Vulpes lagopus (Arctic fox): 121484398 Help Entry 121484398         CDS       T07435                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism vlg  Vulpes lagopus (Arctic fox) Pathway vlg04020   Calcium signaling pathway vlg04371   Apelin signaling pathway vlg04713   Circadian entrainment vlg04921   Oxytocin signaling pathway vlg04970   Salivary secretion vlg05010   Alzheimer disease vlg05012   Parkinson disease vlg05020   Prion disease vlg05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:vlg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121484398 (RYR3)    04020 Calcium signaling pathway     121484398 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     121484398 (RYR3)   09154 Digestive system    04970 Salivary secretion     121484398 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     121484398 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     121484398 (RYR3)    05012 Parkinson disease     121484398 (RYR3)    05020 Prion disease     121484398 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     121484398 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vlg04040]     121484398 (RYR3) Ion channels [BR:vlg04040]  Voltage-gated cation channels   Ryanodine receptor    121484398 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  121484398 NCBI-ProteinID:  XP_041599562 LinkDB All DBs Position 2:80337424..80846081 Genome browser AA seq 4882 aa AA seqDB search MAEGAEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSICFVQHMAS GLWVTYKAQDAKNPRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPIALPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGTAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFIGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRVD GTVDSPPCLKVTHRTFGAQSGGARMVYCRLSMPVECRPSPGHGPCLDGDALRRKQMQEIL SPTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLHSEKFDLNKNCTVTVTLGDERGRVHES VKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPNT KVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWS RMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMHFHYHT LRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLAHAKER KLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEEHQK QSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLVGTLLVMGVFDDD DVRQILLLIDSSVFGEHGGETEDGTEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTQLPE SVKLQLLLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAA LTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEE EEDTSWTGKLRALVYKIKGPPKPEKKQPIEEEERYPTTLKELISQTMIRWAQEDQIQDAE LVRMMFTLLQRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEE LLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFL CYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEP DLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVV VKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDSEDEEIV HMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKL PCLNKDGSISEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASL DTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLT KAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLMNHYEQCWKYYC LPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLD TRISAMLEKQISVDADGNFDPKPINTTNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWK YGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALAQQR ENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKG GGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGILVSSHLCFFLGFTHFQPRGMKDM ELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLP LVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTM VSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKG VSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVE RQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTRTPRERSILGMPDTVEEMCPDLP QLEGLMKEISDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVT SEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKK AVKTVQEEEQLKADTKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPN ADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQER RKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKARYGARDTDEEVKEHL RNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRS KKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHKINNFFLSTFQRVWLEKVNEKTQYDRLI PILMKSPKEEEEEEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQ SGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETL KLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGM VTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIIS TVDYLLRLQESISDFYWYYSGKDVIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQ SLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNG TIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAME GQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDS RLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFI FDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEEDEDSSYMLEIEG EEEDSKSLESASAFAMACASVKRNVANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFF WMLFLELFRLFFAILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAM DSERAEVTEPGITPELIHFVKAEKGDADVMSDLFGFHPKKEGGLKHGPEVGLGDLSEIIG KDEPPTLESTVQKKRKAQAAEMKAAHDAEGKVEPEKMDLEDGEKEDMAKEEEQAEAPWAE VTKKKKPRRGQKVEKPEAFMANFFKGLEVYQTKLLHYLARNFYNLRFLALFVAFAINFIL LFYKVTEEPLEEETEDIANLWNSFNDDEEEEAMVFFVLQESTGYMAPTLRALAVIHTIIS LVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNN YWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKY HIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGK QLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGG GIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDME TKCFICGIGNDYFDTTPHGFETHTVQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQ ERCWDFFPAGDCFRKQYEDQLG NT seq 14649 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggggcagaaggaggcgaggacgagatccagttcctgcggactgaagatgag gtggttctccagtgcatcgcaaacgtccacaaggagcaacgcaagttctgcctggcggcc gaggggcttggcaaccgcctgtgcttcttggaacccacgtcagaagccaagtacgttcct ccagatctctgtgtctgcaattttgtgctggaacagtccctctctgtgagagccctgcag gagatgcttgccaacacaggtgaaaatggtggcgaaggggcggcccaaggcgggggccac cggacgctgctgtacggccacgcggttctgctgcgacactccttcagtggcatgtatcta acttgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgctacaggagaagcctgttggtggaccatacatcccgcttccaaacagagatcc gagggagagaaagttcgaattggtgatgacctcatccttgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatgggaacatacaagtggacgcctcttttatgcaaaca ctctggaatgtacaccctacgtgctcaggaagtagcattgaagaaggatacctacttggt gggcacgtggtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgattcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc agatccctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgactccggcatctcacaacaggccactacctggccttgacagaggac caaggccttatactgcaggaccgggcaaagtcggacaccaagtccacagccttctctttc cgggcttccaaggaaatcaaggagaaattggattccagtcacaaacgagatatagaaggc atgggtgttccagaaatcaagtatggagattccatctgctttgtccagcatatggccagt