Trematomus bernacchii (emerald rockcod): 117477020 Help Entry 117477020         CDS       T09643                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism tben  Trematomus bernacchii (emerald rockcod) Pathway tben04020   Calcium signaling pathway tben04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:tben00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117477020    04020 Calcium signaling pathway     117477020  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tben04040]     117477020 Ion channels [BR:tben04040]  Voltage-gated cation channels   Ryanodine receptor    117477020 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 Ago_Mid Motif Other DBs NCBI-GeneID:  117477020 NCBI-ProteinID:  XP_033979617 LinkDB All DBs Position Unknown AA seq 4887 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICTFVLEQSLSVRALQEMLAKSGQNSEGTRGPDRWAAQSGGHKTLLYGHAILLRHSF SSMYLACLKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERYLHLSISNGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGHDEVVA IPGSDQSEEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYL ALTDDRGLVLQDRERSDTIATAYCFRASKEKLEQSPKRDIDGMGVAEIKYGDSLCFIMHV ATGLWLSYQAPDVKSARLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTLLF KRFIRDLDCLGVKNRILVALPVEEVLQTLNDLITYFQLPDVELEHEERQIKLRSLKNRQN LFKQEGMLTLVSNCIDRLNVYNSAAHFGECAGSEAGAAWKDILNLLYELLAALIRGNRNN CTQFSNNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGS AQYKKWYYELMIDQVDHFVTSEPSHLRVGWANAKGYAPYPGGGEGWGGNGVGDDLYSYGF DGLHLWSGRIPRAVASLNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGL FFPVVSFSAGVKVRFLLGGRHGDFKFLPPSTYAPCYEALLPKEKMKVEPVKEYKRDAEGV RDLLGTTQSMSQASFIPTPVETSQIVMPVHLDKVRDKLAENIHELWGMNKIELGWSYGKI RDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRVVQVNPNAESSLKKIKLP KNFMMSNGYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSK RNPRLVPYVLLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQEGGQVVERLSIDKVRFFR VERTYAVRTGKWYFEFEAVTGGDMRVGWARPGCKPDVEIGTDELAFVFDGYRGHCLNMGS RLFGRCWHAGDIVGCMINMEDKSMIFTLNGEILITSKGSELCFTDFETEDGFIPVCSLGL AQVGRINLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKDHNHIA VTRIDGTIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSIFKTSPVVDMNGIHEDD TLKLKHRYPLRSVRHSDESRRVDYSSITMYYHSVRVFAGQDPAGVWVGWVTPDYHYYSNN FNLSKNRSVTVTLGDERGRVHESVKRSNCYIIWCGDVTNAAHASSRSNVDLEIGCLIDLA TGLVTFTVNGKEITTSYQVEPNTKLFPAVFVRPTSPNLFQFELSKIKNAMPLSSAIFKSE HKNPVPQCPPRLDVQTISSVLWSRMPNTFLKVETARVNERHGWVVQCVEPLQMLAVHIPE ENRCVDIMELSEQEDMRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYL SGMLREGFYNVLISIHLETAKEARLMMKDEFIIPVTAETRSIRLFSNASKKHLPPGVGLS TSLKPRLNFAPPCFISTKREQHLYSPQIPLDALKEKSISMLTEAVQGGGHHIRDPVGGGV