KEGG   PATHWAY: stru04120
Entry
stru04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Salmo trutta (river trout)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
stru04120  Ubiquitin mediated proteolysis
stru04120

Other DBs
GO: 0016567
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115147367  [KO:K10456]
115148451  [KO:K10575] [EC:2.3.2.23]
115148560  [KO:K03094]
115148564  [KO:K10574] [EC:2.3.2.23]
115148624  [KO:K10612]
115148692  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
115148783  [KO:K04707] [EC:2.3.2.27]
115148793  [KO:K10608] [EC:2.3.2.27]
115148848  ubc; polyubiquitin-C isoform X1 [KO:K08770]
115149034  [KO:K03872]
115149042  ube2w; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
115149144  [KO:K03362]
115149232  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
115149280  [KO:K04552] [EC:2.3.2.23]
115149468  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
115149989  [KO:K04554] [EC:2.3.2.23]
115150094  [KO:K06688] [EC:2.3.2.23]
115150110  [KO:K05632] [EC:2.3.2.26]
115150208  [KO:K02207] [EC:2.3.2.23]
115150665  [KO:K10099]
115150783  [KO:K10686] [EC:6.2.1.64]
115151429  [KO:K10587] [EC:2.3.2.26]
115151664  [KO:K02927]
115151839  [KO:K10571]
115151846  [KO:K10685] [EC:6.2.1.45]
115151876  [KO:K05630] [EC:2.3.2.26]
115151925  [KO:K04506] [EC:2.3.2.27]
115152091  [KO:K03347]
115152107  [KO:K10576] [EC:2.3.2.23]
115152175  [KO:K10580] [EC:2.3.2.23]
115152741  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
115153168  [KO:K10586] [EC:2.3.2.23]
115153275  [KO:K06689] [EC:2.3.2.23]
115153309  [KO:K02977]
115153320  [KO:K03348]
115153472  [KO:K04696]
115153498  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
115153626  [KO:K03870]
115153797  [KO:K16060]
115153913  [KO:K10575] [EC:2.3.2.23]
115154025  [KO:K03094]
115154027  [KO:K10574] [EC:2.3.2.23]
115154112  [KO:K10612]
115154239  [KO:K10589] [EC:2.3.2.26]
115154245  [KO:K04707] [EC:2.3.2.27]
115154261  trim37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
115154315  [KO:K08770]
115154601  [KO:K03362]
115154714  [KO:K10447]
115154817  [KO:K03355]
115154820  [KO:K06689] [EC:2.3.2.23]
115155003  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
115155405  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
115155560  [KO:K10687] [EC:2.3.2.34]
115155658  [KO:K20217] [EC:2.3.2.23]
115155766  [KO:K10447]
115155960  [KO:K08285] [EC:2.3.2.27]
115156222  [KO:K03353]
115156334  [KO:K10573] [EC:2.3.2.23]
115156455  [KO:K16065] [EC:2.3.2.27]
115156752  [KO:K02927]
115156993  [KO:K10143] [EC:2.3.2.27]
115157067  [KO:K03347]
115157255  [KO:K03364]
115157400  [KO:K02207] [EC:2.3.2.23]
115157414  [KO:K03364]
115157472  [KO:K03869]
115157717  aire; autoimmune regulator [KO:K10603]
115158095  [KO:K02927]
115158252  [KO:K16065] [EC:2.3.2.27]
115158287  [KO:K02207] [EC:2.3.2.23]
115158407  [KO:K03364]
115158508  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
115158913  [KO:K10587] [EC:2.3.2.26]
115158920  herc2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
115159278  [KO:K04552] [EC:2.3.2.23]
115159543  [KO:K10607] [EC:2.3.2.27]
115159553  ube2i; SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
115159591  [KO:K03349]
115159640  [KO:K10575] [EC:2.3.2.23]
115159715  [KO:K03359]
115159895  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
115160088  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
115160605  [KO:K03353]
115160697  [KO:K10605] [EC:2.3.2.27]
115160881  [KO:K10687] [EC:2.3.2.34]
115161002  [KO:K20217] [EC:2.3.2.23]
115161097  [KO:K10447]
115161200  [KO:K10573] [EC:2.3.2.23]
115161352  [KO:K08285] [EC:2.3.2.27]
115162182  [KO:K03873]
115162911  [KO:K03869]
115162940  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
115162945  [KO:K10596] [EC:2.3.2.27]
115163191  [KO:K10684] [EC:6.2.1.45]
115163199  [KO:K10590] [EC:2.3.2.26]
115163213  [KO:K10611]
115163298  [KO:K10612]
115163383  [KO:K10605] [EC:2.3.2.27]
115163715  [KO:K25228]
