Xenopus laevis (African clawed frog): 108699223 Help Entry 108699223         CDS       T01010                                  Symbol ryr3.L Name (RefSeq) ryanodine receptor 3 isoform X10   KO K04963   ryanodine receptor 3 Organism xla  Xenopus laevis (African clawed frog) Pathway xla04020   Calcium signaling pathway xla04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:xla00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108699223 (ryr3.L)    04020 Calcium signaling pathway     108699223 (ryr3.L)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:xla04040]     108699223 (ryr3.L) Ion channels [BR:xla04040]  Voltage-gated cation channels   Ryanodine receptor    108699223 (ryr3.L) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  108699223 NCBI-ProteinID:  XP_018086656 Xenbase:  XB-GENE-17336711 UniProt:  A0A8J0TMW4 LinkDB All DBs Position 8L:complement(102434361..102702667) Genome browser AA seq 4863 aa AA seqDB search MAEGGEVEDEIQFLRTDDEVVLQCVATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTMANGNEGASQGGGHRTLLYGHAILLRHSFSGMYLT CLTTSRSLTDKLAFDVGLRNTSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERY LHLSISNGMSNIQVDASFMQTLWNVHPTCSGSSVEEGFLLGGHVVRFFHGHDECLTIPST DSGEVQHRKVNYEAGGAGTRARSLWRVEPLRISWSGSHIRWGQTFRLRHITTGQYLTLTE DQGLVLQDRAKADTKSSAFCFRASKEKLDTGSKRDIDGMGAAEIKYGDSICFVQHVNSGL WLTYKSQDAKTARLGPLKRRAILHQEGHMDDGVTLQKCQHEESQAARIIRNTTALFSHFI SDLDSVTGNNRTGSTPITLPIEEVVQTLQDLIAYFQPPEEELEHEDKQNKLRSLKNRQNL FKEEGMLALVLNCIDRLNVYISTAHFSELLGEKEGPAWKEILNLLYELLAALIRGNRSNC AQFSNNLDWLISKLERLESSSGILEVLHCILIESPEALNLIEKGHIRSIISLLDKHGRNH KVLDVLCSLCVCNGVAVRTNQNLICDNLLPRRDLLLQTRLVTDVTSMRPNIFLGVAEGSA QYKKWYFEMIIDQVDPFLTPEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLFSYGFD GLHLWSGRVPRAVASTNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTEGLF FPVVSFSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDFDGVR DYLGTTHFLSQASFIPCPIDTSQIVLPPHLEKIRDKLAENIHELWGMNKIELGWIYGKVR DDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCLIVHSNQTAEENLKKVKLPK NYMMSNGYKPAPLDLSDVKLLPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKR NPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPPDQEITDQMTERVSIDKIRFFR VEKTYAVESGKWYFEFEVVTGGDMRVGWARPGCRPDLELGADEQAFVFEGSRAQCWNMGS SYFGRSWQPGDVVGCMINLDDKSMIFTLNGELLITNQGSELAFADFEIENGFVPVCSLGL SQIGRMNLGKDASTFKYYTMCGLQEGFQPYAVNMNRDVVMWFSKRLPTFVNVPKDHPHIE VTRIDGTVESPPCLKVTHKTFGTQNSNADMIYCRLSMPVEFHSAFNTEENFLKRNQLQEA SSHTTTTYYYSVRIFAGQDPSSVWVGWVTPDYHFYREKFDLSKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDLSAGSQRSSRSSVDIDIGCLVDLATGLLSFTANGKDLGTCYQVEPN TKLFPAVFLQPTSTNLIQFELGRLKNTMPLSAAIFKSEEKNPVPQCPPRLDVQTITPVLW SRMPNNFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCIDILELSEQEDLMKFHYH