Xenopus laevis (African clawed frog): 108700460 Help Entry 108700460         CDS       T01010                                  Symbol ryr3.S Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism xla  Xenopus laevis (African clawed frog) Pathway xla04020   Calcium signaling pathway xla04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:xla00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108700460 (ryr3.S)    04020 Calcium signaling pathway     108700460 (ryr3.S)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:xla04040]     108700460 (ryr3.S) Ion channels [BR:xla04040]  Voltage-gated cation channels   Ryanodine receptor    108700460 (ryr3.S) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 TetR_C_41 Motif Other DBs NCBI-GeneID:  108700460 NCBI-ProteinID:  XP_041430322 Xenbase:  XB-GENE-17336712 UniProt:  A0A8J1LLD9 LinkDB All DBs Position 8S:2184363..2438736 Genome browser AA seq 4874 aa AA seqDB search MAEAAEVEDEIQFLRTDDEVVLQCVATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTMANANEGASQGGGHRTLLYGHAILLRHSFSGMYLT CLTTSRSLTDKLAFDVGLQNTSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSTERY LHLSISNGMSNIQVDASFMQTLWNVHPTCSGSSVEEGFLLGGHVVRFFHGHDECLTIPST DSGEVQHRKVNYEAGGAGARARSLWRVEPLRISWSGSHIRWGQTFRLRHITTGQYLTLTE DQGLVLQDRTKSDTKSSAFCFRASKEKLDTGSKRDIDGMGAAEIKYGDSICFVQHVNSGL WLTYKSQDAKTARLGPLKRRAILHLEGHMDDGVCLQKCQHEESQAARIIRNTTALFSQFI SDLDSMTGNNWTGSTPTALPIEEVVQTLQDLISYFKPPDEELEHEDKQNKLRSLKNRQNL FKEEGMLALVLNCIDRLNVYSGAAHFTELLGKKEGPSWKEILNLLYELLAALIRGNRSNC AQFSNNLDWLISKLERLESSSGILEVLHCILIESPEALNLIEKGHIRSIISLLDKHGRNH KVLDVLCSLCMCNGVAVRTNQNLICDNLLPRRDLLLQTRLVNDVTSMRPNIFLGVAEGSA QYKKWYFEMMIDQVDPFLTPEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLFSYGFD GLHLWSGRVPRAVASTNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTVGLF FPVVSFSAGVKVRFILGGRHGEFKFLPPTGYAPCYEALLPKEKMRVEPVKEYKRDFDGVR DLLGTTHFLSQASFIPCPIDTSQVVLPPHLEKIRDKLAENIHELWGMNKIELGWIYGKVR DDNKRQHPCLVEFSKLPDTEKNYNLQMSTETLKTLLALGCLIVHSNQTAEENLKKLKLPK NYMMSNGYKPAPLDLSDLKLLPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKR NPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPPDQEITDQMTERVGIDKIRFFR VEKTYAVESGKWYFEFEVVTGGDMRVGWARPGCRPDLELGADDQAFVFEGGRAQCWNMGS SYFGSSWQPGDVVGCMIDVDDKSMIFTLNGELLITNQGSELAFADFEIENGFVPVCSIGL SQIGRMNLGKDASTFKYYTMCGLQEGFQPFAVNMNRDIVMWFSKRLPTFVNVPKEHPHIQ VTRIDGTVESPPCLKVTHKTFGTQNSNEDMIYCRLSMPVEFHSAFNTEENFLKRNQIQEA SSHTTTTYYYSVRIFAGQDPSSVWVGWVTPDYHFYSKKFDLAKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDLSAGSERSSRSSVDIDIGCLVDLASGLLSFTANGKDLGTCYQVEPN TKLFPAVFLQPTSTNLIQFELGRLKNTMPLSAAIFKSEEKNPVPQCPPRLDVQTITPVLW SRMPNNFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCIDILELSEQEDLMKFQNH TLQLYCAVCALGNNRVSHALCSHVDQSQLLYTIDNQYLPGLLRSGFYNLLISMFLESAKE GKLMMNNEFIIPITDETRKIRLFPDESKRHGLPGVGRTTCLKSDLHFTMPCFVLTGEERQ QHGPEIPIDILKTKAISMLTEAVQSSGEHIRDPVGGKVEFQFVPVLKLIATLVIMGVFED EDVQQILLLIDPNVFGDNKEEETEEHEKEEVAQVEEKAVEAGEKATRDPTAPTKGLLQTR LPESVKLQMCELLHYFCDCELKHRVESIVSFSDNFVSKLQYNQKFRYNELMLALNMSAAL TAKKTREFRSPPQEQINMLLNFQIQDDCPCPEEIRDELYQFHEDLLMHSGIPLDEEEEEE EDTSMTGRLRTLLYKIKGRPKTEENDADEEEEKSPTTLKELISHTMVRWAEEDHIQDPEL VRIMFTLLRRQYDSTGELLRAMRKTYTISAASVEDTINLLASLGQIRSLLSVRMGKEEEM LMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQQITFPKMVASCCRFL CYFCRISRQNQKAMFEHLGYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALQEP DLEKVVTYLAGCGLQSCPMLIAKGYPDIGWNPIEGERYLSFLRFAVFVNAESVEENASVV VKLLIRRPECFGPSLRGEGGNGLLSAMQEAINISENPALDLPSQGYQREVVENEEEEEIV HMGNAIMSFYSALIDLLGRCAPETHLIEAGKGEAIRIRSILRSLVPTEDLVGIISIPLKL PAFNKDGSVFEPDMAASFCPDHKAPMVLFLDRVYGIKDQSVLLHLLEVAFLPDLRASASL DTASLSVTEMALALNRYICSAVLPLLTRCAPLFSGTEHYAALIDSTLHTIYRLSKGRSLT KAQRDTIEECLLSICHHMRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTDHYELCWKYYC LPSGWGSYGLASEEELHLTEKLFWGIFDSISNKFLSLLQRYDAELFRMSMPCLSAIAGAL PPDYVDTRIKATPEKQMSVDAEGNFDPTPINTANLTLPEKLEYIVNKNAEHSHDKWAYDK IHSGWKYGLSLDENMKTHPLLRPFKTLSEKEKEIYRWPLRESVKTMLTMGWSVERTKEGE ALALHRENEKMRSISQSSQGNGYSPAPEDLGNVVLSRELQGMVEVMAENYHNIWAKKKKM ELENKGGGSHPLLVPYDTLTAKEKARDREKAQELFKFLQVNGYAISRGLKDMELDASSME KRFAFKFLKKVLHYVDSAQEFIAHLEAVVSSGKSEKSPHEQEIKFFAKVLLPLVDQYFQN HCLYFLSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHILA QTLDTRTVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKFTHSRTQMKGVSQNINYT TVALLPILTSIFEHVARHQFGVDLLLDDVQVSCYRILCSLYSLGTGKNIYVERQRPALGE CLAALAGAIPVAFLEPSLNLNNPLTVFNTKSPRERTILGMPETVEQMCPDMPHLEGLMKE INELAESGARYTEMPQVIEVVLPMLCNYLSYWWERGTENVPENAGPCCTQVTSEHLSVIL GNILKIINNNLGIDEASWMKRIAVYAQPIISKAQPDLLKSHFIPTLEKLKKKAIKIVQEE EQLKADSKADTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDIDSDELFR MVAEVFILWCKSNNFKREEQNFVIQNEINNLAFLTGNNKNKMSKSGGQDQERKRIKRRGD LYSIQTSLIVAALKKMLPIGQNMCTPGDQELISLAKSRYNLRDTDDEVKEHLRNNLHLQE KSEDPAVKWQLNLYKDIRISDEQSDSEKIVERVQKISAAIFHLEQVELPLRSKKAVWHKL LSKQRKRAVVACFRMVPLYNLPRHKINNFFLSSYQRFWLEKVHENSDYDSLILVLTKPKK TDEEEEEETEKKPDPLHQIILHFSRNALTERSKLEDDPLYTAYAAMMAKSCQNEEEDEDE EKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMGPMVVETLKLGIAILNG GNTVVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIV RERGEKVLQNDEFTCDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNIIISTVDYLLRLQ ESISDFYWYYSGKEVIDESGQRNFSKSLAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWD AVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDT LVESSSNVEMILKFFDMFLKLKDLTSSDAFKEYDPEGKGVISKKEFQKAMEGQKQYAQSE IEFLLSCAEADENDMFNYVEFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQCLLDPA SSVLSYFSPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGE QEKMELFVNFCEDTIFEMQLASQISESDAVERPEEEEEEESHHIIEDGEEDEEAQALESS SAFIVACTSLKNNTSNFLKMLTLKNIGKQLRKVKKMTLKELVKGFFSFFWMLFVGLFQFV FTIVWGIFQILWSTVFGGGLVEGAKNIKVTKILADMPDPTQFGIHDDVLEAEKVDGTEHA ASTELANLVKGDKGDLDIPDIFGTQAKKEGSKHGPEIGLGDCSEAVTAESAPSLENAVRK KKNALAAELAKEHEEQTKAECEKADLEDGEKKDKVKAEEQSELVESKGNISKKKRRGQKK EESEAFMANFLAGLEIYQTKMLNYLARNFYNLRFFALFVAFAINFILLFYKVNEEHSSED SDNDTNLWDTFQEEEEEEEDANEGAVYFVLQESTGYMAPTLCILAVMHTIISFVCVIGYY CLKVPLVVFKREKEIARNVEFEGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKR KVINKYGDLYGADRIAELLGLDKNALDFSPVKKTKPEEGSLVSWLSSIDTKYHIWKLGVV FTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLALTVGL LAVVVYLYTVVAFNFFRKFYNKSEDEDDPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIED PAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGI GNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFP AGDCFRKQYEDQLS NT seq 14625 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcggctgaagtggaggacgagatccaattcctccgaactgatgatgaagtt gtccttcagtgtgttgctacaatacacaaggaacagcggaaattttgtctggcagccgag ggacttgggaatagactgtgttttttggaaccgacttcagaggctaaatatgttcctcca gatctttgcatctgtaattttgtgctggaacaatcgttatctgtcagggctcttcaggaa atgctggccaacacaatggcaaatgccaatgaaggggcatcacaaggaggaggacacagg acgttgctttatggccatgcaatcttgctccgccattcgtttagtggaatgtatttgacg tgtctgaccacatcaagatccctcaccgataagcttgcgtttgatgtgggactgcagaat acttccacaggtgaggcctgctggtggacaatacaccctgcatccaaacaaaggtctgaa ggagaaaaggtccgcattggtgatgacttaattttggtcagcgtttctacagaaagatac cttcatctctccatatccaatgggatgagtaacatccaggtggatgcctcctttatgcaa actctgtggaacgtccaccctacctgttctggaagcagtgtggaagaaggctttcttctt ggaggacatgtagtccgttttttccatggtcatgatgagtgtttgacaataccatctact gactctggagaggtccagcacagaaaagtcaactatgaagcaggtggagccggtgctcgt gccagatcattatggagagttgagcctctacgaataagttggagtggaagtcatattcga tggggccagacatttcgcctgcgtcacatcacaacgggacagtatttgacactgacagag gaccaaggcttagtgctgcaggacaggacaaaatctgacaccaaatcatccgccttttgt ttcagagcatcaaaggaaaagttggacactggctcaaaacgtgacattgatggcatggga gcagcagagataaagtatggagactccatctgttttgtccaacatgtaaacagcggcctt tggctgacatacaaatcccaagatgccaaaacagcacgactgggaccactaaagagaaga gcgatcctacacctagaaggccatatggatgatggcgtctgtctccagaagtgccaacat gaagagtcccaagctgctagaatcattcgaaacaccacagccttgtttagtcagtttatc agtgatctggattctatgactggaaacaactggactggctcgacccccaccgcgctgcct attgaggaggtggttcaaacgctgcaagacttgatttcttacttcaagcctcccgacgaa gaactggaacatgaagataaacagaacaagctccgttccctcaagaaccgacaaaaccta ttcaaagaggagggaatgctggccctagtgttaaactgcattgatcgcctaaacgtctac agcggcgcagcacactttactgaactcctggggaaaaaagaaggaccatcatggaaggaa atcttgaaccttctctatgaattgttagctgccctgattcgcggtaacagaagcaactgc