Ursus arctos horribilis (North American brown bear): 113258052
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Entry
113258052 CDS
T05909
Symbol
CACNA1C
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1C
KO
K04850
voltage-dependent calcium channel L type alpha-1C
Organism
uah
Ursus arctos horribilis (North American brown bear)
Pathway
uah04010
MAPK signaling pathway
uah04020
Calcium signaling pathway
uah04022
cGMP-PKG signaling pathway
uah04024
cAMP signaling pathway
uah04260
Cardiac muscle contraction
uah04261
Adrenergic signaling in cardiomyocytes
uah04270
Vascular smooth muscle contraction
uah04713
Circadian entrainment
uah04720
Long-term potentiation
uah04723
Retrograde endocannabinoid signaling
uah04724
Glutamatergic synapse
uah04725
Cholinergic synapse
uah04726
Serotonergic synapse
uah04727
GABAergic synapse
uah04728
Dopaminergic synapse
uah04742
Taste transduction
uah04911
Insulin secretion
uah04912
GnRH signaling pathway
uah04921
Oxytocin signaling pathway
uah04924
Renin secretion
uah04925
Aldosterone synthesis and secretion
uah04927
Cortisol synthesis and secretion
uah04929
GnRH secretion
uah04930
Type II diabetes mellitus
uah04934
Cushing syndrome
uah04935
Growth hormone synthesis, secretion and action
uah05010
Alzheimer disease
uah05020
Prion disease
uah05022
Pathways of neurodegeneration - multiple diseases
uah05031
Amphetamine addiction
uah05207
Chemical carcinogenesis - receptor activation
uah05410
Hypertrophic cardiomyopathy
uah05412
Arrhythmogenic right ventricular cardiomyopathy
uah05414
Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
113258052 (CACNA1C)
04020 Calcium signaling pathway
113258052 (CACNA1C)
04024 cAMP signaling pathway
113258052 (CACNA1C)
04022 cGMP-PKG signaling pathway
113258052 (CACNA1C)
09150 Organismal Systems
09152 Endocrine system
04911 Insulin secretion
113258052 (CACNA1C)
04929 GnRH secretion
113258052 (CACNA1C)
04912 GnRH signaling pathway
113258052 (CACNA1C)
04921 Oxytocin signaling pathway
113258052 (CACNA1C)
04935 Growth hormone synthesis, secretion and action
113258052 (CACNA1C)
04924 Renin secretion
113258052 (CACNA1C)
04925 Aldosterone synthesis and secretion
113258052 (CACNA1C)
04927 Cortisol synthesis and secretion
113258052 (CACNA1C)
09153 Circulatory system
04260 Cardiac muscle contraction
113258052 (CACNA1C)
04261 Adrenergic signaling in cardiomyocytes
113258052 (CACNA1C)
04270 Vascular smooth muscle contraction
113258052 (CACNA1C)
09156 Nervous system
04724 Glutamatergic synapse
113258052 (CACNA1C)
04727 GABAergic synapse
113258052 (CACNA1C)
04725 Cholinergic synapse
113258052 (CACNA1C)
04728 Dopaminergic synapse
113258052 (CACNA1C)
04726 Serotonergic synapse
113258052 (CACNA1C)
04720 Long-term potentiation
113258052 (CACNA1C)
04723 Retrograde endocannabinoid signaling
113258052 (CACNA1C)
09157 Sensory system
04742 Taste transduction
113258052 (CACNA1C)
09159 Environmental adaptation
04713 Circadian entrainment
113258052 (CACNA1C)
09160 Human Diseases
09161 Cancer: overview
05207 Chemical carcinogenesis - receptor activation
113258052 (CACNA1C)
09164 Neurodegenerative disease
05010 Alzheimer disease
113258052 (CACNA1C)
05020 Prion disease
113258052 (CACNA1C)
05022 Pathways of neurodegeneration - multiple diseases