EYQFVPILKLISTLLTMGVLGSEDVHKILLLIDPNVFRETREEGVTGATDKEGLKGAEDK AVEAGEEETAKEAKQPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFV SKLQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLTFSMGEDCPCPSGIQE QLYDFHNQLQLHCGIPMEEDGYKQDTSITGRLLMLVNKIKGQSHKAEEPTEKQQAAPSNL KELISQTMVSWAQECHILDSELVRKMFSLLRRQYDSIGELLRAMRKTYTISAASIQDTIN LLAALGQIRSLLSVRMGKEEEKLMIDGLADIMNNKVFYQHPNLMRILGMHETVMEVMVNV LGGHKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGST PLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPILLAKGYPDIGWNPIEGERY LSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPA LDLPGSVHGVNSDVSADGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEAL RIRAILRSLVPTEDIVGIISIPLKMPITNKDGSVTEPDMSACFSPDHKAPMVLFLDRVYG IEDQSFLLHLLEVGFLPDLRAATSLDTDCLCTTETALAMNRFIGSAMLPLLTRCAPLFAG TEHYATLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCKHLRPSMLQQLLHRLVFDVP LLTDYCKMPLRLLTNHYEQNWKYYCLPSGWGSYGTASEDELLLTKKIFWGVFDSLSQRNY DAELFKMAMPCLSAIAGALPPDYVDASISTTVEKPVSVDAQGNFDPKPISTANIALPEKL EHFANKYGEHAHEKWSAEKVLLGWKYGDGVDEKSKIHPQLRIYKALTEKEKEIYRWPIRD SLKSMLAMGWSIDRNKDGESMSQQRESEKMRKISQTSQGNGFNPSPIDMSNVVLSRELQG MVEVLAENYHNIWAKKKKSDLGSRGGGTHPMLVPYDTLTAKEKARDREKALDLFRFLQIN GYSITRGLKDLDQDSSSMEKRFAYKFLKKLLKYVDSAQEFIAHLESMAASGKTDRSPHEQ EIKFFAKVLLPLIDQYFKNHSLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHR ISLFGSDSTTIVSCLHILAHTLDTRTVMKSGSEQVRLGLRTFFENAAEDLEKTFENLKLG KFTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLY ALGTGKNIYVERQLPALGQCLATLAGALPVAFLEPVLNAYNPCSVFNTKSARERSILGIQ DSVAEMCPGMPRLDGLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQP ASGGSVCCTTVTSENLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARADLLKS HFLPTLEKLKKKTVKVVSEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYV DNNRSRWLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDNKT KMSKSFKEKSGGQDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLA KTRYLLRDTDEEVKDHIRQNLHLRERSEDPAVRWQLNLYKDVAMRSDGPPDPDRVVDRIQ RISAAVFNLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHKNNNYFLKAF RHIWLDIIYGNTDYDSLLSTLTKTQPKLEEEEEEEVRKQPDPLHQLILHFSHNALTECSS LEEDPLYIAYADMMAKSCDEGEEEEEEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMV LQMISASKGRLGAMVTFTLKLGISVLNGGNILVQQKMLDYLKEKRDVGFFKSLSGLMMSC SVLDLNAFERQNKAEGLGMVTEEGSSSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRT QTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIIDEAGQRNFSQALAVAKQVFNSL TEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMIV MMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEYDPESK GVISKKDFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNVAV LLTNLSEHMPHDARLATFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQW EKPQVKESKRQFIFDVVNEGGESEKMELFVKFCEDTIFEMQLASQISEPDPVERLEEDEE