gcccaattttccaataaccttgattggcttattagtaaactagagcgtctagaatcctct tcaggtatattagaagttctgcactgcatactgattgaaagcccagaggctttaaatcta atagaaaagggacatatccgatctataatttctcttctggacaaacatggacggaaccat aaggttctggatgtcctctgctctctgtgtatgtgcaatggggtggctgttcgtacaaat cagaacctcatttgtgataacctgctgcctaggagagatttacttctacaaacacgtttg gttaatgatgtcaccagcatgaggcctaacatcttccttggagtggctgaaggctcagcg caatataagaagtggtattttgagatgatgattgatcaggttgacccatttctgacacca gagcccacacacctacgtgtaggctgggcctctacctccggttatgctccatatcctggt ggaggtgaaggatggggtggcaatggtgtaggggatgaccttttctcctatggctttgat ggccttcatttgtggtctggtcgtgttccaagagcagtggcctcaacaaaccagcatctt ctagcatctgatgatgttgtgagctgttgtttggacttaggtgtacccagcatttctttt cgcatcaatggccagcctgttcagggcatgtttgagaactttaatactgtaggcctattt tttcctgtagtcagcttttctgcaggggtgaaggttcgtttcattcttggtggccgtcat ggagagttcaagtttctgccacctactggttatgctccatgctatgaggccttacttcca aaagagaaaatgagagtggaacccgtgaaagagtacaagagggattttgacggagttcga gacctgctgggaactacacatttcctctcccaagcttcttttatcccatgcccaatagac accagccaggttgttttacctcctcatcttgaaaagattagagacaaactggctgaaaac attcatgaactttggggcatgaacaaaattgagcttggctggatttatggcaaggttcga gatgataataaacgccagcatccttgcttggtagagttctccaaacttccagacactgag aaaaattacaatttacagatgtctacagaaacacttaaaactttgctggccctaggatgt ctcattgttcattcaaatcaaacagcagaagaaaatctgaagaaacttaagcttcccaaa aactacatgatgtccaatggctacaaacctgccccattggacctttctgatttgaaacta ttaccggcacaagaagttttagtggataaactggcagagaatgcacacaatgtatgggca aaagataggataaaacaaggatggacctatggcattcagcaggatttgaaaaataaacga aacccccgcttggtgccatatgctttattagatgaacgaactaagaaatcaaatcgagac agtctgcgtgaagcagtgagaacatttattggctatggatataacatcgagccaccagac caagagattactgaccaaatgacagagcgcgtcggcatcgacaagattcgctttttcaga gtagagaagacgtatgccgtcgaatctggcaagtggtactttgagtttgaagttgtgacc ggaggcgacatgcgggtcggatgggccaggcctggctgtagacctgatcttgaactgggt gcagatgaccaggcatttgtatttgagggaggcagggctcagtgttggaacatgggcagc tcctactttggtagtagttggcagcctggagatgtcgtggggtgtatgattgacgtggat gacaaatcaatgatcttcacactaaatggagagctgctcatcacaaatcaggggtctgag ttggcatttgctgattttgaaatcgaaaatggctttgtcccagtctgctccatcggattg tcccaaattggtcgtatgaacctggggaaggatgccagcacgttcaagtactacacaatg tgtggcctgcaggaaggtttccagcccttcgctgtcaatatgaacagagatattgtcatg tggtttagcaaacgcttgcccacattcgtcaatgtgccaaaagaacatcctcatattcag gtaacaaggatagatgggacagtagaaagtcctccatgcctgaaggtcactcacaagacc tttggaacccagaacagtaatgaagatatgatctattgtcgcctaagcatgcctgtagag tttcactctgcctttaacactgaagaaaacttcctgaaaagaaaccagattcaagaggca tcttcacacaccacaacaacatattactactcagtcagaatcttcgctggtcaggatccg tcatctgtgtgggtgggatgggtaaccccagattaccacttttacagtaaaaaatttgac ttggccaagaactgtacagttactgtgactttaggagatgaacgaggcagagtacatgaa agtgttaaacgaagcaactgctacatggtgtggggaggcgacttgtctgctggctccgag agatccagtcgtagcagtgtggacattgatattggctgccttgttgatttggctagtgga