TLKLYCAVCALGNNRVSHALCSHVDQSQLLYTIDNQYLPGLLRSGFYNLLISMFLESAKE GKLMMNNEFIIPITDETRKIRLFPDESKRHGLPGVGRSTCLKSDLHFTVPCFVLTGEERQ QHGPEIPIDILKTKAISMLTEAVQSSGEHIRDPVGGKVEFQFVPVLKLIATLLIMGVFED EDVQQILLLIDPNVFGDNKEEETEEYEKEEVAQVEEKDVEAGEKAIRDPTSPTKGLLQTR LPESVKLQMCELLHYFCDCELKHRVESIVSFSDNFVSKLQHNQKFRYNELMQALNMSAAL TAKKTREFRSPPQEQINMLLNFRLHDDCPCPEEIRDELYEFHEDLLMHCGIPLDELEEEE EDTSWTGRLRTLLYKIKGRPKTEENDPDEEEEKSPTTLKELISQTMVRWAQEDHIQDPEL VRIMFSLLRRQYDSIGELLRAMRRTYTISAASVEDTINLLASLGQIRSLLSVRMGKEEEM LMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQQIAFPKMVASCCRFL CYFCRISRQNQKAMFEHLGYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALQEP DLEKVVTYLAGCGLQSCLMLIAKGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENASVV VKLLIRRPECFGPSLRGEGGNGLLSAMQEAINISENPALDLPSHGYQREVVEEDEEEEIV HMGNAIMSFYSALIDLLGRCAPETHLIEAGKGEAIRIRSILRSLVPTEDLVGIISIPLKL PAFNKDGSVFEPDMAASFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVAFLPDLRASASL DTASLSVTEMALALNRYICSAVLPLLTRCAPLFSGTEHYAALIDSTLHTIYRLSKGRSLT KAQRDTIEECLLSICHHMRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYC LPSGWGSYGLASEEELHLTEKLFWGIFDSLSNKKYDAELFRMSMPCLSAIAGALPPDYVD TRIKATPEKQMSVDAEGNFDPKPINTANLTLPEKLEYIVNKNAEHSHDKWAYDKIHSGWK YGMSLDENMKTHPLLRPYKTLSEKEKEIYRWPVRESVKTMLSMGWSVERTKEGEALALHR ENEKMRSISQSSQGNGYNPAPQDLSNVVLSRELQGMVEVMAENYHNIWAKKKKMELESKG GGSHPLLVPYDTLTAKEKARDREKAQELFKFLQVNGYAISRGLKDMELDASSMEKRFAFK FLKKVIHYVDSAQEFIAHLEAVVGSGKSEKSPHEQEIKFFAKVLLPLVDQYFKNHCLYFL SSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHILAQTLDTR TVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKFTHSRTQMKGVSQNINYTTVALLP ILTSIFEHVARHQFGVDLLLDDVQVSCYRILCSLYALGTGKNIYVERQRPALGECLAALA GAIPVAFLEPSLNHNNPLTVFNTKSPRERAILGMPDTVEEMCPDMPHLEGLMKEINELAE SGARYTEMPHVIEVVLPMLCNYLSYWWERGTENVPENARPCCTLVTSEHLSVILGNILKI INNNLGIDEASWMKRIAVYAQPIISKAQPDLLKSHFIPTLEKLKKKAIKIVLEEEQLKAD SKADTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDIDSDELFRMVAEVF ILWCKSHNFKREEQNFVIQNEINNLAFLTGNTKSKMSKSGGQDQERKRIKRRGDLYSIQT SLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSLKDTDDEVKEHLRNNLHLQEKSEDPA VKWQLNLYKDIRQSDEQSDSEKIVERVQKISAALFHLEQVEQPLRSKKAVWHKLLSKQRK RAVVACFRMAPLYNLPRHRSINLFLHGYQKFWIQTEEYSFEEKLIEDLAKPKKTDEEEEE ETEKKPDPLHQIILHFSRNALTERSKLEDDPLYTAYAAMMAKSCQNEEEDEEKEKTFEEK EMEKQKTLYQQARLHERGAAEMVLQMISASKGEMGPMVVETLKLGISVLNGGNTVVQQKM LDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQ NDEFTRDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWY YSGKEVIDESGQHNFSKSLAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVF ANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVE MILKFFDMFLKLKDLTSSDAFKEYDPEGKGVISKKEFQKAMEGQKQYAPSEIEFLLSCAE ADENDMFNYVEFVDRFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQCLLEPASSVLSYFSP YLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVN FCEDTIFEMQLASQISDSDAVERPEEEEEEESHHIIEVGEEDEEAQSLESSSAFIVACTS LKNNTSNFLKMLTLKNIGKQLRKVKKMTLKELVKVFFSFFWMLFVGLFQFVFTIVWGVFQ ILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVLEAEKVDANEHATSTELANLV KGDKGDVDMPDIFGIQGKKEGSKHSPEVGLGDFSEAVTTETAPSLENAVRKRKNALAAEL AKEQEEQSKAESEKADLEDGEKKDKVKAEEQSELVESKESISKKKRRGPKKEEPEAFMAN FLAGLEIYQTKMLNYLARNFYNLRFLALFVAFAINFILLFYKVTEEHSSEDSEDNETNLW DTFQEEEEDADEGAVYFVLQENTGYMAPTLRILAVMHTIISFVCVIGYYCLKVPLVVFKR EKEIARNVEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYG ADRIAELLGLDKNALDFSPVKKTKPEEGSLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAW YTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDEDDPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRI VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHG FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYED QLG NT seq 14592 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaagtggaggacgaaattcaattcctccgcactgatgatgaagtt gtcctgcagtgtgttgctacaatacacaaagaacagcggaaattttgcctggcagctgag ggacttgggaatagactatgttttttggaaccaacttcagaggctaaatatgttcctcca gacctttgcatctgtaattttgttctggagcagtccttatctgtcagggctcttcaagaa atgctggcaaacacaatggcaaatggcaacgaaggggcatcgcaaggaggaggacatagg acattgctttatggtcatgcaatcttgcttcgccattcgttcagtggaatgtatttaacg tgtttgacaacatcaagatccctcacagataagcttgcttttgatgtgggattgcggaat acttctacaggtgaggcctgctggtggacaatacaccctgcatccaaacaaaggtcagaa ggagagaaagtccgcattggtgatgacctaattttggtcagcgtttcttcagaaagatac cttcatctctccatatccaatggaatgagtaacatccaggtggatgcctcctttatgcaa actctgtggaatgtccaccctacttgttctggaagcagtgtggaagaaggctttcttctt ggaggacatgtagtccgttttttccatggtcatgatgagtgtttgacaataccatctaca gactctggagaggtccagcacagaaaagtaaactatgaagcaggtggagcaggtacccgt gccagatcattatggagagttgagcctctacgaattagttggagtggaagtcatattcga tgggggcagacatttcgcctgcgccacatcacaactggacaatatttgacactgacagag gaccaaggcttagtgctgcaagaccgagcaaaagcagacacaaaatcatctgccttttgt ttcagagcatcaaaggaaaagctggatacgggctcaaaacgtgacattgatggcatggga gcagcagagataaagtatggagactccatctgttttgtccagcatgttaacagcggcctt tggctgacttacaaatcccaagatgccaaaacagcacgcctgggaccactaaagagaaga gcgatactacaccaagaaggccatatggatgatggcgtcactctccagaagtgccagcat gaagagtcccaagctgctagaataattcgaaacaccacagccttgtttagtcattttatc agtgatctggattctgtgactggaaacaacaggactggttcaacccccatcaccctgcct attgaggaggtagttcaaacactgcaagacttgattgcttacttccagcctcccgaggaa gaactagaacatgaagataaacagaacaagctccgttccctcaagaaccgacaaaaccta ttcaaagaggagggaatgctggccctagtgttaaactgcatcgatcgcctaaatgtgtac atcagcacagcacacttttctgaattattgggggaaaaagaaggaccagcatggaaggaa atcttgaaccttctctatgaattgttagctgccctgatacgcggtaacagaagcaactgt