Vulpes vulpes (red fox): 112927407 Help Entry 112927407         CDS       T05911                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism vvp  Vulpes vulpes (red fox) Pathway vvp04020   Calcium signaling pathway vvp04024   cAMP signaling pathway vvp04260   Cardiac muscle contraction vvp04261   Adrenergic signaling in cardiomyocytes vvp04371   Apelin signaling pathway vvp04713   Circadian entrainment vvp04911   Insulin secretion vvp04921   Oxytocin signaling pathway vvp04972   Pancreatic secretion vvp05020   Prion disease vvp05022   Pathways of neurodegeneration - multiple diseases vvp05410   Hypertrophic cardiomyopathy vvp05412   Arrhythmogenic right ventricular cardiomyopathy vvp05414   Dilated cardiomyopathy vvp05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:vvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112927407 (RYR2)    04020 Calcium signaling pathway     112927407 (RYR2)    04024 cAMP signaling pathway     112927407 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     112927407 (RYR2)    04921 Oxytocin signaling pathway     112927407 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     112927407 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     112927407 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     112927407 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     112927407 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     112927407 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     112927407 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     112927407 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     112927407 (RYR2)    05414 Dilated cardiomyopathy     112927407 (RYR2)    05415 Diabetic cardiomyopathy     112927407 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vvp04040]     112927407 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:vvp04990]     112927407 (RYR2) Ion channels [BR:vvp04040]  Voltage-gated cation channels   Ryanodine receptor    112927407 (RYR2) Domain-containing proteins not elsewhere classified [BR:vvp04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    112927407 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  112927407 NCBI-ProteinID:  XP_025864563 UniProt:  A0A3Q7T5C7 LinkDB All DBs Position Unknown AA seq 5059 aa AA seqDB search MGIRQASRKCLYIQGRHSAATCDLEIEKRSRVSIVSYIWVFLSRSPSANMAQACATATLA ARQLLPMCQFVYVLRPESPQHRATGHLSIGKRFKKKCHHLDDEVVLQCTATIHKEQQKLC LAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVE KWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGE ACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNSSLHVDAAFQQTLWSVAP ISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWR LETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKENADVKSTAFTFRSSKE KLDVGVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHE GHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVRASTVDLPIESVSLSL QDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFAD VAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLH CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNL LPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVG WASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLKTDDVIS CCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPP PGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPP HLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMS LETLKTLLALGCHVGISDEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMV DKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRT LLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVG WSRPGCQPDQELGSDEHAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTERTMMFT LNGEVLLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGY EPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSS TDIMFYRLSMPIECAEVFSKTVAGGLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLVP DRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDD YDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLERVRTVTVTLGDEKGKV HESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPS TKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLW SRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYH TLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYAT ARLMMNSEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECY QYSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHN EDLKHILQLIEPSVFKEAATPDEEAEALEKEPCPEDSKSEGAGEEEAKGVKRPKEGLLQM KLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAA LTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGS LDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPIESDSKKSSTLQQLISETMVRWAQESVIE DPDLVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGK EEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANC CRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALA LREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEEN ANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEE EEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVI SIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDL RAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLS KGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYER CWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGAL PPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDK LANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGD SMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKK KMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPS IEKRFAYSFLQQLIRYVDEAHQYILEFDGGGRSKGEHFPYEQEIKFFAKVVLPLIDQYFK NHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHIL GQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINY TTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALG ECLAAFAGAFPIAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLME EIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTL LGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSE EDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLF RMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKG DRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQ GKLEDPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYSLV EHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYF EDKLIEDLAKPGADPPEEEESTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMA KSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASK GDTGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAF ERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTV NIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPC TGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEG NVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDF HKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEH MPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSVSKEESEKEKPEE QGPRMGFFSILTVKSALLALRYNVLTLMRMLSLKSLKKQMKRVKKMTVKDMVMAAFSSYW NIFMSLLHFVASVSRGFFRIICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDSEE GDRKPMEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSN PVPIPDVQEKFQEQKAKEEEKEEKEENKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTH RYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVV EGKELSTHSSSENAKVSSLDSGSPRIITVHYVLEESSGYMEPTLRILAILHTVISFFCII GYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKF VKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMW KLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLV LTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIG DEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKC FICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERC WEFFPAGDCFRKQYEDQLN NT seq 15180 nt NT seq  +upstreamnt  +downstreamnt atgggaattagacaggcgtcgaggaaatgtttatatattcaggggcgacattctgctgcc acttgtgacctggaaatcgagaagaggtctcgtgtctcgattgtctcctatatttgggtg tttctgtcccgctccccttcagctaacatggcccaggcgtgcgctactgctaccctcgca gctcggcagctccttcctatgtgccaatttgtgtatgtgcttcggcctgagagtcctcag caccgagccacaggtcacctgagtattggtaagaggtttaagaaaaagtgccaccatctg gatgatgaagtggttctgcagtgtaccgcaaccatccacaaagaacaacagaagctgtgt ttggcagcagaaggctttggcaacagactttgtttcttggagtccacttcaaattccaag aatgttcctccagacctctccatctgcacctttgtgctggaacagtctctctctgtccgg gctctgcaagagatgctggctaacacggtggagaagtcagaagggcaagttgatgtggaa aaatggaaattcatgatgaagactgctcaaggtggtggtcatcgaacacttctctatgga catgccatattgctacgccattcctacagtggtatgtatctgtgctgcctctccacctcc cggtcttcaactgataaactggcctttgatgttggcttgcaagaggacacaacaggtgag gcttgctggtggactattcaccctgcctctaagcagcggtcggaaggagaaaaggttcga gttggagatgacctcatcttagtcagtgtgtcctctgagaggtacctgcacttgtcttat ggcaacagcagcttacacgtggatgctgctttccagcagactctttggagcgtggcccca atcagctcaggaagcgaagcagcccaagggtatctaattggtggtgacgtcctcaggttg ctgcatggacacatggatgaatgcctcactgtcccttcgggagagcacggtgaagagcag cggagaactgttcactatgaaggtggtgctgtatctgttcatgcacgttccctgtggagg ctagagacactaagagttgcgtggagtggaagccacataagatggggccagcctttccga ctacgccatgtcacaacaggaaaatacttgagtctcatggaagacaaaagccttctactc atggacaaagaaaacgcagatgtaaaatcaacagcatttaccttccgatcttccaaggaa aaattggatgtgggtgtgagaaaagaagtagatggcatggggacatctgaaataaaatat ggagactcagtatgctatatacaacatataaatacaggcctatggcttacctaccagtct gtggatgtaaaatcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaa ggtcacatggatgatggcttaaatttatccagatctcagcatgaagaatcacggactgca cgagtcattcggagcacagttttccttttcaatagatttataaggggcctcgatgcgctc agcaagaaagtgagggcctccactgtggacctccctatagagtctgtgagtctaagtctg caagacttgattggctacttccaccccccggatgagcacttggagcatgaagacaagcag aacagattgcgagctctcaagaaccggcaaaacctcttccaggaagagggaatgatcaac ctcgtgctcgagtgtatagacaggctgcatgtgtacagcagcgcggcacactttgctgat gttgctgggagagaagcaggcgagtcctggaagtcgattttgaattctctctatgagttg ctagcggctttaattagaggaaatcgtaaaaactgtgctcaattttctggctcccttgat tggttgatcagccgactagaaagactggaagcttcttctgggattcttgaagttttacac tgtgtgttagtagaaagtccggaagctctaaatattatcaaggaaggacacattaaatcc ataatctcacttttagacaagcatggaagaaaccacaaggttctggatgtcttgtgctct ctctgtgtctgccatggagtagcagtgcgttctaaccagcacctcatctgtgacaatctg ctgccaggaagagatctcctattacagacgcgccttgtaaaccacgtcagcagcatgaga cccaatatttttctgggcgtcagtgaagggtccgctcagtataagaagtggtactatgag ctgatggtggaccacacggagccatttgtgactgctgaagccacgcacctgcgggtgggc