ctattgtcattcacagccaatggaaaagatcttgggacatgctaccaggttgaaccaaac acaaagctgttcccagctgtcttcctgcagccaaccagcaccaatctcatccaatttgag cttggaaggttaaagaatactatgcctctctctgctgcaatatttaaaagcgaggagaaa aatcctgtaccacagtgcccccccagactggatgtgcagaccattacccctgtcctttgg agccgcatgccaaacaacttccttaaggtggagacagaacgtgtaagtgaacggcatggc tgggtggtgcagtgtctggaacctctgcagatgatggcattgcatatacctgaggagaac aggtgcatagacatccttgaactttctgagcaggaggacttaatgaaatttcagaaccac actttacagctgtactgcgcagtttgtgcacttggcaataaccgtgtttcccatgccctg tgcagtcatgtagaccagtcccagctcctgtacaccattgataaccagtatttacctggt cttctgagatcaggattctacaatcttcttatcagtatgtttctggaatctgccaaggag ggcaaacttatgatgaacaatgagtttattattcccatcacagatgagacacggaagatc agactcttccctgatgagtcaaaaagacatggacttccaggggttgggcgtactacttgc ctaaagtctgaccttcacttcacaatgccttgttttgtgttgactggagaagagagacag caacatggtccagagattcctattgacatactgaagacaaaggccattagcatgttaaca gaagctgtgcagagtagtggagaacacattcgagatcctgttggtggcaaggtggaattt cagtttgtacctgtgctaaaactaattgctaccctggttattatgggagtgtttgaagat gaagatgtacagcaaatacttttgcttattgatcccaatgtttttggggacaacaaggaa gaggagacagaggagcatgaaaaggaagaggttgcgcaagtagaggagaaagctgtggaa gcaggagagaaagcaacacgagatccaactgcccccaccaagggattattgcagacacga cttccagaatctgtcaaactccagatgtgtgagctccttcattacttctgtgactgtgaa ctgaagcaccgcgtagaatcaattgtctcgttctcggataactttgtttcaaaacttcag tacaatcagaagtttcggtacaatgagctgatgctggcactgaatatgtccgctgctctg actgccaagaaaacgagggaattccgctccccaccccaagaacagattaacatgcttttg aacttccaaattcaagatgactgcccttgcccagaagagattcgggatgagctttaccaa tttcacgaggatctccttatgcattctggtattccgcttgatgaagaggaggaagaagaa gaagatacatcaatgacggggcggctgcgaacactgctgtataaaatcaaaggtcggccg aaaacagaagaaaatgatgcagatgaagaggaagaaaaatcccccaccacactgaaggag cttatttcgcacacgatggtgcgctgggctgaagaagatcacattcaggatccagaactt gtgcgcataatgtttactctcctccgacggcagtacgacagcaccggagaactactacgg gctatgcggaaaacctacaccatcagtgctgcttctgttgaggacactatcaaccttttg gcatcacttggccaaatacgatcccttctaagtgttaggatgggtaaagaagaggagatg ttgatgattgacggattgggggacatcatgaacaacaaagtcttctatcaacatccaaac ttgatgcgtgtgctggggatgcacgagacagttatggaagtcatggttaacgtgcttggt ggagacaaatcacagcaaattacatttcccaaaatggtagcgagctgctgccgatttctc tgctacttctgcagaatcagccgacagaatcaaaaggcaatgtttgagcatcttggatac ttattggaaaacagcagcgttggactggcttctccatcgatgagaggttccacacctttg gatgttgctgcagcatctgtcatggacaataatgagcttgccttggctttacaagaacca gatttagagaaggtcgtaacttacttagccggatgtgggctacaaagttgtccgatgcta atagccaagggctacccagacattggatggaatcctatagaaggggagcgttacctctct tttctgcgctttgctgtctttgttaatgctgagagtgtagaagagaatgccagtgtggtg gtgaagctcctcattcgacgtcctgagtgttttggcccatcgctgagaggagaaggagga aatggtttattgtcggccatgcaggaagccattaacatctctgagaacccagctctggac cttccttctcaggggtatcagagggaagtggttgagaatgaagaagaagaagagattgta