Solea solea (common sole): 131443370 Help Entry 131443370         CDS       T10853                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism ssoe  Solea solea (common sole) Pathway ssoe04020   Calcium signaling pathway ssoe04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ssoe00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     131443370 (ryr3)    04020 Calcium signaling pathway     131443370 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ssoe04040]     131443370 (ryr3) Ion channels [BR:ssoe04040]  Voltage-gated cation channels   Ryanodine receptor    131443370 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  131443370 NCBI-ProteinID:  XP_058468924 LinkDB All DBs Position 17:complement(16861615..16993876) Genome browser AA seq 4853 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRICYLESTSEAKNVPP DLCICNFVLEQSLSVRALQEMLANTGQSNEGTADHEKWAGQGGGHRTLLYGHAILLRHSF SNMYLTCLKTSRSMTDKLSFDVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSISNGNIQVDASFMQTLWNVQPTCSSSNMAVGYLTGGHVMRLCHGHDESLT IPGADKSEKEQRIVNYEAGKGASKARSLWRLEPLRISWSGSHIRWGQAFRLRHLSTGHYL ARTEDRGLVLQDREKSDTKATAFCFRPSKEKGDSGPKRDIDGMGVPEVKYGDSVCFVMHV ESGLWLSYLAPDAKSSRLGPLKRRACLHSEGHMDDGLILQRCQHEEFRAARIIRNTTFLF ANFIKALDRTEKGESNVVGGFVEEVLQTLNDLIEYFKQPDSELEHEEKQCLLRSLIKRQD LFKEEGMLTLLSKCIDRMNLYNSAAHFGEVAGEEAGAAWKDILNLLYELLASLIRGNRNN CTQFSCNLDWLVSKLERLESSSGILEVLHCILVESPEALNIIQRGHIKSIISLLYKNGRN HKILDVLCSLCVCNGVAVRANQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGMAEGS AQYKKWYFELVIDQVDHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGL FFPAVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMRIEAVKEYKRDHDGV RDLLGTTQFLSQASFIPTPVDTTQIVLPPHLDNVRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFAKLPETERNYNLQMSSETLKTLLALGCHVAQVNVHAEDDLKKIKLP KDYMMSNGYKPAPLDLSEVKLSPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNR RNPRLVPYALLDERTKKSNRDSLREAIRTVVGYGYDIDPPDQEVLHTDNDHSVETIRFFR VEQTYAVKTGKWYFEFEILSGGDMRVGWARPGCRPDLELGEDDQAFVFDGYRGRRLHAGS RYFGHPWKKGDVVGCMIDMEDKSMIFTLNGELLITSKGSELCFTDFEAEDGFIPVCSLGM SQIGRMNLGKDARTFKYYTMYGLQEGFEPFAVNMKRDITKWFSKRLPTFVNVPKDHMHVE VTRIDGTVDSPPCLKVTHKTFGTQNSNSDMVFCRLSMPVEFYSADKLLDESLKLSHAPKE DGTVDYASITQYYHSVRVFAGQDPALVWVGWVTPDYHYYSKNFSISKTQTVTVTLGDERG RVHESVQRSNCYMVCAADAVGPSPAGNTDLEIGCLIDLATGILSFTANGKELPTSYQVEP NTKLFPAVFIHPTSANLFQFEFVKVKDAMPLSSAIFKSEHRNPVPQCPPRLDVQTIVAVL WSRMPNTFLSVETARVSERHGWVVQCLEPQQMMVVHIPEENRCLDVLELSEHEDLRKFHY HTLRLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETAK EARLMMNNEFIIPLTDETHSIQLFPDESKRHSLPGVGLSTSLKPRVNFSPVSIINTKRHQ YLYSPQIPLVILKEKAISMLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLIMGVLT