Sturnus vulgaris (common starling): 106848953 Help Entry 106848953         CDS       T08833                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism svg  Sturnus vulgaris (common starling) Pathway svg04020   Calcium signaling pathway svg04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:svg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     106848953 (RYR3)    04020 Calcium signaling pathway     106848953 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:svg04040]     106848953 (RYR3) Ion channels [BR:svg04040]  Voltage-gated cation channels   Ryanodine receptor    106848953 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 TBK1_ULD Motif Other DBs NCBI-GeneID:  106848953 NCBI-ProteinID:  XP_014724698 LinkDB All DBs Position Unknown AA seq 4916 aa AA seqDB search MGRPGSALTAPAKPLRMARNSARDPLKERSSTERSELTVEAISLSRADSSRAMAEGGEGG EDEIQFLRTDDEVVLQCVASIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCVCNF VLEQSLSVRALQEMLASTGENASEGAAQGGGHRTLLYGHAILLRHSFSEMYLTCLTSSRS QTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSVSN GNIQVDASFMQTLWNVHPICSGSNITEGYLLGGHVVRFFHGHDECLTIPSTDQNDSQHKK VFYETGGAGIRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGKYLALNEDEGVVILDR EKSDTASTAFCFRASKELKEKQESSLKRDIDGMGVPEIKYGDSICFVQHVATALWLTYKA QDAKSARLGPLKRKVILHQEGHMDDGLTLQRCQLEESQAARIIRNTTSLFSHFISGNNRA LSPTALPVEEMAQTLQDLITYFQLPEEDLQHEDKQNKLRSLKNRQNLFKEEGMLALVLNC IDRLNDYNSAAHFAGIAREEHGGTSWKEILNLLYKLLAALIRGNRKNCAQFSCNLDWLIS KLDRLESSSGILEVLHCILIESPEALNLISEEHIKSIISLLDKHGRNYKVLDVLCSLCVC NGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIID QVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSFGFDGLHLWSGRVPRA VASVNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFSTEGFFFPVVSLSAGVKV RFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMKLEPVKEYKRDFEGVRDLLGTTQFLSQA SFIPCPIDTSQVALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKRHHPCLVE FSKLPETEKNYNLQMSTETLKTLLALGCHIVHAHPAAEEDLKKVKLPKNYMMSNGYKPAP LDLSEVKLLPSQEFLVDRLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDE RTKKSNRDSLREAVRTFAGYGYSIEPPDQDMADQTVEKVSIDKIRFFRVEQSYAVKSGKW YFEFEAVTGGDMRVGWARPACRPDIELGADDQAFVFEGSKGQCWHQGSGFFGRSWQPGDV VGCMINLDDKSIIFTLNGELLITSKGSELAFADFGIENGFVPICALGLSQIGRMNLGMDA STFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIKIWRIDGTIDSPP RLKVTHKTFGTQNSNSDMIYCRLSMPVEFHSSFNFGMGVENASSDVFQKRKHSQEIAPPS TTYFYSLRIFAGQDPSCVWVGWVTPDYHFYSENFDLNKNCTVTVTLGDERGRVHESVKRS NCYMVWGGDVIANSQRSGRSNVDIEIGCFVDLATGMVSFTANGRELGTCYQVEPNTKLFP ATFLQPTSTNLIQFELGKLKNTMPLSAAIFKSEERNPIPQCPPRLDVQTITPVLWSRMPN SFLRVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMMFHYHTLKLY SSVSALGNTRVAYALCSHVDISQLFFTIDNQYLPGLLRSGFYDLLISIHLEHAKQTKLMM