cacatgggaaatgctataatgtccttttattctgcacttatcgaccttcttggacgttgt gctccagaaacccatttgatcgaggccggaaaaggtgaagcaattcgaatccgctccatc cttcgttcacttgttcccactgaggacttggttggaataattagtattcccttaaaactt ccggcatttaacaaagatggctcagtgtttgaacctgacatggcagccagcttctgccca gatcacaaggccccgatggtgctttttctggatcgtgtttatggtattaaggaccaaagt gtcctactgcatttgctggaggtggccttcctacctgatcttagagcatcagcttctctt gatacggcttccctgagtgtgaccgaaatggctcttgctttgaaccgctacatctgctcc gcagttctgcccttgctcactcggtgtgctccccttttctctgggactgaacattatgcc gcactcattgattcaaccctgcataccatctataggttgtctaagggacgttctttaact aaggctcagagagacacaattgaagagtgtctgctctccatttgccatcatatgaggcct tcgatgctccagcagctcctgcgacgccttgtttttgatgttcccttactcaatgagtac tgcaaaatgccactgaagcttttgacagaccattatgagctgtgctggaaatattactgc ctcccttctggatggggaagttatggattagcctcagaggaagaattgcacttgacagag aagcttttctggggaatattcgattctatatctaacaagttcctatctctcctgcagagg tacgatgctgagctcttccgaatgtccatgccatgtctcagtgctatagctggtgctttg cctccagattatgttgataccagaattaaagcaactccagagaaacaaatgtctgtggat gccgaggggaattttgatccaacaccaatcaatactgcaaacttgacactacccgaaaag cttgaatatattgtaaataaaaatgctgaacattcacatgataaatgggcttacgacaag atccacagtggctggaaatatggactttcccttgatgagaacatgaaaactcaccctctg ttgcgaccattcaagacactgtcagaaaaggaaaaagaaatttaccgctggcctttaaga gagtctgtgaaaacgatgttaacaatgggctggagtgtggaacggaccaaagaaggagaa gctttggcattgcatcgtgaaaatgagaagatgcgcagcatatcacagtccagccaggga aatggttatagccccgctccagaagatctcggcaatgttgtcctttccagggagctgcag ggaatggttgaagtgatggcagaaaactaccacaacatttgggctaagaaaaagaagatg gaactggagaacaaaggtggaggtagccatccattactggtgccttatgataccttaact gcaaaggagaaagctcgagatcgtgagaaagctcaggagctgttcaagttccttcaagta aatggctatgccatatccagaggactaaaagatatggagcttgatgcgtcttccatggaa aaaagatttgcctttaaatttctcaaaaaagttcttcattatgtggactctgcacaggaa tttattgcacacctagaggccgttgttagcagtggtaaatctgagaagtcacctcatgag caagagataaaattttttgctaaagttctgcttccccttgttgaccagtactttcagaac cactgtctgtattttctttcctcaccaacgaaaactttaagcagcagtggttatgcctct aacaaagagaaggaaatggtggcaagtctattctgcaaactggcagctcttgtcagacat aggatttctctctttgggagtgattctgccacaatggtgagctgcctccacattctcgct cagacactggacacacgtacagtcatgaaatctggatctgagctggtgaaggcgggagtt cgcgcattttttgaaaatgctgctgaagatttggagaaaactttggaaaacctgaaactg ggaaagtttactcactcgaggactcaaatgaagggagtctcccagaacattaactacacc actgtggcacttttaccaatcctaacatctatctttgagcatgtagctcgccaccagttt ggtgttgatttattattggatgatgtacaagtttcctgttaccgaattttgtgtagtctg tattcgcttggaacaggaaagaacatttacgttgaaagacagcgcccagctctgggagaa tgcctggcagccttggcaggagctattcctgtggctttccttgagccgtctctcaatctc aacaatccactcacagttttcaacacaaagtctcccagagagagaacaattttaggtatg ccggagactgtggagcaaatgtgtccagatatgccgcacctagagggcttgatgaaagag atcaatgagttggcagaatctggagccaggtataccgaaatgccacaagtgattgaagtt gtcttacccatgttgtgtaactacctgtcctactggtgggagagaggaacggagaatgtg