KEGG   Ursus americanus (American black bear): 123802053
Entry
123802053         CDS       T07931                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar01521  EGFR tyrosine kinase inhibitor resistance
uar01522  Endocrine resistance
uar04010  MAPK signaling pathway
uar04012  ErbB signaling pathway
uar04014  Ras signaling pathway
uar04015  Rap1 signaling pathway
uar04022  cGMP-PKG signaling pathway
uar04024  cAMP signaling pathway
uar04062  Chemokine signaling pathway
uar04068  FoxO signaling pathway
uar04071  Sphingolipid signaling pathway
uar04072  Phospholipase D signaling pathway
uar04140  Autophagy - animal
uar04150  mTOR signaling pathway
uar04151  PI3K-Akt signaling pathway
uar04210  Apoptosis
uar04218  Cellular senescence
uar04270  Vascular smooth muscle contraction
uar04360  Axon guidance
uar04370  VEGF signaling pathway
uar04371  Apelin signaling pathway
uar04510  Focal adhesion
uar04540  Gap junction
uar04550  Signaling pathways regulating pluripotency of stem cells
uar04613  Neutrophil extracellular trap formation
uar04625  C-type lectin receptor signaling pathway
uar04630  JAK-STAT signaling pathway
uar04650  Natural killer cell mediated cytotoxicity
uar04660  T cell receptor signaling pathway
uar04662  B cell receptor signaling pathway
uar04664  Fc epsilon RI signaling pathway
uar04666  Fc gamma R-mediated phagocytosis
uar04720  Long-term potentiation
uar04722  Neurotrophin signaling pathway
uar04726  Serotonergic synapse
uar04730  Long-term depression
uar04810  Regulation of actin cytoskeleton
uar04910  Insulin signaling pathway
uar04912  GnRH signaling pathway
uar04914  Progesterone-mediated oocyte maturation
uar04915  Estrogen signaling pathway
uar04916  Melanogenesis
uar04917  Prolactin signaling pathway
uar04919  Thyroid hormone signaling pathway
uar04921  Oxytocin signaling pathway
uar04926  Relaxin signaling pathway
uar04928  Parathyroid hormone synthesis, secretion and action
uar04929  GnRH secretion
uar04935  Growth hormone synthesis, secretion and action
uar05010  Alzheimer disease
uar05022  Pathways of neurodegeneration - multiple diseases
uar05034  Alcoholism
uar05132  Salmonella infection
uar05152  Tuberculosis
uar05160  Hepatitis C
uar05161  Hepatitis B
uar05163  Human cytomegalovirus infection
uar05164  Influenza A
uar05165  Human papillomavirus infection
uar05167  Kaposi sarcoma-associated herpesvirus infection
uar05170  Human immunodeficiency virus 1 infection
uar05200  Pathways in cancer
uar05205  Proteoglycans in cancer
uar05206  MicroRNAs in cancer
uar05207  Chemical carcinogenesis - receptor activation
uar05208  Chemical carcinogenesis - reactive oxygen species
uar05210  Colorectal cancer
uar05211  Renal cell carcinoma
uar05212  Pancreatic cancer
uar05213  Endometrial cancer
uar05214  Glioma
uar05215  Prostate cancer
uar05218  Melanoma
uar05219  Bladder cancer
uar05220  Chronic myeloid leukemia
uar05221  Acute myeloid leukemia
uar05223  Non-small cell lung cancer
uar05224  Breast cancer
uar05225  Hepatocellular carcinoma
uar05226  Gastric cancer
uar05230  Central carbon metabolism in cancer
uar05231  Choline metabolism in cancer
uar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:uar00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123802053 (RAF1)
   04012 ErbB signaling pathway
    123802053 (RAF1)
   04014 Ras signaling pathway
    123802053 (RAF1)
   04015 Rap1 signaling pathway
    123802053 (RAF1)
   04370 VEGF signaling pathway
    123802053 (RAF1)
   04371 Apelin signaling pathway
    123802053 (RAF1)
   04630 JAK-STAT signaling pathway
    123802053 (RAF1)
   04068 FoxO signaling pathway
    123802053 (RAF1)
   04072 Phospholipase D signaling pathway
    123802053 (RAF1)
   04071 Sphingolipid signaling pathway
    123802053 (RAF1)
   04024 cAMP signaling pathway
    123802053 (RAF1)
   04022 cGMP-PKG signaling pathway
    123802053 (RAF1)
   04151 PI3K-Akt signaling pathway
    123802053 (RAF1)
   04150 mTOR signaling pathway
    123802053 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123802053 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    123802053 (RAF1)
   04218 Cellular senescence
    123802053 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123802053 (RAF1)
   04540 Gap junction
    123802053 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    123802053 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123802053 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    123802053 (RAF1)
   04625 C-type lectin receptor signaling pathway
    123802053 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    123802053 (RAF1)
   04660 T cell receptor signaling pathway
    123802053 (RAF1)
   04662 B cell receptor signaling pathway
    123802053 (RAF1)
   04664 Fc epsilon RI signaling pathway
    123802053 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    123802053 (RAF1)
   04062 Chemokine signaling pathway
    123802053 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123802053 (RAF1)
   04929 GnRH secretion
    123802053 (RAF1)
   04912 GnRH signaling pathway
    123802053 (RAF1)