SNEFIIPVTDETRNIKLYPDETKKHGLPGVGLSTCLKPAFNFSTPCFIATSEDHQTSIPE IPLEILKSKAISMLTEAVQCSGSHIRDPVGGQVAFQFVPVLKLIATLLIMGVFDDDDVKQ VLLLIDPTVFGDHKEETEERTEKEEVTQVEEKAVEAGEKAIKQTKAPAKGLLQTRLPESV KLQMCHLLNYFCDCELQHRVEAIVSFADRYVSKLQYNQKYRYNELMQALNMSAALTAKKT KEFRSPPQEQINMLLNFQLGEDCPCPEEIREELYEFHDDLLIHCGIPLEEEEEEEEDSSL TGKLRSLMYKIKGPPKAEKLEPKEEEEKAPTTLKELISQTMVRWSQEDQIQDPELVRIMY SLLRRQYDSIGELLQALRKAYTISAASVKDTINLLAALGQIRSLLSVRMGKEEELLMING LGDIMNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQIAFPKMVASCCRFLCYFCRI SRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALALEEPDLDKVV TYLAGCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFANSESVEENASVVVKLLIR RPECFGPDLRGEGGNGLLAAMQEAIRISENPSRDLPSQAYKREGDDEEEEEEIVHMGNAI MSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIPLKLSTVNKD GTVNEPDMSACFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRASASLDTVSLS TTEAALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSTLHTIYRLSKGRSLTKAQRDA IEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYCLPSGMG SYGIAAEEELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYLDTRIMST LEKQTSVDPEGNFDPKPVSTSNLVLPEKLEYIVSKYAEHSHDKWAFEKTNSGWKYGVSLD ENMKTHPLIRPFKTLAEKEKEIYRWPARESLKTMLALGWSLERTKEGGEATMYQRENEKL RSISQSSQGNGYSPTPLDLSNVALSRELQGMVEVMAENYHNIWAKKKKMELESKGGGSHP LLVPYDTLTAKEKSRDREKAQELFKFLQVNGIIISRGLNDMELDASSMEKRFAFKFLKKI LKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLYFLSSPSK TLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVNCLHILAQSLDTRTVMKS GSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSI FEHISQYHFGIDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPV AFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQLDRLIKEINDLAESGARY TEMPHVIEVILPMLCNYLSYWWERGSESVPQSAGPCCTMITSEHLSIVLGNILKIINNNL GIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLDKLKKKAMKIVMEEEQLKADSKNDT QEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMVAEVFILWCK SHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKSGGQDQERKKSKRRGDLYSIQTSLIVA ALKKMLPIGLNMCTPGDQELISLAKTRYSHRDTDEEVKEHLRNNLHLQEKSDDPAVKWQL NLYKDILKSDGPTDPEKNVERVQRISAALYHLEQVEQPLRSKKAVWHKLLSKQRKRAVVA CFRMAPLYNLPRHRSINLFLNGYQNFWIETEEYSFEEKLVQDLATSPKKDEEEEEETEKN HPDPLHQIILYFSRSALTDRSNLEYDPLYIAYSAMMAKSCQEEEEGDEEKEKTFEEKEME KQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAILNGGNTIVQQKMLDY LKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQHDE FTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWYYSG KDVIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANM QMKLSQDSAQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVEMIL KFFDMFLKLKDLTNSDAFKEYDPDGKGIISKKEFQKSMEAQKQYIQSEIEFLLSCTEADE NDMFNYVDFVERFHEPAKDIGFNVVVLLTNLSEHMPNDPRLQSLLEPAESVLNYFEPYLG RIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCE DTIFEMQLASQISETDSSERLEEEEEAEPAYVVDIGDDEEEEKSLEPASAFAVACVAVKK NVANFLKMVTVKNLRKQYRKVKKMTVKEMVKVFFSFFWIVFVGTFQMFFSIVWGIFQILW STVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVMEAEKAEGAEHGLRAELGEFVKSE KGETDIIADIFGIPTKKEGSKHGHDAGLGDIAEILGTEIQAPLENTVHKKKRLQISEIAK EAGTQSKTEAEKADMEDGEKQDKAKEVQNEQLEEGKMKKKKRRHGQKIEKPEAVMANFFK ALEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLDEVEEDSNLWNSFAE EEEEEGMVFFVLEESTGYMAPALRALAVIHTVISFVCVIGYYCLKVPLVVFKREKEVARK LEFDGLYITEQPTEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAEL LGLDKSALDFSPVEESEPEEASLVSWLSSIDTKYHIWKLGVVFTDNSFLYLAWYTTMSIL GHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRK FYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFF FFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQ EHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14751 nt NT seq  +upstreamnt  +downstreamnt atggggcgaccagggtccgctctcacggcccctgcaaaaccacttaggatggctcgaaac tcagcacgggatccgctgaaggagaggagcagtacagagcgcagtgagctgacggtggag gcgatcagcctcagcagagctgactcctcaagagccatggctgaagggggtgaaggaggg gaagatgaaatacagttcctacgaactgatgatgaagtagtacttcagtgtgttgccagt attcacaaagaacaaaggaagttttgcttggcagctgagggacttgggaatcgcctgtgc tttttggagccaacatcagaagctaaatatgtccctccagacctttgtgtctgtaatttc gtccttgaacaatcactatctgtcagagcacttcaagaaatgctggccagcacaggggaa aatgcaagtgaaggggcagcccaagggggtggccaccggacgctgctgtacggccacgcg atactgctccgacattcctttagtgaaatgtatttgacatgtttaacatcatcaagatcc cagacagataaacttgcatttgatgtgggactacgagaaaatgcagcaggtgaggcatgc tggtggacaatacaccctgcttctaagcaaaggtcagaaggagaaaaagttcgaataggt gatgacctcatcctggtcagtgtgtcctctgaaagatacctgcatctctccgtgtcaaat ggaaatattcaggtggatgcctcctttatgcagacactatggaatgtacatcctatatgc tcaggaagcaatattacagaaggatatcttcttggtgggcatgtagttcgtttcttccat ggccatgatgagtgcttgacaattccatctacagatcagaatgattcacagcacaagaaa gtgttttatgaaactggaggagctggcattcgagcaagatcgttgtggagagtagaaccc cttcgaataagctggagtggaagtaacatcagatgggggcagccttttcgtcttcgacat attacaacaggaaagtacttggctctgaatgaggatgaaggcgtagtgatattagacaga gaaaagtcagacacagcatctacagccttttgtttcagagcatcaaaggagctgaaagaa aagcaggaatctagtctcaagcgtgatattgatggaatgggtgtcccagaaataaagtat ggagattcaatctgttttgtccaacatgtggccactgccttatggttgacttacaaagca caggatgctaaatcagcacgcttaggtcccttgaaaagaaaggttatattacaccaagaa ggtcacatggatgatggtctcacattacaaagatgccagcttgaggaatcccaggctgct cgaatcattcgcaatactacaagcttattcagccactttataagtggaaacaacagagca ctatcacccactgccctgcctgttgaggagatggctcagactctgcaagacctgatcact tacttccagcttcccgaagaagacctgcaacatgaagataagcaaaacaaacttcgctca ctcaaaaacagacaaaatctattcaaagaagagggaatgctggcactagttctaaattgc attgatcgcttgaacgactacaacagcgcagctcattttgcaggaattgcaagggaagaa catggtggtacatcatggaaagaaattttgaatctcctttacaaattgttagctgctctc