SDEVQLILLLIDPNVFGETNEGEEGKADEVAAAGEKEEVNKNEEKAVEAGEEEMKESKSP AKGLLEKSLPESVKRQMCELLHYFCDCELKHRIESIVSFSDSFVSKLQFNQKFRYNELMQ ALNLSAAVTAKKTKEFRSPPQEQINILLNFTAGEDCPCPPEIQEELNAFHEELRLHCGIP MEEEEVEQDTSIKGRLLALLYKIKGPPQKTEEEPTETEQAAPTNLKELISQTITSWAQES HIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLSVR MGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPKMV ASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGL ALALEEPDLEKVVMYLAGCGLQSCAMLVAKGYPDLGWNPIEGERYLSFLRFVVFCNGESV EENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPKTAAGVTTGSG EEEGEIIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLVGI ISIPLRMPMVNKDGTVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGFLPD LRASASLDTEVLSTTESALAMNRYIGSALLPLLTRCATLFANTEHYAQLIDSTLQTIYRL SKGRSLTKAQRDSIEECLLAICKHLRPSMMQQLLRRLVFDVPMLTEYCKIPLQLLTNHYE QNWKYYCLPSGMGSFGIASEEELLLTKKLFWGIFDSLSQKKYDADLFKMAKSCLCAIAGA LPPDFVDSSLGATLEKQGSVDAQGNFDPKPINTANISLPEKLEYIANKYAEHSHDQWSSE KVSAGWKHGDSVDEQNKTHPLLKAYKALSEKERETYRWPVRESLKSMLAIDWSIEWTKEG EAMFQQRESEKQKKMSESQVNGFSPAPMELHNVTLSRELQGMVEVVAENYHNIWAKKKKT ELLSKGGGTHALLVPYDTLTAKEKYRDREKAQELFKFLQISGYAITRGLKDMEHESSSME KRFSFKFLKTMLKYVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLIDQTFKN HCLYFLSTPSKNLSSCGCASNKEKEMLTSLFCKLAALVRHRISLFGSDSAIMVSCLHILT HSLDTRTVMKSGSELVKAGFRTFFENAAEDLEKLLEMLKLGKFMQSRAQMKSVTSSIHYV TVALVPILTALFEHIRSHEFGVDLLLDDVQLSCYRILTCFYCLGTGKNIFVERHLPALGE SLATLVGAMPVAFLEPHLNAHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKLLKD VSDVSESGARYSDMPQVIEVILPMLCNYLSYWWEKGPENSPPDSHCCTMVTSEHLSIILG NILKILNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTLDKLKKKTVKVVAEEE LLKADGKGDNQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDAYSTELFRM VADIFILWCKSNNFKREEQNFVVQNEINNLSFLTGKGKAKMSKSGGDQERKHKLRRGEYY SIQTSLIVAALKKLLPIGLNMCTAGDQELISLAKMRYSLKDTDDEVKEHLRQNLHLRDKS DDPAVQWQLDLYRDVVVKSEEPAPPEQTVNRVQSISNAVFHLEQVEQPLRNKKCVWQKLM SKQRKRAVVACFRMAPLYNLPRHRAINYFVPVYQRLWIEAEEYSFEEKLVQDLAKTPMKI VEEEEEEVAEIQPDPLHQLILHFSHNALTERSYLEEDPLYIAYADMMAKSCAEDEEEEEE EEGKEKTFEEKEMEKQKTLYQQARLHARGAAQMVLQMISASKGRLGPMVTCTLKLGISIL NGGNVQVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSC HSERASKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLRL QESISDFYWYYSGKDVIDETGKLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLW DAVVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMVD TLVESSNNVEMILKFFDMFLKLKDLTTSDNFREYDPECKGIISKKDFQKSMENQKQYTQT EIDFLLSCAEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLATFLDL AESVLSYFEPYLGRIEIMGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGG ESEKMEMFVNFCEDTIFEMQLASQISEPDEVEQPEEEEDEEVHSILDELAAEDGDTMESA