DNQSVVETPEEEEEESVMLESSSAFTIACISMKKSLCHFRQMLTLKSMRRQYRKFRKMSI REMVRGFFSFFWMIITGLFHFVYSLVWGFFHILWTTMFGGGLVEGAKNMKVTDILGNMPD PTQFGIHGDVLEMEKMEASEASALAEMGQMSQGEAGEADLMAELLNIQPKKEGKHGAEPG LGDVSEVVVGDAPSIASAVRQKKAQLAAKKVTVNGDYTSDSEKGDSEDGEKKDHDKSKDE PPPDPPVLKKVPKKRIDVKKELPEAFMASFFAGLEIYQTKMLNYLARNFYNLRFLALFVA FAINFILLFYKVTGDYADDEDPWNGQGRTGEEEDEGALEYFVLQESTGYMAPTLRCLAIL HTIISFLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVINTP SFPNNYWDKFVKRKVIKKYGDLYGAERIAELLGMDKSALDFNPTEETVAKEASLVSWLSS IDTKYHVWKLGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSV THNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVG VRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQV KEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYV WKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14664 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggagaaggagaggatgagattcagttcctcagaactgatgatgaagtg gtgctccagtgcgtggcctgcatccagaaggagaatcgcaagttctgcctggctgccgag gggctgggcaaccggctgtgttacctggagcccacatctgaggccaagtatgttcctcca gacctgtgcatctgcacctttgtgctggaacagtctctgtctgtacgggcgctacaggag atgctggctaagagcggacagaacagtgaagggacacgcggcccggaccgatgggcagcg caaagcggcggacacaagactcttctgtacggacacgccatcctccttcggcattccttc agctctatgtacctggcctgtttgaagacatcaaggtctcagacagataagctgtccttt gacgtcggtctgcaggaggattcaacaggtgaagcctgttggtggaccatccaccctgcc tccaaacagagatcagaaggggagaaagtgcggattggggatgaccttattctcgtcagc gtgtcctcggagcgttaccttcacttatccatctccaacggcaacatccaggtggatgct tccttcatgcaaaccctctggaacgtccatcccatctgctccggcagcaacatagaagaa ggctacctactgggtggtcatgtgatgcggttgttccatggacatgacgaggtggtggcc atcccaggatcagaccagagtgaagagcagcagaggatagtcaactatgagacgggtaaa gccggagccaaggccagatccttgtggaggctggagccgctccgaatcagctggagcggg agccacatccgctggggccagcccttcagactgcggcacctgaccaccggtcactacctg gccctgacggacgatcgggggttggtgctgcaggaccgggagaggtccgacaccatcgcc accgcctactgtttcagagcctctaaggagaagctggagcagagtcccaagcgagacatc gacgggatgggagtggcggagattaaatatggggactcgctctgcttcatcatgcacgtg gccacgggactctggctctcctaccaggcacctgatgtaaaatccgcccgtctgggtccc ctcaagagacgagcgtgcctacattctgaaggtcacatggatgacgggctgaccttgcag cgctgtcaacacgaggagtctcgtgccgcacggatcatccgcaacaccactttactcttc aagcgattcatcagagacctggattgtctgggtgttaagaataggatactggtcgcacta cctgtagaggaggtcctccaaaccctcaatgacctcatcacctacttccagctccccgac gtcgagctggagcacgaagagaggcagatcaagctacgctcgctcaagaaccggcagaac ctattcaaacaggaaggcatgctgactctggtgtccaactgcatcgatcgactaaatgta tacaacagtgccgcccacttcggagagtgtgcggggtcagaggccggagcagcatggaaa gacattctcaacctgctgtatgagctgctggctgcgttaataagagggaacaggaacaac tgcacacagttctccaacaacttggactggctggttagcaagctggagagactggagtct tcttcaggcatcctggaagttctgcactgcattctaattgagagcccagaggcgctcaac