115164138  fbxw8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
115164179  fbxo4; F-box only protein 4 [KO:K10291]
115164198  [KO:K10600]
115164510  [KO:K06689] [EC:2.3.2.23]
115164543  [KO:K07868]
115164665  [KO:K10575] [EC:2.3.2.23]
115164667  [KO:K03354]
115164786  [KO:K10144] [EC:2.3.2.27]
115164820  [KO:K02207] [EC:2.3.2.23]
115164856  [KO:K10588] [EC:2.3.2.26]
115164936  [KO:K07868]
115165028  cdc20b; cell division cycle protein 20 homolog B isoform X1 [KO:K03363]
115165069  [KO:K16063] [EC:2.3.2.-]
115165137  ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
115165258  [KO:K03178] [EC:6.2.1.45]
115165470  [KO:K10592] [EC:2.3.2.26]
115165833  [KO:K05632] [EC:2.3.2.26]
115165917  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
115166780  [KO:K03175] [EC:2.3.2.27]
115167072  [KO:K10601] [EC:2.3.2.27]
115167228  [KO:K10591] [EC:2.3.2.26]
115167334  [KO:K10582] [EC:2.3.2.23]
115167557  [KO:K10610]
115167822  [KO:K10592] [EC:2.3.2.26]
115168034  [KO:K04725] [EC:2.3.2.27]
115168117  uba3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
115168161  [KO:K05632] [EC:2.3.2.26]
115168738  uba1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
115168835  [KO:K16061]
115168980  [KO:K10597] [EC:2.3.2.27]
115169109  [KO:K06689] [EC:2.3.2.23]
115169235  [KO:K16061]
115169330  [KO:K03869]
115169408  [KO:K03364]
115169424  [KO:K02207] [EC:2.3.2.23]
115169683  [KO:K03363]
115169709  [KO:K03347]
115169777  cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
115169942  [KO:K02927]
115169970  ube2a; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
115170057  [KO:K10609]
115170098  ube2u; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
115170929  [KO:K10577]
115170940  [KO:K03350]
115171020  [KO:K10585] [EC:2.3.2.23]
115171044  [KO:K10579] [EC:2.3.2.34]
115171191  [KO:K10577]
115171203  [KO:K10604] [EC:2.3.2.27]
115171287  [KO:K03868] [EC:2.3.2.32]
115171382  [KO:K04678] [EC:2.3.2.26]
115171511  [KO:K03873]
115171823  [KO:K04696]
115171862  [KO:K09561] [EC:2.3.2.27]
115173338  [KO:K06689] [EC:2.3.2.23]
115173353  [KO:K10599] [EC:2.3.2.27]
115173463  [KO:K04649] [EC:2.3.2.23]
115173518  [KO:K03362]
115173777  [KO:K20217] [EC:2.3.2.23]
115173778  [KO:K20217] [EC:2.3.2.23]
115173828  [KO:K10582] [EC:2.3.2.23]
115174921  [KO:K10578] [EC:2.3.2.23]
115175635  ube2ql1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
115175695  [KO:K20217] [EC:2.3.2.23]
115175696  [KO:K20217] [EC:2.3.2.23]
115176647  [KO:K10583] [EC:2.3.2.23]
115176958  [KO:K20217] [EC:2.3.2.23]
115176960  [KO:K20217] [EC:2.3.2.23]
115177357  [KO:K22518] [EC:2.3.2.27]
115177521  [KO:K10593] [EC:2.3.2.26]
115177593  [KO:K03358]
115178087  [KO:K20217] [EC:2.3.2.23]
115178098  [KO:K20217] [EC:2.3.2.23]
115178351  [KO:K04678] [EC:2.3.2.26]
115178771  [KO:K10456]
115178788  [KO:K10581] [EC:2.3.2.24]
115179195  [KO:K08285] [EC:2.3.2.27]
115179496  [KO:K10609]
115179667  [KO:K10587] [EC:2.3.2.26]
115180368  [KO:K10576] [EC:2.3.2.23]
115180556  [KO:K10580] [EC:2.3.2.23]
115181234  [KO:K10593] [EC:2.3.2.26]
115182051  [KO:K03871]
115182075  [KO:K06643] [EC:2.3.2.27]
115182930  [KO:K06643] [EC:2.3.2.27]
115183336  [KO:K22518] [EC:2.3.2.27]
115183943  [KO:K04678] [EC:2.3.2.26]
115184009  [KO:K10605] [EC:2.3.2.27]
115184157  [KO:K04706] [EC:2.3.2.-]
115184159  [KO:K04706] [EC:2.3.2.-]
115185219  [KO:K04649] [EC:2.3.2.23]
115186247  [KO:K10609]
115186282  [KO:K04706] [EC:2.3.2.-]
115187754  [KO:K10602] [EC:2.3.2.27]
115187756  [KO:K10602] [EC:2.3.2.27]
115188825  [KO:K10583] [EC:2.3.2.23]
115188858  [KO:K04678] [EC:2.3.2.26]
115188928  [KO:K04678] [EC:2.3.2.26]
115189460  uba6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
115189576  [KO:K07868]
115189591  [KO:K06689] [EC:2.3.2.23]
115189592  [KO:K06689] [EC:2.3.2.23]
115189603  [KO:K07868]
115191762  [KO:K10614] [EC:2.3.2.26]
115191810  fbxw7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
115191862  [KO:K10599] [EC:2.3.2.27]
115191918  [KO:K10614] [EC:2.3.2.26]