ggtctgtgggtgacctacaaagcacaagatgccaagaacccccgccttggacctctgaag agaaaggtcattctccatcaggaaggccacatggatgatgggttaacactgcagagatgc caacgtgaggagtcccaggctgctcggatcatccggaacacgacagccttattcagccag tttgtaagtggaaacaatcgcacagctgcccccatcgctctgcccatagaagaggtcctg cagaccttacaggacttgattgcctactttcagcccccagaggaggagatgcagcatgaa gacaagcagaacaagctccgctcactcaagaacagacagaacctttttaaggaagaagga atgttggcccttgtgttaaactgcatcgatcgcttgaatatctataacagcgtggcacac tttgcggggattgcaagggaggagagtggcacggcttggaaagagatcctgaaccttctg tacaaactgctggctgctctcattcgtggaaacagaaacaactgcgcccagttctctaat aaccttgattggctcatcagcaaattggacagactagaatcttcctcaggtattttggaa gttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgcagtcagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacacggctgattaatgatgtgaca agcattcggcccaacatcttcctgggagttgctgagggctctgcgcagtacaagaagtgg tacttcgagctaatcatcgaccaggtggaccctttcctaacagctgagcccacacacctg cgggtgggctgggcctcttcctcaggctatgctccgtaccctggcggaggagaagggtgg ggaggcaatggtgttggcgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtagcgtccatcaaccagcacctcctgagatcagatgac gtggtgagctgttgccttgacctcggagtgcccagcatctctttccgcatcaacgggcaa cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctctgcaggtgtcaaagtgcgtttcctgatgggtggacgtcatggcgaatttaagttc ctgcctccatctggctacgccccttgctatgaagccttacttccgaaagaaaagatgaga ctggagcctgtcaaagaatataaacgtgacgctgaaggagttagagatctgctgggtacc acccagtccctctctcaagcctctttcatcccatgtcccatagacaccagtcaggtggtt ttgccacctcacctagaaaagatccgagacagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaaccctcctggcccttgggtgccacatcgctcatgtt aatccagctgctgaggaggacctcaagaaggtcaaattgcccaaaaactatatgatgtcc aacggctataaaccagcccctttggacttgtctgatgtgaagctgttaccgcctcaagaa attttagtagataagcttgcagaaaacgcacataacgtttgggccaaggacagaataaag caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtg ccatatgcattactggatgagcgtaccaagaagtccaacagggacagccttcgtgaagct gttcgcacgtttattggttatggctataacattgagccatctgaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagattcgatttttccgggtagagcggtcttat gcagtaagatctggaaagtggtattttgagtttgaggtggtgacaggaggagacatgcgc gttggctgggccaggccaggctgtcggcctgacattgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgt acatggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgat tatgagattgagaatggctttgtgcccatctgctccctgggactgtctcagatcggccgc atgaatctcgggatggatgccagcaccttcaagttttataccatgtgtggccttcaagag ggctttgagccttttgctgtcaacatgaaccgcgatgtcgcaatgtggttcagcaagcgc ctgccgacgtttgtcaacgtgccaaaggatcatccacatatagaggtggtgagggtggac ggcaccgtggacagccccccgtgcctcaaggtgacccacaggacgttcggcgcgcagagc ggcggcgcccgcatggtctactgccgcctgagcatgcccgtcgagtgccgcccgtccccc ggccacggcccctgtctggacggcgacgccctcaggaggaaacagatgcaagagatactc tctcctacaacaacgcagtgctactatgcaatccgcatctttgctggacaggacccctcc tgcgtctgggtcggttgggtcactccagactatcacttacacagtgagaagtttgacctg aataagaactgtacagtgactgtgactctaggggatgagcgaggccgagtgcatgaaagt gtaaagcgcagcaactgctacatggtctggggtggggatattgtggccacttcccaaaga tcaagtcggagcaacgtggacctggagatcggctgccttgtggatctggcgatgggcatg ttgtctttctccgccaatgggagagaacttggcacctgctaccaggtggagcccaatacc aaagtgtttccagcagtcttcctgcagcccacgagcacctccttgtttcagtttgaactt gggaagctgaagaacgcgatgcccctgtcggcggccatatttaagagtgaagagaagaac ccagttccacagtgtccccctcggctggacgtccaaaccatccagcccgtgctctggagc cgcatgcccagcagcttcctgaaggtggagacagagcgggtgagcgagcgccatggctgg gtggtgcagtgcctggagcccctgcagatgatggcgctccacatcccagaggagaacagg tgtgtggatgtcctagagctctgcgagcaggaggacctgatgcacttccattaccacacg ctgcgcctctacagtgccgtgtgcgccctgggaaacagccgagtggcctacgccctgtgt