Sinocyclocheilus rhinocerous: 107756592 Help Entry 107756592         CDS       T04916                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism srx  Sinocyclocheilus rhinocerous Pathway srx04020   Calcium signaling pathway srx04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:srx00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     107756592    04020 Calcium signaling pathway     107756592  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:srx04040]     107756592 Ion channels [BR:srx04040]  Voltage-gated cation channels   Ryanodine receptor    107756592 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 Ago_Mid EF-hand_6 Motif Other DBs NCBI-GeneID:  107756592 NCBI-ProteinID:  XP_016429253 LinkDB All DBs Position Unknown AA seq 4859 aa AA seqDB search MAEGGEGEDEVQFLRTDDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYFPP DLCICNFVLEQSLSVRALQEMLAGQNGEGRLIRRAAQGGGHRTLLYGHAILLRHSFSGMY LTCLKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSE RYLHLSISNGSIQVDASFMQTLWNVQPTCSRSNLEVGFLLGGHVIRLFRGHDESLTIPGS EQSQEQQRVVNYETGKGGSKARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGYYLGQTE DHGLILLDKEKSDTTATAFCFRPSKEKIDSGPKRDIDGMGVAEIKYGDSFCFIMHVSTGL WLSYLAPDAKSSRLGPPKRRAVLSPEGHMDDGLTLQLCQHEESRAARIIRNTTRLFTQFI RGLDGLNGEKTAEVTLHVCEVLQTLGDLIVYFQQPDSELEHEEKQRQLRSLIKRQDLFKE EGMLTLVSHCIDRLNVYNSVAEFEELAGEEAGEAWKDILNLLYELLATLIRGNRTNCTQF SRKLDWLVSKLERLESSSGILEVLHCILIESPESLNIIQKAHIKSIISLLYKHGRNHKIL DVLCSLCVCNGVAVRANQNFICDHLLPRRDLLLQTRLVNDVQSMRSNIFLGMSEGSAQYK KWYFELIIDQVDHYVTNEPTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLH LWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPCMSFRINGQPVQGMFEDFNIDGFFFPV ISFSAGVKVRFLLGGRHGDFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDLEGVRDLL GTTDFLSQASFIPVPVDTSQIVLPPHLENVRDKLAENIHELWGMNKIELGWMYGKVRDDN KRQHPCLFDFSKLPETEKNYNLQMSTETLKTLLALGCHVAQVNMNAEDDLKKMKLPKNYM MANGYKPTPLDLSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRNPR LVPYALLDERTKKSNRDSLREAIRTLVGYGYFIDPPDQETAHTVEKEGIESIRLFRVEKI YAVKTGKWYFEFEALTGGDMQVGWARPGCRPDKELGLDDQSFIFDGYRGRRVHMGSHFFG RTWNKGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQIG RMNLGKAASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPEDHPHIEVTRI DGTVDTPPCLKVTHKTYGTQTSNDDMVCCRLSMPVEFHSGPRKTTDINEVIAEDQRAKKD DGGKTDYGSITKHFYSVRVFAGQDPSSVWVGWVTPDYHYYSKYFSLSTVRTVTVTLGDEQ GRVHESVRRSNCYMVCAGDVVSGSTGRSNTDLEIGCSIDLASGLVSFTANGRDLPTAYQV KPNTKLFPAVFVQPTSPNLFQFEFPKIPDAMPLSSAIFKSLQRNPEPQCPPRLDAQTLVS VLWSRMPNTFLSVETARVSERHGWVVLCLEPLQMMAVHIPEENRCIDIMELSENEDLRQF HYHTLKLFCALCALGNTRVAHVLCSHFDQSQLLYTIDNQYLSGQLREGFYGVLISIHLET AKEAHLMMNNEFIIPVTDETRSIRLFPDDSKRHSLPGVGLSTSLAPRFNFTPPCFITPKR