tgggcttccaccgaagggtactctccctaccccggaggcggtgaggagtggggtggaaat ggagtcggagatgatctcttttcctacggattcgatggccttcacctctggtcaggttgc attgctcgtactgtaagctcaccaaaccagcacttgctgaaaactgatgacgtcatcagt tgctgtttagatctgagtgccccaagcatctcattccgaattaacggacaacctgttcaa ggaatgtttgagaatttcaacattgatggcctcttctttccagttgttagtttctctgca ggaataaaggtacgctttctgcttggggggagacatggagaatttaaattcctccctcca cctgggtacgctccttgttatgaagccgttctgccgaaagaaaagttgaaagtggagcac agccgagagtacaagcaggaaaggacctacacacgggacctgctgggccccacggtttcc ctgactcaggctgccttcacaccaattcctgtggataccagccagattgtgttgcctcct catctagagagaataagagaaaaactggcagagaatatccatgaactttgggttatgaat aaaatagagcttggctggcagtatggtccggttagagatgacaataagagacaacacccc tgtctggttgagttctccaagctgcctgaacaagagcgcaattacaacttgcagatgtct ctggagaccctgaagactttgctggcattaggatgtcatgtgggcatttcagatgaacat gctgaagaaaaggtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtat aagcctgccccaatggacctgagctttatcaaactcaccccatctcaggaagcaatggtg gacaagttggcagaaaatgctcataatgtatgggctcgagatcgaatccggcagggctgg acttacggcatccaacaggatgtaaagaacagaagaaaccctcgcctggttccctacact cttctagatgaccgcaccaagaaatccaataaagacagcctccgtgaagctgttcgcacg ctgctggggtatggctacaatctggaagcaccagatcaggatcatgccgccagagctgaa gtgtgcagcggcacaggtgagagattcagaatcttccgtgctgagaaaacctacgctgtc aaggcaggaaggtggtattttgaatttgaggctgtcactgcaggcgacatgagagttggc tggagcaggccaggttgtcaacctgatcaagagcttggctccgacgaacatgcctttgct tttgatggcttcaaggctcagcggtggcaccagggcaacgagcattatgggcggtcatgg caagcgggagatgtcgtggggtgtatggtggacatgacagagcgtaccatgatgttcacg ctcaatggcgaagtccttctggacgattcgggctcagaactggcgttcaaggactttgat gttggtgatggattcattcctgtctgtagccttggagtggctcaagtgggcaggatgaac tttggaaaggatgtcagcaccttgaaatatttcaccatctgtggcttacaagagggctat gaaccatttgctgttaacacaaacagggatattaccatgtggctaagcaagaggcttcct cagtttctccaggtcccatcaaatcatgagcatatcgaggtgaccagaatagatggcacc atagacagttctccatgtttaaaggtcactcagaagtcctttggttctcagaacagcagc accgatatcatgttctatcgcctgagcatgcccatcgagtgcgcagaagttttttccaag acggtagcaggaggactcccaggcactggcctctttgggcccaagaatgatctggaggac tatgatgcagattctgactttgaggttctaatgaagaccgctcatggccatctcgtgcca gatcgagttgacaaagacaaggaagccacaaaaccagagtttaataaccacaaagattat gctcaagaaaagccttctcgtctgaaacaaagatttttgcttagaagaaccaagccagat tacagcacgagccattctgcaagactcactgaagatgtccttgcagacgatagggatgat tacgattacttgatgcaaacgtccacgtactattactcagtgagaatctttcctggccaa gaacctgcaaacgtctgggtaggctggattacatcagatttccatcaatatgatacaggc tttgacttggaaagagttcgtacagtaaccgttaccctaggagatgaaaagggaaaagtg catgaaagcatcaaacgcagcaactgctatatggtatgtgcaggcgagagcatgagccct gggcaaggacgcaacaacaatggcctggagatcgggtgtgtggtggacgccgccagtggg ctgctcacattcaccgccaatggcaaggagctgagcacttactaccaggtggagccaagt acaaaattatttcctgcagtgtttgcacaagctacaagtcccaatgttttccagtttgag ttgggaagaataaagaacgtgatgcctctgtcagcgggattgttcaagagtgagcacaaa aaccctgtgccacagtgtcccccacgtctccacgtgcaatttctatcccacgtcctgtgg agcagaatgcccaaccagttcttgaaggtagatgtctctcgaataagtgagcgccaaggc tggctggtgcagtgtttggatcccctgcagttcatgtctcttcatatcccagaggagaac aggtcagtggacatactggaattgacagagcaggaggagctgctgaagttccactatcac actctcaggctttactccgctgtgtgcgcccttgggaaccaccgggtggcccatgccttg tgcagccacgtggatgaacctcagctgctctacgccatcgagaacaaatacatgcctggc ttgctgcgtgctggctactacgacttgctcattgacatccacctcagctcctatgccact gccaggctcatgatgaacagtgagttcatcgtgcccatgacagaggagaccaagagcatc acccttttccctgatgagaacaaaaaacatggcctcccgggaattggcctcagcacttcc ctcaggccacggatacaattttcctcccccagttttgtaagcattaataatgaatgttac