Talpa occidentalis (Iberian mole): 119249121
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Entry
119249121 CDS
T07495
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
tod
Talpa occidentalis (Iberian mole)
Pathway
tod00562
Inositol phosphate metabolism
tod01100
Metabolic pathways
tod01521
EGFR tyrosine kinase inhibitor resistance
tod04012
ErbB signaling pathway
tod04014
Ras signaling pathway
tod04020
Calcium signaling pathway
tod04062
Chemokine signaling pathway
tod04064
NF-kappa B signaling pathway
tod04066
HIF-1 signaling pathway
tod04070
Phosphatidylinositol signaling system
tod04072
Phospholipase D signaling pathway
tod04360
Axon guidance
tod04370
VEGF signaling pathway
tod04380
Osteoclast differentiation
tod04611
Platelet activation
tod04613
Neutrophil extracellular trap formation
tod04625
C-type lectin receptor signaling pathway
tod04650
Natural killer cell mediated cytotoxicity
tod04662
B cell receptor signaling pathway
tod04664
Fc epsilon RI signaling pathway
tod04666
Fc gamma R-mediated phagocytosis
tod04670
Leukocyte transendothelial migration
tod04722
Neurotrophin signaling pathway
tod04750
Inflammatory mediator regulation of TRP channels
tod04919
Thyroid hormone signaling pathway
tod04933
AGE-RAGE signaling pathway in diabetic complications
tod04935
Growth hormone synthesis, secretion and action
tod05167
Kaposi sarcoma-associated herpesvirus infection
tod05169
Epstein-Barr virus infection
tod05170
Human immunodeficiency virus 1 infection
tod05171
Coronavirus disease - COVID-19
tod05200
Pathways in cancer
tod05205
Proteoglycans in cancer
tod05206
MicroRNAs in cancer
tod05214
Glioma
tod05223
Non-small cell lung cancer
tod05225
Hepatocellular carcinoma
Module
tod_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
tod00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
119249121 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
119249121 (PLCG2)
04014 Ras signaling pathway
119249121 (PLCG2)
04370 VEGF signaling pathway
119249121 (PLCG2)
04064 NF-kappa B signaling pathway
119249121 (PLCG2)
04066 HIF-1 signaling pathway
119249121 (PLCG2)
04020 Calcium signaling pathway
119249121 (PLCG2)
04070 Phosphatidylinositol signaling system
119249121 (PLCG2)
04072 Phospholipase D signaling pathway
119249121 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
119249121 (PLCG2)
04613 Neutrophil extracellular trap formation
119249121 (PLCG2)
04625 C-type lectin receptor signaling pathway
119249121 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
119249121 (PLCG2)
04662 B cell receptor signaling pathway
119249121 (PLCG2)
04664 Fc epsilon RI signaling pathway
119249121 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
119249121 (PLCG2)
04670 Leukocyte transendothelial migration
119249121 (PLCG2)
04062 Chemokine signaling pathway
119249121 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
119249121 (PLCG2)
04919 Thyroid hormone signaling pathway
119249121 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
119249121 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
119249121 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
119249121 (PLCG2)
04380 Osteoclast differentiation
119249121 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
119249121 (PLCG2)
05206 MicroRNAs in cancer
119249121 (PLCG2)
05205 Proteoglycans in cancer
119249121 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