SAFSTACSAVKSKLANIRQMFSIKNLRKQFKKVKKLSIREIITGFFSFFWMLFFGFFKGI YSLIFGFFHVIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHSDVIEGDKVEAVESA GSLDTAMAPSGDPAEVDMMLEMLMVPKREGGKHMEPGLGDVSELSGETTSDHKKKAAAQP TETTENVPEKADTENQEKGDKPKEEEAKEPVMEEEKPKTRSSQAKEAAPAFMSYMFAVLD VYRNKTLNYFSRNFYNLRFLALFVCFAINFILLFYKVTGETEEEEDEENSWSEEEDDENT LFDMDEFVLQESTGYMLPTLRFLSKFHTVISLLCLVGYYCLKVPLVVFKREKEIARKLEF DGLYITEQPSDDDIKGQWDRLVINTPSFPSNYWDKFVKRKVINKYGDLYGAERIAELLGL DKSALDFDPTVELVEKEASLVSWLSSIDTKYHIWKMGVVLTDNYFLYLIWYTVMSVFGHF NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYN KSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFV IVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHN LANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14562 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggagaagatgagatccagttcttgagaactgacgatgaggtg gtgctacagagtgtggccaccatccagaaggagcatcgtaagttctgcctggccgctgag ggactcgggaaccgtatatgttacctggaatccacttcagaagctaagaatgttcctcca gacctgtgtatttgtaactttgtgttggagcagtccctgtcggtgcgagccctgcaggag atgctggcaaacaccgggcagagcaacgaagggactgctgaccatgaaaaatgggcgggt cagggaggtggacaccggaccctgctctacggtcacgccatcctccttcgccactcattc agtaatatgtacttgacctgtttgaagacgtcaaggtctatgacagataagctgtcattt gatgttggactgcaagaagattcaataggagaagcctgttggtggacaatccaccctgcg tctaagcagaggtctgagggagagaaagtccgcatcggagacgacctgattcttgtcagc gtgtcaacagagagatacctgcacctctcgatctccaatggcaacatccaggtggatgcg tcctttatgcaaacactatggaacgtccagcctacctgttcttcaagcaacatggctgtt ggttatctaactggtggacacgtgatgcgtctttgtcacggacacgatgagagcttgacc atccccggagcagataagagtgagaaggagcaaaggatagttaactatgaggcgggaaag ggagcgtctaaggcccgatcactgtggagactggagcctctcaggatcagctggagcggc agccacattcgctggggccaggccttcagactacgtcacctctccactggccattacctg gcccggaccgaggaccgtggactggtcctgcaggacagagaaaagtccgacaccaaggcc actgccttctgcttcaggccctcgaaggaaaagggtgactcggggccaaagagggacatc gacggcatgggcgtgccagaggtcaagtatggagactccgtctgcttcgtcatgcacgtg gagtcaggactgtggttgtcttacctggcgcctgatgccaaatcgtctcgcctaggaccc ctaaagagacgggcctgcctccattctgagggccacatggatgatgggctgatcctgcag cgttgtcagcatgaagagttccgcgccgcacgcatcatccgcaataccacctttctcttt gccaacttcatcaaggctctggacaggacagaaaagggtgagtccaacgtggtcggtggg ttcgtggaggaggtgctgcagacgctgaacgatctgatcgagtacttcaaacagcctgac tcagagctggaacacgaggagaaacagtgtctcctccgttcgctcatcaagcgtcaagat ctcttcaaagaggagggtatgctgaccctcttgtccaaatgcatcgatcgtatgaacctg tacaacagtgctgcccactttggagaggtggctggggaggaggctggagctgcgtggaag gacattctcaacctcctctacgagctcttagcctcactgattcgtgggaacaggaacaac tgcacccagttttcctgtaacttggactggttggtcagcaaactggagagactggaatct tcatcagggatcctggaagtcctccactgtatcttggttgaaagcccagaggctctgaac atcatccagagaggtcacattaaatccatcatctctttgctctacaagaacggacgcaac