   04915 Estrogen signaling pathway
    123802053 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    123802053 (RAF1)
   04917 Prolactin signaling pathway
    123802053 (RAF1)
   04921 Oxytocin signaling pathway
    123802053 (RAF1)
   04926 Relaxin signaling pathway
    123802053 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    123802053 (RAF1)
   04919 Thyroid hormone signaling pathway
    123802053 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    123802053 (RAF1)
   04916 Melanogenesis
    123802053 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    123802053 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    123802053 (RAF1)
   04720 Long-term potentiation
    123802053 (RAF1)
   04730 Long-term depression
    123802053 (RAF1)
   04722 Neurotrophin signaling pathway
    123802053 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    123802053 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123802053 (RAF1)
   05206 MicroRNAs in cancer
    123802053 (RAF1)
   05205 Proteoglycans in cancer
    123802053 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    123802053 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    123802053 (RAF1)
   05230 Central carbon metabolism in cancer
    123802053 (RAF1)
   05231 Choline metabolism in cancer
    123802053 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123802053 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123802053 (RAF1)
   05212 Pancreatic cancer
    123802053 (RAF1)
   05225 Hepatocellular carcinoma
    123802053 (RAF1)
   05226 Gastric cancer
    123802053 (RAF1)
   05214 Glioma
    123802053 (RAF1)
   05221 Acute myeloid leukemia
    123802053 (RAF1)
   05220 Chronic myeloid leukemia
    123802053 (RAF1)
   05218 Melanoma
    123802053 (RAF1)
   05211 Renal cell carcinoma
    123802053 (RAF1)
   05219 Bladder cancer
    123802053 (RAF1)
   05215 Prostate cancer
    123802053 (RAF1)
   05213 Endometrial cancer
    123802053 (RAF1)
   05224 Breast cancer
    123802053 (RAF1)
   05223 Non-small cell lung cancer
    123802053 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123802053 (RAF1)
   05161 Hepatitis B
    123802053 (RAF1)
   05160 Hepatitis C
    123802053 (RAF1)
   05164 Influenza A
    123802053 (RAF1)
   05163 Human cytomegalovirus infection
    123802053 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123802053 (RAF1)
   05165 Human papillomavirus infection
    123802053 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123802053 (RAF1)
   05152 Tuberculosis
    123802053 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123802053 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    123802053 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    123802053 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123802053 (RAF1)
   01522 Endocrine resistance
    123802053 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uar01001]
    123802053 (RAF1)
Enzymes [BR:uar01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     123802053 (RAF1)
Protein kinases [BR:uar01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   123802053 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 123802053
NCBI-ProteinID: XP_045668411
LinkDB
Position
Unknown
AA seq 648 aa
MEHIQGAWKTISNGFGFKDTVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaacggttttggattcaaagacaca
gtgtttgacggccccagctgcatctcccctacaatagttcagccctttggctttcagcgt
cgggcatcagatgatggcaaacttacggactcgtctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcacgat
tgccttatgaaagcactcaaggtgaggggcctacagccggaatgctgtgctgtgttcaga
ctgctccatgaacataaaggtaaaaaagcacgtttagattggaatactgatgccgcctcg
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaactcacaac
tttgcacggaagaccttcctgaagcttgccttctgtgacatctgtcagaagttcctgcta
aatggatttcgttgtcagacttgtggctacaaatttcacgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttattgtttccaaattctact
attggtgatagtggggtcccagcactgccttctttgacaatgcgtcgaatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacattc
aactcctccagcccttcctccgaaggttccctctcccagaggcagagatcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacaggctggtcgcagcccaaaactcctgttccagcacagagagagcgggcacca
ggatctgggacccaggagaaaaacaaaatcaggcctcgtggacaaagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctgtccactcggattgggtcaggctccttt
ggaacagtgtataagggcaagtggcacggagatgttgcagtaaagatcctaaaggttgtc
gaccccaccccagagcagttccaggccttcaggaacgaggtggctgtcctccgcaaaaca
cggcacgtgaatatcctgctcttcatggggtacatgacaaaggacaacctggcaatcgtg
acccagtggtgtgaaggcagcagcctctacaaacacctgcatgtccaggaaactaaattc
cagatgttccagctgatcgacatcgcccgtcagactgctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcacgctggagcggttctcag
caggttgaacaacccactggctccgtcctgtggatggcccccgaggtgatccgaatgcag
gataacaacccgttcagcttccagtcggatgtctactcctacggcattgtgctctacgag
ctcatgacaggggagcttccttactcccacatcaataaccgcgatcagatcatcttcatg
gtgggccgagggtacgcctccccagacctcagtaagctgtataagaactgccccaaagca
atgaagaggctcgtagccgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctgccgaaaatcaaccggagcgct
tctgagccatccctgcaccgggcggcccacactgaggatatcaacgcctgcacactgacc
acgtcccctagactgcctgtcttctag

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