ggccacgtggacctgtcccagctcttctatgccatagacaacaagtacctccccggcctc ctccgctctggtttctatgacctgctcatcagcatccacctggcccatgctaaggagagg aagctaatgatgaagaatgagtacatcattcccatcaccagcaccaccaggaaaatccgc ctgtacccagatgagtccaagaggcacgggctacccggagtgggcctcagaacatgcctc aagccaggattcaggttctccaccccttgctttgttgtgactggcgaggagcaccagaag cagagccctgagatccccttggagattctcaagacaaaggcactgagcatgctgacggag gcagtgcagcacagcggggctcatatccgggaccccgtcggcgggtctgtagagttccaa tttgtgcctgtgctgaaactcgtcgggaccctgctggtcatgggggtgtttgatgatgat gacgtccggcagatcctcctcctgattgattcctctgtgtttggggagcatggtggagag acagaggatggcacagagaaggaagaggtgacccaggtggaggagaaggcagtggaggct ggggaaaaggccagcaaggaggctccggtcaagggcttgttgcagacccaactgccagag tccgtcaagcttcagcttctgttgcagatgtgtgagctcctcagctacctctgcgactgt gagctacagcatcgagtggaagccattgtggcgttcggcgacatttacgtctccaaactc caggcaaatcagaagttccgctacaatgagctcatgcaggccttgaacatgtctgcagcc ctgactgcccggaagaccagggagttccgctcacccccacaggagcagatcaacatgctt cttaactttcaactgggagagaattgcccctgcccagaggagatccgggaggagctatat gacttccatgaggaccttctcattcactgtggagttccactggaggaggaggaagaagag gaggaggacacctcctggactgggaaactccgtgccttggtgtataaaatcaaaggccct cccaagcctgagaagaaacagccgatagaagaggaggagagataccctacaaccttgaag gagctcatctcacagaccatgatccgctgggcccaagaggaccagatccaggatgcggag ttggtccggatgatgttcaccctcctgcagaggcagtacgacagcattggggagctgctg caagccctgcggaagacctataccatcagtcaggcctccgtgagcgataccatcaatctg ctggctgccctgggccagatccgctgcctcctcagtgtcaggatgggcaaggaagaggag ctgctcatgatcaatgggctgggagacattatgaacaataaggtgttttaccagcacccc aacctcatgagagtccttggcatgcacgagacggtgatggaggtgatggtgaacgtgttg ggtgcagagaagtcccagattgcttttccaaaaatggttgctagctgctgccgcttcctt tgctatttctgccgaatcagccggcaaaatcagaaggccatgtttgagcatctaagttac ctgctggagaatagcagtgttggcttagcatccccttcaatgagaggatctaccccactg gatgtggcagcttcctctgtgatggacaacaacgagttagcgctgggcttggaggaacca gatcttgagaaggtggtaacctacttggcaggctgtggcctgcagagctgtcccatgctt ctagccaaaggataccctgatgtcggctggaaccccattgaaggggaacgttacctgtcc ttcctgaggtttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtg gtcaagctgctcatcagacgcccagagtgcttcgggccagccctgcgaggtgaaggagga aacggcctattggcagctatgcagggcgccattaagatctctgagaacccggctctcgac ctcccctctcagggatacaagagagaagtcatggaggacagtgaggatgaagagatcgtg cacatgggcaacgcaattatgtccttttattcagctcttatagatctgctgggtcgttgt gctcctgaaatgcatcttatccagacgggaaagggggaagccatccggatcaggtcaatc ctgcgctccctggtccccaccgaggacctggttgggatcatcagcatccccttaaagctg ccctgtctgaacaaagatgggtccatcagcgagccggatatggcagccaacttctgccct gaccacaaggctcccatggtgctgttcttggatcgtgtttatggcattaaggatcagact tttctgctccacttgctagaggttggatttttacccgacttaagagcttctgcctctcta gatacagtttccctaagcaccacggaggctgcgcttgcactcaataggtatttgtgttct gctgtgctcccgctcctcacaagatgcgccccgctctttgccggaacagaacactacact tctttgatcgattctacactacagacaatatataggctttccaagggacggtccctcacc aaagctcagagggacaccatagaagaatgtttgcttgctatttgcaatcacttgaggcct tccatgttacagcaactcttgcgacgtctggtttttgatgtgccgcagctcaacgaatac tgcaaaatgcctcttaagcttctgatgaatcactatgaacagtgctggaagtactactgc ctgccttcaggatgggggagctatggtctagctgtggaagaagaactgcacctgaccgag aagctcttctgggggatttttgactctctctcccataagaagtatgacccagaccttttc cgaatggcccttccttgtctcagtgctatcgccggggccctgccaccggattacttagat accagaatctcggccatgttggagaaacagatctcagtggatgcagatggcaactttgac cccaaacccatcaacaccacaaatttctcgttgcctgaaaaatgggaatacatcgtcacc aagtatgctgagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaag tatggaatttccctggatgaaaacgtgaagacccatccactcataaggccttttaagaca ttaacagaaaaggagaaggagatttaccgctggcctgccagagagtctctgaaaaccatg