gcacaattttccaataaccttgattggcttattagtaaactagaacgtcttgaatcttct tcaggtatattagaagttctgcattgcatattgattgaaagcccagaggctttaaattta atagaaaagggacacatccgatctataatttctcttttggacaagcatggacggaaccac aaggttctggatgtcctctgctctctgtgtgtgtgcaatggggtggctgttcgcacaaat cagaatctcatttgtgataacctgctgcctaggagagatttacttctacaaacacgtttg gttactgatgtcaccagcatgagacccaacatctttcttggagtggctgaaggctcagcg cagtataagaaatggtattttgagatgattattgaccaagtagatccatttctcacacca gagcccacacacctacgtgtaggctgggcctctacctctggttatgctccatatcctggt ggaggtgaaggatggggaggcaatggtgtaggggatgatcttttctcttatggctttgat gggcttcatttgtggtctggtcgtgttccaagagcagtggcttcaacaaaccagcatcta ctagcatctgatgatgtggtcagctgttgtttggacttaggcgtgcccagcatttctttc cgcatcaatggccagcctgttcagggcatgtttgagaactttaatactgaaggcctattt tttcctgtagtcagcttttctgcaggggtgaaggttcgcttccttcttggtggccgtcat ggagagttcaaatttctgccacctgctggttatgcgccatgctatgaggccttacttcca aaagagaaaatgagagtggaacctgttaaagagtacaagagggattttgatggagttcga gactatctgggcactacacatttcctctcgcaagcttcttttatcccatgcccaatagac accagccagattgtcttacctcctcatcttgaaaagatcagagacaaactggctgaaaat attcacgaactttggggcatgaacaaaattgaacttggatggatttatggcaaggttcga gatgataataaacgccaacatccttgcttggtagagttctccaaacttccagagactgag aagaattacaatttacagatgtctacagaaacacttaaaactttgctggctctaggatgt ctcattgttcattcaaatcaaacagcagaagaaaatctgaagaaagttaaacttcccaaa aactacatgatgtccaatggctacaaacctgccccattggacctttccgatgtgaaacta ttacctgcacaagaagttttagttgataaacttgcagagaatgcacacaatgtatgggca aaagataggataaagcaaggatggacatatggcattcagcaggatttgaaaaataaacga aacccccgcttggtgccatatgctttactagatgaacgaacgaagaaatcaaatcgagac agcctgcgtgaagcagtaagaacatttattggctacggatataacatcgagccaccagac caagaaattactgaccaaatgacagagcgggtcagcatcgacaagattcgctttttcaga gtggagaagacatatgctgtagaatctggcaagtggtattttgagtttgaagttgtgaca ggaggtgacatgcgtgtaggatgggccagacctggctgtagacctgatcttgaactgggt gcagatgagcaggcatttgtatttgagggaagcagggctcagtgttggaacatgggcagc tcctactttggtcgcagttggcagcctggagatgttgtgggatgtatgattaacctggat gacaaatcaatgatcttcaccctaaatggagagctgctcataacaaatcaggggtctgag ttggcatttgctgactttgaaattgaaaatggctttgttcccgtctgctcccttggattg tcccaaattggtcgtatgaacctggggaaggatgccagcacgtttaagtactacacaatg tgtggcctgcaggaaggcttccagccctatgctgtcaatatgaacagagatgttgtcatg tggtttagcaaacgcttacccacatttgtcaatgtgccaaaagatcatcctcatattgag gtaacaaggatagatgggacggtagaaagtcctccgtgcctgaaagtcactcacaaaacc tttggaacccagaacagtaatgcagatatgatctattgtcgcctaagcatgcctgtggag ttccactctgcctttaacactgaagaaaacttcctgaaacgaaaccagcttcaagaggca tcttcacacaccacaacaacatattactactcagtcagaatattcgctggtcaggatcct tcatctgtgtgggtgggatgggtaaccccagattaccacttttacagagaaaaatttgac ttgtccaagaactgtacagtgactgtgactttaggagatgaacgtggcagagtacatgaa agtgttaagcgaagcaactgctacatggtgtggggaggcgacttgtctgctggctcacag