attcgtggcaacagaaaaaactgtgctcaattttcctgtaaccttgattggctaatcagc aaattggacagattagaatcttcctcaggtattttggaagtgttgcactgtatcttgatt gaaagcccagaagctttaaatctaatatctgaggaacacatcaaatccattatttcactg ttggataaacatgggcgcaattacaaggttcttgatgtgctttgctctctctgcgtctgt aatggagttgcagtccgtgccaatcaaaatttgatctgtgacaatttgctgcctagaaga gacttacttttgcaaacacgtttgattaatgatgtgacaagcataagaccaaacatattt ttgggtgttgctgagggctctgcacaatacaagaagtggtactttgagttaataattgat caggttgatccattcttgacggcagaacccacccacttacgagttggatgggcctctact tcaggttatgccccctatcctggaggtggggaaggatggggaggcaatggtgttggtgat gacctctactcttttgggtttgatggccttcatctgtggtctggtcgggtacccagagct gtagcatctgtcaatcagcatttattagcatctgatgatgtggttagctgctgcttggat ttaggtgtacccagcatttcattccgcattaatggacagcctgtacagggaatgtttgag aacttcagtacagaagggtttttcttccctgttgtgagcttatcagcaggtgtaaaagtt cgtttcttgttgggcggacgtcatggcgagtttaaatttctgcctcctgctggctatgct ccctgttacgaagcattgcttccaaaagagaagatgaaattggaaccagtcaaagaatat aaaagggattttgaaggagtgagggatttgttgggtacaacacaatttctctcacaagct tcttttatcccttgtccaatagacaccagtcaggttgctcttccttttcatcttgaaaag atcagggacaaactagctgaaaatatccatgaactatggggaatgaataaaatagaacta ggctggacatatggcaagatacgggatgataataaaaggcatcatccttgtcttgtggaa ttctcaaaactgcctgagacagagaagaattataacctacaaatgtcaactgaaaccctc aaaacccttttggcccttggatgtcacattgttcatgctcatccagcagctgaggaagat ctcaaaaaagtcaaacttcctaaaaattacatgatgtcaaatggatataaacctgcccct cttgatctttctgaagtgaaattgttaccttctcaagaatttctagttgacagactagca gaaaatgcacataatgtctgggcaaaagacagaataaagcaaggatggacctatggcatt caacaggatcttaagaacaaacgtaatcctcggctagtgccatatgcattattagatgaa cgtactaaaaaatcaaacagagacagcctccgtgaagctgttagaacatttgcaggctat ggttatagtattgagccacctgaccaagatatggctgaccaaacagtggaaaaagtcagc attgacaagatacgatttttcagagtagaacaatcctatgcagtgaagtctggaaagtgg tactttgagtttgaagctgtgacaggtggagatatgcgtgttggctgggccaggccagcc tgtcgacctgacatagagttgggagctgatgaccaagcatttgtatttgaaggaagcaaa ggccagtgttggcatcaaggcagcggattctttggacgaagctggcaaccaggagacgtg gttggttgtatgataaacttggatgacaagtcaatcatatttactctgaatggagagttg cttataaccagtaaaggttctgaacttgcgtttgctgactttggaatagaaaatggtttt gttccaatttgtgcactgggcctatctcagattggtcgcatgaaccttggaatggatgcc agtacattcaagtattacacaatgtgtggcctccaagaaggttttgaaccttttgctgtt aacatgaaccgagatgttgctatgtggtttagtaaacgcttaccaacatttgtcaatgtg ccaaaaaatcatcctcacattaagatatggagaattgatggaaccattgacagtccacct cggttaaaagttactcacaaaacatttggcacacagaacagcaattcagacatgatatat tgtcgtttgagtatgcccgttgagttccactcatcattcaacttcggcatgggtgtggaa aatgcctcatctgatgttttccaaaaacgaaagcacagccaagaaattgctcctccttct actacatatttttactcactacggatatttgctggccaagacccatcctgtgtctgggtt ggctgggtaacaccagactaccatttttacagtgagaattttgacctaaataaaaattgt acagtgacagttactttaggtgatgagaggggcagagttcatgaaagtgtgaagcgcagc