113258052 (CACNA1C)
09165 Substance dependence
05031 Amphetamine addiction
113258052 (CACNA1C)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
113258052 (CACNA1C)
05412 Arrhythmogenic right ventricular cardiomyopathy
113258052 (CACNA1C)
05414 Dilated cardiomyopathy
113258052 (CACNA1C)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
113258052 (CACNA1C)
04934 Cushing syndrome
113258052 (CACNA1C)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
uah04040
]
113258052 (CACNA1C)
Ion channels [BR:
uah04040
]
Voltage-gated cation channels
Calcium channel, voltage-gated (Cav)
113258052 (CACNA1C)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Ion_trans
Ca_chan_IQ
GPHH
CAC1F_C
PKD_channel
Etmic-2
DUF4834
Motif
Other DBs
NCBI-GeneID:
113258052
NCBI-ProteinID:
XP_026358536
LinkDB
All DBs
Position
Unknown
AA seq
2168 aa
AA seq
DB search
MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAAR
QAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISI
VEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIA
YGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFR
VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYN
QEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI
TMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD
FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVA
GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLT
IASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGI
LETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFL
FIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG
GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR
TASPEKKQEVVEKPAVEETKEEKIELKSITADGESPPTTKINMDDLQPNENEDKCPYPNP
ENTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDT
IFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLH
KGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQ
CVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGE
VDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRV
EISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLR
RYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTG
LFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVV
GSIVDIAITEVNPAEHTQCSPFMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWT
FIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRC
ATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFV
AVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK
LCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKI
WKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQ
AGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQS
DGRSAFPQTFTTQRPLHINKAANSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANN
TALGRFPRPAGYPSAVSTVEGHGPPLSPAVRVQEAAWKLSSKRCHSRESQIAMVCQEEVS
QDETYDVKMSEDTEYCSEPSLISTEMLSYQDDENRQLTPPEEDKRDVRQSPKRGFLRSAS
LGRRASFHLECLKRQKNQGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPSTFPRPC
ATPPATPGSRGWPPQPIPTLRLEGAESSEKLNSSFPSIHCSSWSGEPTPCGAGSSAIRRA
RPVSLTVPSQAGARGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTI
EEMENAADNILSGGAQQSPNGTLLPFVNCRDPGQDRAGGQEGETCAAALACRKSEEELQD
SRAHAGGL
NT seq
6507 nt
NT seq
+upstream
nt +downstream
nt
atggtcaatgagaacacgaggatgtacattccagaggaaaatcatcaaggttctaactat
gggagcccgcgcccagctcatgccaacatgaatgccaatgccgctgcggggctcgcccct
gagcacatccctacgccgggggcagccctgtcctggcaggcggctatcgacgcggcccgg