agatccagtcgtagcagtgtggacattgatattgggtgccttgttgatttggctactgga ctgctgtcattcacagccaatggaaaagatcttgggacatgctaccaggttgaaccaaac acaaagctgttcccagctgtcttcctgcagccaaccagcacaaatctcatccaatttgag cttggcaggttaaagaacactatgcctctctctgctgcaatatttaaaagcgaggaaaaa aatcctgtgccacagtgccctccccgactggatgtgcagaccattacccctgtcctttgg agccgcatgccaaacaacttccttaaggtggagacagaacgtgtaagtgaacggcatggc tgggtggtgcagtgtctggaacctctacagatgatggcattgcatatacctgaggagaac cggtgcatagacatcctggaactttctgagcaggaggacttaatgaaatttcattaccac actttaaagctatactgtgcagtgtgtgcacttggcaataaccgtgtttcccatgccctg tgcagtcatgtagaccagtcccagctcctgtacaccattgataaccagtatttacctggt cttctgagatcaggattctacaaccttcttatcagcatgtttttagaatctgccaaggag ggcaaacttatgatgaacaatgagtttatcattcccatcacggatgagacacggaagatc agactgttccctgatgagtcaaagagacatggactaccaggggttgggcgtagtacttgc ctgaagtctgaccttcacttcacagtgccctgttttgtactgactggagaagagagacag caacatggtccagagattcctattgacatactgaagacaaaggccataagcatgttaaca gaagctgtgcagagtagtggagaacacattcgagatccagttggcggcaaagtggaattc cagtttgtacctgttctaaaacttattgctaccctgcttattatgggagtgtttgaagat gaagatgtacagcaaatacttttgcttattgatcccaatgtttttggggacaacaaggaa gaggaaacagaggagtatgaaaaggaagaagttgcacaagtagaggagaaagatgtggaa gcaggagagaaagcaataagagatccaacttcccccaccaagggtttactgcagacacgt cttccagaatctgtcaaactccagatgtgtgagctccttcattacttctgtgactgtgaa ctgaagcaccgcgtagaatcaattgtctcattctcggataactttgtatcaaaactgcaa cacaaccagaagtttcggtacaacgagctgatgcaggcgctgaatatgtcagctgctctg actgctaagaaaacaagggaattccgctcccccccacaggaacagattaacatgcttttg aatttccgactgcacgatgactgtccatgcccagaagagattcgcgatgagctttacgaa tttcatgaggatctccttatgcattgtggtattccacttgatgaattggaagaagaagaa gaggatacatcatggacaggaaggctgcgaacactgctgtataaaatcaaaggccgacct aaaacagaagaaaatgatccagatgaagaggaagaaaaatcccccaccacactgaaggag cttatttcacaaacgatggtgcgctgggctcaagaggatcacatccaagatccagaactt gtacgcataatgtttagccttctcagacggcagtacgacagcattggagagctgctacgg gctatgcggagaacctataccatcagtgctgcttctgttgaggacaccatcaacctattg gcctcacttggtcaaataagatcactactaagtgttaggatgggtaaagaagaggagatg ctgatgattgatggattaggggacatcatgaacaacaaagtcttctatcaacatccaaat ttgatgcgtgtgttggggatgcatgaaacagttatggaagtcatggttaatgtgcttggt ggagataaatcacagcaaattgcctttcccaaaatggtggcaagctgttgccgatttctc tgctacttctgcaggatcagccgacagaaccaaaaggccatgtttgagcatcttggttac ttattggaaaacagcagtgttggactggcttctccatcaatgagaggttctacacctttg gatgttgctgcagcatctgtcatggacaacaatgagctcgccttggctttacaagaaccg gatttagagaaggttgtaacttatttagccggatgtgggttacaaagttgtctgatgcta atagctaagggctacccagacattggatggaatcctatagaaggggagcgttacctctct tttctgcgctttgctgtctttgttaatggtgagagtgttgaagagaatgccagtgtggta gtaaagctccttattcgacgtcctgagtgttttgggccatccttgagaggagaaggggga aatggtttgttgtcggcgatgcaggaagctattaacatctctgagaacccggctttggac cttccttcgcatgggtatcagagggaagtggtcgaggaagatgaagaagaagagattgta