctcaacatgtcggccgccataacggcaagg aagaccaaagagttcagatcacctcctcaggaacagattaacatgctgctgaccttcagt atgggcgaggactgtccgtgtccaacagacatccaggaggagctctacgatttccacaac cagctgcagctccactgtggaatccctatggaggaagacgaagacgagcaggacacgtct atcaaacgccgcctcctaatgctggtgaacaagatcaaaggccagtctcacaaagcagag gagcccacggagaaggagcaggccgcgccatccaatctgaaggagctgatctctcagacg atggtcagctgggcccaggagtgtcacatccaggacccagagctcgtgcgcaagatgttc agcctgctgaggaggcagtacgacagcatcggggagctgctccgggccatgaggaaggca tacaccatcagcgccgcctcggtgcaggacaccatcaacctcctggcctccctcggtcag atccgatcgctgctgtctgtccgcatggggaaagaagaggagaagctcatgattgacgga ctcggcgacatcatgaacaacaaggtgttctaccagcacccaaacctaatgaggatactg ggcatgcatgagaccgtcatggaagtcatggtcaatgtgcttggaggagacaaatctcag gaaatcgccttccccaagatggtggccagctgctgtcgcttcctgtgctacttctgtcga atcagccgccagaaccagaaagccatgttcgaccacctcagttacctcctggagaacagc agcgtgggtctagcttcaccagctatgaggggctccactcctctagatgtggctgcttcc tctgtgatggacaacaacggcctggctctggcactggaagagcctgatctggataaggtg gtcacctacctggcaggatgtggtctccagagttgtccgatgcttctggctaaaggttat ccagacattggttggaaccccattgaaggcgaacgttacctctccttcttacggtttgct gtctttgtcaacggtgagagcgtggaggagaactccagcgtcgtggtgaagctgctcatc cgtcgtccggagtgtttcggacccgccctgaggggcgagggagggaacggcctgttggct gccatgaaagaagccatcaagatctctgagatgcctgctttggacctgccgggctccgtc catggagtcagctccgacgtgtctgctgatggggacgatgaggaggaggtggttcacatg ggcaacgccattatgtccttctactctgcgctcattgaccttttgggacgttgcgcccca gagatgcatctcatcaacaaggggaaaggcgaagctctgcgtattcgcgccattttgcgc tctctggtgccgaccgaggacctggtgggaattatcagcataccactcaaaatgcccatc atcaacaaagatgggtcaatgaccgagccggatatgtccgcctgcttttgtccggaccac aaggcccccatggtgctgttcctggacagggtgtacggtattgaggaccagagctttttg cttcacctgctcgaagtgggcttcctccccgatctgaaggctgctaccactctggacacg gaggtgctgtgtaccacagagacggccctggccatgaaccgctacatcggctcggccatg ctgcccctcctcacgcgctgcgctcctctcttcgccggcaccgagcactacgccagcctc atcgactccactcttcacaccatctatcgcctttccaagggccgctcgctcacaaaggcc cagagggatgccatagaggagtgcttgctggctgtctgcaaacacctccgtccctccatg cttcagcagctcctgcaccgcctcgtctttgatgtgcccttgctgactgaatactgcaag atgcctctcaggctgctgaccaaccactatgagcagaactggaagtactactgcctcccg tcgggatggggcagctacggcacggcatccgaggacgaactgctgctcaccaagaaaatc ttctggggagtgtttgattctctgtcccagaagaaatatgatgcagagctattcaagatg gccatgccttgcctcagtgccatagctggagctttgccaccagactatgtggacgcctcc attagtaccactgtggaaaagtctgtttcggtggatgctcagggcaactttgaccccaaa cccatcaatactgctaacattgctgtcccagagaagcttgagcactttgccaacaaatat gccgagcactcccatgagaaatggtctgcagagaaggtgttgctgggatggaaatacgga gactgtgttgacgagaaggccaagactcaccctcagcttaggacctacaaagctctaacc gagaaggagaaggagatttacagatggccaatcagagagtccctgaagagcatgctggca atgggctggagcgtcgacaggaccaaggatggagagagcatgtctcagcagcgggagaac gagaaaatgagaaagatctctcagacctcgcaggcaaacggtttcaatccgagcccgata gacaccagcagcgtggtcctatccagggaactgcaggggatggtggagctagtggctgaa aatcatcataacatctgggccaagaagaaaaagagtgaccttggaagcagaggcggagga actcacccgctgttggtgccctacgacacgctgacagccaaggagaaggctcgtgatcgg gagaaggcccaggacctttttcgcttcctgcagatcaatggctacagcatcacaagaggt ttgaaggacttggagcaggattcttcttccatggagaagaggtttgcctataggttcctc aagaagctactcaagtatgtggactcggctcaggagttcatcgcacatctagagtccatg gctgccagtggaaaaacagacaggtcccctcatgaacaagaaattaagttttttgccaaa