119249121 (PLCG2)
05214 Glioma
119249121 (PLCG2)
05223 Non-small cell lung cancer
119249121 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
119249121 (PLCG2)
05171 Coronavirus disease - COVID-19
119249121 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
119249121 (PLCG2)
05169 Epstein-Barr virus infection
119249121 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
119249121 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
119249121 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
tod04131
]
119249121 (PLCG2)
Enzymes [BR:
tod01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
119249121 (PLCG2)
Membrane trafficking [BR:
tod04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
119249121 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
119249121 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
PH
SH3_9
PH_12
SH3_2
PH_14
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
119249121
NCBI-ProteinID:
XP_037372122
LinkDB
All DBs
Position
Unknown
AA seq
1305 aa
AA seq
DB search
MPYQETEATCAPRTPFCLRPITTFPASHFLTPSFSLEWPAVTTMANVDNLAEYEKSQIKR
ALELGTVMTVFSFRKYSSERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSK
DFERAKVVRQKEDCCFTILYGNQFVLSTLSLAADSKEDAAKWLSGLKILHQEAMSASTPT
IIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSAKFLKDKFMEIGAHKDELSFE
QFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAIHLHDFQRFLLHEQQELWAQ
DLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDVVDMQDMNNPLSH
YWISSSHNTYLTGDQLRSESSTEAYVRCLRMGCRCIELDCWDGPDGKPIIYHGWTRTTKI
KFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARVFREVFGDLLLTKPTEASADQ
LPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKEEHKQQGELYMWDSIDQKWTRHYCAIAD
AKLSFSDDIEQTAEDELPQDTPPTELHFGEKWFHKKVEKRTSAEKLLQEYCTETGGKDGT
FLVRESETFPNDYTLSFWRSGRVQHCRIRSTMDGGTMKYYLTDNLMFTSIYALIQHYREA
HLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRVPRDGAFLIRRRESSDSY
AITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMKLRYPVTPELL
ERYNMERDVSSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRGDELSFCRGALIHNVS
KEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQIIEDNPLGSLCRGILDLNTYNV
VKAPQGKNQKTFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNLRYW
EKNQSIAIELSDLVVYCKPTSKTKDNLENPDYREIRSFVETKADSVTRQKPIDLLKYNQK
GLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQVNHALFSLNGRTGYVLQP
ESMRAEKHDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFK
TTVVNDNGLSPVWASTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKS
GFRSVPLKNGYSEDVELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTH
QNLRNASRDALVKEFTVNENQLQLYQEKCNRRLREKRVSNSKFYS
NT seq
3918 nt
NT seq
+upstream
nt +downstream
nt
atgccctatcaagaaacagaagctacctgtgcccccaggacgcccttctgcttgcgtccc
atcaccacctttccagcctcccatttcctcactccttccttctccctggagtggccagca
gtgaccaccatggcgaacgtggacaaccttgcagaatacgagaagagtcagatcaagaga
gccctggagctggggacagtgatgaccgtgttcagcttccgcaagtacagctcggagcgg
aggacggtccaggtgatcatggagacgcggcaggtggcctggagcaagacggcagacaag
atcgagggcttcttggatatcatggaaataaaggaaatccgcccagggaagaactctaag
gactttgagcgtgcaaaggttgtccgccagaaggaagactgctgcttcaccatcttgtat
ggcaaccagtttgtcctcagcaccctcagtttagctgctgactcaaaagaagatgcagcc
aagtggctctccggcttgaagatcttacaccaggaagcaatgagcgcttccacgcccacc
atcattgagagttggctgagaaagcagatttattccgtggatcaaaccagaagaaacagt
atcagcctgcgagagttgaagaccatcttgcccctggtcaacttcaaagtgagcagtgcc