cacatgggaaatgctataatgtcattttattctgcacttattgaccttcttggacgttgc gcaccagaaacccatctgatcgaggccggaaaaggtgaagcaattcgaatccggtctatc cttcgttcacttgttcccactgaggacttggttggaataattagtattccattaaagctt cctgcttttaacaaagatggctcagtgtttgaacctgacatggcagccagcttctgccca gatcacaaggccccaatggtgctgtttctggatcgtgtttatggtattaaggaccaaagc ttcctcctgcatttgctggaggtggccttcttacctgatcttagagcatcagcttctctt gacactgcttccctgagtgtaactgaaatggctcttgctttgaaccgctacatctgctca gcagtgctgcccttgctcactcgatgtgcaccccttttctctgggactgaacattatgct gcgctcattgattcaaccctacatacgatctataggttgtcaaagggacgttctttaacc aaggctcagagagacaccattgaagagtgtttgctgtctatttgccatcatatgaggcct tccatgctccagcagctcctgcgacgcctcgtttttgatgttcccttactcaatgagtac tgcaaaatgccactgaagcttttgacaaaccattatgagcaatgctggaaatattactgc ctcccttctggatggggaagttatggattagcctcagaggaagaattgcacttgacagag aagctattctggggaatattcgattctttatctaacaagaagtatgatgctgagctcttc cgaatgtccatgccatgtctcagtgccatagctggtgctttgccaccagattatgtcgat accagaattaaagcaactccagaaaaacaaatgtctgtggatgctgagggaaattttgat ccaaaaccaattaatactgcaaacttgacactacccgaaaaacttgaatatattgtaaac aaaaatgccgaacattcacatgataaatgggcctatgacaagatccacagtggctggaaa tatggaatgtctcttgatgagaacatgaaaactcacccactgttgcgaccatataagaca ctgtcagaaaaggagaaagaaatttaccgctggcctgtaagagagtctgtgaaaacgatg ttatcaatgggctggagcgtggaacggaccaaagaaggagaagctttggcattgcatcgt gaaaatgagaagatgcgcagcatatcccagtccagccagggaaatggatataaccctgct ccacaggatctgagcaacgttgtcctttccagggagctgcaggggatggttgaagtgatg gcagaaaactaccacaacatttgggctaagaaaaagaagatggaactggaaagcaaaggt ggaggtagccatccattactggtgccttatgataccttaactgcaaaggagaaggctcga gatcgagagaaagctcaggagctgttcaaattccttcaagtaaatggctatgccatatcc agaggactgaaagatatggagctcgatgcatcttccatggaaaaaagatttgcctttaag tttctcaaaaaagttattcattatgtggactcggcacaggagtttattgcacacttagag gctgttgtgggcagtggtaaatctgagaagtcacctcatgagcaagagattaaatttttt gctaaagttctgcttccccttgttgatcagtactttaagaaccactgtctgtattttctt tcctcaccaacgaaaactttaagcagtagtggttatgcctccaacaaagagaaagaaatg gtagcaagtcttttctgcaaactggcagctcttgtcagacataggatttctctctttgga agtgattctgccacaatggtgagctgcctacacattcttgctcagacactggacacacgt acagtcatgaaatctggatctgagctggtaaaggcaggcgttcgggcattttttgaaaat gctgctgaagatttggagaaaacgttggaaaatctgaaactgggaaagtttactcactcg aggactcaaatgaagggagtctcccagaacattaactacaccactgtggcacttttgccc atcctaacatcaatctttgagcatgtagctcgccaccagtttggtgttgatttattgttg gatgatgtgcaagtttcctgctaccgaattttgtgtagtctgtatgcacttggaacagga aagaacatttatgttgaaagacaacgcccagctctgggagagtgcctggcagccttggca ggggctattcctgtggctttccttgagccatctctcaatcacaacaacccactcacagtt ttcaacacaaagtctcccagagagagagccattttagggatgccagatactgtggaggaa atgtgtccagatatgccacacttagagggcttgatgaaagagatcaatgagttggcagaa tctggagccaggtatacagaaatgccacacgtgattgaagttgtcttacccatgctgtgt