EQPLFSPQIPLDILKEKAISMLTEAVQGGGAHIRDPVGGSVEYQFVPILKLIGTLLIMGA LTSEEVRTILLLIDPSVFGDSKEEEEQTAVAEQGAEKEEATSNEEKAVEAGEEESKEAKQ PPKGLLEKSLPESVKRQMCELLHYFCDCELKQRIEAIVAFSDDFVSKLQYNQKFRYNELM QAFNMSAAVTAKKTREFRSPPQEQINMLLNFSAGDDCTCPEELQEELQGFHDDLRLHCGI PMEEEEEEQDTSLKGRLMSLVYKIKGRPQKTEEKPTEQEQAAPTNLKELISQTMVTWAQE CKIQDPALVRSMFSLLRRQYDGIGELLRALRKSYTVSAKSVGDAINLLASLGQIRSLLSV RMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKNKEIAFPKM VASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLACPAMRGSTPLDVAASSVMDNNS LALALEEPDLEKVVTYLAGCGLQNCPMLIARGYPDIGWNPIEGERYLSFLRFAVFVNGES VEENANVVVKLLIRRPECFGPALRGEGGQGLLAVMKEAIKISEDPALDLPNLPEGSAPIV GEDEEEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTKDL VGIISIPLKMPVINKDGTVTEPDMNASFCPEHKAPMVLFLDRVYGIDDQSFLMHLLEVGF LPDLRASASLDSEVLRSTETALAMNRYIGSAVFPLLTRCAHLFAHTEHYAMLVDSTLHTI YRLSKGRSLTKAQRDAIDECLLAICKHLRPSMLQQLLRRLVFDVPQLTEYCKMPINLLTN HYEQNWKYYCLPTGLGSYGMASEEELHLTKKLFWGLFDALSQKKYDAELFKMAMPCLSAI AGAIPPDYVDSSPGSTLVKQASVDAQGNFDPQPINTANISLPEKLDYIASKFAEHSHEKW SSEKIALGWTAGDKVDDKAKTHPLLKPYKALSEKERETYRYPVKETLKSMLALGWNIERT KEGEAMFQQRETEKQRKISEFSQGEFIPAPQDLENVILSRELQAMVETVAENYHNIWAKK KKKELGSKGGGSHPLLVPYDTLTAKEKYRDREKAQELFKFLQVNGYAISRGLKDMEQDSS SMEKRIAYKFLKRLLNYVDSAQEFIAHLEAMASSGKTEKSPHDQEIKFFAKVLLPLLDQY FKNHCLYFLSSPNISLSSSGYASNKEKEMITSLFYKLAALVRHRISLFGSDSTTMVSCLH ILSRSLDFRTVMKSGSELVKAGIRTFFENAAEDMEKTLENLKLGKLGQSHTQMKGVTHII SYTSAALLPILTVLFQHITQHQFGAELLLDDIQQSCYRILTSLYSLGTGKNIYVEKQLPV LGECLSTLVGAMPVAFLEPHLNMHNPQSVFNTKTPRERAILSMPDTVDEMCPEMPQLDGL MKDIGDISESGARYTEMPQVIEVILPMLCNYLSYWWAKGPESSPANTNCSTIVTSEHLSL ILGNILKILNNNLGIDNAPWMKRLAVYTQPIISKASPDLLRTHFLPTLEKLKKKTVKIVA EEELLRSESRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKQPDSDSTEL FKMVSEIFILWCKSHNFKREEQNFVVQNEINNLAFLTGDSKTKMSKSGGQDQERRGKRRK GELYSIQTSLIIAAHKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRKNLHL QEKSADPAVQWQLNLYKDVVVKNEGPPDPEQNVERVQAISAAVYHLDQVEQPLRNKKMVF QKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLSGYQRLWIETEEYSFEEKLVQDLAKT PMTVVEEEEEEEAEVQPDPLHQLILHFSHNALTERSFLEEDPLYIAYADMMAKSCAENEE EEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLKLGIS ILNGGNVLVQQKMLDYLKEKRDAGFFKSLSGLMMSCSVLDLNAFERQNKAESLGMVTEEG STNMRERGSKVLQNDDFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDYL LRLQESISDFYWYYSGKDVIDEAGQLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHS RLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTIGKQ MVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPDRKGVISKKEFHKSMDSQKQY TQSEIEFLLSCVEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLSTF LDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVN EGGESEKMELFVNFCEDTIFEMQLASQISEPDAAERPEEEDEEEMHSLLEGLSEEEDASL