gttcttctgccgctcatcgatcagtacttcaagaaccactctctctacttcctctcctcg cccagtaagaacttgagcagcagcggttacgcctccaacaaggagaaggagatggtcacc agcctgttttgtaaactggcagctcttgtcagacataggatttcactctttgggagcgac tccaccaccatggtgagctgtctgcatatcctggcacacaccctggacaccaggacggtg atgaagtcgggctcggagacggtgcgggtgggcctgaggacgttcttcgagaacgccgca gaggacctggagaagacgttcgagaacctgaagcacgggaagttcactcactcccgctcg cagatgaaaggggtgtcgcagaatatcaactacaccaccgtggctctgctccccatcctg accgctctgtttgaacacatcacccagtaccactttggagtcgacctgctgctggatgac gtccaagtgtcctgctatcgaatcctcaccagcctctacgcactgggcactggaaaaaac atctacgtagagaggcagctgccggccctcggccagtgtctggccaccctggctggggcc atgcctgtggccttcttggagccgctgcttaacacgtacaacccgtgctcggtctttaac accaagagtgcccgggaacgaaccatccttggcataccggactcggttgaagagatgtgt cccgggatgccgcagctggacggcctggtgaaggacatcaatgacatggctgagtccgga gcgcgctacacggagatgcctcacgtcatagaggtggtgctgcccatgctgtgtaactat ctgtcctactggtgggagagggggcccgagaatcagccggccatcgggggcagcgtctgc tgcaccaccgtcacctcggagcacctcagcctcattctcggcaacatcctcaagatcctc aacaacaatctgggtatcgatgaagcctcctggatgaagaggatcgcagtgtacgtgcag cccatcatcggtaaggctcgtgcagacctgctgaagagccacttcctgcccacactggag aagctgaagaagaagacagtgaaggtggtggctgaggaggagctgctgaaggcggacagc aagggggacacccaggaggcagagctgctcatcctggacgagtttgccgtgctctgcagg gacctgtatgccttctaccccatgctcatccgctacgtggacaacaacaggtcccggtgg ctgaaagaacccgatgctgactccaatgagctcttcaggatggtcgctgagatatttatt ctctggtgcaagtcacataatttcaaaagagaggagcagaactttgtggttcaaaatgaa atcaacaacctttccttcttaactggggataataaagccaagatgtcaaagtctggagga caagaccaggagaggaaacacaagaaaaggcgaggtgagttctactctatccagacgtcg ctgatcgtagctgctttgaagaagatgctgccgatcggcctcaacatgtgcacccctggg gatcaggagctcatatcgctggccaagactcgctacctcctgagagacacagatgacgag gtcaaagaccacatccatcagaatctgcatcttcgagaaaagtcagaggaccctgcagtg aggtggcagctaaacctgtacaaggacattgtgatgaggagtgaggggctatcggaccct gagagggtggtggaccgtatccagaggatctccgctgctgtcttcaacctggagcaggtg gagcagccactgagatccaaaaaatgtgtttggcagaagttgctgtccaagcagaggaag agagcggttgtggcctgcttccgcatggctccactttataatctaccgaggcatcgctct attaacctcttcctcctggcctatcagagaatatggatagaaacagaggagtactctttt gaggagaagctagtgcaggatcttgcaaaaacgcagcccaaagtggaggaagaggaagag gaggagatcagaaaacagcccgacccacttcaccagctcattctgcatttcagccacaac gctctgaccgagtgcagttctctggaggaggaccccctgtatattgcatatgcagatatg atggcaaagagttgtgctgaaggtgaagaagaggaagaggaggaaggaaaagagaaaacc tttgaggaaaaggaaatggagaagcaaaagatgctttatcagcaggccagacttcacgac cgaggggctgcagagatggtgctccagatgatcagtgccagcaaaggtcgacttgctgcc atggtgacgttcaccctcaaactgggcatctccatcctgaacgggggaaacacagtggtc cagcagaaaatgctggactatctgaaggaaaaaagagacgttggctttttcaaaagttta tctggactgatgatgtcttgcagcgttctggacttgaatgcttttgaaaggcaaaacaaa gctgaaggtctggggatggtcactgaagaaggatcaatcaacgtgagtgagcggggttcc aaggttctgcagaatgatgagttcaccaaggacctctttaggttcctgcagcttctctgt gagggccataataatgattttcagaacttcctgaggactcagacagggaacacgactaca gtcaacatcatcattagtactgtggactacctactaagactccaggaatccatcagtgat ttctactggtactactctggtaaggatgtcatagatgaggctggacaaaggaacttctcc caagcactggcagtggccaagcaggtcttcaactctttaactgagtacattcagggtccg tgcattgggaaccagcagagtctggctcacagcaggctgtgggatgctgtggtgggattc ctgcacgttttcgccaacatgcagatgaagttatcccaggattccagtcagattgaatta