atcatccagagaggacacatcaagtccatcatatcactgctctacaagcacggacgcaac cacaagattctggatgtgctctgctcgctatgtgtgtgtaacggcgtagctgtgcgaacc aatcagaacctcatctgcgatcacctgctgcccaagagagatctgctgctgcaaacacag ctggtcaatgatgtccagagtatgagaccgaacatcttcctgggggtgagtgagggctcg gctcagtataagaagtggtattacgagctgatgatcgaccaggtggaccacttcgtgacc agcgagccctcgcacctgagggtgggctgggccaacgctaaaggctacgctccctaccct ggaggaggagagggctggggaggcaatggagtaggagatgacctttactcgtatggtttt gatggactccatctttggtcaggtcgtatcccgcgggcggttgcgtccttgaaccagcac atcctgacatcagaggatgtggtcagctgctgtttggatctaggagctcccagcatctct ttcaggatcaacggacagcctgtgcagggcatgtttgagaatttcaacacggacgggctc ttcttccccgtggtcagcttctctgcaggggtcaaggtgcgtttcctgttgggtggtcga catggtgactttaagttcctgcctccgtcgacttacgctccatgttacgaagctctgctg cccaaagagaagatgaaggtggagccggtgaaagagtacaagagggatgctgaaggagtc cgagatctgctcggcacaacgcagtccatgtcgcaggcctccttcatcccaacacctgtt gaaactagccagattgttatgccagttcatttagataaagtccgagataagctcgctgaa aacatccatgaactctgggggatgaataaaatagagctgggctggtcgtatggcaagata agggatgataataagcggcagcatccgtgccttgtggatttctccaagctgccagaaact gaaaagaactacaatctgcagatgtcgacagaaacactgaagaccctgctggcgttgggc tgtcgggtagttcaggtcaatccaaatgctgagagctccctcaaaaagataaaactcccc aaaaacttcatgatgtccaatggttataagccgtctcctctggacctgtctgatataaaa ctgactccaggtcaggagctgctggtggacaaactggcagagaacgcacacaatgtgtgg gccaaggaccgcatcaaacagggctggacttatggcattcagcaggatctgaagagtaag cgtaaccctcgcctggttccctacgtgctgctggacgagcgcaccaagaagtcgaacagg gacagcctgcgagaggctatccgcactctgattggctacggttacaacatcgagccctcg gaccaggaaggcggacaagtggttgagcggctgagcatcgacaaggtgcgcttcttcaga gtggagaggacgtacgcagtgaggaccgggaagtggtactttgaatttgaagccgtgact ggaggagacatgagagtgggctgggccaggcctggatgtaagccagatgtggagatcggc acggatgagctcgctttcgtctttgatgggtacaggggtcactgcctgaacatgggcagc cgtctgttcggccgctgctggcatgctggggacatcgtgggctgcatgatcaacatggag gacaagtccatgatcttcaccctgaacggagagatcctcatcaccagcaagggctctgaa ctctgcttcactgactttgaaactgaggatgggtttattccagtgtgcagcctcggcctg gctcaggtgggccgcataaatctggggaaagatgccagcaccttcaagtactataccatg tgcggccttcaggagggattcgaacccttcgcggtcaacatgaaccgagaggtcaccatg tggttcagcaagcgtctgcctacttttgtcaatgtgccgaaggaccacaaccacatagca gtgaccaggattgacggcaccatcgacagccccccgtgtcttaaagtcacccacaagaca ttcggcacccagaacagcaacgctgacatggtgttttgccgcctcagcatgcctgtagag ttccactccatcttcaaaaccagtcctgttgttgacatgaacgggatccatgaggatgac actcttaaactcaaacacagatatcctctgaggtctgtgcggcacagtgatgaaagcaga cgagtggactacagcagcatcactatgtactaccactcagtgagggtcttcgctggacag gaccctgccggtgtgtgggttggatgggttacacccgactaccattactatagcaacaac ttcaacctcagtaaaaatcgatccgtcactgtaaccctgggtgacgagcgaggacgagtt catgaaagtgtgaagaggagtaactgctacatcatttggtgtggagatgtgaccaacgct gcccacgcctccagtcgcagcaacgtggacctggagattggctgtctcatcgacctggcc