ESASAFIAACASVKKSMSDFRKMLTFKSMRKQFKKFRKLTIREIITGFFSFFWMLFTGFF KGIFSIIFGFFHIIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHSDVLEAEKTESS ELVVSADMVQMTGAAAEKLETDMIMDLLNPAVKKEGKHGAEPGLGDVCEVLTESSAPVEK KKSQNVAAEKPEFEPEKADTENQEKEDKAKEETPEEPAAAKPAPTAKRGSPKEDSPAFMA SFFAGLEVYKTKMLNYLARNFYNLRFLALFVAFAINFILLFYKVTGEFDEEEEGSWGGEE EEGDEDDEGMEYFILQESTGYMAPTLTFLAVLHTIISLLCVVGYYCLKVPLVVFKREKEI ARKLEFDGLYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDLYGAERI AELLGLDKSALDFDPTEEAVVKEASLVSWLSSIDTKYHIWKMGVVLTDNSYLYLIWYTTM SILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNKSEDEDAPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIVDPAGDPYELYRILFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETH TLQEHNLANYLFFLMYLINKDETEYTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14580 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggtggtgaaggggaagatgaggtccagttcttacgaactgatgatgaggtg gtactgcagtgtgtcgccgccattcagaaggagaatcgcaaattctgcctatcagcagag ggactcggcaaccgcctgtgttatctagaacccacatcagaggcgaagtattttcctcct gacctatgcatctgtaactttgtgctggagcagtcgctctcagtgcgggctctacaggag atgctcgccgggcagaacggtgaaggaaggcttataagacgggcagcacagggaggtgga catcggacactgctctacggtcacgccatcctccttaggcattccttcagtggaatgtat ttgacatgtctgaagacttccaggtctctgacagacaaactgtcttttgatgttggcctt caagaggattcaactggggaagcttgttggtggacaattcacccggcatccaagcagagg tcagagggtgagaaggtgcgcattggagatgacctcatcttggtcagcgtgtcctctgag aggtacctgcacctctccatctccaatggaagcattcaagtggatgcctcattcatgcaa acactgtggaacgttcagcctacctgctccagaagcaacttggaagtggggtttcttttg ggtgggcatgtgatacgcttgttccgtgggcacgacgagagtctcaccattccaggatcc gagcaaagccaagagcaacagagagtggtgaactatgagaccggcaaaggagggtccaag gccaggtctttatggagactggagcctcttcggataagctggagcgggagtcacatcaga tggggtcagcccttccgcctccgccatctctccaccggttactacctgggtcagacagag gaccatggcctgatactgctggacaaagagaagtctgacaccactgcaacagccttctgt ttccggccaagcaaggaaaagattgactccggcccaaagcgtgatattgatggtatgggg gtcgcagagatcaaatacggcgattcgttctgcttcatcatgcatgtgtccacggggctg tggttgtcctacctggcacctgacgccaaatcttctcgcctgggaccaccgaagagaagg gctgtcctgtctcctgagggccatatggatgacgggctgactctgcagctttgccagcac gaggagtcccgggcggctcgcatcattcgtaataccacccgcctcttcactcagttcatc aggggtctggatggtttgaatggggagaagacagcagaggtgacactgcatgtgtgtgaa gtgctgcagacactcggtgacctcatcgtgtacttccagcagcctgactctgagctcgaa catgaggagaaacagaggcagctccgatctctcatcaagcgccaagatctcttcaaagaa gagggaatgctaaccctggtctcacactgcatcgatcgcctaaacgtgtacaacagtgtc gctgagtttgaggaattagcaggtgaagaggctggagaggcgtggaaggacattctcaac ctcctctatgagcttctggccactctgattcgaggcaacaggaccaactgcacacagttc tctcgcaagctggattggctagtcagcaagctagagcggctggagtcctcatcaggcatt ttagaggtgcttcattgtatcctaatcgagagtccagaatctctgaacatcatccagaag