ttgaaggagctgctggacctgcagaaggacatgatcgtcatgatgctgtctcttctcgaa ggcaacgtcgtcaacggtaccatcggcaaacaaatggtggacactttggtcgaatcgtcc agcaacgtggagatgatcctcaagttcttcgacatgttcctcaagctgaaggacttgacc acgtcagacagcttcagggagtacgaccctgagagcaaagggatcatctccaagaaggat ttccagaagtccatggagaaccagaaacagtactcccagtctgagattgagtttcttctc tcgtgtgccgaggccgacgagaacgacatgttcaattacgagcagtttgtggagagattt catgaaccggccaaggacattggctttaatgtagccgtgctgctaaccaatctctctgag cacatgcctcatgatgctcgcctctcaacgttcctcgacctggccgagagtgttcacagc tactttgaaccttatctgggtcgtattgagatcatgggtggggcgaagcgcatcgagaga gtctacttcgagatcagcgagtcgagtcgcacgcagtgggagaagccccaggtgaaggag tcgaagcggcagttcatcttcgacgtcgtcaacgaaggtggagagagcgagaagatggaa ctgtttgtcaacttctgcgaggacaccatctttgagatgcagctggcttctcaaatctca gagccagacccggtggagcggccggaggaggacgaagaggacaaacagagtgtggtggat aaccaggaggaagaagaggagaaaagtgtgatgttggagtcttcctctgccttcacaatc gcctgcatctcattgagaaaaagcctctgccacttccgccaaatcttgactcttaagagc atgaggcggcggtacaggaaattcaagaagatgagcgtgaaggagatggtgcgaggcttc ttctccttcttctggatgatcatcacgggactcttccacttcgtctacagcctaatctgg ggtttcttccacattttgtggaccaccatgtttggcgggggccttgtggaaggggctaag aatatgaaggtgacggacattctgggaaacatgcccgatcccactcagtttggcatccat ggggacgtgctagagacggagaagatggaggggagagaggcgtcagcgttggcacagctg ggtcagatggctcagggggacgtggcagaggccgacctgatggctgagctgctgaacata cagcccaagaaggagggaaagcacggggctgagccggggttgggggatgtgtctgaggta gtggtgggagatgccccatccattgccagtgccgtcaggcagaagaaagcacagatggct gcaaagaacagagctacgattggagactacaaatcggattccgagaaaggagattcagaa gatggtgagaagaaggaccatgacaagtccaaagacgaaggccctccagagcgctcggcg gaggagaagaaggcccggaagaagaggctcggcccgaggaaagaaccacctgaggccttc atggccagcttcttcgctggcctggaaatctaccagactaagatgctgaactaccttgcc agaaacttctacaacctccgctttctggcacttttcgtcgcctttgccatcaacttcatc ctgctgttctacaaagtaaccggtgattactcggaggacgaagacccctggaacggtcga ggtagagctggcgaggaggaagatgagggggcgctcgagtactttgtcctgcaggagagc acaggctacatggcgccaacacttcgctgtctggcgatactacacactatcatctctttc ctgtgtgtggtggggtactactacttgaaggtgccactggtggtgttcaaacgtgagaag gagatagcgaggaagttggagttcgccggcctctacatcaccgagcagccgtctgatgat gacatcaaagggcagtgggacagactagtcattaatactccttccttcccaaacaactac tgggataaattcgtcaaacggaaagtgatcaaaaagtacggagacctgtacggagcggag aggatcgcggagctgctgggcttggacaaaagtgccctggatttcaatccaacagaggaa gctgtcgccaaggaggcttcgttggtgtcctggttaagctcaatcgatacgaagtaccac atctggaaactgggggtggtgttcacagacaattctttcctgtatttagtgtggtacacc accatgtccattctgggccactacaacaacttcttcttcgccgcccatcttctggacatc gccatgggcttcaagaccctccgcaccatcctctcctcggtcacacacaacggcaaacag ctggtgttgacggtgggcttgctggcagtcgtggtctatctctacacggtggtggccttc aacttcttcaggaagttctacaacaagagtgaggatgacgacgagccggacatgaagtgt gacgacatgatgacgtgctacctgttccacatgtacgtgggcgtgagagcaggagggggc atcggggacgagatcgaggacccggcgggggacccctatgaactctaccgcatccttttt gacatcactttcttcttctttgtcatcgtcatcctcctggccatcatccagggtttgatc attgatgcctttggagagctgagggatcagcaggaacaagtcaaagaggacatggagacc aaatgtttcatctgcgggatcggtaatgattatttcgacacaacaccgcacggcttcgag actcacaccttacaagagcacaatttggccaactacctgtttttcctgatgtacctcatc aacaaggatgagacagagcacactggtcaggagtcatatgtgtggaagatgtaccaggag cgatgctgggatttcttcccagctggagactgcttccgcaaacagtacgaagatcagctc ggatag

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