cacaagattctggatgtgttgtgttccctctgcgtctgcaatggtgtggcagtgagagcc aatcagaatctgatctgtgacaaccttcttcccaagagggacctgctgctccagactcga ctggttaacgatgttcagagcatgagaccaaatatcttcctgggcatggctgaaggttct gcgcagtataagaagtggtatttcgagctggtgatcgaccaggtggaccactttgtaaca ggagagcccacacacctgagggtgggctgggccaacactaaaggctacgctccgtaccct ggtggaggagagggatggggaggcaacggcgtcggggacgacctgtactcgtacagcttt gatggacttcacctgtggtcaggccgaatcccgagggccgtggcctccattaaccagcac ctgctgaactcggatgacgtggtcagctgctgcctggacttgggcgcccccagcatgtcc ttcaggatcaacgggcagcctgtccagggcatgtttgaggattttaatacagatgggtta ttcttccccgccgtcagcttctctgcaggtgtcaaggtccgtttcctcttgggcggacgc catggagattttaagttcctgcctccggctggttactctccgtgttacgaggcgttgctg cccaaggagaagatgcgcatagaggctgtgaaggagtacaagagagaccatgacggggtt cgtgatctgctgggaaccacccagttcctctcccaggcttccttcatccccactcctgta gacaccacccagattgttcttcctcctcacctggacaacgtccgcgacaagctggcagaa aacattcacgaactgtgggggatgaacaagattgaactgggctggacctatggcaaggtt cgtgatgacaacaagaggcagcacccttgccttgtggatttcgccaagctgcctgaaact gagaggaactacaacctgcagatgtccagtgaaacactaaagaccctgttggcactggga tgccacgttgcacaggtcaatgttcacgctgaggatgatctgaagaaaatcaagctaccc aaagactatatgatgtctaatggatataagcctgcgccactggacctctctgaagtgaaa ctgagcccaggtcaggaggttctagttgataaactggctgagaatgcacacaacgtgtgg gccaaggacagaattaaacaaggatggacctatggcatccagcaggatttaaagaacaga agaaatcctcgcctggtgccgtatgctttactggacgagcgcacaaagaagtccaacaga gacagtctgagagaggccatacggacagtggttggatatggatatgacatcgaccccccg gaccaggaggtcttgcacacggacaacgatcacagcgtcgagaccattcgcttcttccgc gtggagcagacgtatgcggtgaaaactgggaagtggtactttgagtttgagatcctgagt ggaggtgacatgagggtgggctgggccagaccgggctgcagaccggatctggaactggga gaggacgaccaagcctttgtttttgatggatacaggggccgacgtctgcatgcaggcagc cgctactttggacatccctggaaaaagggggacgtggtcggctgcatgatcgacatggag gacaagtcgatgatcttcaccctgaacggagaactcctcatcaccagcaagggctctgag ctttgtttcactgactttgaagcggaagacggtttcatccctgtgtgcagtctggggatg tctcagatcggccgcatgaacctgggcaaggacgccaggacgttcaagtactacaccatg tacggactccaggaaggctttgagccgttcgccgtcaacatgaagagagacatcaccaag tggttcagcaagcgcctgcccacctttgtcaacgtacccaaggatcacatgcatgttgag gtgacgaggatcgatggcacggtggacagtcctccctgcctcaaggtcacccacaagacg tttggcacacagaacagcaacagcgacatggtcttctgtcgactgagcatgcctgtggag ttctactctgcggacaagttactggacgaatcgctgaaactcagccacgccccgaaagaa gacggaacagtcgactacgcaagcatcacgcagtactaccactcagtgagagtgtttgcc ggacaggaccctgctttagtgtgggtgggctgggtcacgccggactatcactactacagc aagaacttcagcatcagcaagacgcagacagtcaccgtcaccctgggagacgagaggggc cgagtccatgagagcgtccagaggagcaactgctacatggtgtgtgcggcggacgccgtc gggccatcccccgccggcaacactgacctggagatcggctgtctgattgacctggccact ggcatcctctccttcactgccaatgggaaggaactgcccacgtcctatcaggtggagcca aatactaagctcttcccagctgtgttcatccaccccaccagtgcaaacctcttccagttt