KEGG   PATHWAY: tca03015Help
Entry
tca03015                    Pathway                                

Name
mRNA surveillance pathway - Tribolium castaneum (red flour beetle)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
tca03015  mRNA surveillance pathway
tca03015

Ortholog table
Module
tca_M00399  Cap binding complex [PATH:tca03015]
tca_M00430  Exon junction complex (EJC) [PATH:tca03015]
Other DBs
BSID: 193404
GO: 0071028
Organism
Tribolium castaneum (red flour beetle) [GN:tca]
Gene
661829  nuclear cap-binding protein subunit 1 [KO:K12882]
663946  nuclear cap-binding protein subunit 2 [KO:K12883]
663859  regulator of nonsense transcripts 3A [KO:K14328]
656135  Tsu; tsunagi [KO:K12876]
656056  mago; mago nashi [KO:K12877]
664590  Btz; barentsz [KO:K14323]
664411  eukaryotic initiation factor 4A-III [KO:K13025] [EC:3.6.4.13]
662665  histone deacetylase complex subunit SAP18 [KO:K14324]
664381  pinin [KO:K13114]
658123  apoptotic chromatin condensation inducer [KO:K12875]
663923  RNA-binding protein with serine-rich domain 1 [KO:K14325]
660256  THO complex subunit 4 [KO:K12881]
103312682  nuclear RNA export factor 2 [KO:K14284]
103312683  nuclear RNA export factor 1 [KO:K14284]
656618  nuclear RNA export factor 1 [KO:K14284]
657794  NTF2-related export protein [KO:K14285]
662877  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:3.6.4.13]
663159  partner of Y14 and mago [KO:K14294]
100142567  serine/arginine repetitive matrix protein 1 [KO:K13171]
660879  mRNA-capping enzyme [KO:K13917] [EC:3.6.1.- 2.7.7.50]
659894  mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
664338  polyadenylate-binding protein 2 [KO:K14396]
657997  cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
658420  cleavage and polyadenylation specificity factor subunit CG7185 [KO:K14398]
103312455  poly(A) polymerase type 3 [KO:K14376] [EC:2.7.7.19]
663900  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
659455  kinesin-5D; kinesin 5D [KO:K14400]
656498  cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
659785  probable cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
103314846  cleavage and polyadenylation specificity factor 73 [KO:K14403] [EC:3.1.27.-]
655471  cleavage and polyadenylation specificity factor subunit 4-like [KO:K14404]
660072  Cpsf4; cleavage and polyadenylation specific factor 4, 30kDa [KO:K14404]
655606  pre-mRNA polyadenylation factor FIP1 [KO:K14405]
657647  pre-mRNA 3' end processing protein WDR33 [KO:K15542]
654994  WD repeat-containing protein 82 [KO:K14962]
656485  FK506-binding protein 59 [KO:K06269] [EC:3.1.3.16]
103312533  serine/threonine-protein phosphatase PP1-alpha-like [KO:K06269] [EC:3.1.3.16]
103312848  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100141788  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
657409  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
656518  cleavage stimulation factor subunit 1 [KO:K14406]
659353  cleavage stimulation factor subunit 2 tau variant [KO:K14407]
661644  protein suppressor of forked [KO:K14408]
103314929  symplekin [KO:K06100]
655156  heterogeneous nuclear ribonucleoprotein 27C [KO:K14411]
656824  RNA-binding protein Musashi homolog 2 [KO:K14411]
656553  RNA-binding protein Musashi homolog Rbp6 [KO:K14411]
657776  polyadenylate-binding protein 1 [KO:K13126]
660632  polyadenylate-binding protein 4-like [KO:K13126]
660337  eukaryotic peptide chain release factor subunit 1 [KO:K03265]
657209  eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
662109  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:3.6.4.-]
658027  regulator of nonsense transcripts 2 [KO:K14327]
658025  serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
657474  protein SMG7 [KO:K14409]
100142092  protein SMG5 [KO:K11125]
663281  uncharacterized LOC663281 [KO:K11124] [EC:3.1.-.-]
662352  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
656557  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
641602  Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha isoform [KO:K03456]
659477  protein phosphatase PP2A 55 kDa regulatory subunit [KO:K04354]
659659  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
658209  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
664455  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
659798  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
657404  HBS1-like protein [KO:K14416]
655490  pelo; pelota [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
KO pathway
ko03015   
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