aactgctacatggtttggggaggagatgtaattgctaattcccagagatcaggtcgcagt aatgtcgacatagaaattggatgctttgttgacctggctactggaatggtgtcattcaca gccaatggaagagagcttggcacttgttatcaggttgaaccaaacacaaagctttttcca gcaacttttttacagcctacaagcactaacttaattcagtttgaacttggtaaattaaag aataccatgcctttatcagcagcaatttttaaaagtgaagaaagaaatcctattcctcag tgtccccctcgccttgatgtccagacaattacacctgttctatggagccggatgccaaac agctttctaagggtagaaacggagcgcgtcagtgaacgccacggctgggtcgtgcagtgc ttggagcccctgcagatgatggcacttcatatcccagaagaaaacagatgcgttgatatt ttggaactatgtgaacaagaagatttgatgatgtttcactaccacactttaaaactctat agctcagtcagtgctcttggtaacactagagttgcttatgcactttgtagccacgtggac atatctcagctattttttacaatagataatcaatacttacctggacttctacgttctgga ttttatgacttgctcattagtattcatttggaacacgccaagcaaaccaagctcatgatg agcaatgaatttatcattccagttaccgacgaaactcgaaatattaaattatatcccgat gaaacaaagaaacatggtctacctggagtaggtcttagtacttgtcttaaaccagccttt aatttttctactccatgctttattgcgaccagtgaagatcatcagacatccatcccagag atacctctggagatacttaaatccaaggccataagtatgttaacagaagcagtacagtgc agtgggagtcatatacgagaccctgttggaggacaggttgcattccagttcgttcctgtt cttaaactgatagcaacactgctcataatgggagtttttgatgatgatgatgtaaaacaa gtgttactcctcattgatcccactgtgtttggagatcacaaggaagaaacagaagagagg acagagaaggaagaagtgacacaagttgaagaaaaagctgtagaagctggggagaaagca atcaaacaaacaaaagctcctgcaaagggcttgttgcagacaagattaccagaatctgtt aagcttcagatgtgtcatttactcaattatttttgtgactgtgaactgcaacatagagtg gaagcaattgtatcatttgcagaccgttatgtatcaaaattgcagtataaccagaaatac aggtacaatgaactgatgcaagccttgaacatgtctgctgctttgacggccaagaagact aaagaatttcggtctcctcctcaagagcagattaatatgttgctgaattttcaactcgga gaggattgtccctgtccagaggagattcgggaggaattatatgaatttcatgatgatctt ctaattcactgtggtattccactagaagaagaggaagaggaagaggaagattcctccttg actggcaaactccgttcattaatgtacaaaatcaaaggtccaccaaaagcagaaaaattg gagcctaaggaagaagaagagaaagctcctactacactgaaagaactcatatcgcagaca atggtgcgctggtcccaggaagatcagatccaggatcccgaattagttcggattatgtac agcctccttcgcaggcagtatgacagcattggtgagctcctgcaggctctgaggaaagca tacaccatcagtgctgcctctgtgaaggacaccattaatctgcttgcagcactgggacag attcgctcactcctcagtgtgaggatgggaaaagaggaggaattgctaatgattaatgga ttaggagatataatgaacaacaaggtattttatcagcatcctaacttaatgagagtcttg ggcatgcatgagactgttatggatgtgatggtcaatgtgcttggaggagataaatctcag attgcttttcctaagatggtggcaagctgttgtcggttcctgtgctacttctgccgcatt agtcgccaaaaccaaaaggccatgttcgagcatctcagttacctactggaaaacagcagc gttggactggcatttccttccatgaggggttcgacaccacttgatgtggcagcagcctct gtaatggacaacaatgagcttgcactcgcattggaggagccagatcttgataaggttgtt acctacctggcgggttgtggcctgcagagttgtccagtattgctggcaaaaggatatcca gacattggatggaacccaatagagggtgaacgttacctgtcattcttacgatttgcagtt tttgctaacagtgaaagtgttgaggaaaatgcaagtgttgttgtcaagctccttattcga cggccagagtgcttcgggccagaccttaggggagagggaggaaatggtttgctggctgct atgcaggaagccatcaggatctcagagaatcctagtcgtgaccttccttcccaggcatat