gagttcgtcaaggtcaaggacgccatgccgctctcgtctgccatatttaagagcgagcac aggaaccccgtgccgcagtgtccaccgcggctggatgtgcagaccatcgtggccgtgctg tggagccgaatgccaaacaccttcctcagtgtggagacggcgcgagtcagcgagcggcac ggctgggtggtgcagtgtctggagccacagcagatgatggttgttcatatacctgaggag aacaggtgtttggacgtcctcgagttatccgagcacgaggacttgaggaagttccactac cacaccctgaggctgtactgtgccctctgtgctctgggaaacacccgcgtcgctcacgcc ctctgcagccacctggatcaatcgcaactcctctataccatcgacaaccagtacctctct ggcatgctgagagagggcttctacaatgtcctcatcagcatccatcttgagactgcgaag gaggctcgcctaatgatgaataacgagttcatcatccccctgacggatgaaactcactcc atccagctgttcccagacgagtccaagcgtcactcgctgcccggcgtgggcctcagcacc tccctcaagcctcgcgtcaacttctcccccgtcagcatcatcaacaccaagcgccaccag tacctctacagcccccagatccctctggtcatcctgaaagagaaggctatcagcatgctg acggaggccgtgcagggtgggggcacacacatccgagacccagtgggtggcagcgtcgag taccagtttgtgcccattctgaagctgattgggacgctgttgatcatgggagtcctgacc agcgatgaagtgcagctgattctcctcctcattgaccccaacgtgttcggagaaaccaat gagggcgaggaaggcaaggctgatgaggtggctgcggcgggagagaaggaggaagtgaac aagaatgaggagaaggccgtggaggccggagaagaggagatgaaggagagtaaatcgccg gcgaaaggtctgctggagaagtcgcttcccgagtcggtcaaacgccagatgtgtgagctg cttcactacttctgtgactgtgagctgaagcaccgcatcgagtccatcgtctcgttctct gacagcttcgtgtccaagctgcagttcaaccagaagttccgctacaacgagctgatgcag gcgctcaacctgtccgccgccgtcactgccaagaagaccaaagagttccgttccccgccg caggagcagatcaacatcttgttgaatttcaccgcaggagaggactgtccctgtcccccg gagattcaggaagaactcaacgctttccatgaagaattgcgtctccactgtggtattcca atggaggaggaggaggtggagcaggacacgtcgataaaaggtcgcctccttgctctgctc tataagatcaagggtccacctcagaagacagaagaggagcccacagagacggaacaggct gctcccaccaacctgaaggagctaatctcccagaccatcaccagctgggcccaggagtct cacatccaggacccagagctggttagagtgatgttcagcctgctgaggagacagtacgac ggcatcggggagttgctgcgggccatgaagaaatcctacaccatcagtgctgcgtctgtg caggatgcgatcaacctgttggcttcgctgggtcaaatcaggtctctgctgtcagtgcgc atgggcaaagaggaggagaaactcatgattgatggactcggcgacatcatgaacaacaag gttttctaccagcatcctaatctgatgagagtgctgggcatgcatgagacggtcatggag gtcatggtcaacgtgctgggaggagacaagtcacaggagattgcgttcccgaagatggtg gccagctgttgtcgtttcttgtgctacttctgccgtattagccgtcagaaccagaaggcc atgtttgaccacctgagctacctgctggagaacagcagcgtcggactggcctctgaagct atgcggggctccacgccgctggacgtggcagcatcttcagtgatggataacaacggcctg gctctggccttggaggagccggatctggagaaggtggtgatgtacctggcaggttgcggt cttcagagttgtgctatgctggttgctaagggatacccagaccttggctggaaccctatt gagggagagcgttacctgtccttcctgaggttcgtcgtcttctgcaacggtgagagcgtg gaggaaaatgctaatgtggtggtaaagctgctgatcagacgccccgagtgttttggccct gcactgagaggagagggaggccaaggcctgctggctgctatgaaggaggccatcaagatc tctgaggatcctgctctggaccttcccaagactgctgctggagtcactactgggtctggt gaggaagaaggagaaatcatccacatgggcaacgccatcatgtccttctactcggctctc atcgatctgctgggacgttgcgctccagagatgcatctgatcaatgcgggtaaaggagag