KEGG   PATHWAY: uar04151
Entry
uar04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Ursus americanus (American black bear)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
uar04151  PI3K-Akt signaling pathway
uar04151

Other DBs
GO: 0043491
Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123775437  THBS2; thrombospondin-2 [KO:K04659]
123775501  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
123775502  INS; insulin [KO:K04526]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123775611  TSC1; hamartin isoform X1 [KO:K07206]
123775703  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
123775714  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
123775752  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
123775866  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
123776118  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
123776226  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
123776278  FGF21; fibroblast growth factor 21 [KO:K22429]
123776329  NTF4; neurotrophin-4 [KO:K12457]
123776347  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
123776417  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
123776440  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
123776695  [KO:K04545]
123776743  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123776744  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
123776779  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
123776788  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
123776820  CHAD; LOW QUALITY PROTEIN: chondroadherin [KO:K06248]
123776839  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
123776873  VTN; vitronectin [KO:K06251]
123777184  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
123777259  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123777305  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
123777458  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123777464  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
123777569  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123777589  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
123777697  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123777751  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
123777771  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
123777792  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123777846  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123777991  [KO:K03456]
123778065  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
123778092  IRS1; insulin receptor substrate 1 [KO:K16172]
123778093  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
123778094  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
123778170  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
123778178  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
123778302  RELA; transcription factor p65 [KO:K04735]
123778304  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
123778359  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
123778371  FGF3; fibroblast growth factor 3 [KO:K04358]
123778372  FGF19; fibroblast growth factor 19 [KO:K22603]
123778404  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
123778440  BAD; bcl2-associated agonist of cell death [KO:K02158]
123778441  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123778493  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123778546  YWHAQ; 14-3-3 protein theta [KO:K16197]
123778699  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
123778756  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123778830  [KO:K02991]
123779016  [KO:K25414]
123779022  [KO:K25414]
123779027  PSPN; persephin [KO:K25416]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779112  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123779137  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
123779139  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
123779180  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123779529  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123779575  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123779697  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123779882  [KO:K04659]
123779913  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
123779916  LAMB2; laminin subunit beta-2 [KO:K06243]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123779986  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
123780205  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
123780295  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123780346  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123780362  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123780411  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
123780440  FGF20; fibroblast growth factor 20 [KO:K04358]
123780489  KITLG; kit ligand isoform X1 [KO:K05461]
123780490  HSP90B1; endoplasmin [KO:K09487]
123780649  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123780665  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123780702  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123780774  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123780861  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
123781031  IFNB1; interferon beta [KO:K05415]
123781164  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123781241  [KO:K05414]
123781249  [KO:K05414]
123781251  [KO:K05414]
123781252  [KO:K05414]
123781255  [KO:K05414]
123781256  [KO:K05414]
123781260  [KO:K05414]
123781283  [KO:K05414]
123781308  RPS6; 40S ribosomal protein S6 [KO:K02991]
123781314  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123781329  [KO:K05414]
123781399  [KO:K04360] [EC:2.7.10.1]
123781472  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123781568  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
123781570  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123781579  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
123781583  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123781630  FGF23; fibroblast growth factor 23 [KO:K22428]
123781637  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
123781679  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
123781751  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
123781804  CSF3; granulocyte colony-stimulating factor [KO:K05423]
123781879  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
123781964  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
123781999  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
123782078  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
123782335  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
123782925  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
123783044  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
123783123  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123783236  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
123783374  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
123783393  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
123783398  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
123783448  EFNA3; ephrin-A3 [KO:K05462]
123783455  EFNA1; ephrin-A1 [KO:K05462]
123783456  EFNA4; ephrin-A4 [KO:K05462]
123783591  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
123783660  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123783731  TSC2; tuberin isoform X1 [KO:K07207]
123783746  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123783761  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
123783974  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
123784023  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784206  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
123784583  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123784761  YWHAG; 14-3-3 protein gamma [KO:K16198]
123784800  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
123784876  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123785469  PRLR; prolactin receptor isoform X1 [KO:K05081]
123785472  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
123785493  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
123785499  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
123785508  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123785520  GHR; growth hormone receptor isoform X1 [KO:K05080]
123785536  FGF10; fibroblast growth factor 10 [KO:K04358]
123785811  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
123785833  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
123785864  ITGA8; integrin alpha-8 [KO:K06584]
123785980  [KO:K02991]
123786035  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123786270  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123786411  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123786667  MTCP1; protein p13 MTCP-1 [KO:K16837]
123786684  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
123787146  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123787201  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123787262  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123787272  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123787285  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123787448  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
123787450  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
123787693  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
123787744  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
123787748  [KO:K04542]
123788027  TLR4; toll-like receptor 4 [KO:K10160]
123788031  TNC; tenascin isoform X1 [KO:K06252]
123788158  OSM; oncostatin-M isoform X1 [KO:K05418]
123788197  YWHAH; 14-3-3 protein eta [KO:K16198]
123788290  [KO:K06253]
123788294  SPP1; osteopontin isoform X1 [KO:K06250]
123788369  [KO:K06238]
123788370  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
123788401  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123788457  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
123788636  FGF18; fibroblast growth factor 18 [KO:K04358]
123788681  IL6; interleukin-6 [KO:K05405]
123788748  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
123788761  RHEB; GTP-binding protein Rheb [KO:K07208]
123788781  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
123788905  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
123788910  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123788912  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123789034  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123789128  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
