KEGG   PATHWAY: tala03015
Entry
tala03015                   Pathway                                
Name
mRNA surveillance pathway - Tyto alba (Barn owl)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
tala03015  mRNA surveillance pathway
tala03015

Other DBs
GO: 0071028
Organism
Tyto alba (Barn owl) [GN:tala]
Gene
104355484  GLE1; nucleoporin GLE1 [KO:K18723]
104355530  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
104355682  SMG1; serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
104355761  CPSF3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
104355832  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X3 [KO:K11583]
104355947  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104356020  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
104356115  PABPC1; polyadenylate-binding protein 1 isoform X1 [KO:K13126]
104356250  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104356284  CPSF4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
104356417  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
104356432  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
104356460  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
104356807  [KO:K12883]
104357088  MSI1; RNA-binding protein Musashi homolog 1 isoform X3 [KO:K14411]
104357683  UPF2; regulator of nonsense transcripts 2 isoform X2 [KO:K14327]
104357957  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
104358164  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104358223  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104358310  SMG7; LOW QUALITY PROTEIN: protein SMG7 [KO:K14409]
104358859  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
104358860  CASC3; protein CASC3 isoform X1 [KO:K14323]
104359065  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
104359307  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
104359359  [KO:K23600]
104359497  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104359737  PELO; protein pelota homolog [KO:K06965]
104360094  PABPC1L; polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
104360228  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
104360335  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104360354  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
104360695  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
104360931  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3 [KO:K11584]
104361000  MAGOH; protein mago nashi homolog [KO:K12877]
104361120  HBS1L; HBS1-like protein [KO:K14416]
104361695  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
104361888  PNN; pinin [KO:K13114]
104362256  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
104362367  ALYREF; THO complex subunit 4 [KO:K12881]
104362719  DAZAP1; DAZ-associated protein 1 isoform X3 [KO:K14411]
104363002  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104363008  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X4 [KO:K14398]
104363074  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
104363158  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
104363196  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
104363348  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
104363714  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
104363936  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104363997  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104364189  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
104364199  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
104364274  CSTF3; cleavage stimulation factor subunit 3 isoform X1 [KO:K14408]
104364434  [KO:K18655] [EC:5.6.2.7]
104364707  RNGTT; mRNA-capping enzyme isoform X2 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
104364839  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
104365524  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
104365614  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
104366332  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
104366477  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
104366628  SMG5; protein SMG5 [KO:K11125]
104367002  ETF1; eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
104367127  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3 [KO:K11584]
104368749  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
104368852  CPSF7; cleavage and polyadenylation specificity factor subunit 7 [KO:K14398]
104368886  [KO:K14405]
104368987  WDR82; WD repeat-containing protein 82 [KO:K14962]
116959608  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
116959841  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
116960340  PYM1; partner of Y14 and mago [KO:K14294]
116962287  SYMPK; symplekin [KO:K06100]
116962574  RBM8A; RNA-binding protein 8A [KO:K12876]
116964042  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
116964635  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
116964682  [KO:K14376] [EC:2.7.7.19]
116964912  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122153863  [KO:K06100]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
tala03013  Nucleocytoplasmic transport
tala03018  RNA degradation
tala03040  Spliceosome
KO pathway
ko03015   

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