accggcctggtgacgttcaccgtcaacggcaaggagataaccacctcctaccaggtggaa ccaaacaccaaactttttcccgctgtgtttgtgcgacccaccagccctaacctcttccag tttgagctgtctaaaataaagaatgccatgcctttgtcatccgccatctttaagagtgaa cacaagaacccggtgccccagtgtccgccccgtttagatgtgcagaccatcagctctgtg ctgtggagccgcatgcccaacaccttcctcaaggtggaaacagcccgggtcaatgagagg cacggctgggtggtccagtgtgtggagcccctgcagatgttggccgttcatattcctgaa gaaaacaggtgtgtcgacatcatggagctgtctgagcaggaggacatgaggaagttccac taccacaccctgaagctctactgtgccctctgcgctctgggcaacacccgtgtggcccac gccctctgcagccacctggaccaatcacagctcttatacaccatcgacaaccagtacctg tccggcatgttacgtgaaggcttctacaacgtcttgatcagcatccacctggagacagcg aaggaggcacgactcatgatgaaggatgagttcatcatcccggtcacggctgagacgcgc tccatccgcctcttctccaatgcttccaaaaagcacctcccgccaggggtggggctcagc acctcgctcaaaccccgcctcaactttgctccgccgtgtttcatcagcaccaaacgagaa caacatctctacagcccccaaatccccctggacgctttgaaggagaaatcaatttcaatg ttgacggaggccgttcagggtggcggtcaccacatcagagaccctgtcggaggaggggtg gagtaccagtttgtgccaatcctgaaactcatcagcaccttgctgacgatgggcgtgcta ggtagcgaggacgtccataagatcttgctgctcatcgaccccaatgttttcagagagaca cgcgaggagggggtcacgggggccacagacaaagaaggactgaaaggggcggaggacaag gcagtggaagctggagaagaggagaccgccaaagaggccaaacagccaatgaaaggactg ctggagaagaggctgcctgagcccgtcaagcgacagatgtgcgagctgcttcactatttc tgcgactgcgagctgaagcatcgcatcgaagccatcgtgtctttctccgacagctttgtc tccaagcttcagtacaaccagaagtttcgctacaacgagctgatgctggccctcaacatg tccgctgctgtcaccgccaagaagaccaaagagtttagatcgccgcctcaagagcagatc aacatgctgctgaccttcagtatgggcgaggactgtccgtgtccatcaggcatccaagag cagttgtatgattttcacaaccagctgcagctacactgtggaatccctatggaggaagac ggatacaagcaagatacatcgatcacaggtcgcctgctgatgctggtgaacaagatcaaa ggccagtctcacaaggcagaggagcccaccgagaaacagcaagctgcaccatccaatctg aaggagctgatctctcagacgatggtcagctgggcccaggagtgtcacatcctggactct gagctggtccgcaagatgttcagcctgctgaggaggcagtacgacagcatcggggagctg ctccgggccatgaggaagacttacaccatcagcgctgcctccatccaggacaccatcaac ctcttggccgccctcggtcaaatcagatctctgctgtctgtgcgcatggggaaagaggag gagaagctcatgattgatggcctcgctgacatcatgaacaacaaagtcttctaccagcac cccaacctgatgagaatcctgggcatgcatgagactgttatggaggtcatggtcaatgtg ctcggaggacacaagtcccaggaaattgcctttcccaaaatggtggccagctgctgtcgc ttcctgtgctacttctgccggatcagccgccagaaccagaaagccatgttcgaccacctc agctacctgctggagaacagcagtgtgggcctagcttcaccagctatgaggggctccact cctctggacgtggctgcttcctcggtgatggacaacaacggcctggctctggcgctggag gagcctgatctggacaaggtggtcacctacctagcaggatgtgggctccagagttgtcca atactcttggctaaaggttatccagacatcggctggaaccccatagagggggagcgttac ctctccttcctgcggtttgctgtctttgtgaatggcgaaagcgtggaggagaactccagc gttgtagtcaaactgctcatccgtcgcccagagtgttttggacccgccctgaggggggag ggggggaacggcctgctggctgccatgaaggaagccatcaagatctctgagacgccggcc ctggacctgccaggctctgtgcacggagtcaactctgatgtgtctgctgatggtgacgat gaggaggaggtggtacacatgggcaacgccatcatgtccttctactctgcactcatcgac