KEGG   Streptococcus pneumoniae R6 (avirulent serotype 2): spr1065
Entry
spr1065           CDS       T00060                                 
Symbol
nrdE
Name
(GenBank) Ribonucleoside-diphosphate reductase (major subunit)
  KO
K00525  ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
Organism
spr  Streptococcus pneumoniae R6 (avirulent serotype 2)
Pathway
spr00230  Purine metabolism
spr00240  Pyrimidine metabolism
spr01100  Metabolic pathways
spr01232  Nucleotide metabolism
Module
spr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP
spr_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:spr00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    spr1065 (nrdE)
   00240 Pyrimidine metabolism
    spr1065 (nrdE)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:spr03400]
    spr1065 (nrdE)
Enzymes [BR:spr01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     spr1065 (nrdE)
DNA repair and recombination proteins [BR:spr03400]
 Prokaryotic type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    spr1065 (nrdE)
SSDB
Motif
Pfam: Ribonuc_red_lgC RNR_N Ribonuc_red_lgN RNR-II_ins_dom
Other DBs
NCBI-ProteinID: AAK99869
UniProt: Q8CWR3
LinkDB
Position
1062287..1064446
AA seq 719 aa
MGLKHLEDVTYFRLNNEINRPVNGQIMLHKDKEALDAFFKENVVPNTMVFDSIKDKINYL
IEHNYIETAFIKKYRPEFLEELAQFIKDQNFQFKSFMAAYKFYNQYALKTNDGEYYLENM
EDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLNAGRARRGELVSCFLIQVTDD
MNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYEGAASGVVPVMKLFEDSFSYSN
QLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVRVKTLSLGVVVPDKFYELARKNEEM
YLFSPYSVEKEYGVPFNYIDITEKYDELVANPNIRKTKIKARDLETEISKLQQESGYPYV
VNIDTANRANPVDGKIIMSNLCSEILQVQEPSLINDAQEFLQMGTDVSCNLGSTNVVNMM
TSPDFGRSIRAMVRALTFVTDSSHIVAVPTIDHGNSQAHTFGLGAMGLHSYLAQQLIEYG
SPESVEFTSIYFMLMNYWTLVESNNIARERGITFHNFEKSDYANGSYFDKYVTGEFVPTS
DRVKELFKNVFIPGVADWAELRDKVQEDGLYHQNRLAVAPNGSISYINDVSASIHPITQR
IEERQEKKIGKIYYPAAGLSTETIPYYTSAYDMDMRKVIDVYAAATEHVDQGLSLTLFMR
SDIPKGLYEWKRENKQTTRDLSILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI
NT seq 2160 nt   +upstreamnt  +downstreamnt
atgggattaaaacatcttgaagacgtgacttacttccgtcttaataacgaaattaaccgt
cctgttaatggacaaatcatgcttcataaagacaaggaagccttggatgctttctttaaa
gaaaatgtagttccaaacactatggtttttgattcaatcaaagacaaaatcaattacctc
attgaacacaactacatcgaaacagcctttatcaagaaataccgtccagagttcttggaa
gaattagctcaatttatcaaagaccaaaacttccaattcaagtcattcatggcagcttat
aaattttacaatcaatatgccttaaagactaatgacggtgaatactatcttgaaaatatg
gaagaccgtgtcttcttcaacgccctttatttcgctgatgggaatgaagctgttgcaatc
gatattgccaatgaaatcatccaccaacgctaccaacctgctactccttccttcttgaat
gctggacgtgctcgccgtggagagttggtatcttgtttcctaatccaagtgacggatgat
atgaactctatcggacgttctatcaactcagctcttcaactttcacgtattggtggtggt
gtgggaattaccctcagcaaccttcgtgaagctggtgcacctatcaaaggctatgaagga
gctgcttcaggtgtcgttcctgttatgaagctttttgaagacagcttctcttactccaac
caattggggcaacgtcaaggtgccggtgttgtctacctcaacgtctttcacccagatatc
atcgctttcctttcaactaagaaagaaaacgctgatgaaaaagtacgtgtcaagactcta
tcacttggtgttgtagtacctgataaattctacgaattggctcgtaaaaatgaagaaatg
tacctcttcagcccttactctgtagaaaaagaatacggtgtgccattcaattacatcgac
attactgaaaaatacgatgaattggtcgcaaatccaaatattcgcaagacaaaaatcaag
gcgcgggatttggaaactgaaatctctaaattgcaacaagagtctggctatccttatgta
gtcaacatcgatacggctaaccgtgcaaatcctgttgatggaaagattatcatgagtaac
ttgtgttctgagattcttcaagttcaagaaccaagcttgatcaacgatgctcaagaattc
cttcaaatgggaacagatgtttcatgtaacctgggttcaaccaacgtggttaacatgatg
acttcacctgattttggtcgttctatccgtgctatggttcgtgcccttactttcgttaca
gatagttcacatatcgtagctgtaccaacgattgaccatggaaatagccaagcccacacc
tttggtctcggtgccatgggactgcacagctaccttgcccaacaactcattgaatatggt
tcacctgagtctgttgaatttacaagcatctactttatgcttatgaactactggaccttg
gtagagtcaaacaatattgcgcgtgaacgtggtattaccttccacaactttgaaaaatca
gactatgctaacggaagttactttgacaagtatgtaactggtgaatttgttccaacatca
gaccgtgttaaagaactcttcaaaaatgtctttatccctggtgttgctgattgggctgaa
cttcgcgacaaggttcaagaagatggtctttaccaccaaaatcgccttgctgtagcgcca
aatggttctatcagctatatcaacgacgtttctgcttctatccacccgattacgcaacgt
atcgaagaacgccaagagaagaaaattggtaaaatctactaccctgctgctggcttgtct
acagaaaccattccttactacacttctgcctacgatatggatatgcgtaaagtcatcgat
gtttacgctgctgcgactgaacacgtggatcaaggactttcactcaccctcttcatgcgt
agtgacattccaaaaggcctttacgaatggaagagggaaaataaacaaacgacacgtgac
ttgtccatccttcgtaactatgcctttaacaagggaatcaagtctatctactacgtccgt
acctttacagatgacggtggagaagtcggcgccaaccaatgtgaaagctgtgtgatttag

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