gcccacatcaaatccattatttctctgctgtacaagcatggacgcaaccacaagattcta gatgttctctgttccctgtgtgtctgcaatggtgtggctgtgagagccaatcagaatttc atctgtgaccacctgcttcccaggagagacctactgctccagacacgactggtcaatgat gtccaaagtatgagatccaacatcttcctgggcatgagtgagggctcggcacagtataag aaatggtactttgagctgatcatcgatcaagtagaccactatgtgaccaatgagcccacc caccttcgtgttggctgggccaccaccaaaggctacgccccctatcctgggggtggagag ggctggggaggaaatggtgtgggtgacgatctttactcctatggttttgatgggcttcat ctgtggtcagggcgaatcccacgggccgtggcctctattaaccagcacttgctgaattca gatgatgttgtgagctgttgtcttgatctcggagccccttgcatgtctttccgaattaac ggtcagcctgttcaaggcatgtttgaagacttcaacatagatggcttcttctttcccgtc atcagtttctctgcaggggtcaaggtccgtttcttgttgggtggtcgccatggagacttt aagttcctgcctccagcaggctatgcaccatgttatgaagccctgcttcccaaagaaaag atgcgtgtggagcctgtgaaggagtataaaagagacctggagggagtgagagatctgctg ggcaccacagatttcctgtcccaggcttccttcattcctgttcctgttgacaccagccag attgtcctgcctccgcatcttgaaaatgtgcgggacaagttagctgagaacatccatgag ctctggggcatgaacaaaatagagcttggctggatgtatggcaaggtccgagatgacaac aagagacagcacccttgtctttttgacttctctaaactgccagaaacagaaaagaattat aacctgcaaatgtcaactgaaactttgaagaccctacttgctttgggatgccatgtcgca caagtcaatatgaatgctgaagacgacctgaaaaaaatgaaactccccaagaactacatg atggcaaatggttataaacctacaccactggacctctctgatgtaaaactgacacctggt caagaggttctggttgataaactggctgaaaatgctcataatgtttgggccaaagatcgc ataaaacaaggatggacctatggtattcagcaggatttgaaaaaccgtcggaatccacgt ctggtgccatatgctttattagacgaacgcactaagaaatcaaacagagacagtcttcga gaggccattcgtactctggttggatatggatatttcatagacccacctgatcaagagact gctcacacagtagagaaggaaggcatcgaatccatccgtctcttccgtgtggagaagatc tacgctgtgaagacagggaagtggtattttgagtttgaggcgctcactggaggtgacatg caggtgggctgggcacggcccggatgcagacctgataaagaactgggactagatgaccag tccttcatctttgatggctacaggggccgccgggttcatatgggcagtcatttctttggg aggacgtggaataaaggagatgtggtgggctgcatgatcaacatggaggacaaatccatg atattcaccctgaatggagagatcttaatcaccaacaagggctctgagctctgctttgcc gactttgaaactgaagatggattcatcccagtgtgcagcctgggtctttcccaaattggc cgcatgaatttaggaaaagccgctagtacttttaagtactacactatgtgtggccttcag gagggctttgaaccctttgctgtcaacatgaatcgagaggtcaccatgtggttcagcaaa cgcctgcctacgtttgttaatgtaccagaggaccatccccatattgaggtcactagaata gatgggactgtggacacacctccatgtctaaaggtaacacacaagacatatgggacccag accagcaatgatgacatggtctgttgtcgtctaagcatgcctgttgagttccactctggc cctcggaagacaactgatatcaatgaggtgatcgctgaggaccaaagagccaagaaggat gatggaggcaagactgattatggcagcattacaaagcacttctactctgtgagagtgttt gctggacaagatccatcgtccgtttgggtgggctgggtgacaccagactaccactactac agcaaatacttcagcctcagcacagttcgcactgtcactgtaacgctgggagatgagcag ggacgtgttcacgagagtgtgaggaggagtaattgttacatggtctgtgctggtgatgtt gtcagcggctccacaggccgtagtaacactgatctggagattggctgctccatagacctg gcctcaggcctggtttcattcactgccaatggcagagatctgcctactgcataccaggtt