KEGG   PATHWAY: ypk01053
Entry
ypk01053                    Pathway                                
Name
Biosynthesis of siderophore group nonribosomal peptides - Yersinia pestis KIM10+ (biovar Mediaevalis)
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
ypk01053  Biosynthesis of siderophore group nonribosomal peptides
ypk01053

Organism
Yersinia pestis KIM10+ (biovar Mediaevalis) [GN:ypk]
Gene
y1659  menF; isochorismate hydroxymutase 2 [KO:K02552] [EC:5.4.4.2]
y2394  ybtS; anthranilate synthase [KO:K04781] [EC:5.4.4.2 4.2.99.21]
y2399  irp2; HMWP2 nonribosomal peptide synthetase [KO:K04784]
y2400  irp1; HMWP1 nonribosomal peptide/polyketide synthase [KO:K04786]
y2401  ybtU; thiazolinyl-S-HMWP1 reductase [KO:K04785]
y2403  ybtE; salicyl-AMP ligase [KO:K04783] [EC:6.3.2.-]
y2584  ybtD; yersiniabactin biosynthesis component [KO:K02362] [EC:6.3.2.14 2.7.8.7]
y3419  [KO:K12241]
Compound
C00196  2,3-Dihydroxybenzoate
C00251  Chorismate
C00805  Salicylate
C00885  Isochorismate
C04171  (2S,3S)-2,3-Dihydro-2,3-dihydroxybenzoate
C05821  Enterochelin
C06769  Vibriobactin
C12037  Pyochelin
C12038  Yersiniabactin
C12216  Mycobactin S
C12219  Corynebactin
C12220  Myxochelin A
C12221  Myxochelin B
Reference
PMID:12040125
  Authors
Crosa JH, Walsh CT.
  Title
Genetics and assembly line enzymology of siderophore biosynthesis in bacteria.
  Journal
Microbiol Mol Biol Rev 66:223-49 (2002)
DOI:10.1128/MMBR.66.2.223-249.2002
Reference
PMID:9818149
  Authors
Gehring AM, DeMoll E, Fetherston JD, Mori I, Mayhew GF, Blattner FR, Walsh CT, Perry RD.
  Title
Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.
  Journal
Chem Biol 5:573-86 (1998)
DOI:10.1016/S1074-5521(98)90115-6
Reference
PMID:11029592
  Authors
Silakowski B, Kunze B, Nordsiek G, Blocker H, Hofle G, Muller R.
  Title
The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15.
  Journal
Eur J Biochem 267:6476-85 (2000)
DOI:10.1046/j.1432-1327.2000.01740.x
Reference
PMID:11112537
  Authors
Keating TA, Marshall CG, Walsh CT.
  Title
Vibriobactin biosynthesis in Vibrio cholerae: VibH is an amide synthase homologous to nonribosomal peptide synthetase condensation domains.
  Journal
Biochemistry 39:15513-21 (2000)
DOI:10.1021/bi001651a
Reference
PMID:10692387
  Authors
Hantash FM, Earhart CF.
  Title
Membrane association of the Escherichia coli enterobactin synthase proteins EntB/G, EntE, and EntF.
  Journal
J Bacteriol 182:1768-73 (2000)
DOI:10.1128/JB.182.6.1768-1773.2000
Related
pathway
ypk00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
ko01053   

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