KEGG   Tachyglossus aculeatus (Australian echidna): 119942057
Entry
119942057         CDS       T10703                                 
Symbol
MAPK3
Name
(RefSeq) mitogen-activated protein kinase 3
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
tacu  Tachyglossus aculeatus (Australian echidna)
Pathway
tacu01521  EGFR tyrosine kinase inhibitor resistance
tacu01522  Endocrine resistance
tacu01524  Platinum drug resistance
tacu04010  MAPK signaling pathway
tacu04012  ErbB signaling pathway
tacu04014  Ras signaling pathway
tacu04015  Rap1 signaling pathway
tacu04022  cGMP-PKG signaling pathway
tacu04024  cAMP signaling pathway
tacu04062  Chemokine signaling pathway
tacu04066  HIF-1 signaling pathway
tacu04068  FoxO signaling pathway
tacu04071  Sphingolipid signaling pathway
tacu04072  Phospholipase D signaling pathway
tacu04114  Oocyte meiosis
tacu04140  Autophagy - animal
tacu04148  Efferocytosis
tacu04150  mTOR signaling pathway
tacu04151  PI3K-Akt signaling pathway
tacu04210  Apoptosis
tacu04218  Cellular senescence
tacu04261  Adrenergic signaling in cardiomyocytes
tacu04270  Vascular smooth muscle contraction
tacu04350  TGF-beta signaling pathway
tacu04360  Axon guidance
tacu04370  VEGF signaling pathway
tacu04371  Apelin signaling pathway
tacu04380  Osteoclast differentiation
tacu04510  Focal adhesion
tacu04517  IgSF CAM signaling
tacu04520  Adherens junction
tacu04540  Gap junction
tacu04550  Signaling pathways regulating pluripotency of stem cells
tacu04611  Platelet activation
tacu04613  Neutrophil extracellular trap formation
tacu04620  Toll-like receptor signaling pathway
tacu04621  NOD-like receptor signaling pathway
tacu04625  C-type lectin receptor signaling pathway
tacu04650  Natural killer cell mediated cytotoxicity
tacu04657  IL-17 signaling pathway
tacu04658  Th1 and Th2 cell differentiation
tacu04659  Th17 cell differentiation
tacu04660  T cell receptor signaling pathway
tacu04662  B cell receptor signaling pathway
tacu04664  Fc epsilon RI signaling pathway
tacu04666  Fc gamma R-mediated phagocytosis
tacu04668  TNF signaling pathway
tacu04713  Circadian entrainment
tacu04720  Long-term potentiation
tacu04722  Neurotrophin signaling pathway
tacu04723  Retrograde endocannabinoid signaling
tacu04724  Glutamatergic synapse
tacu04725  Cholinergic synapse
tacu04726  Serotonergic synapse
tacu04730  Long-term depression
tacu04810  Regulation of actin cytoskeleton
tacu04910  Insulin signaling pathway
tacu04912  GnRH signaling pathway
tacu04914  Progesterone-mediated oocyte maturation
tacu04915  Estrogen signaling pathway
tacu04916  Melanogenesis
tacu04917  Prolactin signaling pathway
tacu04919  Thyroid hormone signaling pathway
tacu04921  Oxytocin signaling pathway
tacu04926  Relaxin signaling pathway
tacu04928  Parathyroid hormone synthesis, secretion and action
tacu04929  GnRH secretion
tacu04930  Type II diabetes mellitus
tacu04933  AGE-RAGE signaling pathway in diabetic complications
tacu04934  Cushing syndrome
tacu04935  Growth hormone synthesis, secretion and action
tacu04960  Aldosterone-regulated sodium reabsorption
tacu05010  Alzheimer disease
tacu05020  Prion disease
tacu05022  Pathways of neurodegeneration - multiple diseases
tacu05034  Alcoholism
tacu05132  Salmonella infection
tacu05133  Pertussis
tacu05135  Yersinia infection
tacu05140  Leishmaniasis
tacu05142  Chagas disease
tacu05145  Toxoplasmosis
tacu05152  Tuberculosis
tacu05160  Hepatitis C
tacu05161  Hepatitis B
tacu05163  Human cytomegalovirus infection
tacu05164  Influenza A
tacu05165  Human papillomavirus infection
tacu05166  Human T-cell leukemia virus 1 infection
tacu05167  Kaposi sarcoma-associated herpesvirus infection