cagtacagtccagagttcccactggacatcctcaaggccaaaaccattcagatgctgaca gaagctgtgaaagagggcagccttcatgcccgggacccagttggggggacaactgagttc ttgtttgtacctctcatcaagcttttctatactttactcatcatggggatcttccacaat gaggacttgaaacacatcttgcagttgatagagcccagcgtattcaaggaagctgccact ccagatgaggaggctgaggcactggagaaggaaccctgcccagaagactccaagtcagaa ggagctggagaagaagaagccaaaggggttaagaggcccaaggaaggcctgctccaaatg aaactgcctgagccagttaaattgcagatgtgcctgctgcttcagtatctctgtgactgt caggtccggcaccggatagaagccattgtggccttttcagatgactttgtagctaagctc caagataatcagcgtttccgatacaatgaagttatgcaagccttaaacatgtcagctgca ctcaccgccaggaaaacgaaggaatttagatcaccacctcaagaacagatcaatatgctt ctcaattttaaggatgacaaaagtgaatgtccatgtcctgaggaaatccgtgaccaactc ttagattttcatgaagatttgatgacacattgtggaattgagcttgatgaagatgggtct ttggatggaaacagtgacttaacaattagaggacgcctgctgtccctggtagaaaaggtg acatacctgaagaagaaacaagctgaaaaaccaattgagagtgactccaagaagtcctcc actcttcaacagttgatttctgagaccatggtccgatgggcacaagagtctgtcattgaa gaccctgacttggtgagggccatgtttgtgttgctccatcgacagtatgatggcattggg ggtctggtccgggctctgccaaagacctacactataaatggtgtctccgtggaggatacc atcaacctgctggcatctcttggtcagattcgttctctgctgagtgtaagaatgggcaaa gaagaagagaagcttatgattcgtggattaggggatatcatgaataataaagtgttttac cagcaccctaatctcatgagggcacttgggatgcatgagacagtgatggaggtcatggtg aatgtccttggcggtggagagtccaaggaaatcacttttcctaagatggtggccaactgt tgccgtttcctctgttacttctgtcgtataagtaggcagaatcaaaaagctatgttcgat catctcagctatttattggagaacagcagtgttggtcttgcctcaccagctatgagaggt tcgacaccactggacgtagcagctgcctcggtgatggataataatgagctggccttagct ctgcgtgagccagatctggaaaaggtagttcgatatttggctgggtgtggactgcagagc tgccagatgctggtgtctaagggttatccagacattggatggaatccagttgaaggagag agatatcttgactttctcagatttgctgtcttctgtaatggggagagtgtggaagagaat gctaatgttgtggtgaggttgctcatccggaggcccgagtgttttggtcctgctttgaga ggggaaggtgggaatggtctgcttgcagccatggaggaagccataaaaatagctgaagat ccttctcgagatggtccctcaccaactagtggatccagtaaaacacttgatacagaagag gaggaagatgacactatccacatggggaatgccatcatgaccttttactcggctttgatt gaccttttgggacgttgtgctcctgaaatgcatttgattcatgctggtaagggggaagcc atcagaatccggtcaattttgagatccctaattcccctgggagatttggtgggagtaatc agcattgcttttcagatgccaacaatagccaaagatgggaatgtggtggagcctgacatg tctgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtctat gggattgaggttcaagatttcctcctccatcttcttgaggttggctttctgccagatctc cgggctgctgcttctttagatacggctgctttgagtgctacagacatggccctggccctc aatcggtacctttgcacagctgtgttgcctttgttaacaagatgtgcccctctttttgct ggcacagagcaccacgcttccctcattgactcattacttcacactgtgtacagactttct aagggctgctctcttaccaaagctcagcgggattccatagaagtttgtttactctctatt tgtggccaattgagaccttctatgatgcagcacttactccgaagattagtatttgatgtt ccattattaaatgaacatgcaaagatgccccttaagctgctgacaaatcattatgaaaga tgctggaaatattactgcctgcctggagggtgggggaactttggagctgcctcagaagaa gagcttcatttatcgagaaagttgttttggggcatttttgacgccctatctcaaaagaaa tatgagcaagaacttttcaaactggcactgccttgcctgagtgcagttgcgggagctttg cctccagactacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggat tctgaagggaactttaacccacaacctgttgatacctcaaatataacaattcctgagaag ttggaatacttcattaacaaatatgcggaacattctcatgacaaatggtcaatggacaag ttggcaaatggatggatttatggagaaatatattcagactcatctaaagttcagccatta atgaagccatataaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaa gagtctctaaaaaccatgcttgcgtggggttggagaattgagagaacacgggaaggagac agcatggccctctataaccggactcgtcgcatttctcagacaagccaggtttctgtagat gctgcccatggttatagccccagagccattgacatgagcaatgtcacactgtccagagac