Streptomyces sp. MOE7: STRMOE7_18345
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Entry
STRMOE7_18345 CDS
T05374
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
stro
Streptomyces sp. MOE7
Pathway
stro00860
Porphyrin metabolism
stro01100
Metabolic pathways
stro01110
Biosynthesis of secondary metabolites
stro01120
Microbial metabolism in diverse environments
stro01240
Biosynthesis of cofactors
Module
stro_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
stro_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
stro00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
STRMOE7_18345
Enzymes [BR:
stro01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
STRMOE7_18345
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
STRMOE7_18345
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Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
ARH91942
UniProt:
A0A1W5XPZ0
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Position
complement(4147169..4148818)
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AA seq
549 aa
AA seq
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MNPTAPNHSASGQVTFLGAGPGDPGLLTLRAVEALASADVLIADPQVLDVVRVHARAQVD
TPLQASADEASIPADIPTLRDTANLVMAAARAGKRVVRAVTGDPGLDGNVAEEMLACASE
GIVFEVVPGIAAAVGVPAYAGVPLRDAEGTDVRFVDARTADDRCWAELGTSDATAVVSTT
LDAVAAAAGELVSAGRKPDTPMTVTVAGTTTRQRTWTATLGSVAQVLKAAKVLPSPDGGQ
PVIAVVGERSAAAQRDRLSWFESKPLFGWRVLVPRTKEQAASLSDQLVSYGAVPHEVPTI
AVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAAVG
EQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLVAGL
IELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNVTV
IACIGPATAKTAEEHGLRVDVMSPEPSVHKLAEALADFGAARRDAALEAGDPVTRPSERR
PGSRRRARS
NT seq
1650 nt
NT seq
+upstream
nt +downstream
nt
ttgaaccccaccgcccctaaccactccgcctccggtcaggtcaccttcctgggtgccggg
ccgggtgacccgggtctgttgacgttgcgtgccgtggaggcgctggcctccgcggacgta
ctgatcgccgacccgcaggtgctggacgtcgtgcgtgtgcacgcccgtgcgcaggtggac
acaccactgcaggcgtcagctgacgaggcgtcaatccccgccgacatccccacccttagg
gacaccgccaatcttgtcatggcggccgcccgtgcgggcaagcgggtcgtccgtgcggtg
accggcgaccccggcctggacggaaacgtcgccgaggagatgctggcgtgcgcctccgag
ggcatcgtcttcgaggtcgtgcccggcatcgccgcggccgtcggcgtgcccgcgtacgcc
ggtgtgccgctgcgcgacgccgagggcaccgacgtgcgcttcgtcgacgcccgtacggcc
gacgaccgctgctgggccgagctgggcaccagcgacgccaccgcggtggtctccaccacc
ctcgacgcggtggccgcggccgccggcgagctggtctccgcgggccgcaagccggacacc
ccgatgaccgtcaccgtcgccggcaccaccacccggcagcgcacctggaccgccaccctc
ggctcggtcgcccaggtgctcaaggccgccaaggtgctgccgtcgcccgacggcgggcag
ccggtcatagccgtggtcggtgagcgcagtgccgcggcccagcgggaccgcctgtcgtgg
ttcgagtccaagccgctgttcggctggcgggtgctcgtaccgcggacgaaggagcaggcc
gcgtcgctctccgaccagctcgtctcctatggcgcggtgccgcacgaggtgccgaccatc
gccgtggagccgccgcgcaccccgcagcagatggagcgggccgtcaagggcctggtcacc
ggccgctacgagtggatcgccttcacctcggtcaacgcggtcaaggcggtgcgggagaag
ttcgaggagtacggcctggacgcccgggcgttcgccgggatcaaggtcgccgcggtcggc
gagcagaccgccaaggcgctggtcgccttcggtgtgaagcccgacctggtgccgtccggt
gagcagtccgccgccggtctgctggaggactggccgccctacgacccggtcttcgacccg
atcgaccgggtgttcctgccgcgcgccgacatcgccaccgagaccctggtcgccgggctg
atcgagctgggctgggaggtcgacgacgtcaccgcctaccggaccgtgcgggcgtcgccg
ccgccggccgagacgcgggaagccatcaagggcggcggcttcgacgccgtgctgttcacg
tcctcgtcgaccgtgcggaacctcgtcgggatcgccggcaagccgcacaacgtgaccgtg
atcgcctgcatcggcccggccaccgccaagaccgccgaggagcacgggctgcgcgtggac
gtgatgtcgcccgagccgtcggtgcacaagctggccgaagcgctcgcggacttcggtgcg
gcgcggcgcgatgccgcgctggaggccggggacccggtcacccgtcccagcgagcgccgg
cccggttcgcgccggagagcgcggagctga
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