Talpa occidentalis (Iberian mole): 119239532 Help Entry 119239532         CDS       T07495                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism tod  Talpa occidentalis (Iberian mole) Pathway tod04020   Calcium signaling pathway tod04371   Apelin signaling pathway tod04713   Circadian entrainment tod04921   Oxytocin signaling pathway tod04970   Salivary secretion tod05010   Alzheimer disease tod05012   Parkinson disease tod05020   Prion disease tod05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:tod00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     119239532 (RYR3)    04020 Calcium signaling pathway     119239532 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     119239532 (RYR3)   09154 Digestive system    04970 Salivary secretion     119239532 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     119239532 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     119239532 (RYR3)    05012 Parkinson disease     119239532 (RYR3)    05020 Prion disease     119239532 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     119239532 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:tod04040]     119239532 (RYR3) Ion channels [BR:tod04040]  Voltage-gated cation channels   Ryanodine receptor    119239532 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  119239532 NCBI-ProteinID:  XP_054556198 LinkDB All DBs Position Unknown AA seq 4866 aa AA seqDB search MAEGAEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREQATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTILTTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDMEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPVPLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNCVAHFAGIAREESGMAWKEVLNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVSSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDSEGIRDLLGT TQFLSQASFIPCPIDTSQIVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYTLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID GTMDSPPCLKVTHKTFGTQNSNGNMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQIQEI LSHTTTQCYYSIRIFAGQDPSCVWVGWVTPDYHLYSEKFDPNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDVVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPLCPPRLDVQTIQPVLW SRMPNSFLKVETERVSERHGWLVQCPEPLQMMALHIPEENRCVDILELCEQEDLMQFHFH TLRLYSAVCALGNSRVAFALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE RKLMMKNEYIIPINSTTRKIRLYPDKAKRHGLPGVGLRTCLKPGFKFSTPCFVMTNEEHQ KQSPEIPLEILKTKALSMLTEAVRCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPCVFGEHSGEMEEGAEKEEVTQVEEKAVEAGEKASKEAPLRGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA KKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEVEEED TSWPGKLRTLVHKIKGPIKAQKEQPTEKEERYPTTLKELVSQTMICWAQEDQIQDAELIR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGTGLLAAVQGAIKISENPALDLPSQGYKREIMDDDENEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEALRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRALTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDQDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKYG ISLDENVRTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTIERTKEGEALAQQREN EKLRSVSQVSQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIMVSRGMKDLELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHHLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAHHQFGVDLLLGDVQISCYRILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINALAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEYLPPSTGPWCTKITSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSSWLKSPDADSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSL IVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHLQEKSDDPAVK WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEET EKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQGGEVEEEEEDKEKTFEE KEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMNPMVVETLKLGIAILNGGNAGVQQK MLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVL QNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIINTVDYLLRLQESISDFYW YYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV EMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYIQSEIDFLLSCA EADENDMFNYMDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFE PYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFV NFCEDTIFEMQLASQISESDSADRPEEEEREEDEDPSYTLELEAEEEEDSSFEPVSAFAM ACASMKRNVANFLKKATLKNLRKQYRKVKKMTVKELVRVFFSFFWMLFVGLFQLFFTILG GIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHEDAVEAERAEVTEPGVTTEL VHFIKGEKGDADVMSDLFGFHAKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVQKQRK AQAAEMKAAHEAEGRVESEKADTEDGEKEDTAKEEEQAEALWTDKAKKKKRRHGQKIEKP EAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETED VANLWNSFNEEEEEEAMVFFVLQESTGYMAPALRALAIIHTVISLVCVVGYYCLKVPLVV FKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGD LYGAERIAELLGLDKNALDFSPVEETKAEAASLLSWLSSIDMKYHVWKLGVVFTDNSFLY LAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM YRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTT PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQ YEDQLG NT seq 14601 nt NT seq  +upstreamnt  +downstreamnt atggccgagggggcagaaggaggcgaggacgaaatccagttcctgcggacggaagatgaa gtggttctccagtgcattgcaaacattcacaaggagcaaaggaagttctgcctggccgct gagggacttgggaatcgcctgtgtttcttggaacccacttctgaagccaagtatgttcct cctgatctctgcgtctgcaattttgtgctggaacagtccctctctgtccgagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctgtatggccacgcgattctcctgcggcattctttcagcggcatgtatctc acgtgcctgactacgtcaagatcccagacagataaacttgcctttgatgtaggtctgcgg gaacaggccacaggagaagcctgttggtggaccatacatccagcttcgaaacagaggtcc gagggagagaaagttcgaattggtgatgacctcatccttgtcagtgtgtcctctgaaaga taccttcatctctctatatcaaatggtaacatacaagtggatgcctcctttatgcagaca ctctggaatgtccatcccacgtgctcaggaagcagcatcgaagaaggatacctacttggt gggcacgtggtacgtcttttccacggtcatgatgagtgtttgactatactgactacagac cagaatgattcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc agatctctgtggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggccaggccttccgactccggcacctcaccacaggccactacctcgccttgacagaggac caagggcttatactgcaggaccggggaaaatcagacaccaaatccacagccttctctttc cgggcatcaaaggaaatcaaggagaaattggattccagtcacaagcgagatatggaaggc atgggagttccggaaatcaagtatggagattccgtctgctttgtccagcatatagccagc ggtctgtgggtgacctacaaagcacaagatgccaaaacatcccgcctgggacctctgaaa aggaaggtcatactccatcaggagggccacatggatgatggactgaccctgcagaggtgc cagcgtgaggagtcccaggctgctcgaatcatccggaacacaactgccttgttcagccag tttgtgagtggaaacaatcgcacagctgccccggtccccctgccgattgaagaggtcctg cagaccttgcaggacttaatcgcctactttcagcccccggaggaggagatgaggcatgaa gacaagcagaacaagctccgctcacttaaaaacagacaaaatctcttcaaagaagaggga atgttggcccttgtgttaaattgcattgatcgcttaaatatctacaactgcgtagcacac tttgcagggattgcaagggaagagagtggcatggcctggaaagaagttctgaacctcctg