aagcctaacactaagctcttccctgctgtgtttgttcaacccacgagtcccaacctcttc cagtttgagtttccaaaaatcccagatgcaatgcccctgtcttcggccatctttaagagt ttacaaagaaacccagagccccagtgtcctcctcggctggatgcgcagacacttgtgtct gtgctgtggagcagaatgcccaacaccttcctgtctgtggagactgcccgcgtgagtgaa aggcatggctgggtggtgctgtgtctagagcccttgcagatgatggctgttcatatccca gaggagaacaggtgtatcgacatcatggaactatcagaaaatgaagatctacggcagttc cactatcacactttaaaactcttctgcgccctatgcgccctgggcaacacccgcgttgca cacgtcctctgtagccattttgaccaatcgcagctcttatacaccattgataaccagtac ctgtctggtcaactgcgtgaaggcttttatggtgtcctcatcagcattcacctggagacg gccaaagaggcccatctcatgatgaacaatgagtttataatcccagtaacggacgagacg aggagcatccgcctcttccctgatgactctaagcgccactctcttcctggcgtaggcttg agcacttcacttgcccctcgtttcaacttcacccctccgtgtttcattacccccaagcgc gagcagcctctcttcagcccacagatccctctggatatcctgaaggagaaagccatcagc atgcttacggaagccgttcagggcggaggcgcccacattcgagatcctgtgggcggaagc gttgagtatcagtttgtgccgattctcaagctgattggcaccctgctgataatgggggcg ctgaccagtgaggaggtgaggaccatcctgcttctcattgaccccagtgtgtttggggac agtaaggaggaggaggaacagacagcagtggcagaacagggagccgagaaagaggaggcc accagtaatgaagagaaggctgtggaggctggagaggaagagagtaaagaggccaagcag cctcccaaaggtctactggagaaaagtttgcctgaatcggtcaaacggcagatgtgtgaa ctgctgcactatttctgtgactgtgagttgaagcagcgcattgaggctatagtggccttc tcagatgattttgtgtccaagctgcaatacaatcagaagttccgctacaacgagttgatg caagccttcaacatgtcagctgctgtcactgccaagaagacaagagagttccgctcacct ccccaagagcagataaatatgttgttgaacttcagtgctggtgatgattgcacctgccct gaggagctgcaagaggagcttcaaggcttccatgatgacctgcgactgcattgtggcatc cctatggaggaggaagaggaggagcaggacacatctcttaaaggccgcctaatgtccctg gtatacaagattaaaggtcgtccccaaaaaactgaggaaaaaccaacagagcaagaacag gctgctcctaccaacctgaaggagctgatatctcagactatggtcacatgggctcaggag tgcaagatccaagacccggcactggtccgcagcatgttcagccttttgagaaggcagtat gatggcatcggtgagctgctcagggccttgaggaagagctacaccgtcagtgccaagtct gtaggggacgcgatcaacctgttggcctcactgggccagatccgttcactactcagcgtc cgcatgggggaagaggagggccagctcatgatcgatggcctgggggacatcatgaacaac aaagtgttttaccagcatccaaatctgatgcgtgttcttggcatgcatgagacagtaatg gaggtcatggtcaatgtgctgggaggagacaagaataaggagattgccttccccaagatg gtggccagctgttgtcgcttcctgtgctacttctgtcgcatcagccgtcagaaccagaag gctatgtttgaccacctgagctacctcctggagaacagcagtgtggggctggcatgccca gccatgagaggatccacacctttagatgtggctgcctcctctgtaatggacaacaacagt ttagctctggcacttgaagaacctgatcttgagaaggtggtgacatatctggcaggctgt ggcttacagaactgcccaatgctcattgccaggggatacccagatatcggctggaaccca atagaaggagaacgctatttgtccttcctacggtttgctgtctttgtcaatggtgaaagt gttgaagagaacgctaatgtagtggtgaagcttttgatcaggcgtccggagtgctttgga cctgctctcagaggagagggagggcaaggtttactcgctgtcatgaaggaagccatcaag atctcagaagatcctgctttagatctgcctaatttacccgaggggtctgcacctatcgtc ggagaggatgaagaggaggaggaggtcgcccacatgggcaactctattatgtccttctac