123789179  AREG; amphiregulin [KO:K09782]
123789193  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123789204  FGF5; fibroblast growth factor 5 [KO:K04358]
123789274  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123789281  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123789282  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123789288  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
123789349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123789355  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
123789379  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
123789397  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
123789409  LAMB1; laminin subunit beta-1 [KO:K05636]
123789415  EREG; proepiregulin [KO:K09784]
123789617  LAMB4; laminin subunit beta-4 [KO:K06245]
123789797  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123789819  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123790031  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
123790062  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
123790190  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123790206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
123790348  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123790366  IL4; interleukin-4 [KO:K05430]
123790499  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123790541  [KO:K04736]
123790672  LAMA5; laminin subunit alpha-5 [KO:K06240]
123790797  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123790824  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
123790969  TNXB; tenascin-X isoform X1 [KO:K06252]
123790975  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
123791081  PRL; prolactin [KO:K05439]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791375  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
123791530  THBS4; thrombospondin-4 [KO:K04659]
123791553  F2R; proteinase-activated receptor 1 [KO:K03914]
123791737  [KO:K07210]
123791848  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
123791948  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123791950  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
123791977  FGF9; fibroblast growth factor 9 [KO:K04358]
123792093  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
123792094  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
123792132  TP53; cellular tumor antigen p53 [KO:K04451]
123792511  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123792556  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123792843  ITGA9; integrin alpha-9 [KO:K06585]
123792966  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123793114  IL2; interleukin-2 [KO:K05429]
123793143  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123793193  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
123793207  TLR2; toll-like receptor 2 [KO:K10159]
123793291  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123793342  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
123793362  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123793519  [KO:K02991]
123793641  ARTN; artemin [KO:K25415]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123793944  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
123793974  [KO:K16197]
123793984  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123794034  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
123794040  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
123794063  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
123794100  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123794615  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
123794668  ITGA5; integrin alpha-5 [KO:K06484]
123794706  ITGB7; integrin beta-7 [KO:K06590]
123794714  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
123794728  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123794804  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
123794868  FGF16; fibroblast growth factor 16 [KO:K04358]
123794928  NGF; beta-nerve growth factor [KO:K02582]
123795037  NRAS; GTPase NRas [KO:K07828]
123795038  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
123795095  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123795244  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
123795265  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
123795269  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123795327  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123795350  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123795384  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
123795550  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123795763  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
123795836  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123795860  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123796025  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123796116  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123796391  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
123796629  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
123796781  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
123796787  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123796818  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123796996  VEGFA; vascular endothelial growth factor A [KO:K05448]
123797004  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
123797024  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
123797262  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123797422  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
123797568  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
123797600  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
123797801  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123797829  [KO:K16197]
123797872  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
123797942  IL7; interleukin-7 [KO:K05431]
123798102  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
123798116  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123798247  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123798269  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123798278  FN1; fibronectin isoform X1 [KO:K05717]
123798407  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
123798497  FOXO3; forkhead box protein O3 [KO:K09408]
123798690  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123798888  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
123798976  PGF; placenta growth factor isoform X1 [KO:K16859]
123799260  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
123799360  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
123799466  BDNF; brain-derived neurotrophic factor [KO:K04355]
123799579  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
123799764  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
123799809  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123800039  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123800367  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123800549  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
123800611  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
123800701  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
123800835  ITGA11; integrin alpha-11 [KO:K06587]
123800861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123800895  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123801399  LAMC2; laminin subunit gamma-2 [KO:K06246]
123801411  TNR; tenascin-R [KO:K06252]
123801422  TNN; tenascin-N isoform X1 [KO:K06252]
123801431  LAMC1; laminin subunit gamma-1 [KO:K05635]
123801660  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123801744  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
123801797  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
123801808  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
123801908  MYC; myc proto-oncogene protein [KO:K04377]
123802053  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123802198  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
123802327  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
123802515  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123802596  VEGFC; vascular endothelial growth factor C [KO:K05449]
123802731  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
123802767  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
123802847  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123802878  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123802938  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123802954  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
123803018  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
123803040  ITGB3; integrin beta-3 [KO:K06493]
123803052  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123803148  ITGA2B; integrin alpha-IIb [KO:K06476]
123803168  GH1; somatotropin [KO:K05438]
123803224  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123803229  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
123803352  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
123803378  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
123803383  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123803628  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123803639  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123803661  ITGA1; integrin alpha-1 [KO:K06480]
123803701  ITGA2; integrin alpha-2 [KO:K06481]
123803961  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
123803962  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
123803979  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123803989  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123804080  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123804137  THBS1; thrombospondin-1 [KO:K16857]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
uar00010  Glycolysis / Gluconeogenesis
uar04010  MAPK signaling pathway
uar04012  ErbB signaling pathway
uar04062  Chemokine signaling pathway
uar04064  NF-kappa B signaling pathway
uar04068  FoxO signaling pathway
uar04110  Cell cycle
uar04115  p53 signaling pathway
uar04150  mTOR signaling pathway
uar04210  Apoptosis
uar04370  VEGF signaling pathway
uar04510  Focal adhesion
uar04620  Toll-like receptor signaling pathway
uar04630  JAK-STAT signaling pathway
uar04662  B cell receptor signaling pathway
uar04910  Insulin signaling pathway
KO pathway
ko04151   

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