ctggctgtgggctggtctgtggagaggaccaaagagggagaggccctggctcaacagcgg gaaaatgagaaacttcggagtgtgtcccaggctagccagggcaacagctacagccctgcc cccctggatctctccaacgtggtgctttccagagagctccaggggatggtggaagtcgtg gctgaaaactatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggt ggcggcagtcaccctctgttggtgccatatgacaccttgacagccaaggagaagttcagg gaccgggagaaggcacaggacctgtttaaattcctccaagtgaacggcatcttggtttct agtcacctctgtttcttcctgggatttacccatttccaacctagaggtatgaaggatatg gagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaagaagatcctg aaatatgttgattccgcccaagagtttattgcccatttggaagccattgtcagcagtggg aaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaagttctcctccca ctcgttgaccagtacttcaccaatcaccgcctctacttcctgtcatcccctctgaagccc cttagcagcagcggctatgcctctcataaggagaaagaaatggtggccagcctcttctgc aaactcgctgctcttgttcgacacaggatctccctctttgggagcgattctacaacaatg gtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatgaagtcaggc tcagagctggtgaaggctgggttacgagcattctttgaaaatgctgcagaagacttagag aagacttcagaaaatctgaagctcgggaagtttacccattccagaacacagattaaaggc gtgtctcaaaatattaactataccacggtggctctgctccccatcctgacatccatcttc gagcatgttgctcagcatcagttcggggtggatttactcttaggtgatgtgcaaatttca tgctaccacatactgtgcagcctctactcccttgggactggaaagaatatctatgttgaa aggcaacgtcctgcccttggagaatgtctggcctccctggcagctgccataccagtagca ttcctggaacccacccttaaccgctacaatccactctcagtcttcaacaccagaaccccc agggagaggtctattctggggatgccggacaccgtggaagagatgtgccccgacctccct cagctggaaggcctgatgaaggaaatcagcgacctggccgagtcaggggcccgatacacg gagatgccccacgtcatcgaggtgatcttgcccatgctctgcaactacctgtcctactgg tgggagcgggggcctgagcacctgcctcccagcacagggccctggtgcaccaaggtcacc tctgaacacctcagtgtcatcctgggaaacattctaaaaatcatcaacaacaatctgggc atcgatgaggcatcctggatgaagcgcattgcagtgtacgcccagccaatcatcagcaaa gcacggccagacctgctgaagagccacttcatcccaactctggagaagctgaagaaaaag gctgtcaagactgtgcaggaggaggagcagctgaaagccgacaccaaaggagacactcaa gaggcggagctcctcatcttggacgagtttgcagtcctctgcagagacctctatgccttc taccccatgctgattcgctacgtggacaacaacagatctaactggctcaaaagtcccaat gctgattctgaccagctcttccgcatggtagctgaggtcttcatcctgtggtgcaaatct cacaacttcaagagggaagagcaaaattttgtgattcagaatgaaattaataatttggca tttttaactggagacagcaaaagcaagatgtcaaaatctggaggccaggaccaggaacgg aggaagaccaagcggaggggagacttgtattccatccagacctctctcatcgtggccgcg ctcaagaagatgctgcccattggtttgaatatgtgcacgccgggcgatcaggagctgatc tcccttgccaaggcccgctacggcgctagggacacagatgaagaggtaaaggaacatctg cggaacaacttgcacctgcaggaaaagtctgatgacccagcagtaaagtggcagctgaac ctctacaaagatgttttaaagagtgaagaaccgttcaatccagaaaagactgtagaacgt gtacagagaatttcagcagctgtcttccacctggagcaggtggaacagcctttgagatcc aagaaggcggtctggcacaaactgttgtcaaagcagcggaaacgggcagtggtggcctgt ttcaggatggcccctctctataacctgcccagacacaaaattaataatttcttcctgagc acctttcaacgggtttggctggaaaaggttaatgaaaaaactcagtatgacaggctaata cccattttaatgaaatcccccaaggaggaagaggaggaggaggaggagacagaaaagcaa ccagacccacttcatcagattattctccattttagccgcaatgctctcacggagaggagc aaattggaagacgaccccttgtacacatcctattccagcatgatggccaagagttgtcag agcggggaggatgaagaagaggaggaagacaaggagaaaacatttgaagagaaagaaatg gaaaagcagaaaactctctatcaacaagcacggctgcatgagcgtggagctgcagagatg gtccttcagatgataagtgccagcaaaggtgagatgagccccatggtggttgagactctg aagctggggatcgccattctgaatgggggcaacgctggtgtacaacagaaaatgctagat tacctaaaggagaaaaaggatgctggattctttcaaagcctgtctggtcttatgcagtct tgcagtgtccttgatttgaatgcctttgagaggcagaataaagctgaaggcctggggatg gttactgaggaaggaacactcattgttcgagagcgtggtgaaaaagtactccagaatgat gagtttacacgagacctctttagattcctgcagttactttgtgaaggacataacagtgac tttcagaacttcctacggactcagatgggcaataccaccactgtaaacgtcatcatcagt accgtggactacctcctacgtctacaggaatccatcagtgatttctactggtattattca