tcagcccttattgatcttctgggccgctgtgcacctgagatgcatcttataaacaaaggc aaaggtgaagcactgcgtatccgtgccatcctccgttccttagttcccactaaggatttg gttggaattatcagtattccactcaaaatgccagtcatcaataaagatggcactgtgaca gagccagatatgaatgccagtttctgtccagagcacaaggcacccatggtgcttttcctg gaccgtgtctatggcattgacgaccaaagcttcttgatgcacctgctggaggtgggcttc ctgccagacctgcgagcatcagcctccctggactcggaggtgctcaggtccacagagaca gccctggccatgaaccgctacattggatccgcagtgtttcctctgttgacccgctgcgct catctgttcgctcacactgagcactatgcaatgctcgttgactccacgctgcacactatc tatcgcctctcaaagggccgatcactcaccaaggcccagagagatgctattgatgaatgt ctactggccatctgcaagcacctgcggccatcaatgctacagcagcttttgcgtcgtctt gtatttgatgttccacagcttacagagtactgcaagatgcccattaatcttttgaccaat cactatgagcagaactggaagtactactgtctgccaacaggcctgggcagctatggaatg gcatcagaggaggaactccacctcaccaagaaactcttctggggactttttgatgctctt tctcaaaagaaatatgacgcagagcttttcaaaatggccatgccgtgtctgagtgccata gctggtgccataccacctgactacgtcgactccagtccaggttccacattagttaagcag gcctctgtggatgcgcaaggcaactttgaccctcagcctattaacactgctaacatctcg ctgcctgaaaagctagattacattgcaagcaagtttgctgagcattcccatgagaaatgg tcctctgagaagatcgctcttggctggactgcgggagataaagtagatgacaaagctaaa actcatccactgctgaaaccgtacaaagcactgagtgaaaaggaaagggagacttaccgc tatcctgtgaaagagactctaaagagcatgttggcattgggatggaacattgagaggacc aaagaaggagaggccatgttccagcaaagggaaacagaaaaacagcgcaagatatcagag ttctcacagggtgagtttattccagccccacaagatttggaaaatgttattctatcaaga gaactacaggcgatggttgaaacagttgcagaaaattaccacaacatttgggcaaagaag aagaaaaaggaacttggcagtaaaggaggaggaagtcatccattgttggtaccatacgac acgctgacggcaaaggagaagtacagagatcgagaaaaggcccaggaactctttaaattc ctgcaggtcaatggatacgccatcagcagaggtctgaaggacatggagcaggattcctct tctatggaaaagaggatcgcctataagttcctcaagaggctcttgaattatgtagattct gcacaggagtttatcgctcatcttgaggctatggcttccagtgggaagacagaaaaatct ccccatgatcaagagatcaagttttttgctaaggttctgctgcccctcctagaccagtac ttcaaaaaccactgcttgtactttctgtcatcccccaacatcagcctgagcagcagtggc tatgcatccaacaaagagaaggagatgatcaccagtctattctataagctggcagccctt gtcagacatagaatatcactctttggaagtgactccaccaccatggtgagctgcttgcac atcctgtcacgctccctggacttcaggactgtgatgaagtctggctcagagctggtgaag gctggtatcaggacgttcttcgagaatgcagcagaagacatggagaagactctggagaac ttaaagctggggaagttgggtcagtcacacacccagatgaagggcgttacgcacatcatc agctacacctcagcggccctgctgcccatcctgacggttctttttcagcatatcacccaa caccagtttggagcagagctgcttttggatgacattcagcagtcctgctaccgcatcctg accagcctctactctttgggcactggcaagaacatctatgtggaaaaacagcttccagtg ctgggtgaatgtttatctactctggttggagccatgcctgttgcattcctggaaccccac ctaaatatgcacaatccccaatctgtcttcaacaccaagacaccaagggaacgagctatt ttgagcatgccagacactgtggatgagatgtgtcctgagatgccccaactggacggcctg atgaaggacattggtgacatttctgaatccggagcacgctacacagagatgccacaggtc attgaggtcatcctgcccatgttgtgtaactacctgtcttactggtgggcaaaaggccca