KEGG   PATHWAY: spo04120Help
spo04120                    Pathway                                

Ubiquitin mediated proteolysis - Schizosaccharomyces pombe (fission yeast)
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
spo04120  Ubiquitin mediated proteolysis

Ortholog table
spo_M00379  SCF-MET30 complex [PATH:spo04120]
spo_M00380  SCF-BTRC complex [PATH:spo04120]
spo_M00386  Cul4-DDB1-CSA complex [PATH:spo04120]
spo_M00407  SCF-CDC4 complex [PATH:spo04120]
spo_M00411  SCF-GRR1 complex [PATH:spo04120]
Other DBs
BSID: 7694
GO: 0016567
Schizosaccharomyces pombe (fission yeast) [GN:spo]
SPBC1604.21c  ptr3; ubiquitin activating enzyme E1 [KO:K03178] [EC:]
SPAC4C5.04  rad31; SUMO E1-like activator enzyme Rad31 [KO:K10684] [EC:]
SPBC16H5.03c  fub2; SUMO E1-like activator enzyme Fub2 (predicted) [KO:K10685] [EC:]
SPAC24H6.12c  uba3; NEDD8 activating enzyme [KO:K10686] [EC:]
SPAC18B11.07c  rhp6; ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:]
SPCC1259.15c  ubc11; ubiquitin conjugating enzyme E2-C, Ubc11 [KO:K06688] [EC:]
SPBC119.02  ubc4; ubiquitin conjugating enzyme Ubc4 [KO:K06689] [EC:]
SPBC1105.09  ubc15; ubiquitin conjugating enzyme Ubc15 [KO:K10575] [EC:]
SPBP16F5.04  ubc7; ubiquitin conjugating enzyme Ubc7/UbcP3 [KO:K04555] [EC:]
SPBC211.07c  ubc8; ubiquitin conjugating enzyme Ubc8 (predicted) [KO:K10576] [EC:]
SPAC30D11.13  hus5; SUMO conjugating enzyme Hus5 [KO:K10577]
SPAC10F6.05c  ubc6; ubiquitin conjugating enzyme Ubc6 (predicted) [KO:K04554] [EC:]
SPCC777.10c  ubc12; NEDD8-conjugating enzyme Ubc12 [KO:K10579]
SPAC11E3.04c  ubc13; ubiquitin conjugating enzyme Ubc13 [KO:K10580] [EC:]
SPBC2D10.20  ubc1; ubiquitin conjugating enzyme Ubc1 (predicted) [KO:K04649] [EC:]
SPAC167.07c  ubiquitin-protein ligase E3 (predicted) [KO:K10589] [EC:]
SPAC12B10.01c  ubiquitin-protein ligase E3 (predicted) [KO:K10590] [EC:]
SPAC11G7.02  pub1; HECT-type ubiquitin-protein ligase E3 Pub1 [KO:K10591] [EC:]
SPAC1805.15c  pub2; HECT-type ubiquitin-protein ligase Pub2 [KO:K10591] [EC:]
SPBC16E9.11c  pub3; HECT-type ubiquitin-protein ligase Pub3 (predicted) [KO:K10591] [EC:]
SPAC19D5.04  ptr1; E3 ubiquitin-protein ligase [KO:K10592] [EC:]
SPAC20H4.10  ufd2; ubiquitin-protein ligase E4 (predicted) [KO:K10597] [EC:]
SPAC21E11.05c  cyp8; cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp8 [KO:K10598] [EC:]
SPAC29A4.08c  prp19; ubiquitin-protein ligase E4 [KO:K10599] [EC:]
SPAC1687.05  pli1; SUMO E3 ligase Pli1 [KO:K04706]
SPBC17D11.02c  hrd1; ubiquitin-protein ligase Hrd1, synviolin family [KO:K10601] [EC:]
SPAC23H4.18c  rbx1; RING-box protein 1 [KO:K03868] [EC:]
SPAC17G6.12  cul1; cullin 1 [KO:K03347]
SPBC409.05  skp1; SCF ubiquitin ligase complex subunit Skp1 [KO:K03094]
SPAC29E6.01  pof11; F-box protein Pof11 [KO:K03362]
SPAC4D7.03  pop2; F-box/WD repeat protein Pop2 [KO:K03361]
SPBC1718.01  pop1; cullin 1 adaptor protein Pop1 [KO:K03361]
SPAC57A10.05c  pof1; F-box/WD repeat protein protein Pof1 [KO:K10259]
SPBC25B2.11  pof2; F-box protein Pof2 [KO:K03360]
SPBC1861.07  elongin C (predicted) [KO:K03872]
SPAC24H6.03  cul3; cullin 3 [KO:K03869]
SPAC3A11.08  pcu4; cullin 4 [KO:K10609]
SPAC17H9.10c  ddb1; damaged DNA binding protein Ddb1 [KO:K10610]
SPBC577.09  ckn1; hypothetical protein [KO:K10570]
SPAC343.03  apc11; anaphase-promoting complex subunit Apc11 [KO:K03358]
SPBP23A10.04  apc2; anaphase-promoting complex cullin family subunit Apc2 [KO:K03349]
SPAC821.08c  slp1; WD repeat-containing protein [KO:K03363]
SPAC144.13c  srw1; CDK inhibitor Srw1 [KO:K03364]
SPBC1198.12  mfr1; fizzy-related protein Mfr1 [KO:K03364]
SPBC106.09  cut4; anaphase-promoting complex subunit Apc1 [KO:K03348]
SPAC17C9.01c  nuc2; anaphase-promoting complex subunit Apc3 [KO:K03350]
SPAC19G12.01c  cut20; anaphase-promoting complex subunit Apc4 [KO:K03351]
SPAC959.09c  apc5; anaphase-promoting complex subunit Apc5 [KO:K03352]
SPAC6F12.15c  cut9; anaphase-promoting complex subunit Cut9 [KO:K03353]
SPAC6F12.14  cut23; anaphase-promoting complex subunit Apc8 [KO:K03355]
SPBC1A4.01  apc10; anaphase-promoting complex subunit Apc10 [KO:K03357]
PMID:16922370 (Japanese)
Kamura T.
[Cullin-based E3 family] Japanese
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
PMID:16922408 (Japanese)
Matsuda N.
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
PMID:16922367 (Japanese)
Tokunaga F.
[E2 ubiquitin-conjugating enzymes: structures and functions]
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Nalepa G, Rolfe M, Harper JW.
Drug discovery in the ubiquitin-proteasome system.
Nat Rev Drug Discov 5:596-613 (2006)
Hsu YJ, Goodman SR.
Spectrin and ubiquitination: a review.
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Hatakeyama S, Nakayama KI.
Ubiquitylation as a quality control system for intracellular proteins.
J Biochem 134:1-8 (2003)
Lee J, Zhou P.
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
Mol Cell 26:775-80 (2007)
KO pathway
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