ctgcatgctatggcagaaatgatggctgaaaactaccataacatatgggcaaagaaaaag aaaatggaactggagtccaaaggaggtggaaatcatccccttctggtaccttatgatacg ctgacagccaaagagaaagccaaagacagggaaaaagcacaggacatcctcaagttcttg caaatcaatggctatgctgtatccagggggtttaaggacctggaattggacacaccttcc attgagaaacgatttgcctacagcttccttcagcaactcattcgctatgtggatgaagcc catcagtatatcctggagtttgatggtggcggcagaagcaaaggagaacatttcccttat gaacaagaaatcaagttctttgctaaagtggttcttcctttaattgatcaatatttcaaa aaccatcgcttatacttcttatctgcagcaagcagacctctctgttctggaggacatgca tcaaacaaggagaaagaaatggtgacgagcctattctgcaaacttggagttcttgtcagg cataggatttcactatttggaaatgatgccacatcaattgtcaactgtcttcatattttg ggtcagactttggatgccaggacagtgatgaagactggtctggaaagcgttaaaagcgcc ctccgagcttttctagacaatgctgcagaggatctggagaagaccatggagaatctcaag caaggccagttcacccacacccgaaaccaacccaaaggtgttactcagattatcaattat accacggtggctctgttgccgatgctgtcatcattatttgagcatattggccagcatcaa ttcggagaagatctaatattggaagatgtacaagtgtcatgttatagaattctgactagt ttatatgctttgggaaccagcaaaagtatttatgtggaaaggcaacgttctgcattagga gaatgtctcgctgcttttgctggtgcctttcccatagcatttttggaaactcatctggac aaacataacatttactctatctacaatactaagtcctcacgagaaagagcagctcttaat ttgccaactaatgtggaagatgtttgcccaaatataccatctttggagaaactcatggaa gaaattgtggaattagctgagtctggcattcgctacacacaaatgccacatgtaatggaa gtcatactgcccatgctttgcagctacatgtctcgttggtgggagcatggacccgaaaac aatccggaaagggctgaaatgtgctgtacagccctgaactccgagcacatgaacacactt ctgggaaatatattgaaaatcatatataacaacttgggaatcgatgagggcgcctggatg aagaggttagcagttttttcacagcccattataaataaagtgaaacctcagctcctgaaa actcatttcttgccattaatggagaaactcaagaaaaaagcagcaatggtggtgtctgag gaggaccatctgaaggctgaggccaggggggatatgtctgaggcagaacttctcattctt gatgagtttaccacactggctagagatctctatgccttctacccactcttgattagattt gtggactataacagggcaaagtggctaaaagagcctaacccagaagcagaggaccttttc cgcatggtggccgaagtatttatctactggtcaaaatctcacaatttcaaaagagaagag cagaacttcgtggtacagaatgaaatcaacaacatgtctttccttattactgacaccaag tcaaagatgtcaaaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaagga gatcgatattccatgcagacttctcttattgtggcagctctgaagcgcttgctgcccatt gggttgaacatctgtgcccctggggaccaggagctcatcgctctggccaaaaaccgattc agtatgaaagacactgaggatgaagtacgagatataattcgcagtaatattcatttacaa ggcaagttggaggatcctgctatcagatggcaaatggctctttacaaagacttaccaaac aggactgaagatacatcagatccggaaaagaccgtagaaagagtattagatatagcaaat gtgctttttcatcttgagcagaagtctacatgtatgcgccggagatattacagtctggtg gagcacccacagagatccaagaaggcagtatggcacaaactgttatccaagcagaggaaa agagcagtggtagcctgttttcgaatggctcctttatacaacctgccaaggcatcgggct gtcaatctctttcttcagggatatgaaaagtcttggattgaaacagaagaacactacttt gaagataaattaatagaagatttagcaaagcctggagccgaccctccagaagaagaggaa agcacgaagagagttgatcctctccatcaactcatccttctgtttagtcgaacagcttta acagaaaaatgcaaactggaagaagactttttatatatggcttatgcagatattatggca aagagttgtcatgatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtc acaggatcccaacgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccaacaa gccaggcttcatgaccgaggggctgcggagatggtgctgcagaccatcagtgccagcaaa ggtgatactggaccaatggtagctgcgactttgaaacttggcattgctatcttaaatggc gggaactctacagtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggc ttctttcagagccttgctggcctgatgcagtcatgtagtgtcctcgacctaaatgcattt gagcgacaaaacaaagctgaaggacttggaatggtgaccgaggaaggatcaggagaaaag gttctccaggatgacgagttcacttgtgacctcttccgcttcctacaactgctttgtgag ggacacaactcagattttcaaaattatctgagaacccagactggcaataacacaactgtc aacatcatcatctctactgtagactacctcctgagagtccaggaatccattagcgatttc tattggtattactctgggaaagatgttattgatgaacaaggacaacggaatttttccaaa