gcgctgcgtatcagagccatcctgcgctctctggttcccacatcagacctggtgggcatc atcagcattcccctcagaatgcctatggtgaataaagatggcacagtgacggagcccgac atgtcggcctgtttctgtccggaccacaaggcacccatggtgctcttcctggacagagtg tatggcattgaggaccagagcttcctgctccagatgttggaggtcggtttcctgcccgac ctccgagcctcagcatctttggatacggaggtgctaagcaccactgaatcagcgttggcc atgaacaggtacatcggctcagccctgctgcctctgctgacccgctgcgccactctcttt gccaacaccgagcactacgcccagctgatcgactccacgctgcagaccatctaccggctg tctaaaggccgctcactcaccaaagcccagcgggactccatcgaggagtgtctgctggcc atctgcaagcatctgcgtccgtccatgatgcagcagctgctcaggcggctggtgtttgac gttcccatgctcactgaatattgcaagattcctctgcagctgctgaccaaccactacgag cagaactggaagtactactgcctgccttctggtatgggtagctttggcatcgcctctgag gaggaactgctcctcactaagaaactattctggggaatatttgactccctgtctcagaag aagtacgatgccgatcttttcaaaatggccaagtcgtgcctgtgtgccatcgctggagcg ctgcctcccgactttgtggattccagtctcggggcaacactggagaaacaaggatcagtg gatgcgcagggcaactttgaccccaaacccatcaacactgccaatatctcccttcctgaa aaacttgagtacattgccaacaaatatgcagagcattcccatgaccagtggtcctcagag aaggtgtcagcgggctggaaacatggagatagtgtggatgaacagaataaaactcatcct ctgctgaaagcgtacaaagctctgagtgagaaggagagagaaacataccgctggccagtg agggagtcgttgaagagcatgttggctatagactggagcattgagtggaccaaggaggga gaagccatgttccaacaacgagagagcgaaaagcaaaagaagatgtcagagtctcaggtt aatggattcagtcctgctccgatggaactgcataatgtcacgctgtctagagagttacag ggcatggtggaggtggttgcagaaaattaccacaacatctgggccaagaagaagaaaact gaactccttagcaaaggaggagggacccacgcgctgctggttccctatgacaccctgact gctaaagagaagtatagagaccgagagaaggcccaggagctcttcaagtttctgcagatc agtggctatgctatcacaagaggtctgaaggacatggaacatgagtcatcatccatggaa aagcgcttttccttcaagttcctaaagacgatgctaaaatatgtcgactctgcccaggag tttatcgctcacctggaggctatggccaccagtgggaagacggacaaatcaccccatgac caggaaataaagttctttgccaaggtgttgcttcctctaatagaccaaacctttaagaac cattgcctctacttcctctccactcccagcaagaacctgagcagctgtggttgtgcctcc aacaaagagaaagagatgttgaccagcctcttctgtaaactggcagctcttgtcagacat aggatttctctctttggaagtgactctgccataatggtgagctgcctgcacatcctcacc cactcacttgacaccagaacagtgatgaagtccggctcagaactggtcaaagccgggttc aggaccttcttcgagaacgcagccgaggacctggagaagctgctggagatgctgaaactg gggaagttcatgcagtcccgcgcacagatgaaaagcgtcacctccagcatccactacgtg acggtggcgctggtgcccatcctcactgccctgtttgaacacatcaggtcacatgagttt ggagtggacctgctgttggatgacgtgcagctatcctgctaccgaatcctgacgtgtttc tactgtctgggaacaggaaagaacatctttgtggagaggcatcttcccgcactgggggag agtctggcaaccttggtgggagccatgcctgtcgctttcctggagccgcacctgaacgcc cacaatccgctctccgtcttcaacaccaagactccccgagagagagccattctcagtatg ccggacacagtagaggagatgtgtccagagatgcctcgtctggataaactcctgaaagac gtcagcgacgtttcagagtctggtgctcgctacagcgacatgccacaggtcattgaggtg atcctccccatgctgtgtaactacctttcctactggtgggagaaaggtccggagaactcg