gaaagctccccagctaataccaattgcagcacaattgtcacatctgagcatctcagtcta attctgggcaatatccttaagattctcaataacaaccttggcattgacaacgccccgtgg atgaaaagacttgcagtatacacccagcctatcattagcaaggctagcccagatcttctt agaacgcacttcctgccgacgctggagaaactgaagaagaagacagtgaagatagtggct gaggaggagctgctgaggtctgaaagcagggcagacactcaggaagctgaactgcagatt ctggatgagtttgctgttctctgcagggatctgtatgccttctatccaatgctcattcgt tatgtggacaacaacagatccaaatggctgaagcaaccagattcagattcaactgaactt ttcaaaatggtgtcagagattttcatcctttggtgtaaatctcataactttaaaagggaa gagcaaaattttgtggtgcaaaatgaaattaacaacctggcgttcctcactggagacagc aagacgaagatgtcaaaatctggaggtcaggaccaagagagaagaggaaaaaggagaaaa ggagagttgtactccatccagacttcccttatcatagcagctcacaagaagatgttgccc attggtctgaacatgtgcactcctggagaccaggagctcatttcccttgccaagatccgt tacagtctgaaagacacagatgatgaggttaaggattacctgaggaagaacctccatctt caggagaagtcagcagatccagcagtgcagtggcagctgaacctctacaaagatgttgtg gtgaagaatgagggacctccagacccagagcaaaacgtggagagagttcaggccatctcc gcggctgtctaccaccttgatcaggttgagcagccgctgaggaacaagaagatggtgttt caaaagctgctgtcaaagcaaagaaagcgtgccgtggtggcctgtttccgcatggcacca ctctacaacttaccaaggcatcgctcaattaacctcttcctcagtggctatcagagactt tggatagagacagaggagtactcctttgaggagaagctagtgcaggacctggcaaaaact cccatgactgtggtagaggaagaagaggaagaagaagctgaagttcagccagaccctctt catcagctcatccttcacttcagtcacaatgctctgacagagagaagtttcctagaagag gatccactctacattgcttatgctgacatgatggcaaagagctgtgccgagaatgaggaa gaggaagaggagggaaaagaaaaaacttttgaggaaaaagaaatggagaagcagaagatt ctttaccagcaggccagacttcacgcccgaggggctgctgagatggtgctacagatgatc agtgccagtaaaggccgacttggtcccatggtgactggcacccttaaactgggcatttct atcctaaatggaggcaacgttcttgttcagcagaaaatgctggattatttgaaggaaaaa cgagatgcgggtttctttaaaagtttatctggactaatgatgtcatgcagtgtgctggat ttaaatgcatttgaaaggcaaaataaggcagagagtcttggaatggtgactgaagagggg tcaaccaacatgagagagcggggttccaaagtcttacaaaatgatgactttacaaaggat ctattcaggtttttgcaacttctgtgcgagggacacaataatgatttccaaaacttcttg cggacacagaccggaaacactactacagtcaacatcatcattagcactgtggactacttg ttgcgtctacaggaatctataagtgatttttactggtattactctgggaaagatgtcatt gacgaggctgggcaacttaacttctccaaagctttggcagtagccaaacaaatctttaac tcactcactgagtacattcagggcccttgtattgggaatcagcaaagtttggcacacagc aggttgtgggacgcagtggtcggattcctgcatgtttttgcaaacatgcaaatgaaactg tcacaggattctagtcaaatcgagttattgaaagagctgatggatttgcagaaagatatg gtggtcatgatgttatctcttttggagggtaatgtggtgaatggaactatcggtaagcag atggttgacacattagtggagtcctccagcaatgtggaaatgatcctcaagttcttcgac atgttcctcaaactgaaggacctcactacatctgataacttcaaggagtacgacccagat cgcaaaggcgttatatccaagaaggagttccacaagtctatggatagccaaaagcaatac acacagtctgagatcgagtttcttctctcctgtgtggaggcagatgaaaatgacatgttc aactacaaggagtttgtggaacgcttccatgaaccagccaaggacatcggcttcaacgtg gctgtgcttcttactaacctatcagagcacatgcctcacgactcacgcctgtccaccttt