Ursus arctos (brown bear): 113242078 Help Entry 113242078         CDS       T05909                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism uah  Ursus arctos (brown bear) Pathway uah04020   Calcium signaling pathway uah04371   Apelin signaling pathway uah04713   Circadian entrainment uah04921   Oxytocin signaling pathway uah04970   Salivary secretion uah05010   Alzheimer disease uah05012   Parkinson disease uah05020   Prion disease uah05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:uah00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113242078 (RYR3)    04020 Calcium signaling pathway     113242078 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     113242078 (RYR3)   09154 Digestive system    04970 Salivary secretion     113242078 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     113242078 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     113242078 (RYR3)    05012 Parkinson disease     113242078 (RYR3)    05020 Prion disease     113242078 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     113242078 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:uah04040]     113242078 (RYR3) Ion channels [BR:uah04040]  Voltage-gated cation channels   Ryanodine receptor    113242078 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_8 EF-hand_5 Phage_TAC_15 Motif Other DBs NCBI-GeneID:  113242078 NCBI-ProteinID:  XP_044248391 LinkDB All DBs Position Unknown AA seq 4866 aa AA seqDB search MRFLQATLQSRAKRSGIALFTTVSSEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEP TSEAKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLR HSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLI LVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDE CLTIPSTDQNDAQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTG HYLALTEDQGLILQDRVKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSV CFVQHVASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIR NTTALFSQFVSGNNRTAAPVTLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKVRSLKNR QNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGVAWKETLNLLYKLLAALIRGNR NNCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHG RNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAE GSAQYKKWYFELIIDQVEPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSY GFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTD GLFFPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAE GVRDLLGTTQSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFG KIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCRIAHVNPAAEEELKKVK LPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLK NKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIR FFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWH QGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEVENGFVPICS LGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPRDHP HIEVVRIDGTTDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSDAFQ KRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLG DERGRVHESVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELG TCYQVEPNTRVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDV QTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQE DLMQFHYHTLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNQYLPGLLRSGFYDLLIS VHLASAKERKLMMKNEYIIPITSSTRKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCF VVTGEEQQKQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTL LVMGVFDDDDVRQILLLIDPSVFGEHSAETEDGAEKEEVTQVEEKAVEAGEKASKEAPVK GLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQAL NMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLE EEEEEEEDTSWTGKLRALVYKIKGPPKPETEQPTEEEERSPTTLKELISQTMIRWAQEDQ IQDAELVRMMFSLLRRQYDSIGELLQALRRTYTISQASVSDTISLLAALGQIRCLLSVRM GKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVAS CCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELAL GLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEE NASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDSE DEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIIS IPLKLPSLSKDGSVCEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLR ASASLDTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSK GRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQC WKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALP PDYLDTRISATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKS QNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEA LVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLE LESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGVKDMELDASSMEK RFASKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNH RLYFLSSPLKPLSSGGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQ TLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTT AALLPILTSIFEHVAQHQFGVDLLLGDVQLSCYHILCSLYSLGTGKNIYVERQRPALGEC LASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEI GDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPGTGPWCTKVTSEHLSVILG NILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEE QLKADTRGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRM VAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERRKTKRRGDL YSVQTSLIVAALKKMLPIGLNMCTPGDQELISLAKARYGFRDTDEEVKEHLRNNLHLQEK SDDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLL SKQRKRAVVACFRMAPLYNLPRHKINNFFLSTFQRVWLEKVNEKTQYDRLIPILMKSPKV EEEEEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEE DKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNG GNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTREK VLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDF YWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFL HVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESST NVEMILKFFDMFLKLKDLTSSDTFKVYDPDGKGIISKKEFQKAMEGQKQYTQSETDFLLS CAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNY FEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMEL FVNFCEDTIFEMQLASQISESDSADRPDDEEEDEELSSMLEIEGEEEDDKSFESASAFAM ACASVKRNVANFLKKATLKNLRKQYRKVKKMTVKELVKVFLSFFWMLFVGLFRLFFTILG GVFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTLDAERVEVTEPGVPPEL IHFVKGEKGNAEVMSDLFGFRPKKEGGLKHGPEGGLGDLSEIIGKDEPPTLESTVRKKRR AQAAEMRAAHEAEGKVEPEKTDLEEGEKEVMAKEEEQAEALWTDVTKKKKRRRGQKVEKP EAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETED VANLWSSFNDEEEEEAMVFFVLQESTGYMAPTLRALAAIHTVISLVCVVGYYCLKVPLVV FKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGD LYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLY LAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLALTVGLLAVVVYLY TVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM YRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTT PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQ YEDQLG NT seq 14601 nt NT seq  +upstreamnt  +downstreamnt atgcggttcctacaagccaccctccagagcagggccaagaggtcgggcattgccttgttt accactgtctcctcggaagatgaggtggttctccagtgcatcgcgaacattcacaaggag caaaggaagttctgcctggcagccgagggccttgggaaccgcctgtgcttcctggagccc acttcagaagccaagtatgttcctccagatctctgcgtctgcaattttgtgctggaacag tccctctctgtgagagccctgcaggaaatgcttgccaacacaggtgaaaatggcggtgaa ggggcagcacaagggggcggccacaggaccctgctatatggccacgcaattctcctgcgg cactccttcagtggaatgtatctaacatgtttgaccacatcaagatcccagacagacaaa ctagcatttgatgtaggtctacgggaacatgccacaggagaagcctgttggtggaccata catcctgcttccaaacagagatctgagggagagaaagttcgaattggtgatgacctcatc ctcgtcagcgtgtcctctgaaagataccttcatctctcagtatcaaacgggaacatacaa gtggacgcctcttttatgcagacactctggaatgtgcatcctacgtgctcaggaagcagc attgaagaaggatacctacttggtgggcacgtagtacgtctcttccacggtcatgatgag tgtttgacgataccatctacagaccagaatgatgcccagcacaggaggatattctatgaa gctgggggagctgggacacgagccagatctctgtggagagtggaaccccttcggataagc tggagtggcagtaacatcagatggggccaggctttccgcctccggcatctcaccacaggc cactatctggccttgacggaggaccaaggccttatactgcaggaccgggtgaagtcagac accaagtccacagccttctctttccgggcttctaaggagatcaaggagaaattggattcc agtcacaagcgagatatagaaggcatgggcgttccagaaatcaagtacggcgattccgtc tgctttgtgcagcatgtagccagtggtctgtgggtgacctacaaagcacaagatgccaag acctcccgccttggacctctgaaaagaaaggtcatactccatcaggaaggccacatggac gacgggttaacactacagagatgccagcgcgaggagtcgcaggctgctcggatcattcgg aacacaacagctttattcagccagtttgtaagtggaaacaatcgcacggctgccccagtc accctgccgatcgaagaggtcctgcagaccttacaggacttgattgcctactttcagccc ccagaggaggagatgcggcacgaagacaaacagaacaaggtccgctcactcaagaacagg cagaatcttttcaaggaagaaggaatgttggccctcgtgttaaactgcattgaccgcttg aacatctacaacagcgtagcacacttcgcggggattgcaagggaggagagcggcgtggct tggaaggagaccctgaacctcctgtacaaactgctggctgctctcattcgtggaaacagg aacaactgcgctcaattctctaataaccttgattggctaatcagcaaattggacagacta gaatcttcctcaggtatcttggaagttttgcactgcatcctgactgaaagcccagaagcc ttaaatctgatagccgagggacacatcaagtccatcatctccctgttggataagcatggg cggaatcacaaggttctggatgtgctgtgctccctctgtctctgcaatggggtcgcagtc agagccaaccagaatctgatttgtgacaacttgctgccccggagaaacctgcttctgcag acacggctgattaatgatgtgaccagcatccggcccaacatcttcctgggagtcgccgag ggctcggcgcagtacaagaagtggtactttgagctgatcatcgaccaggtggagcccttc ttaacagccgagcccacacacctgcgggtgggctgggcctcttcctcaggctatgctccg taccctggcggaggggaaggatggggaggcaatggtgtcggcgatgacctgtactcctat ggctttgacggacttcacctttggtcaggccgcatacccagagccgtagcctccatcaac cagcacctcctgagatcagatgacgtggtgagctgttgccttgacctcggagtgcccagc atctccttccgcatcaacgggcagcctgtgcaggggatgtttgagaacttcaacacagat gggctcttcttccctgtggtgagcttctcagcaggtgtcaaagtacgtttcctgatgggt ggacgtcatggagaatttaagttcctgcctccctctggctacgccccttgctatgaagcc ttacttccaaaagaaaagatgagattggagcctgtcaaagaatataaacgtgacgctgaa ggcgttagagatcttctgggtaccacccagtccctctcccaagcctccttcatcccatgc