tacaaattgctggctgctctcattcgtggaaatagaaacaattgtgctcaattctccaat aaccttgattggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctaattgaaagcccagaagccttaaatcttatagcagagggtcat atcaagtccatcatctccctgttggacaagcatggccggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggttgcagtgagagccaaccagaatctgatctgt gacaacttgctgccccggagaaacctgctcctgcagactcgactgattaacgatgtaacg agtattcggccaaacatcttcttgggagtggccgaaggctcggcacagtacaagaagtgg tacttcgagctcatcatcgaccaggtggaccccttcctgacagcagagcccacacacctg cgggtgggctgggcctcctcttcaggatatgcaccctatcccggaggtggggaaggctgg ggaggcaacggtgttggcgatgacctgtactcttatggctttgacggacttcacctttgg tcaggccggatacccagagctgttgcctccatcaaccagcacctcctgaagtcagatgat gtggtgagctgttgccttgacctgggagtgtccagcatctccttccgcatcaatgggcag cctgtacaagggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgtttcttgatgggtggacgtcatggagaatttaaattc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagagaagatgaga ctggagcccgtcaaagaatacaagcgtgattctgaaggcattagagatctgctgggtacc acccagttcctgtcccaagcctccttcatcccctgtcccatagacaccagtcagattgtc ttgccgcctcacctagagaagatccgagacagactggctgaaaatatccatgagctttgg ggaatgaataagatcgagctcggctggacttttggcaagatacgggatgacaataaaaga caacacccctgccttgtggagttctcaaagctccccgaaactgagaagaattataacctg caaatgtcaactgaaaccttaaagaccctcctggccctgggatgccacattgcccatgtt aatccggctgctgaggaggatctcaaaaaggtcaaactgcccaaaaactacatgatgtcc aatggctataaaccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcacataatgtttgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggatttgaagaacaaaaggaatccccggctggtg ccatatacattgctggacgagcgaaccaagaagtctaacagggacagtctccgcgaagct gtccggacatttgttggatatggatacaacatagagccatcagatcaagagctagctgac cctgctgtggagaaagtcagcatagacaagattcgatttttccgggtagagcggtcttat gcagtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgt gttggctgggccagaccaggctgtcggcctgacattgagctgggggccgatgaccaagcc tttgtgtttgaaggaagcaggggccagcgttggcatcaagggagtgggtattttggacgt acctggcagccaggagatgtggttggatgtatgattaacctagatgatgcctcaatgatc ttcacattgaatggggagctgctgatcaccaacaaaggctctgaacttgcctttgctgac tacgagattgagaatggctttgtgcccatctgctccctgggactgtctcagattggccgc atgaatctcgggatggatgccagtaccttcaagttttataccatgtgtggccttcaagag ggctttgagccttttgctgtcaacatgaaccgagacgttgcaatgtggttcagcaagcgc ctcccaacattcgtcaacgtgccaaaggatcatccacatatagaggtcatgaggatcgat ggcaccatggacagccctccatgcctcaaggtgacccacaagacgtttggcacacagaat agcaatggcaacatgatctactgccgcctgagcatgcctgtcgagtgccactcctccttc agccacagcccctgcctggacagtgaggctttccagaaaaggaaacagattcaagaaata ctctctcatacaacaacgcagtgctactactcaatccgcatctttgctggacaggacccc tcctgcgtctgggtcggatgggtgactccagattatcacttgtacagtgaaaagtttgac ccgaataaaaattgtacggtgactgtcaccctgggggatgagagaggccgggttcacgaa agtgtgaagcgcagcaactgctacatggtctggggtggggatgttgtggctacttcccaa agatcaagtcggagcaatgtggacctagagatcggctgcctcgtggacctggcaatgggc atgttgtccttctctgcgaatgggcgagaactcggcacctgctaccaggtggagcccaac accaaagtatttccagccgtgttcctgcagcccacaagtacatctttgtttcagtttgaa cttgggaagctgaagaatgccatgcccctgtcagcagccatatttaagagtgaagagaag aacccagtcccactgtgtccccctcggctggacgttcagaccatacagcctgtgctctgg agccgcatgcccaacagcttcctgaaggtggagacagagagagtgagcgagcgccatggc tggctggtgcagtgcccggagcccctgcagatgatggcactccacatccccgaggagaac aggtgtgtggacatcctggagctctgtgagcaggaggacctgatgcagttccatttccac acgctgaggctctacagtgccgtgtgtgccctgggaaacagccgagtggccttcgccctg tgcagccacgtggacctctcacagctcttctatgccattgacaacaagtatctcccgggc ctccttcggtctggtttctatgacctgctcatcagcatccacctggccagcgctaaggag