aactacctatcctactggtgggagaggggaactgagaatgtgccagaaaatgccaggcct tgctgtacactggtgacatctgagcaccttagtgtcatccttgggaatatcctcaagata ataaacaacaatcttggcattgatgaagcctcatggatgaagagaattgcagtttatgct caaccaatcattagcaaagcacagccagacctcctaaagagtcacttcattcccacattg gagaaactcaagaagaaagcaataaagattgtgctagaggaggaacaactgaaagcagac agtaaagcagatacgcaggaggcagagctactcattttagatgaatttgctgttttatgt agagatttgtacgccttctatccaatgctgataagatatgtggacaacaacaggtcaaac tggctcaaaaagccagatatagactctgatgagctgttcagaatggtcgccgaggttttc attctttggtgtaaatcgcataattttaaaagagaagaacaaaattttgtgattcagaat gagatcaacaatctggcatttttaactgggaacaccaagagcaagatgtcaaagtctgga gggcaagaccaggagaggaaaagaataaagcgacgtggggacctttactccattcagaca tctttgattgtggcagctttaaagaagatgcttcctattggtctgaacatgtgtacccct ggggaccaggagctgatttcattggctaagagcagatacagccttaaagatacagatgat gaagtaaaagaacatctacgaaataacctccaccttcaagaaaagtctgaagatccagca gtgaagtggcaacttaacctctacaaggatattaggcaaagtgacgaacaatcagattct gagaagatagtggaacgtgttcagaaaatatctgcagcattattccatcttgagcaggtg gagcaacccttgagatctaaaaaagcagtttggcacaaactcttgtcgaagcagaggaaa agagccgtggtggcctgctttcgtatggcacccttgtacaaccttccaaggcaccgttct attaacctcttcctccatggttatcagaaattttggatacaaactgaggaatattccttt gaggagaaactaattgaggatttggctaaacccaagaaaactgatgaggaagaagaagag gagacagaaaagaagcctgatcctcttcaccagattatattacatttcagtcgcaatgct cttactgaaaggagcaaattggaagatgatcctttatacacagcatatgcagcaatgatg gcgaagagctgtcagaatgaagaggaagatgaagagaaagaaaagacatttgaagagaag gaaatggaaaaacaaaagaccttatatcaacaagcacgcctgcacgaaaggggagctgct gaaatggtcttgcaaatgatcagcgcaagtaaaggtgaaatgggccccatggtagtggaa accctaaaacttggaatttcagttttgaatggcggtaacaccgtggtgcaacagaaaatg ctcgattacttgaaggagaagaaagatgctggctttttccagagtttgtctggcctgatg cagtcatgcagtgttcttgacttgaatgcatttgaaaggcaaaacaaggcagaaggactt ggaatggtcacagaagaaggaacgctcattgtccgggaacgtggtgaaaaggttttacag aatgatgagttcacacgtgatctcttcagattcttgcagcttctatgtgaagggcataat aacgacttccagaatttcctacgaacccagatgggcaacacaacaaccgtgaacataatt ataagcactgtagattatcttctccgcctccaggaatctatcagtgatttctactggtac tactcagggaaggaggtgattgatgaatctgggcaacacaacttttccaagtctcttgct gtgaccaaacaaatatttaactcgctcacagaatatattcagggtccgtgcattggaaat cagcagagcttggcacatagccgtctatgggatgccgttgttggttttctccatgtcttt gcaaatatgcaaatgaaactatcacaggattctagccagattgagttattaaaagaacta ctggacctcttacaggacatggttgtgatgctgctgtcccttttagaaggaaatgtagtg aatgggacaattggaaaacaaatggtggacacactggtagagtcctctagcaatgtagaa atgatcctcaagttctttgatatgttccttaagctgaaagacttgaccagctctgatgcc tttaaggaatatgatcctgaggggaaaggtgtcatctccaagaaagagttccagaaggcg atggagggacagaagcaatatgcaccatcagaaattgaattcctgctctcctgtgctgaa gctgatgaaaacgatatgtttaattatgttgaatttgtggatagatttcatgaacccgca aaagacatcggcttcaatgtggctgttctgctgacaaatctttctgaacatatgccacat gattcccggctccagtgtctattagaacctgctagtagtgttttaagttacttttcccca