gcaattcaagtagcaaagcaagtctttaacactctcacagagtatattcagggtccttgc actgggaatcagcagagcctggcccacagcaggctgtgggacgcagttgtgggctttctt catgtatttgcccacatgcagatgaagctatctcaggattccagtcaaattgagctatta aaagaattaatggatcttcagaaggatatggtggtcatgttgctgtccatgttagaaggt aatgtcgtcaatggaaccattggcaaacagatggtcgatatgcttgtggaatcttccaac aatgtggagatgattctcaagttttttgacatgtttttaaaactaaaagatttgacgtcc tcagacacatttaaggaatacgatcccgatggcaaaggagtcatttccaagagggacttc cataaagcgatggagagtcataagcactatacacagtcagaaaccgagtttctgctgtcc tgtgcagagaccgatgaaaacgagactcttgactatgaagagtttgtcaaacgcttccat gagcccgcaaaggacataggcttcaatgttgccgtcctcctgacaaacctgtctgaacac atgcccaatgacacccggctgcagacgtttctggagttggcagagagtgtgctgaattac ttccagccctttctgggccgcatcgagatcatgggaagtgccaaacgcatcgagagggtc tattttgaaatcagtgagtccagccgcacccagtgggagaagccccaggtcaaggagtcc aaacggcagttcatatttgacgttgtcaatgaagggggagaaaaggagaagatggaactt tttgtgaacttctgtgaggacaccatatttgaaatgcagttggcggcacagatctcggag tcggatttgaatgagaggtcagtgagtaaggaggagagtgagaaggagaagcctgaagag caggggcccaggatgggtttcttttccattctgacagtcaagtcagccctgttggctctc aggtacaatgtcttgaccctcatgcgaatgctcagcctgaagagcctgaagaagcagatg aaaagagtgaagaagatgactgtgaaggatatggttatggctgccttttcatcctattgg aatattttcatgagcctcctgcacttcgtggccagcgtttccagaggctttttccgtatc atttgcagcctgctgctggggggcagcctagtagaaggggcaaagaagatcagggtggca gagctcttagccaacatgccggaccccacacaggatgaagtgaggggggatagcgaggag ggggacaggaaacccatggaagctgccctgccctcagaagacctgacagacctaaaggag ctgacagaggaaagtgaccttctttcggatatattcggcttggacctgaagagagaagga ggacagtacaaactcattcctcataatcccaatgctggcctcagcgacctcatgagcaac ccggtccccatccctgacgtgcaggaaaaatttcaggaacagaaggccaaagaggaagaa aaggaggaaaaagaagaaaacaagtctgaacctgaaaaggctgagggagaagatggagaa aaagaagaaaaagccaaggaagataagggtaaacagaagctgaggcaactccacacacat agatatggagagccagaagttcccgagtcagcgttctggaagaaaatcatagcatatcaa cagaaacttctaaactattttgctcgcaacttttacaacatgagaatgttagccttattt gtcgcatttgcaatcaatttcatcttgctgttttataaggtctccacttcttctgtggtt gaaggaaaggagctctccactcacagttcaagtgaaaatgccaaagttagcagcctagac agtgggtcacccagaatcatcacggttcactatgtcctggaggagagcagcggctacatg gagcccacactgaggatcttagctattctccacacggtcatttctttcttctgcatcatc ggatactactgcttgaaagtcccattggttatttttaagcgagaaaaggaagttgctcga aaattggaatttgatgggctttatattacagaacagccttcagaagatgatattaaaggc cagtgggatagacttgtaatcaacacacagtcatttcccaacaactattgggacaaattt gttaaaagaaaggttatggataaatatggagagttctatggccgggacagaatcagtgag ctccttggtatggacaaagcagctctggacttcagcgatgccagggaaaagaagaagcca aaaaaagacagctccctgtcggctgtactgaactctatcgacgtgaagtatcagatgtgg aaattaggagtcgtctttactgacaattcttttctctacctggcctggtatatgactatg tccattcttggacactataacaactttttttttgctgctcatctccttgacattgctatg gggttcaaaacactaagaaccatcttgtcatcggtaacgcacaatggcaaacagcttgta ttaaccgttggcttattagctgttgttgtatacctatatactgttgtggcattcaatttt ttccgaaaattctacaataaaagtgaagatggtgatacaccagatatgaaatgtgatgat atgctaacgtgctatatgttccacatgtatgttggggtacgtgctggagggggtattggt gatgaaattgaagacccagcaggcgatgaatatgagatctatcgaatcatctttgacatc accttcttcttcttcgtgatcgtcatcctcttggctataatacaaggtttaattattgat gcttttggagaactaagagaccaacaggagcaagtcaaagaagacatggagactaaatgc ttcatctgtgggataggcaatgattacttcgacacagtgccacatggctttgaaacccac actttacaggaacacaacttggctaattacctgttttttctgatgtatctcataaacaag gatgaaacagagcacacaggacaggaatcttatgtctggaagatgtatcaagaaaggtgc tgggaattcttcccagcaggagactgtttccggaaacagtatgaggaccagctaaattaa

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