aagttcctcaaagacaagtttatggaaattggtgcccacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcagaaatcgattctggatgaa
ttcaaaaaagattcctctgtgttcattttgggcaacaccgaccggccggatgcctccgcc
atccacctgcacgacttccagcggtttctcttacatgaacagcaggagctttgggctcag
gatctaaacaaagtccgagagcggatgacaaagttcatcgatgacaccatgagggagact
gccgagccctttttgtttgtggatgagttcctcacgtacctgttctcccgggagaatagc
atctgggatgagaagtatgatgtggtggacatgcaggacatgaacaatcccttgtcacat
tactggatctcctcatcacataacacgtacctcacaggtgaccagctgcggagtgagtcc
tccacggaagcctacgtccgctgtctgcgcatgggctgtcgctgcatcgagctggactgc
tgggacgggcctgacgggaagcccatcatctatcatggttggacgcggaccaccaagatc
aagtttgacgatgtcgtgcaggccatcaaagaccatgcgtttgtcacctccagcttccct
gtgatcctgtccatcgaggagcactgctgtgtggagcagcagcggcacatggcccgggtg
ttcagggaggtgtttggcgacctgctgctgaccaagcccacagaggccagtgccgaccag
ctgccctcacccagccagctgcgggagaagatcatcatcaagcataagaagctgggccca
cggggtgatgtggatgtcaacatggaggacaagaaggaagagcacaagcagcagggcgag
ttgtacatgtgggactccatcgaccagaaatggactcggcactactgcgccatcgctgac
gccaagctgtccttcagcgacgacattgaacagacggcggaggacgagctgccccaggat
acaccccccacagagctgcattttggggagaagtggttccacaagaaggtggagaagagg
accagcgcggagaagctgttgcaggaatactgtactgagacggggggcaaggatgggacc
ttcttggtgcgggagagcgagaccttccccaacgactacaccctgtccttctggcggtcg
ggccgggtccagcactgtcggatccgctccaccatggatggcgggaccatgaagtactac
ctgactgacaacctcatgtttaccagcatctacgcgctcatccagcactaccgcgaggcg
cacctgcgctgtgccgagttcgagctgcggctcacggatccggtgcccaaccccaacccc
cacgagtctaagccctggtactatgatgggctgagccgcggggaagcggaggacatgctg
atgagggtcccccgggacggggccttcctcatccggaggcgggaaagttctgactcctac
gccatcaccttcagggccaggggcaaggtcaaacactgccgcatcaaccgggatggccgg
cactttgtactgggcacctccgcctactttgagagcctggtggagctggtcagctactac
gagaagcacgcgctctaccgcaagatgaagctgcgctaccctgtgacccccgagctcctg
gagcgctacaacatggaaagagatgtaagctccctctatgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccctccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaggtgatgagctgagcttctgccgaggcgccctcatccacaacgtctcc
aaggagcctgggggctggtggaaaggagactatggaactcgaatccagcagtacttccca
tccaattacgtggaggacatctcgacggccgacgtggaggagctggaaaagcagattatt
gaagacaatcccttagggtctctttgcagagggatattggatcttaacacctacaatgtc
gtgaaagccccccaagggaaaaaccagaagactttcgtctttatcctggagcccaagaag
cagggggaccctcccgtggagtttgcaacggaccgggtggaggaactcttcgagtggttc
cagagcatccgggagatcacctggaagatcgacaccaaggagaacaacctgaggtactgg
gagaagaaccagtccatcgccatcgagctctccgacctggtcgtctactgcaagcccacc
agcaagacgaaggacaacctagaaaaccccgactacagagaaatccgctccttcgtggag
acaaaggccgacagcgtgacgagacagaagcccatcgatctgctgaaatacaaccagaag
ggcctgacgcgggtgtaccccaagggacagagggtggactcctccaactacgatcccttc
cgcctctggctgtgcggctcccagatggtggcgctcaacttccagacccccgataagtac
atgcaggtgaatcatgccttgttttcactcaatgggcggacgggctatgtcctccagccg
gagagcatgagggcggagaagcacgaccccatgccgccggagagccagcgcaagatcctc
atgacgctgaccgtcaaggtgctgggcgctcgccatcttcccaaacttggacgaagcatc
gcttgtccctttgtggaggtggaaatatgtggagccgagtatgacaacaataagtttaag
acaacagttgtgaatgacaatggtctcagccctgtttgggcgtcaacacaggaaaaggtg
acatttgagatttacgacccaaacctggcatttctgcgctttgtggtttatgaggaagat
atgttcagcgatcccaactttctggctcatgccacttaccccattaaaggaatcaaatca
gggtttaggtcagtccctctgaagaatgggtacagtgaagatgttgagctggcttccctc
ctggttttctgcgagatgcggccagtcctggagagtgaagaggagctctactcctcctgt
cgccagctgcggaggcggcaggaggagctcaacaaccagctctttctgtacgacacgcac
cagaatttgcgcaatgccagccgggatgccctggtcaaggagttcactgtcaatgagaac
cagctccagctgtaccaggagaagtgtaaccggaggttgagagagaagagagtcagcaac
agcaagttttactcgtga
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integrated database retrieval system