ctgctgggacgttgcgcaccggagatgcatcttatcaacaaggggaaaggtgaagctctg cgtattcgtgccatcctgcgctctctggtgccgactgaagacattgtgggaattatcagc ataccgctcaaaatgccaatcaccaacaaagatgggtcggtgactgagccggacatgtct gcctgtttcagtccggaccacaaggcccccatggtgctgtttttggacagggtgtatggt atcgaggaccagagctttctgcttcacctcctcgaagtgggctttcttcctgacctgagg gcggctacatctctggatacggattgtctttgtaccacggagacagccctggccatgaac cgcttcatcggctcagccatgctccccctcctcacccgctgcgcccctctcttcgccggc acggagcactacgccactctcatcgactccactctgcacaccatctaccgcctttccaag ggccgctccctcaccaaggcccagagagacgccatagaggagtgcctgctggccgtctgc aagcaccttcgtccctccatgctgcagcagctcctgcaccgcctcgtctttgacgtgccc ttgctgactgattactgcaagatgcctctgagactgctcaccaaccactatgagcagaac tggaagtactactgcctcccgtcgggctggggcagctacggcacagcatccgaggatgaa ctgctgctcaccaagaaaatcttctggggagtgtttgattctctgtcccagaggaattac gacgcagagctattcaagatggccatgccttgcctcagtgccatagctggagctctgcca ccggactacgtggacgcctccattagcaccacggtggagaagccagtttctgtagatgct cagggcaactttgaccccaaacccatcagtactgctaatattgctcttccagagaagctt gagcactttgccaacaaatacggagagcacgcccatgagaaatggtcagcagagaaggtg ctgcttggatggaaatatggagatggtgttgatgagaagtccaagattcacccccagctc agaatatacaaagccctgacagagaaggagaaagagatttacagatggccaattagagac tccctgaagagtatgctggcaatgggctggagcatcgacaggaacaaggatggagagagc atgtctcaacagagggagagtgagaaaatgcgaaagatctctcagacttcacagggaaat ggctttaatccgagcccgatagacatgagcaacgtggttttatccagagaattgcagggg atggtggaggtgttggctgaaaattaccataacatctgggccaagaagaaaaagagtgac cttggaagcagaggcggggggacacaccctatgttggtgccctacgacacactgacagcc aaagagaaggcccgtgatcgagagaaggccctggaccttttccgcttcctgcagatcaat ggatacagcatcacacggggtttgaaggacttagatcaggactcctcctccatggagaag aggtttgcttacaagttcctcaagaagctgctcaagtatgtcgactccgctcaggagttc atcgctcacctggagtccatggccgcaagtggcaaaacagacagatcgcctcatgaacaa gaaatcaagtttttcgccaaagttctcctccccctcatcgaccaatacttcaagaaccac tcgctctacttcctctcctccccgagtaagaacctgagcagcagcggttacgcctccaac aaggagaaggagatggtcaccagcctgttttgtaaactggcagctcttgtcagacatagg atttctctctttgggagcgactctactaccattgtcagctgtcttcacatcctggcacac actctggacaccaggacggtgatgaagtcgggctcggagcaggtgaggctggggctgagg acgttctttgagaatgctgcagaggatctcgagaagacgttcgagaacctgaagctggga aagttcactcactctcgctcccagatgaaaggggtgtcgcagaatatcaactacaccacc gtggctctgctccccattttaaccgctctgtttgaacacatcactcaacaccactttgga gtcgacctgcttttggatgatgtacaagtttcctgctatcgaatcctgaccagtctctat gcactaggaactgggaaaaacatctatgtagaaagacagctgccagctctcggtcagtgt ctggccaccctggccggggctttgcctgttgccttcctggagccggtgctcaacgcatac aacccctgctccgtcttcaataccaagagtgctagagaacgatccatcctaggcatacag gactcggtggcggagatgtgtcccgggatgccgcggctggacggtctgatgaaggacatc aacgatatggctgaatctggggcgcgctacacggagatgccccacgtcatcgaggtggtg ctgcccatgttgtgtaactatctgtcctactggtgggagagggggcctgagaaccagccg