KEGG   PATHWAY: uar04010
Entry
uar04010                    Pathway                                
Name
MAPK signaling pathway - Ursus americanus (American black bear)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
uar04010  MAPK signaling pathway
uar04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123775501  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
123775502  INS; insulin [KO:K04526]
123775505  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123775802  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
123775960  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
123776003  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
123776065  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
123776209  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123776212  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123776255  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
123776278  FGF21; fibroblast growth factor 21 [KO:K22429]
123776329  NTF4; neurotrophin-4 [KO:K12457]
123776347  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
123776460  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123776483  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
123776816  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
123776860  NF1; neurofibromin isoform X1 [KO:K08052]
123776898  CRK; adapter molecule crk isoform X1 [KO:K04438]
123777097  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
123777099  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
123777458  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123777460  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123777544  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123777569  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123777686  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
123777697  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123777708  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
123777846  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123777895  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
123777961  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123778232  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
123778278  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
123778280  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
123778284  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
123778290  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
123778302  RELA; transcription factor p65 [KO:K04735]
123778359  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
123778371  FGF3; fibroblast growth factor 3 [KO:K04358]
123778372  FGF19; fibroblast growth factor 19 [KO:K22603]
123778493  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123778737  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
123778823  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123778843  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
123778945  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
123778968  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
123779016  [KO:K25414]
123779022  [KO:K25414]
123779027  PSPN; persephin [KO:K25416]
123779518  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
123779529  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123779537  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
123779716  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
123779755  MAPK7; LOW QUALITY PROTEIN: mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
123779970  JUND; transcription factor jun-D [KO:K04449]
123780295  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123780346  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123780414  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123780440  FGF20; fibroblast growth factor 20 [KO:K04358]
123780489  KITLG; kit ligand isoform X1 [KO:K05461]
123780582  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
123780589  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
123780649  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123780665  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123780666  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
123780748  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
123780774  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123780787  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123780921  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
123781022  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123781069  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
123781314  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123781399  [KO:K04360] [EC:2.7.10.1]
123781572  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123781579  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
123781630  FGF23; fibroblast growth factor 23 [KO:K22428]
123781637  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
123781747  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123781846  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123782064  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
123782153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123782215  STMN1; stathmin [KO:K04381]
123782282  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
123782436  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
123782828  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123782858  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
123783398  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
123783448  EFNA3; ephrin-A3 [KO:K05462]
123783455  EFNA1; ephrin-A1 [KO:K05462]
123783456  EFNA4; ephrin-A4 [KO:K05462]
123783522  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
123783734  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
123783795  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784117  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
123784520  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123784541  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
123784572  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123784609  TAOK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
123784760  HSPB1; heat shock protein beta-1 [KO:K04455]
123785493  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
123785536  FGF10; fibroblast growth factor 10 [KO:K04358]
123785661  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
123785675  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
123785743  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
123785763  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
123785786  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
123786008  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
123786035  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123786270  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123786368  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
123786515  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
123786994  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
123786995  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123787038  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
123787039  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
123787128  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
123787151  RAP1B; ras-related protein Rap-1b [KO:K07836]
123787214  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123787262  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123787495  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123787808  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
123787940  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
123788054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123788300  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
123788418  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
123788433  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123788597  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
123788636  FGF18; fibroblast growth factor 18 [KO:K04358]
123788829  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
123788872  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123788880  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123788912  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123789034  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123789179  AREG; amphiregulin [KO:K09782]
123789204  FGF5; fibroblast growth factor 5 [KO:K04358]
123789347  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
123789349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123789415  EREG; proepiregulin [KO:K09784]
123790179  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
123790206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
123790266  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
123790496  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123790499  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123790718  [KO:K04370]
123790797  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123790921  DAXX; LOW QUALITY PROTEIN: death domain-associated protein 6 [KO:K02308]
123790987  [KO:K03283]
123790988  [KO:K03283]
123790989  [KO:K03283]
123791076  TNF; tumor necrosis factor [KO:K03156]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791493  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
123791499  RASA1; ras GTPase-activating protein 1 [KO:K04352]
123791523  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
123791661  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
123791737  [KO:K07210]
123791948  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123791950  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
123791977  FGF9; fibroblast growth factor 9 [KO:K04358]
123792071  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123792132  TP53; cellular tumor antigen p53 [KO:K04451]
123792189  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
123792511  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123792681  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123792836  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
123793143  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123793179  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123793193  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
123793291  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123793342  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
123793362  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123793641  ARTN; artemin [KO:K25415]
123793733  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
123793985  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
123794000  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
123794040  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
123794063  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
123794100  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123794692  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
123794694  SRF; serum response factor [KO:K04378]
123794728  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123794793  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
123794834  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
123794860  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
123794868  FGF16; fibroblast growth factor 16 [KO:K04358]
123794928  NGF; beta-nerve growth factor [KO:K02582]
123795037  NRAS; GTPase NRas [KO:K07828]
123795072  RAP1A; ras-related protein Rap-1A [KO:K04353]
123795095  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123795272  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123795327  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123795328  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123795545  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
123795577  DUSP9; LOW QUALITY PROTEIN: dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123795650  CRKL; crk-like protein [KO:K04438]
123795836  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123795860  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123795903  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
123795951  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123796025  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123796292  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
123796334  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123796781  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
123796818  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123796881  RASGRF1; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
123796996  VEGFA; vascular endothelial growth factor A [KO:K05448]
123797028  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
123797184  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
123797262  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123797349  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
123797428  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
123797525  [KO:K04373] [EC:2.7.11.1]
123797538  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
123797801  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123797846  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
123798269  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123798551  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
123798700  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
123798705  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
123798722  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123798762  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
123798769  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
123798888  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
123798894  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
123798962  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
123798968  FOS; proto-oncogene c-Fos [KO:K04379]
123798976  PGF; placenta growth factor isoform X1 [KO:K16859]
123799026  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
123799260  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
123799319  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
123799411  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123799466  BDNF; brain-derived neurotrophic factor [KO:K04355]
123799493  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
123799584  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
123799624  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123799741  IL1B; interleukin-1 beta [KO:K04519]
123799742  IL1A; interleukin-1 alpha [KO:K04383]
123799806  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
123799809  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123799845  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
123800112  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123800125  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
123800287  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123800367  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123800571  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
123800635  MAX; protein max isoform X1 [KO:K04453]
123800861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123800880  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
123800895  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123801281  [KO:K04723]
123801371  [KO:K04852]
123801377  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123801736  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
123801768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123801808  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
123801908  MYC; myc proto-oncogene protein [KO:K04377]
123801972  RELB; transcription factor RelB isoform X1 [KO:K09253]
123802053  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123802208  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123802264  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
123802492  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
123802515  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123802596  VEGFC; vascular endothelial growth factor C [KO:K05449]
123802878  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123802932  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
123802938  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123802960  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123803011  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
123803048  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
123803052  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123803085  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
123803163  [KO:K04393]
123803189  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
123803222  MAPT; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380]
123803224  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123803240  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
123803353  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123803502  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123803514  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
123803628  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123803639  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123803776  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123803793  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
123803805  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
123803827  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
123803837  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
123803979  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123803989  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123804080  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123804087  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
123804163  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123804179  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
uar04070  Phosphatidylinositol signaling system
uar04110  Cell cycle
uar04115  p53 signaling pathway
uar04210  Apoptosis
uar04310  Wnt signaling pathway
uar04668  TNF signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system