ttagacctggctgaaagcgttctcagttactttgagccgtacctgggccgcattgagatc atggggggtgccaagaggattgagagggtttactttgagatcagcgagtctagcagaacc caatgggaaaagcctcaggtcaaagagtccaaacggcaattcatctttgatgtggtcaat gaaggtggtgagagtgagaagatggagttatttgtgaacttctgtgaggacactatcttt gagatgcagctggcctctcagatctctgagccagatgcagcagaacgacctgaggaggag gatgaagaggagatgcacagtctgcttgaaggcttgtctgaggaggaagatgcatctctt gagtcggcctcggccttcatagcggcctgcgcctctgtgaagaagagcatgtctgatttc cgtaaaatgctgacgtttaagagtatgaggaaacagtttaagaaattcaggaaactgacc atcagggaaattatcacagggttcttctccttcttctggatgctcttcaccgggttcttc aaaggcattttcagcatcatcttcgggttcttccatattatttggtcctccatgtttgga gggggtcttgtggagggtgctaaaaacatgaaagtgacagatatcttgggtaacatgcct gatccaacacagtttgggatccatagtgatgtactggaagcagaaaaaactgagagcagc gagttggtggtgtcggcagatatggtgcagatgactggcgctgctgctgagaagctggag acagatatgatcatggatctacttaatccagctgtgaagaaggaggggaagcatggggca gaacctggtcttggtgatgtctgtgaagtcctgacagagtctagcgcccctgttgagaaa aagaagagccagaatgtagcagcagagaagccagaattcgagccagagaaagctgacact gagaatcaggagaaagaagacaaggctaaagaggaaacacctgaggaaccagcagcggca aaaccagctccaacagccaaacgtggctcaccaaaggaagactctccagcattcatggcc agcttctttgcagggcttgaagtctacaaaaccaaaatgctgaactacctggctcgcaat ttctacaaccttcgttttctggccctgtttgtggcctttgccatcaacttcatcctgctc ttctacaaggtgactggagaattcgatgaagaggaagagggatcctggggtggtgaagag gaggaaggtgatgaagatgatgaaggaatggaatacttcattcttcaggagagcactggc tacatggcacccacattgacgttcttggctgtactgcacacgatcatctccttactctgt gtcgttggatattactgccttaaggttcctttagttgtgttcaagcgggagaaggagatc gctaggaagcttgagtttgatggtttgtatattaccgagcagccgtctgatgatgacatc aaaggacagtgggatcgtttggtcattgcaactccgtccttccctaacaattactgggac aaatttgttaagaggaaggtcatcaataaatatggtgacttgtacggggctgaacgcata gctgaactcttgggtctggataagagtgctctggactttgatcccactgaagaagccgtg gtgaaggaagcctccctggtgtcctggttgagctcaattgataccaagtaccacatctgg aaaatgggggtggtgctgacggacaactcttacctctacttgatctggtacaccaccatg tctattttgggacattacaataacttcttctttgccgctcatttgctggacattgccatg ggcttcaagaccttgaggaccatcctctcttctgtgacccacaatggcaaacagctggtg ttgaccgtggggctcctggcggtcgtggtctacctgtacaccgtggtggcttttaacttc ttccgcaagttctacaacaagagcgaggatgaggatgcgcctgacatgaagtgtgatgat atgatgacttgctacctgttccacatgtacgtgggtgtgagagctggcggtggcatcggt gatgaaatcgtggacccagccggtgacccatacgagctctaccgcattctgtttgacatc accttcttcttctttgtcatcgtcattctgctggccatcattcagggtttgatcattgat gccttcggtgagttgagagaccagcaggagcaggtgaaagaggacatggagacaaaatgc ttcatctgtggaattggaaatgactacttcgacagaaccccgcatggctttgagacccat accttacaagagcacaatctggccaactatttattcttcctgatgtatcttatcaacaaa gatgagactgaatacactggtcaggagtcgtatgtttggaagatgtatcaggagaggtgc tgggatttcttccctgccggagactgtttccggaagcaatacgaggaccagctgggctag

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