gccagcggggggagcgtctgctgcaccaccgtcacctcagaaaacctcagcctcattctg ggcaacatcctcaagatcctcaacaacaacctgggcatcgacgaggcctcctggatgaag aggattgcagtgtacgtgcaacccatcatcagcaaggcccgtgccgacctgctgaagagc cacttcctgcctactctggagaagctgaagaagaagacggtgaaggtggtgtctgaggag gagctgctgaaggcggacagtaagggagacacccaggaggccgagctgctcatcctggac gagtttgccgtactctgcagggacctgtacgccttctaccccatgctcatccgctatgtg gacaacaacaggtcgaggtggctgaaggagccagacgctgactccaatgagctcttcaga atggtcgctgagatatttatcctctggtgcaagtcacacaatttcaaaagagaagagcag aactttgtggttcagaatgaaatcaacaacctttccttcttaacgggagataataaaacc aagatgtctaagtcctttaaggagaagtctggaggacaagatcaagagaggaaacacaag aaaaggcgtggtgagttctactccatccagacctcgctgattgtggccgctctgaagaag atgctgccgatcggcctcaacatgtgtaccccaggagaccaggagctcatctcattggcc aagactcgctacctgctgagagacacagacgaagaggtcaaagatcatatccggcagaac ctgcaccttcgagaaagatcagaggaccccgcagtgaggtggcagctaaacctgtacaag gacgtagcgatgagaagcgacggacccccagaccctgacagggtggtggaccgcatccag aggatctctgctgctgtcttcaacctggagcaggtggagcagccattgagatccaagaag tgtgtgtggcaaaagctgttgtcaaagcagagaaagcgagcggtcgtcgcctgcttccgc atggctccactttataatctgccaaggcacaaaaataataattacttcctgaaagccttc cgacatatttggctggacataatttatgggaacacagactatgacagtctgctctccacg ttgacgaaaacgcagcccaaactggaggaggaggaagaggaggaggtcagaaagcagcca gaccctcttcaccagctcatcctgcatttcagccacaacgctctgactgagtgcagttct ttggaagaggatcccttatatattgcatatgcagatatgatggcaaagagttgtgatgaa ggtgaagaagaagaagaggaggaaggaaaagagaaaacatttgaggaaaaggaaatggag aagcaaaagatgctttaccagcaagcccgcctacacgaccgaggcgctgcggagatggtg ctccagatgatcagtgccagcaaaggtcgactcggtgctatggtgactttcaccctcaaa cttggcatctcagtcctcaacgggggaaacatactggtgcagcagaaaatgctggactac ctgaaggagaaaagagatgttggctttttcaaaagtttgtctggactcatgatgtcttgc agtgtcctggacttaaatgcatttgaaagacaaaataaagctgaaggtctggggatggtt actgaagaaggatcaagttccaaagtactgcagaatgatgagttcactaaggatctcttt aggtttctgcagcttctctgcgagggacacaacaatgattttcagaacttcctgaggact cagacaggaaacacaacaacagttaacattataattagtactgtagactacctgctaaga ctccaggaatccatcagtgatttctactggtactactctggtaaggatataatagatgag gcgggtcagaggaacttctctcaagcactagcagtggccaagcaggtcttcaactcttta actgagtatatacagggtccatgcattgggaaccagcagagtctggctcacagcaggctg tgggacgcagtggtcggcttcctgcatgtttttgccaacatgcagatgaagctatcccag gactccagtcagattgaattattgaaggagctgctggacctgcagaaggacatgatcgtc atgatgctctcgctactcgaaggtaatgttgtcaatgggaccattggcaaacaaatggtg gacaccttggtggaatcttcaagcaacgtggagatgatcctgaagtttttcgacatgttc ctcaagttgaaggacctgactacctcagacagcttcaaggagtacgacccagagagcaaa ggggtgatctcaaagaaagatttccagaagtccatggagaaccagaagcagtactcgcag tctgagatcgagtttctcctctcgtgcgctgaggctgatgagaacgacatgttcaactac gagcagtttgtggagagatttcatgaacctgccaaggacattggctttaatgtagctgtg ttactgacgaatctctccgagcacatgcctcatgacgctcgactcgccacattcctcgac