{
	"name":"aaa02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"Acav_2571 PAS\/PAC sensor signal transduction histidine kinase\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"Acav_2572 two component transcriptional regulator PhoB, winged helix family\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"Acav_1630 integral membrane sensor signal transduction histidine kinase\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"Acav_1631 two component transcriptional regulator, winged helix family\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)",
			"children":[
			{
				"name":"Acav_0384 integral membrane sensor signal transduction histidine kinase\tK07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]"
			},
			{
				"name":"Acav_0385 two component transcriptional regulator, winged helix family\tK07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB"
			}
			]
		},
		{
			"name":"BaeS-BaeR (envelope stress response)",
			"children":[
			{
				"name":"Acav_1533 integral membrane sensor signal transduction histidine kinase\tK07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]"
			},
			{
				"name":"Acav_1532 two component transcriptional regulator, winged helix family\tK07664 baeR; two-component system, OmpR family, response regulator BaeR"
			}
			]
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"Acav_0428 Osmosensitive K channel His kinase sensor\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"Acav_0429 two component transcriptional regulator, winged helix family\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)",
			"children":[
			{
				"name":"Acav_0816 integral membrane sensor signal transduction histidine kinase\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"Acav_2284 integral membrane sensor signal transduction histidine kinase\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"Acav_4007 integral membrane sensor signal transduction histidine kinase\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"Acav_2285 two component transcriptional regulator, winged helix family\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			}
			]
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR",
			"children":[
			{
				"name":"Acav_2685 integral membrane sensor signal transduction histidine kinase\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
			},
			{
				"name":"Acav_2684 two component transcriptional regulator, winged helix family\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
			}
			]
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"Acav_3863 integral membrane sensor signal transduction histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"Acav_4497 histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"Acav_0051 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_0815 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_1981 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_3302 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_3720 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_3864 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_4008 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_4498 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_4503 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"Acav_4570 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)",
			"children":[
			{
				"name":"Acav_0624 signal transduction histidine kinase, nitrate\/nitrite-specific, NarQ\tK07673 narX; two-component system, NarL family, nitrate\/nitrite sensor histidine kinase NarX [EC:2.7.13.3]"
			},
			{
				"name":"Acav_0625 two component transcriptional regulator, LuxR family\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			}
			]
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)",
			"children":[
			{
				"name":"Acav_3770 two component transcriptional regulator, LuxR family\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			},
			{
				"name":"Acav_4279 two component transcriptional regulator, LuxR family\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			}
			]
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"Acav_1119 integral membrane sensor signal transduction histidine kinase\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"Acav_4112 integral membrane sensor signal transduction histidine kinase\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)",
			"children":[
			{
				"name":"Acav_3217 integral membrane sensor signal transduction histidine kinase\tK08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]"
			},
			{
				"name":"Acav_3218 two component transcriptional regulator, LytTR family\tK08083 algR; two-component system, LytTR family, response regulator AlgR"
			}
			]
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"Acav_1483 signal transduction histidine kinase, nitrogen specific, NtrB\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"Acav_1484 nitrogen metabolism transcriptional regulator, NtrC, Fis Family\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)",
			"children":[
			{
				"name":"Acav_4442 multi-sensor signal transduction histidine kinase\tK13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]"
			},
			{
				"name":"Acav_4441 two component transcriptional regulator, Fis family\tK13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX"
			}
			]
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)",
			"children":[
			{
				"name":"Acav_3259 two component, sigma54 specific, transcriptional regulator, Fis family\tK07714 atoC; two-component system, NtrC family, response regulator AtoC"
			}
			]
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)",
			"children":[
			{
				"name":"Acav_0799 integral membrane sensor signal transduction histidine kinase\tK02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]"
			},
			{
				"name":"Acav_0798 two component, sigma54 specific, transcriptional regulator, Fis family\tK02667 pilR; two-component system, NtrC family, response regulator PilR"
			}
			]
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)",
			"children":[
			{
				"name":"Acav_0806 integral membrane sensor signal transduction histidine kinase\tK07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]"
			},
			{
				"name":"Acav_0804 putative two component, sigma54 specific, transcriptional regulator\tK07715 glrR; two-component system, NtrC family, response regulator GlrR"
			}
			]
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"Acav_0284 ATP-binding region ATPase domain protein\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"Acav_0285 two component, sigma54 specific, transcriptional regulator, Fis family\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			}
			]
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"Acav_3030 CheA signal transduction histidine kinase\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"Acav_3454 CheA signal transduction histidine kinase\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"Acav_4275 CheA signal transduction histidine kinase\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"Acav_3026 response regulator receiver protein\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Acav_3452 response regulator receiver protein\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Acav_4276 response regulator receiver protein\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Acav_4305 response regulator receiver protein\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"Acav_3461 response regulator receiver modulated CheB methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"Acav_3897 CheB methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"Acav_4271 response regulator receiver modulated CheB methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"Acav_2794 signal transduction histidine kinase with CheB and CheR activity\tK13924 cheBR; two-component system, chemotaxis family, CheB\/CheR fusion protein [EC:2.1.1.80 3.1.1.61]"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)",
			"children":[
			{
				"name":"Acav_0854 CheA signal transduction histidine kinase\tK06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase\/response regulator)"
			},
			{
				"name":"Acav_0850 response regulator receiver protein\tK02657 pilG; twitching motility two-component system response regulator PilG"
			},
			{
				"name":"Acav_0851 response regulator receiver protein\tK02658 pilH; twitching motility two-component system response regulator PilH"
			}
			]
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)",
			"children":[
			{
				"name":"Acav_2318 multi-sensor signal transduction histidine kinase\tK11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)",
			"children":[
			{
				"name":"Acav_2111 PAS\/PAC sensor hybrid histidine kinase\tK13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]"
			},
			{
				"name":"Acav_3895 response regulator receiver protein\tK13589 cpdR; two-component system, cell cycle response regulator CpdR"
			}
			]
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"Acav_4590 multi-sensor signal transduction histidine kinase\tK11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]"
			},
			{
				"name":"Acav_4589 two component transcriptional regulator, LuxR family\tK11712 dctR; two-component system, LuxR family, response regulator DctR"
			}
			]
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)",
			"children":[
			{
				"name":"Acav_2924 integral membrane sensor signal transduction histidine kinase\tK15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]"
			},
			{
				"name":"Acav_2925 two component transcriptional regulator, Fis family\tK15012 regA; two-component system, response regulator RegA"
			}
			]
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT",
			"children":[
			{
				"name":"Acav_2998 response regulator receiver and ANTAR domain protein\tK07183 nasT; two-component system, response regulator \/ RNA-binding antiterminator"
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"Acav_3096 multi-sensor hybrid histidine kinase\tK11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]"
			}
			]
		}
		]
	}
	]
}