cccatagacaccagtcaggtggttttgccccctcacctagaaaagatccgagacagactg gctgaaaacatccacgagctttggggaatgaataaaatagagcttggatggacttttggc aagatacgggatgacaataaaagacagcacccctgtcttgtggagttttcaaagctgcct gaaactgagaagaattataacctacaaatgtcaactgaaaccttaaaaaccctcctggcg ctggggtgccgcattgctcatgtgaatccggctgctgaggaggagctcaagaaggtcaaa ttgcccaaaaactatatgatgtccaatggctataagccagcccctttggatctgtctgat gtgaagctgttacctcctcaagaaattttagtggataagcttgcagaaaatgcacataac gtttgggccaaagacagaataaaacaaggatggacctatggcatccaacaggatttgaag aacaagagaaatccccgcctggtgccatatgcattactggatgagcgtaccaagaagtcc aacagggacagcctccgcgaagccgtgcgcacatttgttggttatggctacaacattgag ccgtcggaccaagaactggcggacccagctgtggagaaagtcagcatagacaagatccga tttttccgggtagagcggtcttatgcagtgagatctggaaagtggtattttgagtttgag gtggtgaccggaggagacatgcgcgttggctgggccaggccgggctgtcggcctgacatt gagctgggcgccgatgaccaagcctttgtgtttgaaggcagcaggggccagcgctggcat caaggcagtgggtattttggacgtacgtggcagccaggagatgtggttggatgtatgatt aacctggatgatgcttcgatgatcttcacgctgaacggggagctgctcatcaccaacaaa ggctctgaactcgccttcgctgattacgaggttgagaatggctttgtgcccatctgctct ctgggactttctcaaatcggccgcatgaatctcgggatggatgccagtaccttcaagttc tataccatgtgcggcctccaagagggctttgagccttttgccgtcaacatgaaccgcgac gtggcgatgtggttcagcaagcgcctcccgacgttcgtcaatgtgccaagggatcacccc catatagaggtggtgaggatcgatggcaccacggacagcccgccatgcctcaaggtgact cacaagacgttcggcacacagaacagcaatgccagcatgatctactgccgcttgagcatg cccgtcgagtgccactcctccttcagccacagcccctgtctggacagtgacgctttccag aaaaggaaacagatgcaagaaatactctctcatacaacaacacagtgctactacgcaatc cgcatctttgctggacaggacccttcctgcgtctgggtcggatgggtgacgccagactat cacttatacagtgaaaagtttgacctgaataaaaactgtacggtgactgttactctaggg gatgaaagaggccgggtccacgaaagtgtgaaacgcagcaactgctacatggtctggggc ggggatatcgtggccacctcccaaagatcaagtcggagcaacgtggacctggagatcggc tgcctcgtggatctggccatgggcatgttgtccttctcggccaacgggcgagaactcggc acctgctaccaggtggagcccaataccagagtgtttccagcagtcttcctgcagcccacg agcacttccttgtttcagtttgaacttgggaagctgaagaacgcgatgcccctgtcggcg gccatatttaagagtgaagagaagaacccagttccgcagtgtccacctcggctggatgtc cagaccatccagcccgtgctctggagccgcatgcccagcagcttcctgaaggtggagacg gagcgggtgagcgagcgccatggctgggtggtgcagtgcctggagcccctgcagatgatg gccctccacatccccgaggagaacaggtgtgtggacgtcctggagctctgtgagcaggag gacctgatgcagttccattaccacacgctgcgactctacagcgccgtgtgcgccctggga aacagccgggtggcctacgccctgtgcggccacgtggacctctcccagctcttctacgcc attgacaaccagtacctccccggcctcctccgctctggtttctatgacctgctcatcagc gtccacctggccagcgctaaggagaggaagctaatgatgaagaacgagtacatcattccc atcaccagcagcaccaggaagatccgcctgtacccagacgagtccaagaggcacgggctg ccaggggtgggcctgagaacgtgcctcaagccagggttcaggttctccaccccttgcttt gtggtgaccggcgaggagcagcagaagcagagccctgagatccccttggagattctcaag acgaaggcgctgagcatgctgacggaggccgtgcagcacagcggggctcacatccgggac cccgtgggtgggtctgtggagttccagtttgtacctgtgctgaaactcatcgggaccctg ctggtcatgggggtgtttgatgacgacgacgtccggcagatcctcctcctgatcgacccc tctgtgtttggggagcacagtgcggagacagaggatggagcagagaaggaggaggtgacc caggtggaggagaaggcagtggaggctggggaaaaggccagcaaggaggctccagtcaaa ggcttgttgcagacccgactgccagagtccgtcaagctgcagatgtgcgagctcctcagc tatctctgtgactgtgagctgcagcatcgagtggaagccattgtcgcatttggcgacatt tatgtctccaaactccaggcaaatcagaagttccgctacaatgagctcatgcaggccttg