ctggctgagagcgtcctcagttactttgaaccttacttgggtcgtattgagatcatgggg ggagctaagcgcatcgagagggtctactttgagatcagtgagtccagccgcacccagtgg gagaagcctcaggtgaaagagtcaaagaggcagtttatcttcgacgtcgtcaacgaaggc ggggagagcgagaagatggagctgtttgtcaagttctgcgaggacaccatcttcgagatg cagctagcttctcagatttccgagcctgacccggtggagcgtctggaggaagatgaggag gacaaccagagtgtggtggaaacccccgaggaggaagaggaggagagtgtgatgttggag tcttcctccgcgtttacaattgcctgcatctccatgaaaaaaagcctgtgccacttccgc cagatgctcacactcaagagcatgaggcggcagtacaggaagttcaggaagatgagcatc cgggagatggtgcgaggcttcttctctttcttctggatgatcatcaccggcctcttccac tttgtctacagcctggtttggggtttctttcacatcttgtggaccactatgtttgggggc ggcctggtggaaggggccaaaaacatgaaagtgactgacattttgggaaacatgccagac cccacccagtttgggatccacggcgatgtgttagagatggagaagatggaggcgagtgaa gcgtcggcgctggcagagatgggtcagatgtctcagggagaggcaggagaggcagacctg atggctgagctgctgaacatacagcccaagaaggaggggaagcacggggccgagcccggt ttgggggacgtgtctgaggtggtggtgggagatgctccatccatagccagcgctgtcagg cagaagaaagcacagttggctgcaaagaaggtgactgttaatggagactacacatctgat tcagagaaaggagattcagaggatggtgagaaaaaggaccatgataagtctaaagacgaa ccccctccggaccccccagtgctgaagaaagtccccaagaagaggatcgatgtgaagaaa gaactaccagaggccttcatggccagcttcttcgctggcctggaaatctaccaaaccaag atgctgaactacctggcaagaaacttttacaacctccgtttcctggcactttttgttgcc tttgctatcaacttcattctgctcttctacaaagtgaccggtgattacgcagacgatgaa gacccttggaatggtcagggtagaacaggggaggaggaagatgagggggccctggagtat ttcgtgctgcaggagagcacaggctacatggcgccaacgctccgatgtctggctatcctg cacaccatcatctctttcctgtgtgtcgtgggatactactacttgaaggtgcccctggtg gtgttcaaacgtgagaaggagatagcgaggaagttggagtttgccggcctctacatcaca gagcagccgtcagacgatgacatcaaagggcagtgggacagattggtcatcaatactcca tccttccccaacaactattgggacaaatttgtcaaacgcaaagtgatcaaaaagtacgga gacctgtatggagctgagaggatagcagagctgctggggatggataagagcgcccttgat ttcaaccctacagaggaaactgtcgccaaagaggcctcgcttgtgtcatggttgagctca atcgacacaaagtatcatgtgtggaaattgggagtggtgtttacggacaattccttcctg tatctagtgtggtacaccaccatgtccatcctgggtcactacaacaacttcttcttcgct gctcacctgctggacatcgccatggggttcaagaccctccgcaccatcctctcctccgtc acacataatggcaaacagctggtgttgacggtcggcctgctggcggttgtggtctatctc tacactgtggtggccttcaacttcttcaggaagttctacaataagagcgaagacgaggat gagccagatatgaagtgtgacgacatgatgacttgttacctgttccacatgtacgtcggg gtgagagccggggggggcatcggggatgagatcgaggaccccgctggtgacccctatgag ctctaccgcatcctgtttgacataactttcttcttcttcgtcatcgtcatcctcctggcc atcatccagggtttgatcatcgatgcctttggagagctgagagaccagcaggaacaagtg aaagaggacatggagaccaaatgcttcatctgtgggatcggcaacgactacttcgacaca acacctcacggctttgagactcacaccttacaagagcacaatttggccaactacctgttc ttcctgatgtacctcatcaacaaggacgagacggagcacactggccaggagtcttatgtg tggaagatgtaccaggagcgctgctgggatttcttcccagccggagactgcttccgcaag cagtacgaagatcagcttggatag

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