KEGG   PATHWAY: tvp00230
Entry
tvp00230                    Pathway                                
Name
Purine metabolism - Trichosurus vulpecula (common brushtail)
Class
Metabolism; Nucleotide metabolism
Pathway map
tvp00230  Purine metabolism
tvp00230

Module
tvp_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:tvp00230]
tvp_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:tvp00230]
tvp_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:tvp00230]
tvp_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:tvp00230]
tvp_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:tvp00230]
tvp_M00546  Purine degradation, xanthine => urea [PATH:tvp00230]
tvp_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:tvp00230]
tvp_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:tvp00230]
Other DBs
GO: 0006163 0042278
Organism
Trichosurus vulpecula (common brushtail) [GN:tvp]
Gene
118827889  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
118827957  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
118828162  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
118828331  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
118828519  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
118828566  [KO:K03783] [EC:2.4.2.1]
118828654  [KO:K03783] [EC:2.4.2.1]
118828861  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
118829213  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
118829566  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
118829591  [KO:K22600] [EC:4.6.1.2]
118830071  [KO:K18532] [EC:2.7.4.3]
118830153  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
118830235  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
118830602  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
118830833  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
118830848  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
118830945  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
118830974  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
118831094  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118831168  [KO:K12324] [EC:4.6.1.2]
118831205  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
118831235  [KO:K18532] [EC:2.7.4.3]
118831236  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
118831308  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
118831436  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
118831721  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
118832313  FHIT; LOW QUALITY PROTEIN: bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
118832584  [KO:K00939] [EC:2.7.4.3]
118832810  [KO:K18532] [EC:2.7.4.3]
118832827  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
118832839  [KO:K00940] [EC:2.7.4.6]
118833078  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
118833080  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
118833758  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
118833880  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
118834863  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
118835313  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
118836689  [KO:K12319] [EC:4.6.1.2]
118836725  GUCY2F; retinal guanylyl cyclase 2 [KO:K12321] [EC:4.6.1.2]
118837516  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
118837671  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase isoform X1 [KO:K13485] [EC:4.1.1.97]
118837732  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
118837733  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
118838034  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
118838108  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
118838137  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
118838251  [KO:K08042] [EC:4.6.1.1]
118838578  [KO:K00940] [EC:2.7.4.6]
118838745  [KO:K00760] [EC:2.4.2.8]
118838831  [KO:K00760] [EC:2.4.2.8]
118838917  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
118838926  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
118838946  [KO:K00940] [EC:2.7.4.6]
118839360  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
118839589  PDE8B; LOW QUALITY PROTEIN: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
118839913  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
118840753  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
118841431  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
118841594  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
118841724  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
118841809  [KO:K00759] [EC:2.4.2.7]
118841815  [KO:K07127] [EC:3.5.2.17]
118841840  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
118841906  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
118841937  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
118842256  [KO:K18532] [EC:2.7.4.3]
118842697  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
118842788  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
118843304  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
118843317  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
118843321  [KO:K01081] [EC:3.1.3.5]
118843374  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
118843429  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
118843479  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
118843512  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
118843640  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
118844029  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
118844193  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
118844654  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
118844848  [KO:K01510] [EC:3.6.1.5]
118845556  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
118845580  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
118846099  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
118846169  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
118846290  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
118846301  [KO:K01466] [EC:3.5.2.5]
118846419  [KO:K00940] [EC:2.7.4.6]
118846420  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
118846458  [KO:K00365] [EC:1.7.3.3]
118846497  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
118846502  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
118846544  ADSS2; LOW QUALITY PROTEIN: adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
118846635  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
118846740  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
118847032  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
118847502  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
118847529  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
118847574  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
118847640  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
118848154  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
118848214  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
118848492  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
118849684  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
118850008  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
118850104  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118850254  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
118850373  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
118850509  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
118850658  [KO:K13988] [EC:3.6.1.13]
118850711  [KO:K00948] [EC:2.7.6.1]
118850728  GUCY2C; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
118851486  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
118851822  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
118851951  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
118852067  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
118852106  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
118852377  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
118852666  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
118852716  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
118852778  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
118853092  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
118853099  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
118853100  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
118853186  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
118853728  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
118853743  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
118853773  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
118853989  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
118854000  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
118854150  [KO:K18532] [EC:2.7.4.3]
118854446  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
118854491  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
118854529  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
118854947  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118855786  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
118856088  [KO:K11265] [EC:4.6.1.1]
118856283  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
118856570  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
118856588  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
118856659  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
118856913  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
118856972  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
118857337  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
118857581  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
118858111  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
118858228  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
118858319  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
118858364  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
118858684  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
tvp00030  Pentose phosphate pathway
tvp00220  Arginine biosynthesis
tvp00250  Alanine, aspartate and glutamate metabolism
tvp00260  Glycine, serine and threonine metabolism
tvp00340  Histidine metabolism
tvp00630  Glyoxylate and dicarboxylate metabolism
tvp00730  Thiamine metabolism
tvp00740  Riboflavin metabolism
tvp00790  Folate biosynthesis
KO pathway
ko00230   

DBGET integrated database retrieval system