cctccagattcccattgctgcactatggtgacttccgaacacctcagcatcatcctggga aatatcctcaagattctcaacaacaacctgggcattgatgatgcgccctggatgaagagg attgcagtctactctcagccaatcatctgcaaggctggagcagatctgctcagaacccac ttcctgcccacgctggacaaattaaagaagaagaccgtgaaggttgtggccgaagaggag ctgctgaaggccgacggcaaaggtgacaaccaggaggctgagctgctcatcctggacgag tttgctgtgctctgcagagacctgtacgctttctaccccatgctcatccgttatgtggac aacaacaggtccaggtggttgaaggagcctgacgcgtactccactgagctcttcaggatg gtggctgacatctttattctctggtgcaagtccaataactttaagcgtgaggagcagaac tttgtggttcagaatgaaatcaacaatttgagcttcctgactggaaaaggcaaggctaag atgtccaagtcaggtggggaccaggagaggaaacataagctccgccgtggggaatactac tccatccagacctctttgattgtcgctgccctgaagaagctgctgcccattggcctcaac atgtgcaccgcaggtgaccaggagctcatctctttggccaagatgcgctacagtctgaaa gacacagatgacgaggtgaaggagcacctgcgccagaatctccatctccgggacaagtct gatgacccagcggtccagtggcagctggacctctatagggacgtggtggtgaagagcgag gaacctgcacccccggaacaaacagtgaatcgagtccagagcatctctaatgcagttttc cacttggagcaggtggagcaacctctgaggaacaagaagtgtgtgtggcagaagctcatg tccaaacagcgtaagcgtgctgtggtggcttgtttccgtatggctccgctctacaatctg cccaggcatcgcgctatcaactacttcgtcccggtctatcagaggctttggatagaggca gaggagtactcttttgaggagaagctagttcaggatctggcaaaaacccccatgaagatt gtggaggaggaggaagaggaggtggctgagatccagcccgaccctctccatcagctcatt ctccacttcagccacaatgctctgacagagaggagttatttggaagaagatcctttgtat attgcgtatgcagacatgatggcaaagagctgtgcagaagacgaggaagaagaagaagaa gaagaagggaaagaaaagacgtttgaggaaaaggagatggaaaagcagaagaccctttat cagcaggcgcggctgcacgctcgcggagcagctcagatggtgttgcagatgatcagtgcc agtaaaggtcgccttggcccaatggtgacctgcaccctcaaactgggaatctccatcctc aatggaggcaatgtgcaagttcagcagaaaatgcttgattacctgaaagagaagagagat gcaggctttttcaagagcctgtcaggactgatgcagtcttgcagtgtcctggacttaaat gcatttgagaggcagaacaaagcagagggtcttggcatggtgacagaggaaggctcatgc cactctgagcgggcctccaaggtgctacagaatgatgagtttactaaagatctgttccgg tttttgcaacttctgtgtgaggggcataacggagatttccagaacttccttagaacccaa actggaaacacaaccacagtcaacatcattatcagcactgttgactatctgctccgtctt caggagtctatcagtgacttctactggtactactcgggcaaagatgtcattgatgagact ggaaaactcaacttctcaaaggctttagctgtagccaagcagatattcaactcactgact gagtatattcagggcccgtgtattgggaaccagcagagtctcgctcatagcagactgtgg gatgcagtagtgggcttcttgcacgtatttgccaacatgcagatgaagctatctcaggat gccagtcaaatcgagctgttgaaggagctgatggatttacagaaagacatggttgtcatg ttactgtctcttctggagggtaacgtggtgaatggaacaattggaaagcagatggtcgac actctggtggagtcttctaacaatgtggagatgatcctcaagttctttgatatgttcctc aagctgaaggatctgaccacctcggacaacttcagggagtatgaccctgagtgcaaaggc atcatttcaaagaaggacttccagaagtccatggagaatcagaaacagtacacacagacc gagattgatttcctgctctcgtgtgcggaggctgatgagaacgatatgtttaattacaaa gagtttgtggagagattccatgaaccagccaaagatatcggcttcaacgtggcggtgctg ctcaccaacctgtctgaacacatgccacacgactctcgacttgccaccttcttggatctg