caggccaagctgatgggcagcgccggcaacgcgaccatctccacggtcagctccacgcag
cggaagcggcagcagtatgggaaacccaagaagcagggcagcacgactgccacgcgcccg
ccccgcgccctgctctgcctgactctgaagaaccccatccggagggcatgcatcagcatc
gtcgaatggaaaccatttgaaataattattttactgactatttttgccaattgtgtggcc
ttagcgatctatattccctttccagaagacgactccaacgccaccaattccaacctggaa
cgagtggaatatctctttctcataatttttactgtggaagcatttttaaaagtaatagcc
tatggacttctctttcatcccaacgcttacctccgcaatggttggaatttactagatttt
ataattgtggttgtagggctttttagtgcaattttagaacaagcaaccaaagctgacggg
gcaaatgctctgggagggaaaggagctggatttgacgtgaaggcactgagggcattccgc
gtgctgcgccccttgcgcctggtatctggagtcccaagtctccaggtggttctgaattcc
attatcaaggccatggtgcccctgctgcatattgctctgttagtgctgtttgtaatcatc
atctatgccatcattggcctggagctcttcatggggaagatgcataagacctgctacaac
caggagggcatagcagatgttccagcagaagatgatccttccccttgtgctctggagaca
ggccatgggcgtcagtgtcagaacggcactgtgtgcaagcctgggtgggacgggcccaag
cacggcatcaccaacttcgacaattttgccttcgccatgttgacagtgttccagtgcatc
accatggagggctggacagacgtcctgtactgggtcaatgatgccgtaggaagggactgg
ccctggatctattttgttacactaatcatcatagggtcattttttgtacttaacttggtt
ctcggtgttcttagcggagagttctccaaagagagggagaaggccaaggctcggggagat
ttccagaaacttcgagagaagcagcagctggaagaggatctgaagggctacctggactgg
atcacccaggcagaggacattgaccctgagaatgaggatgaaggcatggatgaggagaag
ccccgaaacatgagtatgcccacaagcgagaccgagtctgtcaacaccgaaaacgtggct
ggaggtgacatcgagggagagaactgcggggccaggctggcccaccggatttccaaatca
aagttcagccgctactggcgccgctggaatcggttctgcagaagaaagtgtcgtgccgca
gtcaagtctaatgtcttctactggcttgtgatcttcctggtgttcctcaacactctcacc
attgcctcggaacactacaaccagccccactggctcacggaggtgcaagacacggccaac
aaggcgctgctggcccttttcactgcagagatgctgctgaagatgtacagcctgggcctg
caggcctacttcgtgtccctcttcaaccgcttcgactgtttcatcgtgtgtggtggcatc
ctggagaccatcctggtggagaccaagatcatgtctcccttgggcatctctgtgttgaga
tgtgtccggctactgcggatatttaaaatcacaaggtactggaactccttaagcaacctg
gtggcatccttgctgaattctgtgcgctccattgcctccctactgctgctcctcttcctc
ttcatcatcatcttctccctcctggggatgcagctctttggaggaaagttcaactttgat
gaaatgcagacccggaggagcacatttgataactttccccagtccctcctcaccgtgttt
cagatcctgaccggggaggactggaattcggtgatgtatgatgggatcatggcttatggc
ggcccctcttttccagggatgttagtctgtatttacttcatcatcctcttcatctgtgga
aactatatcctactgaatgtgttcttggccattgctgtggacaacctggctgatgctgag
agcctcacatctgcccaaaaggaggaagaagaagagaaggagagaaagaagctggccagg
actgccagcccagagaagaaacaagaggtggtggagaagccagcagtagaggagaccaag
gaggagaaaattgaactgaaatccattacagctgatggagagtccccacccaccaccaag
atcaacatggatgacctccagcccaatgaaaatgaggataagtgcccctacccaaaccca
gaaaatacaggagaagaggatgaggaggagcctgagatgcctgtgggcccccgcccacga
ccactctctgagctgcaccttaaggaaaaggcagtgcccatgccagaagccagtgcgttt
ttcatcttcagccccaacaacagatttcgcctccagtgtcaccgcattgtcaatgacacg
atcttcaccaacctgatcctcttcttcattctgcttagcagcatttccctggcagctgag
gaccccgtccagcacacctccttcaggaaccatattctgttttattttgacattgttttc
actaccattttcaccattgaaattgctctgaagatgactgcttatggggctttcctacac
aagggctctttttgccgaaactacttcaacatcttggacctgctggtggtcagcgtgtcc
ctcatttcctttggcatccagtcaagtgcaatcaacgtggtgaagatcttacgagtcctg
cgagtcctcagacccctaagggccatcaacagggccaaggggctgaagcacgtggttcag
tgcgtgttcgtcgccatccggaccatcgggaacatcgtcattgtcaccacgctactccag
ttcatgttcgcctgcatcggggtccagcttttcaagggaaagctctacacctgctcagat
agttccaaacagactgaggcggaatgcaagggtaactacatcacatacaaggacggggag
gtcgaccaccccatcatccaaccccgcagctgggagaacagcaagtttgactttgacaat
gttctggcagccatgatggccctctttaccgtctctacctttgaggggtggccagagctg