aggaagctgatgatgaagaatgagtacattatccccattaacagcaccaccaggaaaatc cgcctgtacccggacaaggccaagaggcatgggctgcctggggtgggcctgagaacgtgt ctcaagccagggttcaagttctccaccccatgctttgtcatgaccaatgaggagcaccaa aagcagagccccgagatccccttggagattctcaagacgaaagccctgagcatgctgacg gaggcggtgcggtgcagcggggctcacatccgggatcctgttgggggctccgtggagttc cagtttgtgccggtgctgaaactgattggaaccctgctcgtcatgggggtgtttgatgac gatgatgttcggcagattctcctcttgatcgacccctgtgtgtttggggagcacagtgga gagatggaagagggagcagagaaagaagaagtgacccaggtggaggagaaggcagtggag gctggggaaaaggccagcaaggaggctcccctcagaggcttgctgcagactcgattacca gagtctgtcaaactgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag caccgagtggaggccattgtggcatttggtgacatctatgtctccaagctccaggcaaat cagaagtttcgctacaatgaactcatgcaggccctgaacatgtctgctgccctgaccgcc aagaagaccagggagttccgctcacctccccaggagcagatcaacatgctccttaatttt caactgggagagaattgcccctgtccagaggagatccgagaggagctctatgacttccat gaggatcttcttattcactgtggggttcccctggaggaagaggaagtggaggaagaggac acttcctggcctggaaagctccgcaccttggtgcacaaaatcaaagggcctatcaaggcg cagaaggagcagccgacagagaaggaggagagataccccaccacactgaaggagcttgtc tcacagacaatgatctgctgggcccaagaggaccagatccaggatgcagagctgatccgg atgatgttcaacctgctccgccggcagtacgacagcatcggagagctgctgcaggcactg cgcaagacctacaccatcagccaggcctctgtgagcgacaccatcagcctgctggccgcc ctgggccagattcgctgcctcctcagcgtcagaatgggcaaggaagaggagctactcatg atcaatgggctgggagacataatgaacaacaaggtgttttaccagcaccccaatctcatg agagtcctcggcatgcacgagacagtgatggaggtgatggtgaacgtgttgggtgcagag aaatctcagatcgcgtttccaaagatggttgccagctgttgccgcttcctttgctatttc tgccgaattagccggcaaaaccagaaggcgatgtttgagcatctgagttacctgctggaa aatagtagtgttggcctagcctccccgtcaatgaggggatccaccccgctggatgtggca gcttcttctgtgatggacaacaacgagctagcactgggcttggaggaaccagaccttgag aaggtggtgacctatttggcaggctgcggcctccagagctgccctatgcttctggccaaa ggataccctgatgttggctggaaccccattgaaggggagcgctacttgtccttcctgagg tttgccgtcttcgtaaacagtgaaagtgtggaagaaaatgctagtgtcgtggtgaagctg ctcatcagacgcccggagtgcttcggcccagccctgcggggtgaaggaggaactggtcta ctggcagctgtgcagggggccattaagatctctgaaaacccagccctagacctgccttca cagggatacaagagagaaatcatggatgatgacgaaaacgaagaggagattgtgcacatg ggcaatgcaattatgtcattttattctgctcttatagatctcctgggccgctgtgctcct gaaatgcacctcatccagacgggaaaaggggaagccctcaggatcaggtcaatcctgcgc tccctggtccccacagaggacttggttgggatcatcagtatccccctgaaactgccgtcc ctgaacaaagatgggtctgtcagtgagccagatatggcagccaacttctgtcctgatcac aaggctcctatggtgctcttcctggaccgtgtttatggcatcaaggatcaaactttcttg ctccacttgttagaggttggatttttacctgacttaagagcctctgcctctctagataca gtgtccctaagtaccacagaggctgcgctggctctgaatcgttatctctgttccgctgtg ctcccgctcctcacgagatgcgcccccctctttgctggaacagaacactgtacctctctg atcgactccacgctacagacaatatacaggctctccaagggccgtgccctcaccaaagct caaagggacaccatagaagaatgtttgcttgccatttgcaaccatctgagaccttccatg ttacagcaactcttgagacggcttgtctttgatgtgccccagctcaacgaatactgcaaa atgccccttaagcttctgaccaatcactatgagcagtgctggaagtattactgtctgcct tcaggatgggggagctatggcctcgctgtggaggaagagctgcacctgacagagaagctc ttctgggggatttttgactctctctcccataagaagtacgaccaagaccttttccgaatg gctctgccttgtctcagtgctatcgctggggccttgccaccagattatctggacaccaga atctcagccacattggagaaacaggtctcagtagatgcagatggcaactttgaccccaag cctatcaacaccatgaatttctccttgcctgaaaaattggaatacatcgtcaccaagtat gctgagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatgga atctccctggatgaaaatgtgaggacccatccactcataagacctttcaagacattaaca gagaaggagaaggaaatttatcgctggccagccagagagtccctgaaaaccatgctggct gtaggctggaccatagagagaactaaagagggagaagctctggctcagcagcgagaaaat gagaagcttcgaagcgtgtcccaggtcagccagggtaacagctacagcccagctcccttg