tacu05170  Human immunodeficiency virus 1 infection
tacu05171  Coronavirus disease - COVID-19
tacu05200  Pathways in cancer
tacu05203  Viral carcinogenesis
tacu05205  Proteoglycans in cancer
tacu05206  MicroRNAs in cancer
tacu05207  Chemical carcinogenesis - receptor activation
tacu05208  Chemical carcinogenesis - reactive oxygen species
tacu05210  Colorectal cancer
tacu05211  Renal cell carcinoma
tacu05212  Pancreatic cancer
tacu05213  Endometrial cancer
tacu05214  Glioma
tacu05215  Prostate cancer
tacu05216  Thyroid cancer
tacu05218  Melanoma
tacu05219  Bladder cancer
tacu05220  Chronic myeloid leukemia
tacu05221  Acute myeloid leukemia
tacu05223  Non-small cell lung cancer
tacu05224  Breast cancer
tacu05225  Hepatocellular carcinoma
tacu05226  Gastric cancer
tacu05230  Central carbon metabolism in cancer
tacu05231  Choline metabolism in cancer
tacu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tacu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tacu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119942057 (MAPK3)
   04012 ErbB signaling pathway
    119942057 (MAPK3)
   04014 Ras signaling pathway
    119942057 (MAPK3)
   04015 Rap1 signaling pathway
    119942057 (MAPK3)
   04350 TGF-beta signaling pathway
    119942057 (MAPK3)
   04370 VEGF signaling pathway
    119942057 (MAPK3)
   04371 Apelin signaling pathway
    119942057 (MAPK3)
   04668 TNF signaling pathway
    119942057 (MAPK3)
   04066 HIF-1 signaling pathway
    119942057 (MAPK3)
   04068 FoxO signaling pathway
    119942057 (MAPK3)
   04072 Phospholipase D signaling pathway
    119942057 (MAPK3)
   04071 Sphingolipid signaling pathway
    119942057 (MAPK3)
   04024 cAMP signaling pathway
    119942057 (MAPK3)
   04022 cGMP-PKG signaling pathway
    119942057 (MAPK3)
   04151 PI3K-Akt signaling pathway
    119942057 (MAPK3)
   04150 mTOR signaling pathway
    119942057 (MAPK3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    119942057 (MAPK3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119942057 (MAPK3)
   04148 Efferocytosis
    119942057 (MAPK3)
  09143 Cell growth and death
   04114 Oocyte meiosis
    119942057 (MAPK3)
   04210 Apoptosis
    119942057 (MAPK3)
   04218 Cellular senescence
    119942057 (MAPK3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119942057 (MAPK3)
   04520 Adherens junction
    119942057 (MAPK3)
   04540 Gap junction
    119942057 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    119942057 (MAPK3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119942057 (MAPK3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119942057 (MAPK3)
   04613 Neutrophil extracellular trap formation
    119942057 (MAPK3)
   04620 Toll-like receptor signaling pathway
    119942057 (MAPK3)
   04621 NOD-like receptor signaling pathway
    119942057 (MAPK3)
   04625 C-type lectin receptor signaling pathway
    119942057 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    119942057 (MAPK3)
   04660 T cell receptor signaling pathway
    119942057 (MAPK3)
   04658 Th1 and Th2 cell differentiation
    119942057 (MAPK3)
   04659 Th17 cell differentiation
    119942057 (MAPK3)
   04657 IL-17 signaling pathway
    119942057 (MAPK3)
   04662 B cell receptor signaling pathway
    119942057 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    119942057 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    119942057 (MAPK3)
   04062 Chemokine signaling pathway
    119942057 (MAPK3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119942057 (MAPK3)
   04929 GnRH secretion
    119942057 (MAPK3)
   04912 GnRH signaling pathway
    119942057 (MAPK3)
   04915 Estrogen signaling pathway