gggaaggacgtcattgatgaatctggacagcacaatttttccaaagctctggcagtcacg aagcagattttcaattctcttacagaatacatccagggcccttgcattgggaaccaacaa agcctggctcacagcaggctgtgggacgcggtggtcggcttcctccatgtatttgctaac atgcagatgaaactctctcaggattccagtcagatcgagctgctgaaggaactcttggat ctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtggtaaatgga actattggcaagcagatggttgacacactggtagaatcatctaccaatgtagaaatgatc ttgaaattctttgacatgttcttgaaacttaaagacctaaccagctcagacaccttcaaa gaatatgacccagatggtaaagggattatctccaaaaaagagttccagaaggccatggaa gggcaaaaacagtacacacagtcagagattgactttctcctttcatgtgcagaagctgat gagaatgatatgtttaattacattgattttgtagaccggttccatgagccggccaaggac atagggtttaatgtggcagtgttactgacgaatctctccgaacatatgccaaatgattct cgcctgaagtgtctgttggacccagcagaaagtgtactaaattactttgaaccctacctg gggcgtattgagatcatgggaggggccaagaagattgagcgcgtttattttgaaatcagt gaatccagtcgaacccaatgggagaagccccaagtgaaggaatctaagcggcagttcatc tttgatgtggtcaatgaaggtggagagcaagaaaagatggaactgtttgtgaacttctgt gaggataccatttttgaaatgcagttagcatctcagatctctgaatctgactcagctgac agacccgaagaagaggaggaagaagatgaagattcatcttatatgttagaaatcgagggt gaggaggaggacagcaagtctctcgagtctgcctctgcatttgccatggcctgtgcctca gtgaagagaaatgttgccaactttctgaagaaggcaaccctgaagaacctccggaagcag tacaggaaggtgaaaaagatgactgtgaaggagctggtgaaggtgtttttctctttcttc tggatgttgtttctggagctgttccggttgttcttcgccatattgggaggaatctttcag atcctctggaacacagtgtttggagggggcctagtggaaggggcaaagaacatcagagtg accaagatcctgggtgacatgcctgacccaacccaatttggtatccatgatgatgccatg gattctgagagggcagaggtgaccgagccaggtattacacctgaattgattcacttcgtg aaggctgaaaagggagacgcagacgtcatgtcagatctctttggattccacccaaagaaa gaaggtggcttaaagcatgggcccgaagtgggtttgggtgacctctctgagattattggc aaggatgagccacctacactagagagtactgtacagaagaaaagaaaagcacaggcagca gagatgaaagcagcacatgatgcagaaggaaaagtggaacccgagaaaatggacctagaa gatggggagaaggaggatatggccaaagaggaagaacaggccgaggccccgtgggcagaa gtgacaaagaagaagaagccacggcggggccagaaagtcgagaagcctgaagccttcatg gctaatttcttcaaagggctggaagtctatcagaccaagttactgcattacctggccagg aatttctacaacctgaggttcctcgctctgtttgtcgccttcgctatcaacttcattctg ctcttttacaaggtcactgaagaacctctagaagaagagacagaggacattgcaaatctg tggaattcctttaatgatgatgaagaagaagaagcgatggtgttctttgttctgcaggag agcactgggtatatggcaccgacgttgcgggccttggccgttatccacaccatcatctct ttggtctgtgtggtgggctattactgcctgaaggtccctctggtggtgttcaaaagggaa aaagaaattgccaggaagctggagttcgatggcctgtacatcactgaacagccatctgaa gatgacatcaaggggcagtgggaccgcctggtaatcaacacaccatctttccctaataac tactgggacaagtttgtcaagagaaaggtgatcaacaagtatggagatctctacggagca gaacgcattgcggaactcctaggtttggacaaaaatgcccttgatttcagcccagtcgaa gagagcaaagcagaggcggcctctctggtgtcatggctgagctccattgacatgaagtac catatctggaaactgggagttgttttcaccgacaactcgtttctctaccttgcctggtac acaaccatgtcagtcctgggccactacaacaacttcttttttgctgcgcatctgctggac atcgcaatgggcttcaagacgctgaggactattctgtcatctgtaactcacaacggcaaa cagctggtcctgaccgtgggtctcctggctgtggtggtctacctctacaccgtggtggcc ttcaacttctttcgcaagttctacaacaagagtgaagatgacgatgagcccgacatgaag tgtgacgacatgatgacgtgttacctgttccacatgtacgtgggagtgcgcgccgggggc ggcatcggagacgaaattgaagaccccgccggagacccctacgagatgtaccgcattgtc ttcgacatcacgttcttcttcttcgtcatcgtcatcctgctggccatcatccaaggtctc atcattgacgcctttggagagctgagagaccagcaggaacaagtgcgggaggacatggag actaagtgcttcatctgcgggattggcaacgactactttgacacgactcctcatggcttc gagacacacaccgtacaggagcacaacttggccaactatctgttcttcctgatgtatctg attaataaagatgaaacggaacacacggggcaggaatcttatgtctggaagatgtaccaa gaaaggtgttgggatttcttcccagctggtgactgctttcggaaacagtatgaagatcag cttggataa

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