Ursus americanus (American black bear): 123798200 Help Entry 123798200         CDS       T07931                                  Symbol CASP8 Name (RefSeq) caspase-8 isoform X1   KO K04398   caspase 8 [EC:3.4.22.61] Organism uar  Ursus americanus (American black bear) Pathway uar01524   Platinum drug resistance uar04115   p53 signaling pathway uar04210   Apoptosis uar04215   Apoptosis - multiple species uar04217   Necroptosis uar04620   Toll-like receptor signaling pathway uar04621   NOD-like receptor signaling pathway uar04622   RIG-I-like receptor signaling pathway uar04623   Cytosolic DNA-sensing pathway uar04625   C-type lectin receptor signaling pathway uar04657   IL-17 signaling pathway uar04668   TNF signaling pathway uar04932   Non-alcoholic fatty liver disease uar04936   Alcoholic liver disease uar05010   Alzheimer disease uar05016   Huntington disease uar05022   Pathways of neurodegeneration - multiple diseases uar05132   Salmonella infection uar05134   Legionellosis uar05142   Chagas disease uar05145   Toxoplasmosis uar05152   Tuberculosis uar05160   Hepatitis C uar05161   Hepatitis B uar05162   Measles uar05163   Human cytomegalovirus infection uar05164   Influenza A uar05165   Human papillomavirus infection uar05167   Kaposi sarcoma-associated herpesvirus infection uar05168   Herpes simplex virus 1 infection uar05169   Epstein-Barr virus infection uar05170   Human immunodeficiency virus 1 infection uar05200   Pathways in cancer uar05203   Viral carcinogenesis uar05416   Viral myocarditis uar05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     123798200 (CASP8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     123798200 (CASP8)    04215 Apoptosis - multiple species     123798200 (CASP8)    04217 Necroptosis     123798200 (CASP8)    04115 p53 signaling pathway     123798200 (CASP8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     123798200 (CASP8)    04621 NOD-like receptor signaling pathway     123798200 (CASP8)    04622 RIG-I-like receptor signaling pathway     123798200 (CASP8)    04623 Cytosolic DNA-sensing pathway     123798200 (CASP8)    04625 C-type lectin receptor signaling pathway     123798200 (CASP8)    04657 IL-17 signaling pathway     123798200 (CASP8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     123798200 (CASP8)    05203 Viral carcinogenesis     123798200 (CASP8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     123798200 (CASP8)    05161 Hepatitis B     123798200 (CASP8)    05160 Hepatitis C     123798200 (CASP8)    05164 Influenza A     123798200 (CASP8)    05162 Measles     123798200 (CASP8)    05168 Herpes simplex virus 1 infection     123798200 (CASP8)    05163 Human cytomegalovirus infection     123798200 (CASP8)    05167 Kaposi sarcoma-associated herpesvirus infection     123798200 (CASP8)    05169 Epstein-Barr virus infection     123798200 (CASP8)    05165 Human papillomavirus infection     123798200 (CASP8)   09171 Infectious disease: bacterial    05132 Salmonella infection     123798200 (CASP8)    05134 Legionellosis     123798200 (CASP8)    05152 Tuberculosis     123798200 (CASP8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     123798200 (CASP8)    05142 Chagas disease     123798200 (CASP8)   09164 Neurodegenerative disease    05010 Alzheimer disease     123798200 (CASP8)    05016 Huntington disease     123798200 (CASP8)    05022 Pathways of neurodegeneration - multiple diseases     123798200 (CASP8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     123798200 (CASP8)    05416 Viral myocarditis     123798200 (CASP8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     123798200 (CASP8)    04932 Non-alcoholic fatty liver disease     123798200 (CASP8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     123798200 (CASP8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:uar01002]     123798200 (CASP8) Enzymes [BR:uar01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      123798200 (CASP8) Peptidases and inhibitors [BR:uar01002]  Cysteine peptidases   Family C14: caspase family    123798200 (CASP8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Peptidase_C14 DED Motif Other DBs NCBI-GeneID:  123798200 NCBI-ProteinID:  XP_045662442 LinkDB All DBs Position Unknown AA seq 486 aa AA seqDB search MNFSKCLYNIGEQLDSDELASLKFLSMDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLS FLKELLFRINRLDLLVTYLDTSKEEMEQELQIPGRAQISAYRVMLFQISEDVSKLELRSF KFFLSQEISRCKLHDDLNLFDIFIEMEKRVILGERNLDTLKRICDQINKSLLKKITDYEE LSREQTLSPQRSLDEISNDMSQLLVGEESLRVPPMSDSPGEQDCEPETSDKVYRMESKPR GYCLIFNNYDFSIARKEVPKLQSIKDRNGTDLDADALCQTFSELHFEIVPFKDCTAKKIC EVLKSYQSMDHSSRDCFICCILSHGDKGIIYGSDGQEVPIYELTSYFTGSKCPSLAGKPK IFFIQACQGDNYQKGIAVETDSEQKEAYLEMDSSYQKRYIPEDADFLLGMATVNNCVSYR NPMEGTWYIQSLCQSLRERCPRGEDILTILTEVNFEVSNKDDRKNMGKQMPQPTFTLRKK LFFPLN NT seq 1461 nt NT seq  +upstreamnt  +downstreamnt atgaatttcagcaaatgcctctataatattggagaacagctggacagtgatgagctggcc tccctcaagttcctgagcatggactacatcccacagaagaagcaggaacccatcaaggat cccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaacctgtcc ttcttgaaggagctgcttttccgaattaacagactggacctactggttacctacctggac accagcaaggaggagatggagcaggagcttcaaataccaggcagagcccagatctctgcc tacagggtcatgctttttcagatttcagaagatgtaagcaaattggaattgaggtccttt aagttttttttgagccaggagatctccagatgtaaactgcacgatgacttgaacttgttt gatattttcatagagatggagaagagggtcatcctcggggaaagaaatctggataccctg aaaagaatctgtgaccaaattaacaagagcctgctgaagaaaatcacggattatgaagaa ttaagcagagagcaaacactgagccctcaaagaagtctagatgaaatttcaaatgatatg tctcagttgcttgtaggggaggaatccctgagggtaccgccaatgtcggactctccagga gaacaggactgtgaaccagagacatcggacaaagtttaccgaatggaaagcaaacctcga ggatattgtttgatctttaacaattacgactttagcatagcacggaaggaagtgcccaaa cttcagagcattaaggataggaatggaacagacttggatgcagatgctttgtgtcagacc tttagtgagcttcattttgagatcgtgcctttcaaagactgtacagccaagaaaatctgt gaggttctgaaatcctaccaaagcatggaccactctagcagggattgcttcatctgctgc atcctctcccatggagacaagggcatcatctatggctctgatgggcaagaagtccccatc tatgagctgacttcttacttcactggttcaaagtgcccttcccttgcaggcaagcccaaa atcttttttattcaggcttgtcaaggggataactaccagaaaggtatagctgttgagact gactctgaacagaaggaagcctatttagaaatggactcatcctatcagaagagatatatc ccagaagatgctgactttctgctggggatggccactgtgaataattgtgtttcctaccga aaccccatggaggggacctggtatatccagtcactttgccagagcctgagagaaagatgt cctaggggcgaagatattctcaccatccttaccgaggtgaactttgaagtgagcaataag gatgacaggaaaaacatggggaaacaaatgccacaacctactttcacactgaggaaaaaa ctctttttccctcttaattga

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