aaaagagaaggtgatgatgaggaggaggaagaggagattgtgcacatgggaaatgcaatc atgtcattttattcagctctcatagatttacttggacgctgtgcaccagaaatgcatctt attcaaagtggaaaaggggaagctattcgaatcaggtcaattcttcgatccctagtgcct actgaagatttggtggggattataagtataccactaaagctgtctacagttaacaaagat ggcacagtaaatgagccagacatgtctgcctgtttctgtcctgatcataaagcacccatg gtactcttcttggaccgtgtctatggtattaaggaccaaagcttcctccttcacctattg gaagttggatttttaccagatttaagagcttctgcctctttggatacagtttctctaagt accacagaggcagccctcgcactaaatagatatatttgctcagctgtgtttccgttactc aaaagatgtgctcccctcttttctggaacagagcatcatgcctctctggttgactccaca cttcacacaatatataggttatccaagggacgctccctcacaaaagctcaaagagatgct attgaggaatgcctgcttgctatttgccaccatttgcgtccctctatgctacaacagctg ttgagaaggctggtttttgatgtgcccctgctcaatgaatactgtaaaatgcctctcaag cttctgacaaatcactatgagcagtgctggaaatattactgtctgccttcaggaatggga agctatggaattgcagcagaagaagaattacatttaactgaaaaacttttctggggaata tttgattccttgtctcataagaagtatgatccagagctctttcgaatggctttgccctgt ttaagtgctatagctggtgccttgcccccagattatttagatacacgaattatgtcaact ttggaaaagcagacttcagtcgatccagaaggaaattttgatcccaaacctgtcagcaca tcaaaccttgtacttcctgagaagctggagtatatcgtaagcaagtatgctgaacattcc cacgataaatgggcctttgaaaagactaatagtggatggaaatatggtgtttcactggat gaaaatatgaaaactcacccattaataaggcctttcaaaactttagctgaaaaggaaaag gaaatttatcgttggcctgccagagaatcattgaaaacaatgctggccttgggatggagc ctggaaaggaccaaggagggaggagaagcaacaatgtaccagcgtgaaaatgaaaagctt cgaagcatatctcagtctagccagggaaatgggtatagcccaacaccacttgatctgtct aatgtggcactttctagggagcttcagggaatggttgaggtaatggcagaaaactaccat aatatatgggccaaaaagaagaaaatggagttggaaagcaaaggtggaggtagtcatcct ctattggtaccttatgacacgttgacagccaaggagaaatcacgggaccgtgaaaaggca caagagctgtttaaattccttcaagtcaatggcataatcatatctcggggcctgaatgac atggagttggatgcttcatccatggaaaagaggtttgcctttaagtttctgaagaaaatt ttaaaatatgttgattctgctcaagagtttattgcacatttagaagccattgtaaccagt ggaaaaactgaaaaatctccacatgaccaagaaataaaattctttgctaaagttcttttg cctctggttgatcaatacttcacaaatcactgcctctacttcctgtcttctccatcaaaa accctcagtagcagtggatatgcatcaaataaggaaaaggaaatggtagcaagcttattc tgcaaactagctgctcttgttagacataggatctcactttttggtagtgattctgccaca atggtgaactgcctgcacatcttagctcagtctcttgacacacgaactgttatgaaatca ggatctgagctggttaaagcgggattgcgtgccttttttgaaaatgcagctgaagacttg gaaaaaacttcagaaaatcttaaactgggcaaatttactcattcacgaacacaaatcaaa ggtgtttcacagaatatcaattatactacagtagcactgttaccaatcttaacatcaatt tttgaacatatttcacaatatcactttggaatagatttacttttgggtgatgtacaagtt tcatgttacagaattctttgtagcctctattctcttgggactggaaagaacatctatgtt gaaaggcagcgtcccgcactcggtgagtgtttagcatctcttgcggcagccattccagta gcattccttgaaccttccctcaaccattacaatccactgtctgttttcaacacaaaaagt gcaagagaaagagcaattttaggtatgcctgatacagtagaagaaatgtgtccagagatc cctcagttggatagactaataaaggaaataaatgatttagcagagtctggagcaaggtat actgaaatgcctcatgtaattgaggtgatcttacccatgctatgcaactatttatcctac