ctgtaccgctccatcgactcccacacagaagacaagggccccatctacaactaccgtgtg
gagatctccatctttttcatcatctacatcatcatcattgccttcttcatgatgaacatc
ttcgtgggtttcgtcatcgtcaccttccaagagcagggggagcaggaatacaagaactgt
gagctggacaagaaccagcgacagtgcgtggaatatgccctcaaggcccggcccctacgg
aggtacatccccaagaaccagcaccagtacaaagtgtggtacgtggtcaactccacctac
tttgaatacctgatgttcgtcctcatcctgctcaacaccatctgcttggccatgcagcac
tatggccagagctgcctcttcaaaattgccatgaacatcctcaacatgctcttcactggc
ctcttcaccgtggagatgattctgaagctcattgccttcaaacccaagggttactttagt
gatccctggaatgtttttgacttcctcatcgtaattggcagcataattgacgtcattctc
agtgaaactaatcactatttctgtgatgcatggaatacatttgacgccttgattgttgtg
ggtagcattgttgatatagcaatcaccgaggtaaacccagctgaacatacccaatgctct
ccctttatgaacgcagaggagaactcccgcatctccatcaccttcttccgcctcttccgg
gtcatgcgcctggtcaagctgctgagccgcggagagggcatccggaccctgctgtggacc
ttcatcaaatccttccaggccctgccctatgtggcccttctgatagtgatgctgttcttc
atctatgcggtgattgggatgcaggtgtttgggaaaattgccctgaatgacaccacagag
atcaaccggaacaacaacttccagaccttcccccaagctgtgctgcttctcttcaggtgt
gccaccggggaggcatggcaggacatcatgctggcctgcatgccagggaagaagtgtgcc
cccgaatcggagcccagcaacagcacagaaggcgaaacaccctgtggcagcagcttcgcg
gtcttctacttcatcagcttctacatgctttgtgccttcctgatcatcaacctctttgta
gctgtcatcatggacaactttgactacctgacaagggactggtcaattcttggtccccat
catctggatgaatttaaaagaatctgggcagagtatgatcctgaagccaagggtcgtatc
aagcacctagatgtggtgaccctgcttcgacggatccagcccccactgggttttgggaag
ctgtgccctcaccgcgtggcttgcaaacgcctggtctccatgaacatgcctctgaacagt
gatgggacagtcatgttcaatgccaccctgtttgccctggtccggacagccctgcgaatc
aaaacagaagggaacctagaacaagccaatgaggagctgcgggccataatcaagaagata
tggaagcggaccagcatgaagctgttggaccaagtggtgcccccagcaggtgatgacgag
gtcacagttggcaagttttatgctactttcctgatccaagagtatttccggaaattcaag
aagcgcaaagagcagggcctagtgggcaagccctcccagaggaacgccctgtccctacag
gccggcttgcgcacgctgcatgacatcgggcctgagatccgacgggccatctctggggat
ctgacggctgaagaggagctggacaaggccatgaaggaggctgtgtctgctgcctccgaa
gacgacatcttcaggagggccggtggcctgttcggcaaccacgtcacctactaccaaagc
gacggccggagcgccttcccccagaccttcaccacccagcgcccactgcacatcaacaag
gcggctaacagccaaggcgacaccgagtcgccatcccacgagaaactggtggactccact
ttcacccccagcagctactcgtccactggctccaacgccaacatcaacaatgccaacaac
actgccctgggccgcttcccccgccccgctggttaccccagcgcggtcagcaccgtggag
ggccatgggccccccttgtctcctgccgtccgggtacaggaggcagcatggaagctcagc
tccaagaggtgccactcccgggagagccagatagccatggtgtgtcaggaggaggtctct
caggacgagacctatgacgtgaagatgagcgaagacaccgagtactgcagcgagcccagc
ctgatctccacagagatgctctcctaccaggatgatgaaaatcggcaattaacaccacct
gaggaggacaagagagacgtccggcaatctccaaagaggggtttcctccgctctgcctca
ctaggtcgaagggcctccttccacctggaatgtctgaagcgacagaagaatcaaggggga
gacatctctcagaagacagtcctgcccttgcatctggttcaccatcaggcattggcagtg
gcgggcctgagccccctcctccagagaagccattcccccagcacgttccccaggccatgt
gccacccccccagccacgccgggcagccgaggctggcccccacagccgatccccaccctg
cggctggagggggccgagtccagcgagaaactcaacagcagcttcccgtccatccactgc
agctcttggtccggggagcccacgccctgcggtgcgggcagcagcgccatccggagagcc
cggccggtgtccctcactgtgcccagccaggctggggcccggggcaggcagttccacggc
agcgccagcagcctggtggaagcggtcttgatttcagaaggactggggcagtttgctcaa
gatcccaagtttatcgaggtcacaacccaggagctggctgacgcctgtgacatgaccata
gaagagatggagaacgccgccgacaacatcctcagtgggggcgcccagcagagccccaac
ggcaccctactaccttttgttaactgcagggacccagggcaggacagagcggggggccaa
gagggcgagacctgcgccgcggctctggcgtgtcggaaaagcgaggaggagctccaggac
agcagagcccacgccggcggcctgtag
DBGET
integrated database retrieval system
