KEGG   PATHWAY: tbr03015Help
Entry
tbr03015                    Pathway                                

Name
mRNA surveillance pathway - Trypanosoma brucei
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
tbr03015  mRNA surveillance pathway
tbr03015

Ortholog table
Other DBs
BSID: 193325
GO: 0071028
Organism
Trypanosoma brucei [GN:tbr]
Gene
Tb927.6.1970  nuclear cap binding protein, putative [KO:K12883]
Tb927.7.1170  hypothetical protein, conserved [KO:K12876]
Tb927.6.4950  mago nashi-like protein,putative [KO:K12877]
Tb11.12.0011  ATP-dependent DEAD/H RNA helicase, putative [KO:K13025] [EC:3.6.4.13]
Tb11.22.0004  hypothetical protein, conserved [KO:K14284]
Tb927.7.5760  nuclear transport factor 2 protein, putative [KO:K14285]
Tb10.70.7730  ATP-dependent DEAD/H RNA helicase, putative [KO:K12812] [EC:3.6.4.13]
Tb10.70.2720  mRNA capping methyltransferase, putative [KO:K00565] [EC:2.1.1.56]
Tb927.7.1620  hypothetical protein, conserved [KO:K14397]
Tb927.3.3160  poly(A) polymerase [KO:K14376] [EC:2.7.7.19]
Tb927.7.3780  poly(A) polymerase, putative [KO:K14376] [EC:2.7.7.19]
Tb927.6.3690  pre-mRNA cleavage complex II Clp1-like, conserved [KO:K14399] [EC:2.7.1.78]
Tb927.4.4110  hypothetical protein, conserved [KO:K14399] [EC:2.7.1.78]
Tb11.01.6170  cleavage and polyadenylation specificity factor-like protein, putative [KO:K14401]
Tb11.03.0910  cleavage and polyadenylation specificity factor, putative [KO:K14402]
Tb927.4.1340  cleavage and polyadenylation specificity factor subunit, putative [KO:K14403] [EC:3.1.27.-]
Tb11.01.4600  cleavage and polyadenylation specificity factor 30 kDa subunit [KO:K14404]
Tb11.01.0450  serine/threonine protein phosphatase catalytic subunit, putative [KO:K06269] [EC:3.1.3.16]
Tb10.61.0570  hypothetical protein, conserved [KO:K14406]
Tb09.211.0930  polyadenylate-binding protein 1, putative [KO:K13126]
Tb11.22.0012  eukaryotic peptide chain release factor subunit 1, putative [KO:K03265]
Tb11.02.4030  eukaryotic release factor 3, putative [KO:K03267]
Tb927.5.2140  regulator of nonsense transcripts 1, putative [KO:K14326] [EC:3.6.4.-]
Tb927.3.1240  serine/threonine-protein phosphatase, putative [KO:K04382] [EC:3.1.3.16]
TB927.1.1380  serine/threonine protein phosphatase 2a regulatory subunit, putative [KO:K03456]
Tb10.26.0590  protein phosphatase 2a regulatory subunit, putative [KO:K04354]
Tb927.3.4470  hypothetical protein, conserved [KO:K11583]
Tb927.7.6810  hypothetical protein, conserved [KO:K11583]
Tb927.7.1710  eukaryotic peptide chain release factor subunit 1, putative [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
KO pathway
ko03015   
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