tggtgggaaagagggtccgagagtgtccctcagagtgctgggccttgctgtacaatgata acatctgagcatctgagcattgttcttggaaacattctcaaaatcattaacaacaatctg ggaatagatgaagcatcttggatgaaaagaattgcagtttatgctcaacccatcatcagc aaggccagacctgatcttctcagatctcactttattccaacactggataaattgaagaaa aaagctatgaagatagtgatggaagaagagcaactgaaagcagacagtaaaaatgacacc caagaagctgagctcctcattcttgatgagtttgctgtactttgtagagacctttatgcc ttctatccaatgttgatacgatatgtagacaacaacagagctaattggctaaagaaacca gatgcggactcggatgaactctttcgaatggttgctgaagtttttattctgtggtgtaaa tcacataattttaaaagagaagaacagaattttgtgattcagaatgaaatcaacaatttg gcatttttaacaggagacaccaagagcaagatgtctaaatctggaggacaagatcaagag aggaagaaatcaaaacgtagaggggatttgtactccatacaaacatccttgattgtggct gcacttaaaaagatgcttcctattggtttgaatatgtgcactcctggagaccaagagctc atatctttggctaagactagatacagccatagggatacagatgaggaagtcaaagaacac ttacgcaacaacttacacttgcaggaaaagtctgatgatccagctgtgaaatggcagcta aatctgtacaaagatattttaaagagtgatggacctactgaccctgagaaaaacgtggaa cgtgtgcagaggatatcagctgctctgtatcatctggagcaggttgaacaaccactgaga tcaaaaaaagctgtttggcacaaactcctgtcaaagcaacggaaaagggctgttgttgca tgtttcagaatggcaccactatacaacctgccaaggcaccgttctattaacctcttcctc aatggctatcagaacttttggatagaaacagaggaatattcatttgaggagaaactagtt caggatttggctacatctccaaaaaaagatgaagaggaagaagaagagactgagaaaaac catcctgatccacttcatcagattatcctctattttagtcgcagtgctctgacagataga agcaatctagaatatgatcctctatatattgcctattctgccatgatggcaaaaagctgt caggaagaagaagagggagacgaagaaaaagaaaagacatttgaggagaaagaaatggaa aaacagagaactctctaccagcaagctcgcttgcacgatcgtggagctgctgagatggtc cttcagatgattagtgcaagcaaaggtcatacaggacccatggttgttgaaacactgaaa cttggtattgctattctaaatggtggaaacaccatagtacaacagaaaatgctagactat ctgaaggagaaaaaggatgctggattttttcaaagcctctctggcttgatgcagtcctgc agtgttctggacttgaatgcgtttgagagacagaataaagcagaaggcctgggaatggtt actgaagaaggaactctcatcgttcgtgagcgtggtgaaaaagtcttgcagcatgatgaa tttactcgagatctatttagatttttgcaacttctctgtgaagggcataacaatgatttt caaaattacttacgtactcagatgggcaacaccacaacagtgaatattatcattagtact gttgactatctcttgcgtcttcaggaatccatcagtgacttctattggtactattcagga aaagatgtcattgatgaatcaggacaacgtaacttttctaaagccttggctgtcaccaaa caaatattcaattctcttacagaatatatccagggcccttgcataggtaatcaacagagt ctggctcatagtaggctgtgggatgcagttgttggctttcttcatgtgtttgccaatatg caaatgaaactttcacaggactctgctcagattgaattgcttaaggaactgctagatcta ctaaaggatatggtagtgatgctcttgtcactgcttgaaggtaacgttgtaaatggaact attggaaaacaaatggtggacacgcttgtagaatcatctagcaacgtagaaatgattttg aagttctttgacatgttcctgaagttaaaagatctgactaattcagatgctttcaaagag tatgatccagatggtaaaggcatcatttccaagaaggaatttcagaaatcaatggaggct caaaaacaatacatacagtcagagattgaattcctgctgtcctgtacagaagctgatgaa aatgacatgtttaattatgttgactttgtggaaagattccatgaaccagccaaagacatt ggatttaatgtagtagtattgctaacaaacctttcagagcacatgcctaatgatccacgc