KEGG   PATHWAY: xco04218
Entry
xco04218                    Pathway                                
Name
Cellular senescence - Xiphophorus couchianus (Monterrey platyfish)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
xco04218  Cellular senescence
xco04218

Other DBs
GO: 0090398
Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114133604  mRNA decay activator protein ZFP36L1-like [KO:K18753]
114133890  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
114134066  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
114134077  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114134100  calmodulin [KO:K02183]
114134115  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114134122  histone-binding protein RBBP4 [KO:K10752]
114134172  mRNA decay activator protein ZFP36L1-like [KO:K18753]
114134222  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
114134297  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
114134372  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
114134429  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
114134676  lin52; protein lin-52 homolog [KO:K21775]
114134723  forkhead box protein O3-like [KO:K09408]
114135071  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114135196  GTP-binding protein Rheb-like [KO:K07208]
114135318  rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
114135419  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114135479  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
114135515  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
114135726  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
114135737  hras; GTPase HRas [KO:K02833]
114135759  uncharacterized protein LOC114135759 isoform X1 [KO:K21776]
114135983  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
114136008  transcriptional regulator Myc-2-like [KO:K04377]
114136099  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
114136126  mybl2; myb-related protein B isoform X1 [KO:K21769]
114136140  G1/S-specific cyclin-D2-like isoform X1 [KO:K10152]
114136183  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114136221  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
114136223  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
114136244  rbl1; retinoblastoma-like protein 1 [KO:K04681]
114136274  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
114136461  hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
114137130  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
114137485  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114137919  zfp36l2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753]
114137948  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114137969  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
114138091  voltage-dependent anion-selective channel protein 2 [KO:K15040]
114138153  calm2; calmodulin-2 [KO:K02183]
114138179  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114138276  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
114138433  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
114138434  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114138435  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114138532  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114138772  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
114138794  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
114139015  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
114139167  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
114139206  ccna2; cyclin-A2 [KO:K06627]
114139330  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114139396  ADP/ATP translocase 2 [KO:K05863]
114139436  transforming growth factor beta-2 proprotein-like [KO:K13376]
114139461  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114139605  sqstm1; LOW QUALITY PROTEIN: sequestosome-1 [KO:K14381]
114139735  ADP/ATP translocase 2-like [KO:K05863]
114140323  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
114140577  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114140896  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
114141097  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114141391  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
114141922  lin37; protein lin-37 homolog isoform X1 [KO:K21774]
114142137  nbn; nibrin [KO:K10867]
114142233  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
114142331  e2f3; transcription factor E2F3 [KO:K06620]
114142529  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114142627  hipk3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
114142996  mothers against decapentaplegic homolog 3 [KO:K23605]
114143027  rras2; ras-related protein R-Ras2 [KO:K07830]
114143062  calml4; calmodulin-like protein 4 [KO:K02183]
114143114  histone-binding protein RBBP7 isoform X1 [KO:K10752]
114143123  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
114143167  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114143200  G2/mitotic-specific cyclin-B2-like [KO:K21770]
114143366  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
114143740  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K04681]
114143743  transcription factor E2F4-like [KO:K04682]
114143947  interleukin-8-like [KO:K10030]
114144099  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
114144102  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114144319  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114144509  hamartin-like [KO:K07206]
114144576  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
114144594  tsc2; tuberin isoform X1 [KO:K07207]
114144636  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
114144651  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114144722  cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
114145015  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
114145231  slc25a4; ADP/ATP translocase 1 [KO:K05863]
114145370  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114145631  interleukin-8-like [KO:K10030]
114145865  e2f1; transcription factor E2F1 [KO:K17454]
114145908  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
114146103  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
114146318  transcriptional regulator Myc-like isoform X1 [KO:K04377]
114146524  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
114146763  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114146827  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
114146937  transcription factor E2F5-like [KO:K04682]
114147079  rheb; GTP-binding protein Rheb [KO:K07208]
114147177  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