gacctctccaacgttgtgctctccagagagctccagggaatggtggaggtcgtggctgag aactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggcggc agtcaccctcttttggtgccatatgacaccttgactgccaaggaaaagttcagggaccga gagaaagcacaggacctgtttaaattcctccaggtgaatggcatcatggtttctagagga atgaaggatttggaactggatgcctcctccatggaaaagaggtttgcctataaattttta aagaagatcctgaaatatgttgattctgctcaagagtttattgcccatttggaagccatt gtcactagtgggaaaactgaaaagtctcctcatgaccaagagatcaaattctttgccaaa gttctgctcccactagtagaccagtacttcaccaatcaccacctctacttcctgtcgtcc cctttgaagcccctgagcagcagtgggtatgcctcccacaaggagaaggaaatggtggcc agcctgttctgcaaactcgctgcccttgttagacacaggatttccctctttgggagtgat tctactacaatggtgagctgtcttcacatcttagcacagacgcttgacacaaggactgtc atgaagtcaggctcggagctggtgaaggctgggttgcgagcattttttgaaaatgctgcc gaagacttagagaagacttcagaaaacctgaagcttgggaagtttacccattccagaacg cagatcaagggcgtgtctcagaatattaactacaccactgtggctctgctccccatcctg acatccatctttgaacacgtcgcccaccatcagttcggggtggatttgctcttgggagat gtgcagatttcatgctaccgcatactgtgcagcctctactcccttgggacaggaaaaaac atctatgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactagcagctgcc ataccagtggcgttcctggagcccacccttaaccgctataatccgctctccgtcttcaac accaaaacccccagggagaggtctattctgggaatgccagacacagtggaggagatgtgt cctgacatcccacagctggaaggactgatgaaggaaatcaacgcactggctgagtcaggg gcccgctacacagagatgccccatgtcattgaggtgatcttgcccatgctctgcaactac ctgtcttactggtgggagcggggccctgagtacctgcccccaagcacaggaccctggtgc accaagatcacttctgaacacctcagtgtcatcctggggaacattctgaaaatcatcaac aacaacctgggcatcgatgaggcctcctggatgaagcgcattgcagtatatgcccagcca atcatcagcaaagccaggcctgacctgctgaggagccacttcatcccgactctggagaag ttgaaaaaaaaggctgtcaagactgtgcaggaagaggagcagctaaaagctgatggcaaa ggggacactcaggaggcagagctcctcatcctggatgagtttgcagtcctctgcagagac ctctacgccttctaccccatgctaatccgctacgtggacaacaacaggtctagctggctc aaaagccccgatgctgactccgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgtaaatctcataacttcaagagggaagagcaaaattttgtgattcagaatgaaatt aataatttggcatttttaactggggacagcaaaagcaagatgtcaaaatctggaggacag gaccaggaacggaagaagacaaagcggaggggagacttgtattccattcagacctccctc atcgtagcagcactcaagaaaatgctgcccattggtttgaatatgtgcaccccaggcgat caggagctgatctccctcgcaaaatcacgatacagctgtagggacacagatgaagaggtc aaggagcacctgcggaataatttgcacttgcaggaaaagtctgatgatccagctgtaaaa tggcaactgaacctctacaaagatgttttgaagagtgaagaaccttctaatccagaaaag acagtggagcgtgtgcaaagaatttcagcagctgtcttccacctggagcaggtagaacag cctttgaggtccaagaaggcagtctggcacaaactgttgtcaaagcaacggaaacgggct gtagtggcctgtttcaggatggccccactttacaacctgcccaggcaccgctctattaac ctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagag aaactagtacaggatttggctaaatctcccaaggtggaagaggaggaggaggaggagaca gaaaagcagccagatccacttcatcagatcatcctccatttcagccgcaatgctctcacg gagaggagcaaattggaagacgaccctctgtacacctcctactccagcatgatggccaag agttgccagggtggggaggtcgaagaagaagaggaggacaaggagaaaacatttgaagag aaagaaatggaaaagcagaaaaccctctaccagcaagctcggctgcatgagcgcggagca gcagagatggtcctgcagatgatcagtgctagcaaaggtgagatgaaccccatggtggtt gagactctgaagctggggatcgccattctgaatgggggcaacgctggcgtacaacagaaa atgctagattacctaaaggagaaaaaggatgctggattcttccaaagcctttctggtctt atgcagtcttgcagtgtccttgacctgaatgcatttgagagacagaataaagctgaaggc ctggggatggttactgaagaaggaacactcattgttcgtgagcgtggtgaaaaagtcctc cagaatgacgagtttacccgcgatctctttcgatttctacagctactttgtgaaggacat aacagcgactttcagaacttcctgcggactcagatgggcaacaccaccaccgtgaatgtc atcatcaatactgtggactacctcctgcgtctgcaggaatcaatcagtgatttctactgg tattattcagggaaggacatcattgatgaatctggacagcacaatttttccaaagccctg