Ursus americanus (American black bear): 123790797
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Entry
123790797 CDS
T07931
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor isoform X1
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
uar
Ursus americanus (American black bear)
Pathway
uar01521
EGFR tyrosine kinase inhibitor resistance
uar01522
Endocrine resistance
uar04010
MAPK signaling pathway
uar04014
Ras signaling pathway
uar04015
Rap1 signaling pathway
uar04066
HIF-1 signaling pathway
uar04068
FoxO signaling pathway
uar04081
Hormone signaling
uar04114
Oocyte meiosis
uar04140
Autophagy - animal
uar04144
Endocytosis
uar04150
mTOR signaling pathway
uar04151
PI3K-Akt signaling pathway
uar04152
AMPK signaling pathway
uar04211
Longevity regulating pathway
uar04213
Longevity regulating pathway - multiple species
uar04510
Focal adhesion
uar04518
Integrin signaling
uar04520
Adherens junction
uar04550
Signaling pathways regulating pluripotency of stem cells
uar04730
Long-term depression
uar04913
Ovarian steroidogenesis
uar04914
Progesterone-mediated oocyte maturation
uar05200
Pathways in cancer
uar05202
Transcriptional misregulation in cancer
uar05205
Proteoglycans in cancer
uar05214
Glioma
uar05215
Prostate cancer
uar05218
Melanoma
uar05224
Breast cancer
uar05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
uar00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
123790797 (IGF1R)
04014 Ras signaling pathway
123790797 (IGF1R)
04015 Rap1 signaling pathway
123790797 (IGF1R)
04066 HIF-1 signaling pathway
123790797 (IGF1R)
04068 FoxO signaling pathway
123790797 (IGF1R)
04151 PI3K-Akt signaling pathway
123790797 (IGF1R)
04152 AMPK signaling pathway
123790797 (IGF1R)
04150 mTOR signaling pathway
123790797 (IGF1R)
09133 Signaling molecules and interaction
04081 Hormone signaling
123790797 (IGF1R)
04518 Integrin signaling
123790797 (IGF1R)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
123790797 (IGF1R)
04140 Autophagy - animal
123790797 (IGF1R)
09143 Cell growth and death
04114 Oocyte meiosis
123790797 (IGF1R)
09144 Cellular community - eukaryotes
04510 Focal adhesion
123790797 (IGF1R)
04520 Adherens junction
123790797 (IGF1R)
04550 Signaling pathways regulating pluripotency of stem cells
123790797 (IGF1R)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
123790797 (IGF1R)
04914 Progesterone-mediated oocyte maturation
123790797 (IGF1R)
09156 Nervous system
04730 Long-term depression
123790797 (IGF1R)
09149 Aging
04211 Longevity regulating pathway
123790797 (IGF1R)
04213 Longevity regulating pathway - multiple species
123790797 (IGF1R)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123790797 (IGF1R)
05202 Transcriptional misregulation in cancer
123790797 (IGF1R)
05205 Proteoglycans in cancer
123790797 (IGF1R)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
123790797 (IGF1R)
05214 Glioma
123790797 (IGF1R)
05218 Melanoma
123790797 (IGF1R)
05215 Prostate cancer
123790797 (IGF1R)
05224 Breast cancer
123790797 (IGF1R)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123790797 (IGF1R)
01522 Endocrine resistance
123790797 (IGF1R)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uar01001
]
123790797 (IGF1R)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
uar04090
]
123790797 (IGF1R)
Enzymes [BR:
uar01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
123790797 (IGF1R)
Protein kinases [BR:
uar01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
123790797 (IGF1R)
CD molecules [BR:
uar04090
]
Proteins
123790797 (IGF1R)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Furin-like
Pkinase
fn3
Motif
Other DBs
NCBI-GeneID:
123790797
NCBI-ProteinID:
XP_045651366
LinkDB
All DBs
Position
Unknown
AA seq
1240 aa
AA seq
DB search
MKSGSGGGSPTSLWGLLFFSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTENNECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPTCPPNTYRFEGWRCVDRDFCANIPSAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTWKNHIIIRWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVDPGILLQGLKPWTQYAVYVKAVTLTMVNDHIRGAKSEI
LYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRHN
YCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKV
FENFLHNSIFVPRPERKRRDVTQITNTTMSSRGRNSTVADTYNITDPEELETEYPFFESR
VDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWE
SRPENSIFLKWPEPENPNGLILMYEIKYGSQIEDQRECVSRQEYRKYGGAKLNRLNPGNY
TARIQATSLSGNGSWTDPVFFYVPAKITYENFIHLIIALPVAVLLIVGGLVIMLYVFHRK
RNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGV
VKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMEL
MTRGDLKSYLRSLRPEIENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNC
MVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSCLHY
AYIGLLVIPIGPSLWHSCTPALFLVRQALESQGSGLFSLV
NT seq
3723 nt
NT seq
+upstream
nt +downstream
nt
atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcctgtttttctcc
gccgcgctctcgctctggccgacgagtggagaaatctgcgggccgggcatcgacatccgc
aacgactatcagcagctgaagcgtctggagaactgcacggtgatcgagggctacctccac
atcttgctcatctccaaggcagaggactaccgcagctaccgcttccccaagctcacggtc
atcaccgagtacctgctgctgttccgcgtggccggcctcgagagcctcggggacctcttc
ccgaacctcacggtcatccgcggctggaaactcttctacaattacgccctggtcatcttt
gagatgaccaatctcaaggatattgggctttacaatctgaggaacattactcggggggcc
atcaggattgagaaaaatgccgacctctgttacctctccacggtggactggtccctgatc
ctggacgcggtgtccaataactacatcgtgggaaacaaacccccaaaggaatgcggggac
ctgtgtccggggacgatggaggagaagcccttgtgcgagaagacgaccatcaacaacgag
tacaactaccgctgctggactacaaaccgctgccagaaaatgtgcccgagcgcgtgcggg
aagcgagcgtgcaccgagaacaacgagtgctgtcaccccgagtgtctgggcagctgcagc
gcgccggacaacgacacggcctgcgtggcctgcaggcattactactacgccggcgtctgc
gtgcccacctgcccgcccaacacctaccgcttcgagggctggcgctgcgtggaccgcgac
ttctgcgccaacatccccagcgccgagagcagcgactccgaggggttcgtgatccacgac
ggcgagtgcatgcaggagtgcccctccgggttcatccggaatggcagtcagagtatgtac
tgcatcccttgcgaaggtccttgccccaaggtctgtgaggaagagaagaaaacaaagacc
attgattctgttacctctgctcaaatgctccaaggatgcaccatcttcaagggcaatttg
ctcattaacatccgccgaggcaataacattgcctcggaactggagaacttcatggggctc
atcgaggtggtgacaggctacgtgaagattcgccattcccacgccttggtctccttgtcc
ttcctaaaaaaccttcgccagatcttaggagaggagcagctggaggggaactactccttc
tacgtccttgacaaccagaacttgcagcagctgtgggactgggaccaccgcaacctgacc
atcaaagctgggaaaatgtactttgctttcaatcccaagttgtgcgtctccgagatttac
cgcatggaggaagtgacagggactaaggggcgccagagcaaaggggacataaacaccagg
aacaacggagagcgagcctcctgtgaaagcgacgtcctgcacttcacctctacgaccaca
tggaagaatcacatcatcataaggtggcaccgttaccggccccccgactacagggacctc
atcagcttcactgtctactacaaggaagcaccttttaaaaacgtcacggagtacgatggc
caggatgcctgtggctccaacagctggaacatggtggatgtggacctccctcccaacaag
gacgtcgatcctggcattttactgcagggactgaagccctggacgcagtatgccgtgtat
gtcaaggcggtgaccctcaccatggtgaacgaccacatccgtggggccaagagtgaaatc
ttgtacattcgtaccaatgcttcagttccttccattcccctggacgttctgtccgcgtcc
aactcgtcttctcagctcatcgtgaagtggaacccgccgtccctgcccaacgggaacctc
agttactacatcgtgaggtggcagcggcagcctcaggacagctacctgtaccggcacaat
tactgctccaaagacaaaatccccatcaggaagtatgccgacggcaccatcgacgtcgaa
gaggtgacggagaatcccaagaccgaggtgtgcggcggagagaaggggccttgctgcgcc
tgccccaaaaccgaggccgagaagcaggccgagaaggaggaggccgagtaccgcaaagtc
ttcgagaacttcctgcacaactccatctttgtgcccagaccggaaaggaagcggagagac
gtcacacaaatcaccaacaccaccatgtccagccgaggcaggaacagcacagtggcggac
acctataatatcacagacccagaagagctcgagacagaataccctttctttgagagcaga
gtagataacaaggagagaactgtcatctctaacctccggccttttactttgtaccgcatt
gacatccacagctgtaaccatgaggctgagaagctgggctgcagcgcctccaactttgtt
tttgcaagaaccatgcctgcagaaggagcagatgacattcctgggccggtgacctgggag
tcgaggcctgaaaactccatctttctaaagtggccagaacctgagaatcccaatggattg
attctaatgtatgaaataaaatacggatcccaaatcgaggatcagcgggaatgtgtatcc
agacaggagtacaggaaatatggaggcgccaagcttaaccggctcaacccggggaactat
acagcccggatccaggccacctctctctccgggaatgggtcgtggacggatcctgtgttc
ttctatgtcccagccaaaataacgtatgagaacttcatccatctgatcatagctctgccc
gttgccgtcctgttgatagtgggagggctggttataatgttgtacgtcttccacaggaaa
agaaacaacagcaggctggggaatggagtgctgtacgcgtccgtgaacccagagtacttc
agcgccgccgacgtgtacgtacctgacgagtgggaggttgctcgagagaagatcaccatg
agccgagagctgggccagggctcctttgggatggtatacgaaggagtcgccaaaggcgtg
gttaaagatgagcccgaaaccagggtggccattaaaacagtgaacgaggctgcgagcatg
cgcgaaaggattgaatttctcaatgaggcttcagtgatgaaggagttcaattgtcaccac
gtggtgcggttgctgggcgtggtgtcccagggccagccgacgctggtcatcatggaactg
atgacacggggggatctcaaaagctatctcaggtctctgaggccagaaatagagaataat
ccagtcctagcacctccaagcctgagcaagatgatccagatggctggggagattgcagat
ggcatggcatacctcaacgccaacaagtttgtccacagagaccttgctgcccggaactgc
atggtggccgaagatttcacggtcaaaatcggagatttcggtatgacgagagacatctat
gagacagactattacaggaaaggaggaaaggggctgctgcctgtgcgctggatgtccccc
gagtctctcaaggatggagtcttcaccactcactctgacgtctggtcttgcttgcactat
gcttacatcggtctcttggtgatacccattggcccttctctgtggcacagttgcacacct
gctctgtttttggtaagacaggccttggagtcacaaggaagtggtctcttttctctagtt
tga
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