114147198  insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
114147892  ras-related protein R-Ras2-like [KO:K07830]
114147906  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
114148180  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114148358  mras; ras-related protein M-Ras [KO:K07831]
114149262  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114149406  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114149511  hamartin-like isoform X1 [KO:K07206]
114149548  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114149588  lin54; protein lin-54 homolog isoform X1 [KO:K21776]
114149782  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
114149794  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114149816  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114149912  rad1; cell cycle checkpoint protein RAD1 isoform X1 [KO:K02830] [EC:3.1.11.2]
114149923  voltage-dependent anion-selective channel protein 3-like isoform X1 [KO:K15041]
114150205  eukaryotic translation initiation factor 4E-binding protein 3-like [KO:K07205]
114150541  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
114150599  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114150673  uncharacterized protein LOC114150673 isoform X1 [KO:K21124]
114150685  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
114151072  insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
114151477  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114151556  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114152119  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
114152162  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
114152335  e2f4; transcription factor E2F4 [KO:K04682]
114152343  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
114152470  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
114152717  ccna1; cyclin-A1 isoform X1 [KO:K06627]
114152865  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114152903  ADP/ATP translocase 3 [KO:K05863]
114153224  rb1; retinoblastoma-associated protein [KO:K06618]
114153347  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114153478  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
114153516  forkhead box protein O1-A-like [KO:K07201]
114154083  homeodomain-interacting protein kinase 3-like isoform X1 [KO:K08826] [EC:2.7.11.1]
114154145  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114154263  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
114154264  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
114154312  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114154457  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
114154618  hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
114154787  serine/threonine-protein kinase Chk2-like isoform X1 [KO:K06641] [EC:2.7.11.1]
114155135  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
114155224  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114155259  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114155341  transcription factor E2F6-like [KO:K06620]
114155380  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like [KO:K06269] [EC:3.1.3.16]
114155407  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
114156039  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
114156140  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
114156288  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114156351  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
114156401  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
114156418  forkhead box protein O6-like [KO:K09408]
114156478  major histocompatibility complex class I-related gene protein-like [KO:K06751]
114156479  hereditary hemochromatosis protein-like [KO:K06751]
114156480  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
114156481  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
114156567  kras; GTPase KRas isoform X1 [KO:K07827]
114156771  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
114156816  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
114157035  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
114157038  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
114157055  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114157072  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114157270  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114157275  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
114157299  permeability factor 2-like [KO:K10030]
114157395  transcription factor p65-like isoform X1 [KO:K04735]
114157534  transforming protein p54/c-ets-1-like [KO:K02678]
114157824  tp53; cellular tumor antigen p53 [KO:K04451]
114158035  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
114158174  transforming growth factor beta-3 proprotein-like [KO:K13377]
114158311  calm1; calmodulin-1 [KO:K02183]
114158350  foxo3; forkhead box protein O3 [KO:K09408]
114158473  traf3ip2; adapter protein CIKS isoform X1 [KO:K21124]
114159074  lin9; protein lin-9 homolog [KO:K21773]
114159076  gata4; transcription factor GATA-4 [KO:K09183]
114159833  cyclin-dependent kinase 4-like isoform X1 [KO:K02091] [EC:2.7.11.22]
114159890  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
114160036  GTPase HRas-like [KO:K07827]
114160039  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
114160221  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
114160373  G1/S-specific cyclin-D2-like [KO:K10151]
114160618  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
114160673  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
114160881  G1/S-specific cyclin-D2-like [KO:K10151]
114160947  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114161013  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
114161205  foxm1; forkhead box protein M1 [KO:K09406]
114161348  mRNA decay activator protein ZFP36L1-like [KO:K18753]
114161405  transforming growth factor beta-1 proprotein-like [KO:K13375]
114161563  calm3; calmodulin-3 [KO:K02183]
114161603  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114161604  G2/mitotic-specific cyclin cdc13-like isoform X1 [KO:K21770]
114161639  foxo1; forkhead box protein O1 [KO:K07201]
114161826  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114161883  ets1; protein C-ets-1 isoform X1 [KO:K02678]
114161901  mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
114161922  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
xco04020  Calcium signaling pathway
xco04068  FoxO signaling pathway
xco04110  Cell cycle
xco04115  p53 signaling pathway
xco04150  mTOR signaling pathway
KO pathway
ko04218   
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