    119942057 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    119942057 (MAPK3)
   04917 Prolactin signaling pathway
    119942057 (MAPK3)
   04921 Oxytocin signaling pathway
    119942057 (MAPK3)
   04926 Relaxin signaling pathway
    119942057 (MAPK3)
   04935 Growth hormone synthesis, secretion and action
    119942057 (MAPK3)
   04919 Thyroid hormone signaling pathway
    119942057 (MAPK3)
   04928 Parathyroid hormone synthesis, secretion and action
    119942057 (MAPK3)
   04916 Melanogenesis
    119942057 (MAPK3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    119942057 (MAPK3)
   04270 Vascular smooth muscle contraction
    119942057 (MAPK3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    119942057 (MAPK3)
  09156 Nervous system
   04724 Glutamatergic synapse
    119942057 (MAPK3)
   04725 Cholinergic synapse
    119942057 (MAPK3)
   04726 Serotonergic synapse
    119942057 (MAPK3)
   04720 Long-term potentiation
    119942057 (MAPK3)
   04730 Long-term depression
    119942057 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    119942057 (MAPK3)
   04722 Neurotrophin signaling pathway
    119942057 (MAPK3)
  09158 Development and regeneration
   04360 Axon guidance
    119942057 (MAPK3)
   04380 Osteoclast differentiation
    119942057 (MAPK3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    119942057 (MAPK3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119942057 (MAPK3)
   05206 MicroRNAs in cancer
    119942057 (MAPK3)
   05205 Proteoglycans in cancer
    119942057 (MAPK3)
   05207 Chemical carcinogenesis - receptor activation
    119942057 (MAPK3)
   05208 Chemical carcinogenesis - reactive oxygen species
    119942057 (MAPK3)
   05203 Viral carcinogenesis
    119942057 (MAPK3)
   05230 Central carbon metabolism in cancer
    119942057 (MAPK3)
   05231 Choline metabolism in cancer
    119942057 (MAPK3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119942057 (MAPK3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119942057 (MAPK3)
   05212 Pancreatic cancer
    119942057 (MAPK3)
   05225 Hepatocellular carcinoma
    119942057 (MAPK3)
   05226 Gastric cancer
    119942057 (MAPK3)
   05214 Glioma
    119942057 (MAPK3)
   05216 Thyroid cancer
    119942057 (MAPK3)
   05221 Acute myeloid leukemia
    119942057 (MAPK3)
   05220 Chronic myeloid leukemia
    119942057 (MAPK3)
   05218 Melanoma
    119942057 (MAPK3)
   05211 Renal cell carcinoma
    119942057 (MAPK3)
   05219 Bladder cancer
    119942057 (MAPK3)
   05215 Prostate cancer
    119942057 (MAPK3)
   05213 Endometrial cancer
    119942057 (MAPK3)
   05224 Breast cancer
    119942057 (MAPK3)
   05223 Non-small cell lung cancer
    119942057 (MAPK3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119942057 (MAPK3)
   05170 Human immunodeficiency virus 1 infection
    119942057 (MAPK3)
   05161 Hepatitis B
    119942057 (MAPK3)
   05160 Hepatitis C
    119942057 (MAPK3)
   05171 Coronavirus disease - COVID-19
    119942057 (MAPK3)
   05164 Influenza A
    119942057 (MAPK3)
   05163 Human cytomegalovirus infection
    119942057 (MAPK3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119942057 (MAPK3)
   05165 Human papillomavirus infection
    119942057 (MAPK3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119942057 (MAPK3)
   05135 Yersinia infection
    119942057 (MAPK3)
   05133 Pertussis
    119942057 (MAPK3)
   05152 Tuberculosis
    119942057 (MAPK3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    119942057 (MAPK3)
   05140 Leishmaniasis
    119942057 (MAPK3)
   05142 Chagas disease
    119942057 (MAPK3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119942057 (MAPK3)
   05020 Prion disease