taccttggtcgcattgaaattatgggaggagcaaagagaatagaaagagtgtattttgag attagtgagtcaagccgaacacagtgggaaaaaccacaggtcaaggaatcaaagagacag ttcatatttgatgtggtgaatgaaggtggagaacaagagaagatggaactatttgttaac ttctgtgaagacactatttttgagatgcagttggcatctcagatctctgattcagatgct gtagagagacccgaggaagaagaagaggaagaatcacatcacatcatagaagttggtgaa gaagatgaggaagcacagtctttagaatcttcttcagcatttattgtagcatgtacatct cttaaaaacaatacttccaatttcctaaaaatgcttacattaaaaaatattggtaaacag cttcggaaggtgaagaagatgactttgaaggagctagtgaaggttttcttctcatttttc tggatgcttttcgttggactgtttcagtttgtgtttacgattgtatggggcgtattccag atactttggagcactgtgtttggaggaggtttagtggaaggggccaaaaacattaaagtt acaaagatcttaggtgatatgccagaccctactcagtttggaattcacgatgatgtcctg gaagctgaaaaggtagatgctaatgaacatgcaacttccactgaacttgctaatcttgta aaaggagacaagggggacgtagatatgccagatatttttggcattcaggggaaaaaggaa ggctcgaagcatagcccagaagttggacttggtgatttctcagaagctgtaactacagag actgctccaagcttggagaacgcagtccgaaagagaaaaaacgcacttgctgccgaactt gccaaagaacaagaggagcaatctaaggccgaatctgagaaggcagacctggaagatggt gaaaaaaaggacaaggttaaggcagaggaacagtccgagttagtggaaagtaaagagagt ataagtaagaaaaagagacggggacctaagaaagaggaacccgaagcatttatggcaaac ttcttggctggcttggagatctaccaaacaaagatgctgaattatctggccagaaatttc tacaatctaaggttccttgctctgtttgtcgcatttgccattaacttcattcttttgttc tacaaggtgactgaagaacattccagtgaagacagtgaagacaatgaaacaaacttatgg gacacgtttcaagaagaagaagaggacgcagatgagggggctgtatattttgttctgcag gaaaacacaggttacatggctccaacactgcgcatattggctgttatgcacaccattatc tccttcgtctgtgtcattggatactactgcctcaaggttcctctggtggtatttaagcgt gaaaaggaaattgctcgcaatgtggagtttgatggcctgtacatcacagagcagccttca gaggatgatataaaagggcaatgggaccggcttgtcattaacaccccgtcattccctaat aattactgggataaatttgttaaaagaaaggtaatcaacaaatatggagacctgtatggg gctgaccgaatagcagagctcctgggtttggacaaaaatgccctagacttcagcccagtg aagaagaccaaaccagaagaaggttcacttgtatcttggctgagttccatcgatatgaag taccacatctggaaacttggtgtcgtcttcacagacaattcattcctgtatcttgcctgg tataccaccatgtcgatcctggggcattacaacaatttcttttttgccgcccatctgttg gacattgcaatgggctttaagactctgagaacgattctttcttccgtaacgcacaatgga aaacaattggtgctgacagttggacttctggctgtcgtcgtttatctgtacactgttgtg gccttcaacttcttccgcaaattctacaacaaaagtgaggacgaggacgatcctgacatg aagtgtgatgacatgatgacatgttatctgttccacatgtacgtgggtgtgagagcagga ggaggcattggagatgagattgaagaccctgcaggagacccctatgaaatgtatagaatt gtgtttgacatcactttcttcttcttcgttattgtcattctcttggcaattatccaaggt ttgattattgatgcttttggtgagttgagagatcagcaagaacaagttagagaagatatg gagaccaaatgtttcatttgtgggattgggaatgactactttgacacgacgcctcacgga tttgaaacacatacgttacaagagcacaacttggccaattacctgttcttcctcatgtat cttattaataaggatgagacagaacacaccggccaggaatcctatgtgtggaagatgtac caggagagatgttgggacttcttcccggccggtgactgtttccgcaaacaatatgaagat cagcttggctaa

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