gcagagagtgttctcagctactttgaaccttacctgggtcgcattgagatcatgggcagc gcaaagcgcatagagagggtttactttgagatcagtgagtcgagccgtgaacagtgggag aagcctcaggtcaaggagtccaagcgtcagttcatctttgatgtggtcaatgagggtgga gagagcgagaagatggaaatgtttgtgaatttctgtgaggacaccatctttgagatgcag ctggcctcgcagatctctgagcccgacgaggtggaacaacctgaagaggaggaagatgag gaagtacacagcatcctggacgagctggctgcagaggatggagacaccatggagtcagcc tccgctttctccaccgcctgtagcgctgtcaaaagcaaattagcaaatatccgtcaaatg ttttctattaaaaatttacgcaagcagttcaagaaggtcaagaaactgagcatcagggag attatcacaggcttcttctccttcttctggatgctcttctttggcttctttaaaggaatc tacagcctcatctttggtttcttccatgtcatctggtcgtccatgtttggtggcggcttg gtggagggagcgaagaacatgaaggtgacggacatcctcggaaacatgcctgacccgact caattcggtatccacagtgatgtgatagaaggagataaggtggaggctgtagagtcagca ggaagcctggatacagccatggcaccatcaggagacccagcagaggtggacatgatgctg gagatgctgatggtacctaaaagggaaggagggaaacacatggagcctggcctgggtgat gtttctgagctgagcggagaaacaacctccgaccacaaaaagaaagctgctgcccagccc actgagaccactgagaatgtaccagaaaaagcagacacagagaaccaggagaagggggat aagccaaaggaggaggaggcgaaggaaccagtgatggaagaggagaagccgaagaccaga tcgagtcaggctaaagaggcagcgcctgccttcatgtcctacatgtttgctgtcctggac gtgtaccgcaacaaaacactgaactacttctctcgtaacttctacaacctgcgtttcctg gctctctttgtgtgttttgccatcaatttcattctgctcttctacaaggtaactggtgaa actgaagaagaagaagacgaagaaaacagctggtccgaagaagaggacgatgagaacacg ctgtttgacatggatgagtttgtgcttcaggaaagcactggctacatgttaccaaccctg cgcttcttgtccaaattccacacggtcatctcactcctctgtttggtcggatactactgt ctgaaggttcctctggtggtgttcaaaagggagaaggagatcgccaggaagcttgaattc gacggcctctacatcactgagcagccgtctgacgatgacatcaagggccaatgggatcga ctcgttatcaacaccccgtctttccccagtaactactgggacaagtttgtgaagcgcaag gttatcaacaaatacggcgacctatatggagctgaacgcatcgctgagctcctgggcctg gataagagcgctcttgactttgaccccacggtggagcttgtagagaaggaagcgtccctc gtctcctggctgagctccattgacacaaagtaccacatctggaaaatgggcgtggttctg actgacaattacttcctgtatctgatctggtatactgtcatgtccgtgtttggacacttc aacaacttcttctttgccgctcacttgctggacatcgccatgggcttcaagacccttcgc accatcctgtcctctgtcactcacaacggcaagcagctcgtgctgactgtgggtcttctg gccgtggtcgtctatctctacaccgtggtggccttcaacttcttcaggaagttctacaac aagagcgaggatgaagacgagccggacatgaagtgtgacgacatgatgacgtgctacttg ttccacatgtacgtcggtgtgagagccggaggaggaatcggagacgagctggaggatcca gccggagatccctacgagctttaccgcatcctgtttgatatcaccttcttctttttcgtc attgtcatcctcctggccatcattcagggtttgatcatcgatgcctttggtgagctgaga gaccagcaggagcaggtgaaggaggacatggagaccaaatgcttcatctgcggcatcggc aatgactattttgataggactcctcacgggtttgaaacccacaccttacaagagcacaac ctcgccaactacctgttcttcctcatgtacctgattaacaaggacgagactgagcacacg ggtcaggagtcgtacgtgtggaagatgtaccaggagcggtgctgggacttcttccccacc ggcgactgcttccgtaaacaatacgaggaccagctgggttag

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