    119942057 (MAPK3)
   05022 Pathways of neurodegeneration - multiple diseases
    119942057 (MAPK3)
  09165 Substance dependence
   05034 Alcoholism
    119942057 (MAPK3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119942057 (MAPK3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    119942057 (MAPK3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119942057 (MAPK3)
   04934 Cushing syndrome
    119942057 (MAPK3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119942057 (MAPK3)
   01524 Platinum drug resistance
    119942057 (MAPK3)
   01522 Endocrine resistance
    119942057 (MAPK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tacu01001]
    119942057 (MAPK3)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:tacu03036]
    119942057 (MAPK3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:tacu04147]
    119942057 (MAPK3)
Enzymes [BR:tacu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     119942057 (MAPK3)
Protein kinases [BR:tacu01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   119942057 (MAPK3)
Chromosome and associated proteins [BR:tacu03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     119942057 (MAPK3)
Exosome [BR:tacu04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   119942057 (MAPK3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase FTA2
Other DBs
NCBI-GeneID: 119942057
NCBI-ProteinID: XP_038618641
LinkDB
Position
21:13125274..13194278
AA seq 542 aa
MDLGTPSPAVHSPSIPHPSICTPLFPLPLPWVRSRRRGEARNQCEFSAALAPAFSHSPAL
RQPTESPRGRGGPDPKTGVPQPGCPPTRVSEEPGELGLGGFEESGDPETLTLAPGPAGLD
GWHKWARLTAWVGERVVGDPGRAGGEWQSLAPHRPSPTPAYSEYEQRGPAAAGVPAAGPA
GGEADGAAPKVETVKGQPFDVGPRYTDLQYIGEGAYGMVSSAYDHVRKARVAIKKISPFE
HQTYCQRTLREIQILLRCRHENVIGIRDILRAPALEAMRDVYIVQDLMETDLYKLLKSQQ
LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQDDLNCIINMKARNYLQSLPPKPKVPWAKLFPKADSKALDLLDRMLTFNPNK
RITVEDALAHSYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGHPG
AP
NT seq 1629 nt   +upstreamnt  +downstreamnt
atggacttgggcacccccagccctgctgttcattccccgtccatcccccacccctccatc
tgcaccccgctcttcccgctgccgctgccctgggtgagaagccgacgaaggggggaagcg
aggaaccagtgtgaattttctgctgctctcgcccccgctttctcacactcgcccgctctg
cgtcagccgaccgagtccccgagggggaggggaggcccggatcccaaaacgggtgtcccc
caacccgggtgtcccccaacccgggtgtcggaagaaccgggggagctggggctcggtggc
tttgaggagagcggtgaccccgagacgctgaccctcgcccctgggccggccggcctcgat
ggctggcacaagtgggcccgtctcacggcttgggttggggagagggtggtcggggacccc
gggcgggctggtggggagtggcagagcctggcaccccaccggccctcccccaccccagct
tattccgagtacgaacaacgcgggccggcggcggcgggggttcccgcggcgggtccggcg
ggcggggaggccgacggggccgcgcccaaggtggagaccgtgaagggtcagcccttcgac
gtggggccgcgctacaccgacctgcagtacatcggggagggcgcctacggcatggtcagc
tcggcgtacgaccacgtgcggaaggcccgggtagccatcaagaagatcagccctttcgag
catcagacctactgccagcgcacactgcgagagatccagatcttgctgcgctgccgccat
gagaatgtcatcggcatccgcgacatcctgcgggctccggcgctggaggccatgcgggat
gtctacatcgtgcaggacctgatggagacagacttgtataagctgctgaagagccagcag
ctgagcaatgaccacgtctgctacttcctgtaccagatcctgcgcggcctcaagtacatc
cactcggccaacgtgctccaccgagacctcaagccgtccaacctgctcatcaacaccacc
tgtgacctcaagatatgtgacttcggcctggcccggatcgccgatcctgagcacgatcac
acgggcttcctgacggagtacgtggccacccgctggtaccgggcaccggagatcatgctc
aactcgaagggctacacaaaatccatcgacatttggtctgtgggttgcatcctagccgag
atgctctccaaccgccccatcttccccgggaagcattacctggaccaactcaaccacatc
ctgggcatcctgggctccccgtcccaggacgacctaaactgcatcatcaacatgaaggcg
cggaattacctgcagtccttaccgcccaagcccaaggtgccctgggccaagctgttcccg
aaggccgactccaaagccctggacctcctggaccggatgttgaccttcaaccccaacaag
cgcatcacagtggaagatgccctggcccactcctacttggagcagtactacgacccgacg
gacgagccagtggcggaggagcccttcacctttgacatggagctggatgacctgcccaag
gagcggctgaaggagctcatattccaggagacggcgcgtttccagcctgggcatcctgga
gcaccctga

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