115192591  [KO:K02207] [EC:2.3.2.23]
115192624  [KO:K16065] [EC:2.3.2.27]
115192867  [KO:K10582] [EC:2.3.2.23]
115192953  [KO:K10140]
115193648  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
115193684  [KO:K06689] [EC:2.3.2.23]
115193791  fancl; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
115193824  [KO:K10586] [EC:2.3.2.23]
115193909  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
115194016  herc4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
115194372  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
115194734  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
115194744  [KO:K10260]
115195324  [KO:K03872]
115195325  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
115195883  [KO:K03870]
115196084  [KO:K08285] [EC:2.3.2.27]
115196157  [KO:K10456]
115196352  [KO:K10577]
115196391  [KO:K10587] [EC:2.3.2.26]
115196412  [KO:K03350]
115196839  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
115196889  [KO:K05630] [EC:2.3.2.26]
115196919  [KO:K10685] [EC:6.2.1.45]
115196927  [KO:K10571]
115197052  [KO:K10585] [EC:2.3.2.23]
115197197  [KO:K10579] [EC:2.3.2.34]
115197291  [KO:K10576] [EC:2.3.2.23]
115197369  [KO:K10580] [EC:2.3.2.23]
115197687  [KO:K10582] [EC:2.3.2.23]
115197741  pias1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
115198024  [KO:K10260]
115198748  [KO:K10577]
115198875  [KO:K10604] [EC:2.3.2.27]
115199046  [KO:K10580] [EC:2.3.2.23]
115199136  [KO:K10576] [EC:2.3.2.23]
115199743  [KO:K07868]
115199804  [KO:K10588] [EC:2.3.2.26]
115199836  [KO:K02207] [EC:2.3.2.23]
115199867  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
115199956  [KO:K03868] [EC:2.3.2.32]
115199969  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
115199970  [KO:K10575] [EC:2.3.2.23]
115200012  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
115200102  [KO:K07868]
115200135  [KO:K06689] [EC:2.3.2.23]
115200412  ercc8; DNA excision repair protein ERCC-8 [KO:K10570]
115200457  [KO:K10600]
115200586  [KO:K04552] [EC:2.3.2.23]
115200659  [KO:K16063] [EC:2.3.2.-]
115200667  ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
115200925  [KO:K10577]
115201647  [KO:K04696]
115201867  [KO:K04678] [EC:2.3.2.26]
115202167  [KO:K10599] [EC:2.3.2.27]
115202215  [KO:K10260]
115202260  [KO:K10614] [EC:2.3.2.26]
115202851  [KO:K10610]
115203016  [KO:K10582] [EC:2.3.2.23]
115203107  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
115203637  [KO:K03175] [EC:2.3.2.27]
115203688  [KO:K03873]
115203878  [KO:K04551]
115203956  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
115204014  [KO:K10575] [EC:2.3.2.23]
115204046  [KO:K03349]
115204091  trim32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
115204324  [KO:K10447]
115204429  [KO:K03355]
115204434  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
115204697  [KO:K16060]
115205055  [KO:K10573] [EC:2.3.2.23]
115205069  [KO:K10609]
115205319  [KO:K06689] [EC:2.3.2.23]
115205334  [KO:K04649] [EC:2.3.2.23]
115205340  [KO:K03362]
115205562  [KO:K06689] [EC:2.3.2.23]
115205647  [KO:K04725] [EC:2.3.2.27]
115205736  [KO:K10601] [EC:2.3.2.27]
115205866  [KO:K03869]
115205894  [KO:K04707] [EC:2.3.2.27]
115205899  [KO:K10596] [EC:2.3.2.27]
115206135  [KO:K10684] [EC:6.2.1.45]
115206143  [KO:K10590] [EC:2.3.2.26]
115206158  [KO:K10611]
115206239  [KO:K10612]
115206593  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
115207250  [KO:K04554] [EC:2.3.2.23]
115207342  [KO:K04696]
115207456  [KO:K03178] [EC:6.2.1.45]
115207586  [KO:K09561] [EC:2.3.2.27]
115207849  vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
115208252  [KO:K02207] [EC:2.3.2.23]
115208362  [KO:K05632] [EC:2.3.2.26]
115208372  ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
115208608  [KO:K04678] [EC:2.3.2.26]
115208634  [KO:K10581] [EC:2.3.2.24]
115208656  [KO:K03358]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
stru03050  Proteasome
KO pathway
ko04120   

DBGET integrated database retrieval system