cttcagagcttacttgagcctgcagagagtgttcttaattactttgaaccataccttggc cgtattgaaataatgggtggggccaagaaaatagagcgagtttactttgaaatcagtgaa tcaagtagaatgcagtgggagaagccacaggtgaaggaatctaaaagacagttcatattt gatgttgtaaatgaaggtggagagcaagaaaaaatggaactctttgtgaatttctgtgag gatacaatttttgaaatgcagttagcatcccagatctctgaaacagattcatctgagagg cttgaggaggaggaagaggcagaacctgcttatgtagtggatattggagatgatgaggaa gaagaaaagtccctggaacctgcttcagcttttgcagtggcctgtgttgcagtgaagaag aatgttgccaactttttaaaaatggtcactgtgaagaacctaaggaaacaatacagaaaa gttaaaaagatgacagttaaagagatggtgaaagtgtttttctcctttttctggattgta tttgtagggacattccaaatgttcttttctatagtgtgggggatattccagattctttgg agcactgtatttgggggtggcctggttgaaggagccaaaaacataaaagttacaaaaata ctaggggatatgcctgatccaacacagtttggaatccatgatgatgttatggaggcagaa aaagctgaaggtgctgagcacggcctaagagctgaacttggggagtttgtgaagagtgaa aagggagaaactgacataattgcagacatttttggcattcctacaaagaaagaaggatca aaacatggtcatgatgctggacttggagatattgcagaaatccttggtactgagatccag gcacctttggaaaacacagttcacaagaaaaaaagattacagatatctgaaattgcaaaa gaagctggaacacaaagcaaaacagaagctgagaaggctgacatggaagatggtgagaaa caagataaagcaaaggaagtacaaaatgagcagctagaagagggaaaaatgaagaaaaag aagagaaggcatggacaaaaaattgagaaaccagaagctgttatggctaacttcttcaaa gctttggaaatttatcaaacaaagatgcttcactacttggcaagaaatttttacaattta aggtttcttgctctatttgttgcatttgctatcaattttattcttctgttttacaaggtg acagaagagccacttgatgaagtagaggaagactctaatctctggaactcctttgctgaa gaggaagaggaggagggcatggtgttttttgttttagaagaaagtacggggtacatggca cctgctctcagagcactggcagtaattcatactgtcatctcctttgtctgtgtgattgga tactactgcttaaaggtccctctggttgtattcaagagggaaaaggaggtagccagaaag ctggaatttgatggactatacataactgaacaaccaactgaggatgatattaaaggacaa tgggatcgccttgttattaatactccgtccttccctaacaattactgggacaaatttgtg aaacggaaggttattaacaagtatggagacttatatggagcagagcgcattgcagaactt ttgggtttggacaaaagtgccctcgattttagtccagtggaagagagtgagcccgaagag gcatctcttgtgtcatggctaagctccattgatacaaagtaccacatttggaagctcgga gttgttttcactgataattcatttttatacttagcttggtacacaactatgtctatcctt gggcactacaacaacttcttctttgctgctcatctgctggatattgctatgggttttaag acattacgaactattttgtcttcagtcactcacaatggcaaacagcttgtgcttactgtg ggactcctcgctgtagtagtgtacctgtacactgtggtggcgttcaacttcttccgcaaa ttctacaacaaaagtgaagatgaagatgaaccagacatgaagtgtgatgatatgatgacg tgttacctgttccacatgtatgtgggtgtaagagctggtggtggcattggagacgaaatt gaggatcctgctggagacccttatgaaatgtaccgaattgtctttgacatcacattcttc ttctttgtcattgttatcctactggccattattcaaggtctgattattgatgcttttggt gaattaagagaccagcaagaacaagtgagggaagacatggagaccaaatgctttatttgt ggaatcggcaatgactactttgacacaaccccacatggctttgaaacacatactttgcaa gaacataacttggcaaactatctgtttttcttaatgtatctaattaacaaggatgaaact gagcatactggccaggaatcatttgtgtggaagatgtaccaagaaagatgttgggacttc ttcccagcaggggactgcttccgaaaacagtatgaggatcaacttggctaa

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