gcagtcaccaagcagattttcaattctcttacagaatacatccagggcccttgcattgga aaccagcagagcctggcgcacagcaggctgtgggacgcggtggtcggcttcctccacgtc tttgctaacatgcagatgaaactctcccaggattccagtcagatcgagctgctgaaggaa ctcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaaggaaatgtg gtaaatggaactattggcaagcagatggttgacacactggtagagtcatctaccaatgta gaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctcagac accttcaaggagtatgacccagatggtaaaggaattatctccaaaaaagaattccagaag gccatggaagggcagaaacagtacatacagtcagagattgattttctcctctcgtgtgcg gaagctgatgagaatgacatgtttaattacatggattttgtagaccggttccatgagcca gccaaggacatagggtttaatgtggccgtgttgttgacgaatctttcggaacacatgccg aatgactctcgccttaagtgtctgttggacccagcagaaagcgtgctcaattactttgag ccgtacctaggacgcattgagatcatgggcggggccaagaaaatcgagcgtgtttatttt gagatcagtgaatccagccgaactcagtgggagaagccccaggtgaaggaatctaagaga cagttcatctttgatgtcgtcaatgaaggtggagagcaagagaagatggaactgtttgtg aacttctgcgaggacaccatcttcgaaatgcagctagcgtcgcagatctctgaatccgat tcagccgacaggccggaggaggaggagagggaagaagatgaagatccttcttacacatta gaactggaggctgaagaggaggaagactcatcttttgagccggtctctgcatttgccatg gcctgtgcctccatgaagagaaatgtcgccaactttctgaagaaggcaaccctgaagaat ctcaggaagcagtacaggaaggtgaaaaagatgactgtgaaggagctggtgagggtgttc ttctctttcttctggatgttgttcgtggggcttttccaattgttcttcaccatcttggga ggaatctttcagatcctctggagcacagtgtttggagggggcctggtagaaggggcaaag aacatcagggtgaccaagatcctgggggacatgcctgacccaacccaattcggtatccat gaggatgcagtggaggctgagagagcggaagtgactgagccgggtgtcacaactgaactg gtacacttcataaagggtgagaagggagatgcggatgttatgtcagatctctttggattc cacgcaaagaaggaaggtggcttaaaacacgggcccgaagtgggtttgggtgacctctca gagattattggcaaggacgaaccccctacactagagagtacagtgcagaagcaaaggaaa gcacaggcggcagagatgaaagcagcacatgaagctgaaggaagagttgagtctgagaag gcagacacggaagatggggagaaggaggatacagccaaagaggaggagcaagccgaggct ctgtggacagacaaagcaaaaaagaagaaacggcgacatggccagaaaattgagaagcct gaagctttcatggccaatttctttaaaggactggaaatctatcagaccaagttactgcat tacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatc aacttcatcctgctcttttacaaggtgactgaagaacctttagaagaagagacagaggac gttgcaaacctgtggaattcctttaatgaggaggaagaggaagaggccatggtgttcttc gtcctgcaggagagcacaggctacatggcaccagccttgcgggccctggccatcatccac accgtcatctctctcgtctgcgtggtgggctattactgcctgaaggtccctttggtggtt tttaaaagggaaaaagaaattgccagaaagctggagtttgacggcctgtacattactgaa cagccatctgaagatgacatcaaggggcagtgggaccgcttggtaatcaacacaccatct tttcctaataactactgggacaagtttgtaaagagaaaggtgatcaacaagtacggggat ctctacggagcagagcgcattgctgaactcctgggtttggacaaaaacgcccttgacttt agcccagtagaagaaaccaaagctgaagcggcctctctgctgtcatggctaagttccatc gacatgaagtaccacgtctggaagctgggagttgtttttactgacaattcctttctctac cttgcctggtacaccaccatgtcagtcctgggtcactacaacaacttcttctttgctgct catctgctggacatcgccatgggcttcaagaccctgaggaccattctgtcatcggtaacg cacaacggcaaacagttggtcctgaccgttggcctcctggccgtggtggtttatctctac accgtggtggctttcaacttcttccgcaagttctacaacaaaagtgaagatgacgatgag cctgacatgaagtgcgatgacatgatgacatgttacctgttccacatgtacgtgggagtg agagctggaggcggcatcggcgatgaaatcgaagaccctgctggggatccctatgagatg tatcggattgtctttgacatcaccttcttcttcttcgtcattgtcatcttgttggccatc attcaaggtctcatcattgatgcttttggagagctgagggaccaacaggagcaagtacga gaagacatggagacaaaatgtttcatctgtgggattggcaatgactactttgacacgacc cctcacggttttgaaacgcataccttgcaagagcacaatttagccaactacttgtttttt ctgatgtatttgatcaataaagatgaaacagagcacacaggccaggaatcttacgtctgg aagatgtaccaggagaggtgctgggatttcttcccggcgggcgactgctttcggaaacag tatgaagaccagctgggataa

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