ccagaaaatgccgggccttgctgtacacaggtgacatctgagcaccttagtgtcatcctt gggaatatcctcaagataatcaacaacaatcttggcattgatgaagcttcgtggatgaag agaattgcagtttatgctcaaccaatcattagcaaagcacagccagaccttctaaagagt cacttcattcccaccctggaaaaactgaagaagaaagcaataaagattgtacaggaggag gagcaactgaaagccgacagcaaagcagatacacaggaggcagaactacttattttagat gaatttgcagttttatgtagagatctgtacgccttctatccaatgctgatcagatatgtg gacaacaacaggtcaaactggctcaaaaagccagatatagactctgatgagctgttcaga atggtggctgaggttttcatcctttggtgtaaatcgaataattttaagagagaagaacag aattttgtgattcagaatgagatcaacaatctggcatttttaactgggaacaacaagaac aagatgtcaaagtctggaggacaagaccaggaaaggaaaagaataaagagacgtggggac ctttactctattcagacatctttgattgtggcagccttaaagaagatgctccccattggt cagaacatgtgtacccctggagaccaggagctgatatcattggctaagagcagatacaac cttagagatacagatgatgaagtaaaagaacatctacgcaataaccttcaccttcaggaa aagtctgaagatccagcagtgaagtggcaacttaacctctacaaggatatcaggataagc gatgagcagtcagattctgagaagatagtggaacgtgttcagaaaatatctgcagcaata ttccatcttgagcaggtggagctgcctttgagatctaaaaaggcagtttggcacaaactc ttgtcgaagcagaggaaaagagctgtggtggcctgctttcgtatggtacccttgtacaac cttccaagacacaaaattaacaatttcttcctgagctcctaccaacgtttttggctggaa aaagtacatgagaactcagactatgacagtctaatactcgtgttaacgaaacccaagaaa accgacgaggaagaagaagaggagacagaaaagaagcctgatcctcttcaccagattatt ttacatttcagccgcaatgctcttactgaaaggagcaaattggaagatgatccattatac acagcatatgcagcaatgatggcaaagagctgccagaatgaagaggaagatgaagatgaa gaaaaagaaaagacatttgaagagaaggaaatggaaaaacagaagaccttatatcagcag gcgcgtctgcacgaaaggggagccgctgaaatggtcttgcaaatgatcagcgcaagtaaa ggtgaaatgggccccatggtagtggaaaccctaaaacttggaattgccattttgaatggt ggtaacaccgtggtgcaacagaaaatgctagattacttgaaggagaagaaggatgctggc tttttccagagtctgtcgggcctgatgcagtcatgcagtgttcttgatttgaatgcattt gaaaggcaaaacaaggcagaaggactgggaatggtcacagaagaaggaacccttattgta cgggaacgtggtgaaaaggttttacagaatgatgagttcacctgtgatctcttccgattc ctgcagcttctgtgtgaagggcataataacgacttccagaatttcctacgaacccagatg ggcaacacaacaaccgtgaacataattataagcactgtggattatcttctgcgcctccag gaatctatcagtgatttctactggtattactcagggaaggaggtgattgatgaatctggg caacgcaacttttccaagtctcttgctgtgaccaaacaaatatttaattcactcacagaa tatattcagggtccgtgcattggaaatcagcagagcttggcgcacagccgtctctgggat gccgttgttggttttctccatgtctttgcaaacatgcaaatgaaactttcacaggattct agccagattgagttgttaaaagaacttctggacctcttacaggacatggttgtcatgcta ctgtcccttctagaaggaaatgtagtgaatgggacaattggaaaacaaatggtggacaca ctggtagagtcatctagcaatgtagaaatgatcctcaagttctttgatatgttccttaag ctgaaagacttgaccagctctgatgccttcaaagaatatgatcccgagggcaaaggcgta atctccaagaaagagttccaaaaggcgatggagggacagaagcaatatgcacaatcagaa attgaattcctactctcttgtgctgaagctgatgaaaatgatatgtttaattatgttgaa tttgtagatcgatttcatgaacctgcaaaagacatcggattcaatgtggctgtcctgttg acaaatctttctgaacatatgccaaatgattcccggctccagtgtctattagatcctgct