aacatgtccgcagcgctgactgcccggaagaccagggagttccgctcccccccacaggag cagatcaacatgcttcttaattttcaactgggagagaattgcccctgcccagaggagatc cgggaggaactctatgacttccatgaggaccttcttattcactgtggcgttcccctggag gaggaggaagaggaggaggaggacacctcctggactgggaaactccgtgccttggtgtat aaaatcaaaggccctcccaagcctgagacggaacagccaacagaagaggaagagagatcc cctaccaccttgaaggagctcatctcacagaccatgatccgctgggcccaggaggaccag atccaggatgcggagttggtccggatgatgttcagcctcctccggagacagtatgacagc atcggggagctgctgcaggccctgcggaggacctacaccatcagtcaggcctccgtgagc gacaccatcagcctgctggccgcgctgggccagatccgctgcctgctcagtgtcaggatg ggcaaggaggaggagctgctcatgatcaacgggctgggagacattatgaacaacaaggtg ttctaccagcatcccaacctcatgcgagtccttggcatgcacgagacggtgatggaggtg atggtgaacgtgttgggcacagagaagtctcagattgcttttccaaaaatggtcgcgagc tgttgccgcttcctctgctatttctgtcgaattagccggcaaaatcagaaggccatgttt gagcatctgagttacctgttggagaatagcagtgttggcctagcttccccttcgatgaga ggatctaccccactggatgtggcggcttcctccgtgatggacaacaacgagttagcgctg ggcttagaggaaccagacctcgagaaggtggtgacctacttggcaggctgtggtctgcag agctgccccatgcttctagccaaaggataccctgatgtcggctggaaccccattgaaggg gaacgttatctgtccttcctgaggtttgccgtctttgtgaacagcgaaagcgtggaagaa aatgcaagtgtcgtggtcaagctgctcattagacgcccggagtgcttcggcccagccctg cggggtgaaggaggaaacggtctattggcagccatgcagggcgccattaagatctctgag aaccctgccctcgacctgccttcccagggatacaagagagaagtcatggaggacagcgaa gatgaagagatcgtgcacatgggcaacgcaattatgtctttttattcagctctcatagat ctgctgggccgctgtgcgcctgaaatgcacctcatccagacaggaaagggggaagccatc cggatcaggtcaatcctgcgctccctggtccccaccgaggacctggtcgggatcatcagc atccccttgaagctgccctccctgagcaaagatgggtctgtctgcgagccagatatggca gccaacttctgccctgaccacaaggcacccatggtgctgttcttggatcgtgtttatggc attaaggatcaaacttttctgctccacttgctagaggttggatttttacctgacttaaga gcctctgcctctctagatacggtttccctgagcaccacagaggctgcgcttgccctcaat aggtatctatgttctgccgtgctcccactcctcacaagatgtgcccctctctttgccgga acagaacactacacgtctctgatcgactctacactacagacaatatacaggctttccaag ggacgttccctcaccaaagctcagagggacaccatagaagaatgtttgcttgccatttgc aatcacttgaggccttccatgttacagcaactcttgcgacgtctggtgtttgacgtgcca cagctcaacgaatattgcaaaatgcctcttaagctcctgacaaatcactatgaacagtgc tggaagtattactgtctgccttcaggatgggggagctacgggctggctgtggaagaagag ttgcatctgacggagaaactcttctgggggatttttgactccctctcccataagaagtat gacccagaccttttccgaatggcccttccttgtctcagtgctatagcgggggccctgcca ccagattatttagataccagaatctcagccacattggagaaacagatctcagtggatgca gatggcaactttgaccccaaacccatcaacaccatgaatttctccttgcctgaaaaatgg gaatacatcgtcaccaagtacgcggagcattcacatgataaatgggcctgtgacaagagt cagaatggttggaaatatggaatttcactggatgaaaatgtgaagacccatccactgatc cggcctttcaagactttaacggaaaaggagaaggaaatctaccgctggcctgccagggag tccctgaaaaccatgctggctgtgggctggtctgtggagaggaccaaagagggagaggcc ctggttcaacagcgggaaaacgagaagcttcggagcgtgtcccaggccagccagggcaac agctacagccctgctcccctggacctctccaatgtggtgctctccagggagctccaggga atggtggaggtcgtggctgaaaactatcacaacatctgggccaagaagaagaagctggaa ctggagagcaaaggtggcggcagtcaccctctgttggtgccatatgacaccttgacagcc aaggagaagttcagggaccgagagaaggcacaggacctgtttaaattcctccaagtgaat ggcatcgtggtttcgagaggtgtgaaggatatggagctggatgcctcctccatggaaaag aggtttgcctctaaatttttgaagaagatcctgaaatatgttgattccgcccaagagttt attgcccatttggaagccattgtcagcagtgggaaaacggaaaagtctccccacgaccag gagatcaaattctttgccaaagttctcctcccactggttgatcagtacttcaccaaccac