agtagtgttttaagttacttttctccatacttaggtcgcattgaaattatgggaggagca aagagaatagaaagagtatattttgagatcagtgagtcaagccgaacacagtgggaaaaa ccacaggtcaaggaatcaaagagacagttcatatttgatgtggtgaatgaaggtggagaa caagaaaagatggaactatttgttaacttctgtgaagacactatttttgagatgcagttg gcatctcagatctcggaatccgatgctgtagagaggcctgaggaagaagaggaggaagaa tcacatcacatcatagaagatggtgaagaagatgaagaagcacaggctttagaatcttct tcagcatttattgtagcttgtacatctcttaaaaacaatacttctaatttcctaaaaatg cttacattaaaaaatattggtaaacagctgcggaaagtaaagaagatgactttgaaggaa ctagtgaagggtttcttctcatttttctggatgctttttgttggactgttccagtttgtg tttacgattgtatggggcatattccagatactttggagcactgtgtttggaggtggttta gtggaaggggccaaaaacattaaagttacaaagatcttagctgatatgccagaccctact cagtttggaattcacgatgatgtcctggaggctgaaaaggtagatggtactgaacatgca gcttccactgaacttgctaatcttgtaaaaggagacaagggggacctagatattccagat atttttggcactcaggcgaaaaaggaaggctcaaagcatggcccagaaattggacttggt gattgctcagaagctgtaactgcagagagtgctccaagcttggagaacgctgtccgcaag aaaaaaaatgcacttgctgctgaactggcaaaagaacacgaggagcaaactaaggctgaa tgtgagaaagcagacctggaagacggtgaaaagaaggacaaggtgaaggcagaggaacag tccgagttagtggaaagtaaagggaatataagtaagaaaaagagaaggggacagaagaaa gaagagtctgaagcatttatggccaacttcttggctggtttggagatctatcaaacaaag atgctgaattatctggccagaaatttctacaatctacggttctttgctctgtttgtcgca ttcgccattaacttcatccttttgttctacaaggtgaatgaagaacattccagtgaagac tcagacaacgatacaaacttatgggacacatttcaagaagaagaagaagaagaggaagac gctaatgagggggctgtatattttgttctgcaggaaagcacaggttacatggctccaaca ctgtgcatattggctgtgatgcataccattatctccttcgtctgtgtcattggatactac tgcctaaaggttcctctggtggtatttaagcgtgaaaaggaaattgctcgcaatgtggag tttgagggcctgtacatcacagagcagccctcagaggatgatataaaagggcaatgggac cgacttgtcattaacaccccgtcatttcctaataattattgggataagtttgtgaaaaga aaggttatcaacaagtatggagacctgtatggggctgaccgaatagcagagctcctgggt ttggacaaaaatgccctagatttcagcccagtgaagaagaccaaacctgaagaaggttca cttgtatcttggctcagttccatcgatacgaagtatcacatctggaaacttggcgtcgtc ttcaccgacaactcattcttgtatcttgcctggtacaccaccatgtctatcctgggacat tacaacaatttcttctttgccgcccatctgttggacattgcaatgggctttaagactctg agaactattctttcttcagtaactcacaatggaaaacaattggcgctgacagttggactt ctagccgtcgttgtttatctgtacactgtcgtggccttcaacttcttccgcaaattctac aacaaaagtgaagacgaggatgaccctgacatgaagtgtgatgacatgatgacatgttat ctgttccacatgtacgtgggcgtcagggcaggaggtggcattggagatgagattgaagac cctgcaggagacccctatgaaatgtatagaattgtgtttgacatcactttcttcttcttc gttattgtcattctcttggcaattatccaaggtttgattattgatgcttttggcgagttg agagatcagcaagaacaagttagagaagatatggagaccaaatgtttcatatgtgggatt ggaaacgactactttgacactacgcctcatgggtttgaaacacatactttacaagagcac aacctggctaattacctgttcttcctcatgtatcttattaataaggatgagacagaacac accggccaggaatccttcgtctggaagatgtaccaggagagatgttgggacttcttccca gctggtgactgtttccgcaaacaatatgaagaccagcttagctaa

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