cgcctctacttcctgtcgtccccgttgaagccccttagcagcggcggctatgcctctcat aaggagaaagaaatggtggccagcctcttctgcaaactcgctgctcttgttcgacacagg atttccctctttgggagcgattctactacaatggtgagctgtcttcacatcttagctcag acacttgacacaaggactgtcatgaagtcaggctcagagctggtcaaggccggcttacga gcgttctttgaaaatgctgcagaagacttagagaagacttcagaaaacctgaagctgggg aagtttacccattccaggacgcagattaaaggcgtgtctcagaatattaactataccacg gcagccctgctccccatcctgacgtccatctttgagcacgttgctcagcaccagttcggg gtggatttactcttaggtgatgtgcagctttcatgctaccacatcctgtgcagcctctac tcccttgggaccggaaagaatatctatgttgaaaggcaacgtcctgcccttggagaatgt ctggcctcactggcagctgccatcccagtggcattcctggagcccacccttaaccgctac aatccactctcagtcttcaacaccaaaacccccagggagaggtctattctgggcatgccg gacacagtggaagagatgtgtcctgacatcccgcagctggaaggcctgatgaaggagatc ggcgacctggccgagtcaggggcccggtacacggagatgcctcacgtcatcgaggtgatc ttgcccatgctctgcaactacctgtcctactggtgggagcgggggcctgagcacctgcca cccggcactgggccctggtgcaccaaggtcacctctgaacacctcagtgtcatcctggga aacattctgaaaatcatcaacaacaacctgggcatcgacgaggcgtcctggatgaagcgc atcgcagtgtacgcccagccaatcatcagcaaagcccggcctgacctgctgaaaagccac ttcatccccactctggagaagctgaagaaaaaggctgtcaagaccgtgcaggaggaggag cagctgaaagccgacaccagaggagacactcaggaggcagagctcctcatcctggacgag tttgctgtcctctgcagagacctctacgccttctaccccatgctgatccgctacgtggac aacaacaggtctaactggcttaaaagccccgatgccgactctgaccagctcttccgcatg gtggcagaggtcttcatcctgtggtgtaaatctcacaacttcaagagggaagagcagaat tttgtgattcagaatgaaattaataatttggcatttttaactggcgacagcaaaagcaag atgtcaaaatccggagggcaggaccaggagcgcaggaagacaaagcggaggggagacctg tattccgtgcagacctctctcatcgtggccgcgctcaagaagatgctgcccatcggtttg aatatgtgcacgccgggcgatcaggagctcatctccctggccaaggcccgatacggcttc agggacacagacgaagaggtgaaggaacacctgcggaacaacctgcacctgcaggagaag tctgacgacccagcagtaaagtggcaactgaacctctacaaagatgttttaaagagcgaa gaacctttcaatccagaaaagaccgtagagcgtgtccagagaatttcagcagctgtcttc cacctggagcaggtggaacagcctttgaggtccaagaaggcagtctggcacaaactgttg tcaaagcagcggaaacgggcggtggtggcctgtttcaggatggcccctctctacaacctg cccagacacaaaattaacaatttcttcctgagcacctttcaacgggtttggctggaaaag gttaatgaaaaaactcagtatgacaggcttatacccattttaatgaaatcccccaaggtg gaagaggaggaggaggaggagacagaaaagcagccagatccacttcatcagatcattctc cattttagccgcaatgctctcacggagaggagcaaattggaagatgaccccttgtacacg tcctattccagcatgatggccaagagttgtcagagtggggaggacgaagaagaggaggaa gacaaggaaaaaacatttgaagagaaagaaatggaaaagcagaaaaccctctaccaacaa gcgcggctgcatgagcgtggagccgcagagatggtccttcagatgataagcgccagcaaa ggtgagatgagccccatggtggttgagactctgaagctggggatcgccattctgaatggg ggcaacgctggtgtacaacagaaaatgctagattacctgaaggaaaaaaaggatgctgga ttctttcaaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcattc gaaaggcagaataaagctgaaggcctggggatggttactgaggaaggaacccgtgaaaaa gtacttcagaatgacgagtttacacgagatctcttcagattcctgcagttactttgtgaa ggacataacagtgactttcagaacttcctgcggactcagatgggcaataccaccaccgta aacgtcatcatcagtaccgtggactacctcctgcgtctgcaggaatcaatcagtgatttc tactggtattattcagggaaggacatcattgatgagtctggacagcacaatttttccaaa gctctggcggtcacgaagcagattttcaattctcttacggagtacatccagggcccttgc attgggaaccaacagagcctggctcacagcaggctgtgggacgcggtggtcggcttcctc catgtgtttgctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctg aaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaaggg aatgtggtaaatggaactattggcaagcagatggttgacacactggtggagtcatctacc aatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacctaaccagc tcagacaccttcaaagtatatgacccagacggtaaagggattatctccaaaaaagagttc cagaaggccatggaagggcaaaaacagtacacacagtcagagactgactttctcctttcg tgcgcagaagctgatgagaacgatatgtttaattacattgattttgtagaccggttccat gagccggccaaggacatagggtttaatgtggcggtgttactgacaaatctctccgaacat atgccaaatgattctcgcctgaagtgtctgttggacccagcagaaagcgtactgaattac tttgagccctacctgggacgtattgagatcatgggtggggccaagaaaattgagcgcgtt tatttcgagatcagtgaatccagtcgaactcaatgggagaagccccaagtgaaggaatcg aaacggcagttcatcttcgatgtggtcaatgaaggtggagagcaagaaaagatggaactg ttcgtgaacttctgtgaggataccatctttgaaatgcagttagcctctcagatctccgaa tctgactcagcggacaggcctgacgacgaggaagaagatgaagaattatcttctatgtta gaaattgagggtgaagaggaggatgacaagtcttttgagtctgcctctgcgtttgccatg gcctgcgcctcagtgaagagaaatgttgccaactttctgaagaaggccaccctgaagaac ctccggaagcagtacaggaaggtgaaaaagatgaccgtgaaggagctggtgaaggtgttc ctctctttcttctggatgttgtttgtggggctcttccggttgttcttcaccatattggga ggagtctttcagatcctctggaacacggtgtttggagggggcctagtggaaggggcaaag aacatcagagtgaccaagatcctgggtgacatgcctgaccccacccagttcgggatccat gatgacactctggatgcggagcgggtggaggtgactgagccaggtgtgccaccggaactg attcacttcgtgaagggtgagaagggaaatgcagaagtcatgtcagatctctttggattc cgcccaaagaaagaaggcggcttaaagcacgggcccgaagggggcttgggtgacctctca gagattattggcaaggatgaacccccaacgctagagagtactgtacggaagaaaaggaga gcacaggcagcagagatgagagcagcacatgaagcagaagggaaagtggagccagagaag acagacctggaagaaggggagaaggaggttatggccaaagaggaagagcaagccgaggcc ctgtggacagacgtgacaaagaagaagaagcgacggcggggccagaaagtcgagaagccg gaagccttcatggctaacttcttcaaagggctggaaatctatcagaccaagttactgcat tacctggccaggaatttctacaacctgaggttcctcgctctgttcgtagccttcgcgatc aacttcatcctgctcttttacaaggtcactgaagaacctttagaagaagagacggaggac gttgcaaacctgtggagctcctttaacgacgaggaagaggaggaagcgatggtgttcttc gtcctgcaggagagcactgggtacatggcgccgacgttgcgggccttggccgccatccac accgtcatctctttagtgtgcgtggtgggctattactgcctgaaggtccctctggtggta ttcaaaagggaaaaagaaattgccaggaagctggagttcgatggcctgtatatcactgaa cagccatctgaagatgacatcaaggggcagtgggaccgcctggtaatcaacacaccatct tttcctaataactactgggacaagtttgtcaagagaaaggtgatcaacaagtacggagat ctctatggagcagaacgcattgctgagctcctgggtttggacaaaaatgcccttgatttc agcccggtcgaagagagcaaagcagaagcggcctctctggtgtcatggctgagttccatc gacatgaagtaccatatctggaaactgggagtagtttttaccgacaactcctttctctac cttgcctggtatacaaccatgtccgtcctgggccactacaacaacttcttcttcgccgct catctgctggacattgcaatgggcttcaagacgctgaggactattctgtcatctgtcact cacaatggcaagcagctggctctgactgtcgggctcctggccgtggtggtttacctttac accgtcgtggctttcaacttcttccgaaagttctacaacaaaagtgaagacgacgacgag cccgatatgaagtgtgacgacatgatgacgtgttacctgttccacatgtacgtgggagtg agagctggaggtggcatcggcgacgaaattgaagaccctgctggcgacccttatgagatg taccgcattgtctttgacatcaccttcttcttctttgtcatcgtcatcttgctggccatc attcaaggtctcattatcgatgcttttggagagctaagagaccagcaggaacaagtgcga gaagatatggagactaaatgtttcatctgtgggattggcaatgactattttgacacaacg cctcatggctttgagacacataccttacaagagcacaacttagccaactatttgttcttc ctgatgtatctcattaataaagatgaaacagaacacacgggacaggaatcttatgtctgg aagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgctttcggaaacaa tacgaagatcagcttgggtaa

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